DE69838250T2 - Voraussage koronarer arterienerkrankung - Google Patents
Voraussage koronarer arterienerkrankung Download PDFInfo
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- DE69838250T2 DE69838250T2 DE69838250T DE69838250T DE69838250T2 DE 69838250 T2 DE69838250 T2 DE 69838250T2 DE 69838250 T DE69838250 T DE 69838250T DE 69838250 T DE69838250 T DE 69838250T DE 69838250 T2 DE69838250 T2 DE 69838250T2
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- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/32—Cardiovascular disorders
- G01N2800/324—Coronary artery diseases, e.g. angina pectoris, myocardial infarction
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- Gastroenterology & Hepatology (AREA)
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- Food Science & Technology (AREA)
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- General Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7820383B2 (en) | 1997-03-10 | 2010-10-26 | Interleukin Genetics, Inc. | Method for diagnosing myocardial infarction |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6210877B1 (en) * | 1997-03-10 | 2001-04-03 | Interleukin Genetics, Inc. | Prediction of coronary artery disease |
| US6524795B1 (en) | 1997-03-10 | 2003-02-25 | Interleukin Genetics, Inc. | Diagnostics for cardiovascular disorders |
| US6720141B1 (en) | 1999-11-01 | 2004-04-13 | Interleukin Genetics, Inc. | Diagnostics and therapeutics for restenosis |
| US20050282198A1 (en) * | 1997-05-29 | 2005-12-22 | Interleukin Genetics, Inc. | Diagnostics and therapeutics for diseases associated with an IL-1 inflammatory haplotype |
| GB9711040D0 (en) * | 1997-05-29 | 1997-07-23 | Duff Gordon W | Prediction of inflammatory disease |
| US6437216B1 (en) | 1997-11-13 | 2002-08-20 | Interleukin Genetics Inc. | Transgenic models of inflammatory disease |
| GB9723835D0 (en) * | 1997-11-13 | 1998-01-07 | Nicklin Martin | Interleukin knockout |
| US6746839B1 (en) * | 1998-01-12 | 2004-06-08 | Interleukin Genetics, Inc. | Diagnostics and therapeutics for an obstructive airway disease |
| US20050032077A1 (en) * | 1998-03-10 | 2005-02-10 | Duff Gordon W. | Detecting genetic predisposition to sight-threatening diabetic retinopathy |
| US6733967B1 (en) | 1998-04-21 | 2004-05-11 | Interleukin Genetics, Inc. | Fetal testing for prediction of low birth weight |
| WO1999054707A2 (en) * | 1998-04-21 | 1999-10-28 | Interleukin Genetics, Inc. | Fetal testing for prediction of low birth weight |
| US6251598B1 (en) | 1998-10-30 | 2001-06-26 | Interleukin Genetics, Inc. | Methods for diagnosing sepsis |
| JP2003500005A (ja) * | 1999-02-10 | 2003-01-07 | インターリューキン ジェネティックス インコーポレイテッド | ＩＬ−１β遺伝子の突然変異に基づく治療および診断 |
| JP2003500069A (ja) * | 1999-05-24 | 2003-01-07 | インタールーキン ジェネティックス インク | 再狭窄の診断及び治療薬 |
| JP2003508022A (ja) * | 1999-06-30 | 2003-03-04 | インターリューキン ジェネティックス インコーポレイテッド | Ｉｌ−１炎症性ハプロタイプと関連する病気の診断および治療方法 |
| US20030152947A1 (en) * | 2001-06-15 | 2003-08-14 | Crossman David C. | Methods for detecting and treating the early onset of aging-related conditions |
| EP1463745A4 (en) * | 2001-11-19 | 2007-11-07 | Interleukin Genetics Inc | FUNCTIONAL POLYMORPHISMS OF THE INTERLEUKIN-1 SITE AFFECTING TRANSCRIPTION AND SUSCEPTIBILITY TO INFLAMMATORY AND INFECTIOUS DISEASES |
| US20080311581A1 (en) * | 2001-11-19 | 2008-12-18 | David Wyllie | Functional polymorphisms of the interleukin-1 locus affecting transcription and susceptibility to inflammatory and infectious diseases |
| EP1327639A1 (en) * | 2002-01-15 | 2003-07-16 | Bayer Ag | Prediction of cardiovascular disease by genetic polymorphisms in cardiovascular associated genes |
| WO2003064600A2 (en) * | 2002-01-25 | 2003-08-07 | Interleukin Genetics, Inc. | The il-1 gene cluster and associated inflammatory polymorphisms and haplotypes |
| US20070264645A1 (en) * | 2002-01-25 | 2007-11-15 | Kenneth Kornman | IL-1 gene cluster and associated inflammatory polymorphisms and haplotypes |
| BR0314552A (pt) * | 2002-09-30 | 2005-08-09 | Novartis Ag | Métodos para prognosticar elevações de colesterol durante terapia imunossupressora |
| US20050053956A1 (en) * | 2002-11-13 | 2005-03-10 | Dietz Harry C. | Detection of a predisposition for the development of coronary artery disease |
| US20060204962A1 (en) * | 2003-02-03 | 2006-09-14 | Udo Stropp | Genetic polymorphisms as predictive diagnostics for adverse drug reactions (adr) and drug efficacy |
| WO2004081186A2 (en) * | 2003-03-10 | 2004-09-23 | Applera Corporation | Single nucleotide polymorphisms associated with stenosis, methods of detection and uses thereof |
| CA2566257A1 (en) * | 2004-05-07 | 2005-11-24 | Applera Corporation | Genetic polymorphisms associated with vascular diseases, methods of detection and uses thereof |
| US7597884B2 (en) | 2004-08-09 | 2009-10-06 | Alios Biopharma, Inc. | Hyperglycosylated polypeptide variants and methods of use |
| US8105775B2 (en) * | 2005-10-25 | 2012-01-31 | Interleukin Genetics, Inc. | IL-1 gene cluster and associated inflammatory polymorphisms and haplotypes |
| RU2310862C1 (ru) * | 2006-05-02 | 2007-11-20 | Государственное образовательное учреждение высшего профессионального образования "Тверская государственная медицинская академия Федерального агентства по здравоохранению и социальному развитию" | Способ выявления риска развития ишемической болезни сердца |
| US7935498B2 (en) * | 2006-07-07 | 2011-05-03 | Siemens Healthcare Diagnostics Inc. | Methods for identifying patients with increased risk of an adverse cardiovascular event |
| WO2008060627A2 (en) * | 2006-11-15 | 2008-05-22 | Interleukin Genetics, Inc. | The il-1 gene cluster, insulin resistance and coronary artery disease associated polymorphisms and haplotypes and methods of using same |
| US20090170105A1 (en) * | 2007-11-08 | 2009-07-02 | Interleukin Genetics, Inc. | Diagnostics for Aging-Related Dermatologic Disorders |
| US20100112570A1 (en) * | 2008-10-22 | 2010-05-06 | Interleukin Genetics, Inc. | Genetic Markers for Weight Management and Methods of Use Thereof |
| CN102747075B (zh) * | 2012-06-07 | 2014-07-23 | 中国医学科学院阜外心血管病医院 | 与冠心病相关的6号染色体易感区域标签单核苷酸多态性位点及其组成的单体型与应用 |
| CA3011363A1 (en) | 2016-01-12 | 2017-07-20 | Interleukin Genetics, Inc. | Methods for predicting response to treatment |
| CN106202936A (zh) * | 2016-07-13 | 2016-12-07 | 为朔医学数据科技（北京）有限公司 | 一种疾病风险预测方法及系统 |
| US10329620B2 (en) | 2017-01-12 | 2019-06-25 | Cardioforecast Ltd. | Methods and kits for treating cardiovascular disease |
| CA3142662A1 (en) | 2019-06-06 | 2020-12-10 | Sitokine Limited | Compositions and methods for treating lung, colorectal and breast cancer |
| CN110277137B (zh) * | 2019-06-13 | 2022-03-18 | 南方医科大学顺德医院(佛山市顺德区第一人民医院) | 一种用于检测冠心病的基因芯片信息处理系统及方法 |
| WO2021028469A1 (en) | 2019-08-12 | 2021-02-18 | Sitokine Limited | Compositions and methods for treating cytokine release syndrome and neurotoxicity |
| WO2021205013A1 (en) | 2020-04-09 | 2021-10-14 | Sitokine Limited | Compositions and methods for treating covid-19 |
Family Cites Families (12)
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| US5110920A (en) | 1982-01-22 | 1992-05-05 | Cetus Corporation | HLA typing method and DNA probes used therein |
| US4582788A (en) | 1982-01-22 | 1986-04-15 | Cetus Corporation | HLA typing method and cDNA probes used therein |
| US4623619A (en) | 1982-03-03 | 1986-11-18 | Nordisk Insulinlaboratorium | Method for the determination of liability in human individuals to develop atherosclerosis |
| US4666828A (en) | 1984-08-15 | 1987-05-19 | The General Hospital Corporation | Test for Huntington's disease |
| US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| US4801531A (en) | 1985-04-17 | 1989-01-31 | Biotechnology Research Partners, Ltd. | Apo AI/CIII genomic polymorphisms predictive of atherosclerosis |
| US5268267A (en) | 1987-08-21 | 1993-12-07 | The General Hospital Corporation | Method for diagnosing small cell carcinoma |
| GB9301453D0 (en) * | 1993-01-26 | 1993-03-17 | Clonit Spa | Nucleotide proves |
| US5658729A (en) | 1994-10-11 | 1997-08-19 | The University Of British Columbia | Method, reagent and kit for evaluating susceptibility to premature atherosclerosis |
| US5686246A (en) | 1995-08-03 | 1997-11-11 | Kornman; Kenneth S. | Detecting genetic predisposition to periodontal disease |
| US5698399A (en) | 1996-04-05 | 1997-12-16 | Duff; Gordon W. | Detecting genetic predisposition for osteoporosis |
| US6210877B1 (en) * | 1997-03-10 | 2001-04-03 | Interleukin Genetics, Inc. | Prediction of coronary artery disease |
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1998
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- 1998-03-09 WO PCT/US1998/004725 patent/WO1998040517A1/en not_active Ceased
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- 1998-03-09 EA EA199900813A patent/EA199900813A1/ru unknown
- 1998-03-09 BR BR9808313-9A patent/BR9808313A/pt not_active Application Discontinuation
- 1998-03-09 PT PT98910298T patent/PT983381E/pt unknown
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- 1998-03-09 EP EP98910298A patent/EP0983381B1/en not_active Expired - Lifetime
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2008
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7820383B2 (en) | 1997-03-10 | 2010-10-26 | Interleukin Genetics, Inc. | Method for diagnosing myocardial infarction |
Also Published As
| Publication number | Publication date |
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| JP2009077727A (ja) | 2009-04-16 |
| EP0983381A1 (en) | 2000-03-08 |
| ES2156843T1 (es) | 2001-08-01 |
| EP0983381B1 (en) | 2007-08-15 |
| CN100523214C (zh) | 2009-08-05 |
| EA199900813A1 (ru) | 2000-06-26 |
| PL335603A1 (en) | 2000-05-08 |
| CA2282746A1 (en) | 1998-09-17 |
| ES2156843T3 (es) | 2008-04-16 |
| ATE370246T1 (de) | 2007-09-15 |
| US6210877B1 (en) | 2001-04-03 |
| JP2001514522A (ja) | 2001-09-11 |
| PT983381E (pt) | 2007-11-26 |
| CN1255948A (zh) | 2000-06-07 |
| WO1998040517A1 (en) | 1998-09-17 |
| EP0983381A4 (en) | 2004-05-12 |
| AU6457498A (en) | 1998-09-29 |
| NO994365D0 (no) | 1999-09-09 |
| DK0983381T3 (da) | 2007-12-17 |
| NO994365L (no) | 1999-11-09 |
| NZ337642A (en) | 2001-02-23 |
| DE69838250D1 (de) | 2007-09-27 |
| CA2282746C (en) | 2009-02-24 |
| MXPA99008223A (es) | 2003-07-21 |
| JP4250765B2 (ja) | 2009-04-08 |
| AU738875B2 (en) | 2001-09-27 |
| IL131745A0 (en) | 2001-03-19 |
| DE983381T1 (de) | 2000-11-09 |
| ZA981937B (en) | 1999-09-06 |
| BR9808313A (pt) | 2000-05-16 |
| AR011943A1 (es) | 2000-09-13 |
| GR20010300016T1 (en) | 2001-04-30 |
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