DE69835776D1 - Gerät und Verfahren zur Mikroskopie unter Verwendung räumlich modulierten Lichtes - Google Patents

Gerät und Verfahren zur Mikroskopie unter Verwendung räumlich modulierten Lichtes

Info

Publication number
DE69835776D1
DE69835776D1 DE69835776T DE69835776T DE69835776D1 DE 69835776 D1 DE69835776 D1 DE 69835776D1 DE 69835776 T DE69835776 T DE 69835776T DE 69835776 T DE69835776 T DE 69835776T DE 69835776 D1 DE69835776 D1 DE 69835776D1
Authority
DE
Germany
Prior art keywords
light
sample
microscopy
illumination
image plane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69835776T
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English (en)
Other versions
DE69835776T2 (de
Inventor
E Macaulay
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MOTIC CHINA GROUP CO., LTD., XIAMEN, CN
Original Assignee
Macaulay Calum E
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Macaulay Calum E filed Critical Macaulay Calum E
Publication of DE69835776D1 publication Critical patent/DE69835776D1/de
Application granted granted Critical
Publication of DE69835776T2 publication Critical patent/DE69835776T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/36Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/0004Microscopes specially adapted for specific applications
    • G02B21/002Scanning microscopes
    • G02B21/0024Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052Optical details of the image generation
    • G02B21/006Optical details of the image generation focusing arrangements; selection of the plane to be imaged
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/0004Microscopes specially adapted for specific applications
    • G02B21/002Scanning microscopes
    • G02B21/0024Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052Optical details of the image generation
    • G02B21/0072Optical details of the image generation details concerning resolution or correction, including general design of CSOM objectives
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/06Means for illuminating specimens
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B26/00Optical devices or arrangements for the control of light using movable or deformable optical elements
    • G02B26/08Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light
    • G02B26/0816Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light by means of one or more reflecting elements
    • G02B26/0833Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light by means of one or more reflecting elements the reflecting element being a micromechanical device, e.g. a MEMS mirror, DMD
    • G02B26/0841Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light by means of one or more reflecting elements the reflecting element being a micromechanical device, e.g. a MEMS mirror, DMD the reflecting element being moved or deformed by electrostatic means
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S359/00Optical: systems and elements
    • Y10S359/90Methods

Landscapes

  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Multimedia (AREA)
  • Microscoopes, Condenser (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
DE69835776T 1997-10-29 1998-10-27 Gerät und Verfahren zur Mikroskopie unter Verwendung räumlich modulierten Lichtes Expired - Lifetime DE69835776T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6389397P 1997-10-29 1997-10-29
US63893P 1997-10-29

Publications (2)

Publication Number Publication Date
DE69835776D1 true DE69835776D1 (de) 2006-10-12
DE69835776T2 DE69835776T2 (de) 2007-08-30

Family

ID=22052206

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69806496T Expired - Lifetime DE69806496T2 (de) 1997-10-29 1998-10-27 Gerät und verfahren zur mikroskopie unter verwendung räumlich modulierten lichtes
DE69835776T Expired - Lifetime DE69835776T2 (de) 1997-10-29 1998-10-27 Gerät und Verfahren zur Mikroskopie unter Verwendung räumlich modulierten Lichtes

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69806496T Expired - Lifetime DE69806496T2 (de) 1997-10-29 1998-10-27 Gerät und verfahren zur mikroskopie unter verwendung räumlich modulierten lichtes

Country Status (8)

Country Link
US (4) US6483641B1 (de)
EP (3) EP1207415B1 (de)
JP (1) JP4372996B2 (de)
AT (1) ATE220465T1 (de)
AU (1) AU9617598A (de)
CA (1) CA2307315C (de)
DE (2) DE69806496T2 (de)
WO (1) WO1999022262A1 (de)

Families Citing this family (136)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1207415B1 (de) * 1997-10-29 2006-08-30 MacAulay, Calum, E. Gerät und Verfahren zur Mikroskopie unter Verwendung räumlich modulierten Lichtes
DE69730030T2 (de) * 1997-11-17 2005-07-21 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Konfokales Spektroskopiesystem und -verfahren
SE9800665D0 (sv) 1998-03-02 1998-03-02 Micronic Laser Systems Ab Improved method for projection printing using a micromirror SLM
US6220730B1 (en) 1998-07-01 2001-04-24 Light & Sound Design, Ltd. Illumination obscurement device
US6734962B2 (en) 2000-10-13 2004-05-11 Chemimage Corporation Near infrared chemical imaging microscope
WO2001029265A1 (en) * 1999-10-15 2001-04-26 Ventana Medical Systems, Inc. Method of detecting single gene copies in-situ
US6663560B2 (en) 1999-12-17 2003-12-16 Digital Optical Imaging Corporation Methods and apparatus for imaging using a light guide bundle and a spatial light modulator
ES2252083T3 (es) * 1999-12-17 2006-05-16 Digital Optical Imaging Corporation Metodos y aparatos para imagenes usando un haz de guias de luz y un modulador espacial de luz.
US6922483B2 (en) * 1999-12-28 2005-07-26 Texas Instruments Incorporated Methods for measuring DMD low frequency spatial uniformity
US20030017491A1 (en) * 2000-09-14 2003-01-23 Zuo-Rong Shi Chromogenic in situ hybridization methods, kits, and compositions
EP1953580B1 (de) * 2000-09-18 2014-09-17 Vincent Lauer Vorrichtung zur konfokalen optischen Abtastung
WO2002053020A2 (de) * 2001-01-03 2002-07-11 Walthard Vilser Vorrichtung und verfahren zur bildgebung, stimulierung, messung und therapie insbesondere am auge
US20020122237A1 (en) * 2001-03-01 2002-09-05 Torbjorn Sandstrom Method and apparatus for spatial light modulation
EP1397668A2 (de) * 2001-06-06 2004-03-17 Digital Optical Imaging Corporation Mikroarray-leser mit moduliertem licht und darauf bezogene methoden
US20030020958A1 (en) * 2001-07-30 2003-01-30 Bean Heather Noel Non-polarizing shutter/CCD module
DE10155142C2 (de) 2001-11-12 2003-09-04 Friz Biochem Gmbh Dunkelfeld-Abbildungsvorrichtung zur ortsaufgelösten Dunkelfeldabbildung einer flächigen Probe
US7180660B2 (en) * 2002-02-04 2007-02-20 Carl-Zeiss-Stiftung Trading As Carl Zeiss Stereo-examination systems and stereo-image generation apparatus as well as a method for operating the same
US7508608B2 (en) * 2004-11-17 2009-03-24 Illumina, Inc. Lithographically fabricated holographic optical identification element
US7923260B2 (en) 2002-08-20 2011-04-12 Illumina, Inc. Method of reading encoded particles
US7901630B2 (en) * 2002-08-20 2011-03-08 Illumina, Inc. Diffraction grating-based encoded microparticle assay stick
US7619819B2 (en) * 2002-08-20 2009-11-17 Illumina, Inc. Method and apparatus for drug product tracking using encoded optical identification elements
US7164533B2 (en) * 2003-01-22 2007-01-16 Cyvera Corporation Hybrid random bead/chip based microarray
US7872804B2 (en) * 2002-08-20 2011-01-18 Illumina, Inc. Encoded particle having a grating with variations in the refractive index
US7900836B2 (en) * 2002-08-20 2011-03-08 Illumina, Inc. Optical reader system for substrates having an optically readable code
US20100255603A9 (en) * 2002-09-12 2010-10-07 Putnam Martin A Method and apparatus for aligning microbeads in order to interrogate the same
EP1575707A1 (de) * 2002-09-12 2005-09-21 Cyvera Corporation Verfahren und vorrichtung zur ausrichtung von länglichen mikroperlen zu deren untersuchung
US7092160B2 (en) * 2002-09-12 2006-08-15 Illumina, Inc. Method of manufacturing of diffraction grating-based optical identification element
US7339148B2 (en) * 2002-12-16 2008-03-04 Olympus America Inc. Confocal microscope
JP4003129B2 (ja) * 2003-01-22 2007-11-07 ソニー株式会社 立体撮像装置、立体表示装置、立体撮像表示装置および情報記録方法
DE10306067A1 (de) * 2003-02-13 2004-09-02 Schwind Eye-Tech-Solutions Gmbh & Co. Kg Vorrichtung und Verfahren zum Beleuchten eines Auges
AU2003900902A0 (en) * 2003-02-27 2003-03-13 Varian Australia Pty Ltd Spectrophotometer
JP2004309702A (ja) * 2003-04-04 2004-11-04 Olympus Corp 顕微鏡
US7302109B2 (en) * 2003-08-28 2007-11-27 General Electric Company Method and system for image processing for structured light profiling of a part
US20060057729A1 (en) * 2003-09-12 2006-03-16 Illumina, Inc. Diffraction grating-based encoded element having a substance disposed thereon
US7532323B2 (en) * 2003-10-28 2009-05-12 Cha-Min Tang Spatial light modulator apparatus and method
DE10352040A1 (de) * 2003-11-07 2005-07-21 Carl Zeiss Sms Gmbh In Lage, Form und/oder den optischen Eigenschaften veränderbare Blenden-und/oder Filteranordnung für optische Geräte, insbesondere Mikroskope
US6853454B1 (en) 2004-01-15 2005-02-08 Alpha Innotech Corporation Optical analysis systems
US6995901B2 (en) * 2004-01-15 2006-02-07 Alpha Innotech Corporation Optical analysis systems
US20050157299A1 (en) * 2004-01-15 2005-07-21 Heffelfinger David M. Optical analysis systems
US7433123B2 (en) * 2004-02-19 2008-10-07 Illumina, Inc. Optical identification element having non-waveguide photosensitive substrate with diffraction grating therein
DE602005007403D1 (de) * 2004-03-25 2008-07-24 Olympus Corp Scannendes konfokales Mikroskop
DE102004016253B4 (de) 2004-04-02 2006-02-23 Leica Microsystems Cms Gmbh Rastermikroskop und Verfahren zur rastermikroskopischen Untersuchung einer Probe
US7720264B2 (en) * 2004-05-10 2010-05-18 Avago Technologies General Ip (Singapore) Pte. Ltd. Method and system for pupil detection for security applications
US7580126B2 (en) * 2004-06-30 2009-08-25 Chemimage Corp. Method and apparatus for producing a streaming Raman image of nucleation, aggregation, and chemical interaction
US7394542B2 (en) 2004-08-18 2008-07-01 Chemimage Corporation Method and apparatus for chemical imaging in a microfluidic circuit
US20060098194A1 (en) * 2004-11-08 2006-05-11 David Tuschel Method and apparatus for determining change in an attribute of a sample during nucleation, aggregation, or chemical interaction
US7046359B2 (en) * 2004-06-30 2006-05-16 Chemimage Corporation System and method for dynamic chemical imaging
JP2006023221A (ja) * 2004-07-09 2006-01-26 Tokyo Seimitsu Co Ltd 外観検査装置及び投影方法
US7218822B2 (en) * 2004-09-03 2007-05-15 Chemimage Corporation Method and apparatus for fiberscope
JP4425098B2 (ja) * 2004-09-06 2010-03-03 浜松ホトニクス株式会社 蛍光顕微鏡および蛍光相関分光解析装置
US7136209B2 (en) * 2004-10-20 2006-11-14 Hewlett-Packard Development Company, L.P. Light modulators
DE102004051969A1 (de) * 2004-10-25 2006-05-04 Deutsches Zentrum für Luft- und Raumfahrt e.V. Optisches System mit veränderlichen Abbildungseigenschaften und Verfahren zur Einstellung veränderlicher Abbildungseigenschaften
US7604173B2 (en) * 2004-11-16 2009-10-20 Illumina, Inc. Holographically encoded elements for microarray and other tagging labeling applications, and method and apparatus for making and reading the same
DE602005019791D1 (de) * 2004-11-16 2010-04-15 Illumina Inc Verfahren und vorrichtung zum lesen von kodierten mikrokugeln
US7602952B2 (en) * 2004-11-16 2009-10-13 Illumina, Inc. Scanner having spatial light modulator
US7436524B2 (en) * 2004-11-26 2008-10-14 Olympus Corporation Apparatus and method for three-dimensional measurement and program for allowing computer to execute method for three-dimensional measurement
JP2006154290A (ja) * 2004-11-29 2006-06-15 Hamamatsu Univ School Of Medicine 蛍光顕微鏡システム
US8346346B1 (en) * 2005-01-24 2013-01-01 The Board Of Trustees Of The Leland Stanford Junior University Optical analysis system and approach therefor
US7307774B1 (en) * 2005-01-24 2007-12-11 The Board Of Trustees Of The Leland Standford Junior University Micro-optical analysis system and approach therefor
WO2006085894A1 (en) * 2005-01-31 2006-08-17 Chemimage Corporation Apparatus and method for chemical imaging of a biological sample
US7060955B1 (en) 2005-01-31 2006-06-13 Chemimage Corporation Apparatus and method for defining illumination parameters of a sample
US20060170916A1 (en) * 2005-01-31 2006-08-03 Voigt Thomas C Method and apparatus for variable-field illumination
US7283241B2 (en) * 2005-01-31 2007-10-16 Chemimage Corp. Method and apparatus for a microscope image selector
DE102005009188A1 (de) * 2005-03-01 2006-09-07 Carl Zeiss Jena Gmbh Punktscannendes Laser-Scanning-Mikroskop sowie Verfahren zur Einstellung eines Mikroskopes
US20060221335A1 (en) * 2005-04-04 2006-10-05 Bangalore Arjun S Method and apparatus for interactive hyperspectral image subtraction
US7956991B2 (en) 2005-04-04 2011-06-07 Chemimage Corporation Method and apparatus for interactive hyperspectral image subtraction
JP4894161B2 (ja) * 2005-05-10 2012-03-14 株式会社ニコン 共焦点顕微鏡
TWI301207B (en) 2005-06-13 2008-09-21 Chen Wei Chiu Image system and miniature deformable mirror thereof
JP4837325B2 (ja) * 2005-07-26 2011-12-14 オリンパス株式会社 顕微鏡照明装置
US20070109667A1 (en) * 2005-08-25 2007-05-17 Chen-Wei Chiu Optical focus system and zoom system including at least one deformable mirror therein
US7593156B2 (en) * 2005-08-26 2009-09-22 Leica Microsystems (Schweiz) Ag Microscope with micro-mirrors for optional deflection and/or beam splitting
DE102005040471B4 (de) * 2005-08-26 2007-06-21 Leica Microsystems (Schweiz) Ag Mikroskop
US8504140B2 (en) * 2008-04-08 2013-08-06 Bruker Biospin Corporation Apparatus and method for fluorescence imaging and tomography using spatially structured illumination
DE102005046753A1 (de) * 2005-09-29 2007-04-12 Carl Zeiss Jena Gmbh Mikroskopierverfahren und Mikroskop
US8179296B2 (en) * 2005-09-30 2012-05-15 The Massachusetts Institute Of Technology Digital readout method and apparatus
DE102005047593A1 (de) * 2005-10-05 2007-04-12 Carl Zeiss Jena Gmbh Vorrichtung zur Variation und Einstellung der Durchlichtbeleuchtung für Mikroskope
DE102005049378A1 (de) * 2005-10-12 2007-04-19 Carl Zeiss Jena Gmbh Automatisches Mikroskop
US8024406B1 (en) 2005-11-18 2011-09-20 Convergys Cmg Utah, Inc. System and method for dispensing e-Care
US7623624B2 (en) * 2005-11-22 2009-11-24 Illumina, Inc. Method and apparatus for labeling using optical identification elements characterized by X-ray diffraction
US7830575B2 (en) * 2006-04-10 2010-11-09 Illumina, Inc. Optical scanner with improved scan time
US7764424B2 (en) * 2006-05-15 2010-07-27 Olympus Corporation Light source apparatus and microscope apparatus
US7460248B2 (en) * 2006-05-15 2008-12-02 Carestream Health, Inc. Tissue imaging system
DE102006022592B4 (de) * 2006-05-15 2008-02-07 Leica Microsystems (Schweiz) Ag Mikroskop mit Beleuchtungseinheit
US7764433B2 (en) * 2006-05-18 2010-07-27 The Regents Of The University Of California Method and system for correcting optical aberrations, including widefield imaging applications
DE102006025149A1 (de) * 2006-05-30 2007-12-06 Leica Microsystems (Schweiz) Ag Optisches Gerät mit erhöhter Tiefenschärfe
US20100226495A1 (en) 2007-10-29 2010-09-09 Michael Kelly Digital readout method and apparatus
US7990532B2 (en) 2007-01-16 2011-08-02 Chemimage Corporation Method and apparatus for multimodal detection
WO2008124397A1 (en) * 2007-04-03 2008-10-16 David Fishbaine Inspection system and method
DE102007022218A1 (de) * 2007-05-11 2008-11-13 Robert Bosch Gmbh Objektivanordnung für eine Bildverarbeitung und Verfahren zur Reduzierung von Bildfehlern bei dieser Objektivanordnung
US9395534B2 (en) * 2007-11-27 2016-07-19 Wisconsin Alumni Research Foundation Optical system for correction of tissue induced aberration
CN102084280B (zh) 2008-04-24 2015-07-15 麦克罗尼克迈达塔有限责任公司 具有结构化反射镜表面的空间光调制器
US8077386B2 (en) 2008-10-22 2011-12-13 Microbrightfield, Inc. Movable objective lens assembly for an optical microscope and optical microscopes having such an assembly
JP2012519876A (ja) * 2009-03-05 2012-08-30 エイジェンシー・フォー・サイエンス,テクノロジー・アンド・リサーチ 顕微鏡画像を強調する方法及びシステム
US8730573B2 (en) * 2009-07-09 2014-05-20 Howard Hughes Medical Institute Adaptive optics microscopy with phase control of beamlets of a light beam
US8451450B2 (en) * 2009-09-14 2013-05-28 Bio-Rad Laboratories, Inc. Near real time optical phase conjugation
JP5554965B2 (ja) * 2009-11-06 2014-07-23 オリンパス株式会社 位相変調型空間光変調器を用いたレーザ顕微鏡
JP5393406B2 (ja) * 2009-11-06 2014-01-22 オリンパス株式会社 パターン投影装置、走査型共焦点顕微鏡、及びパターン照射方法
US8497934B2 (en) * 2009-11-25 2013-07-30 Massachusetts Institute Of Technology Actively addressable aperture light field camera
FR2960308B1 (fr) * 2010-05-18 2012-07-27 Thales Sa Systeme optique a correction dynamique de l'image.
EP2439514A1 (de) * 2010-10-01 2012-04-11 Aqsens Oy Verfahren, Vorrichtung und System zur optischen Untersuchung einer in mehreren Vertiefungen enthaltenen Probe
US8649024B2 (en) * 2010-12-03 2014-02-11 Zygo Corporation Non-contact surface characterization using modulated illumination
US8866107B2 (en) 2011-01-19 2014-10-21 Howard Hughes Medical Institute Wavefront compensation for deep tissue optical microscopy
US9069175B2 (en) 2011-04-08 2015-06-30 Kairos Instruments, Llc Adaptive phase contrast microscope
US8531753B1 (en) 2011-05-09 2013-09-10 Los Alamos National Security, Llc Adaptive optical filter
US8237835B1 (en) 2011-05-19 2012-08-07 Aeon Imaging, LLC Confocal imaging device using spatially modulated illumination with electronic rolling shutter detection
EP2535681B1 (de) * 2011-06-17 2016-01-06 Thomson Licensing Vorrichtung zur Schätzung der Tiefe eines Elements einer 3D-Szene
WO2013006188A1 (en) 2011-07-01 2013-01-10 Schultz Kenneth I Methods and apparatus for in-pixel filtering in focal plane arrays
JP6195830B2 (ja) 2011-07-14 2017-09-13 ホワルド フグヘス メドイクアル インストイトウテ 適応光学系を有する顕微鏡検査法
EP2757402B1 (de) * 2013-01-22 2016-03-30 FEI Company Verfahren zum Betrachten von Proben mit einem Fluoreszenzmikroskop
WO2014144053A2 (en) * 2013-03-15 2014-09-18 Intelligent Imaging Innovations, Inc. Multi-channel simultaneous photostimulation
EP2899583A3 (de) 2014-01-26 2015-08-12 Matthew Stefan Muller Periodische Randbildgebung mit strukturierter Musterbeleuchtung und elektronische Rollladenerkennung
DE102014101219A1 (de) * 2014-01-31 2015-08-06 Carl Zeiss Ag Beleuchtungseinrichtung zur Fourier-Ptychographie
WO2015156783A1 (en) * 2014-04-08 2015-10-15 Pandata Research Llc Optical detection system including a micromirror array
US9678326B2 (en) 2014-09-30 2017-06-13 Agilent Technologies Inc. Generating perspective views in microscopy
WO2016141339A1 (en) * 2015-03-04 2016-09-09 Aramco Services Company Adaptive optics for imaging through highly scattering media in oil reservoir applications
US10436409B2 (en) * 2015-05-28 2019-10-08 Texas Instruments Incorporated Methods and apparatus for light efficient programmable headlamp with anamorphic optics
US10386300B2 (en) 2015-12-21 2019-08-20 Verily Life Sciences Llc Spectrally and spatially multiplexed fluorescent probes for in situ cell labeling
EP3414612A4 (de) * 2016-02-11 2020-03-04 Montana State University Mikroskopobjektiv mit integrierter breitfeldkamera und strahlabtastvorrichtung
US10551604B2 (en) 2016-05-27 2020-02-04 Verily Life Sciences Llc Spatial light modulator based hyperspectral confocal microscopes and methods of use
KR101875515B1 (ko) * 2016-11-17 2018-07-10 주식회사 토모큐브 디지털 마이크로미러 소자를 활용한 구조 입사 3차원 굴절률 토모그래피 장치 및 방법
US10976532B2 (en) 2016-06-10 2021-04-13 Tomocube, Inc. Structured illumination microscopy system using digital micromirror device and time-complex structured illumination, and operation method therefor
US11073472B2 (en) 2016-11-14 2021-07-27 Siemens Healthcare Diagnostics Inc. Methods and apparatus for characterizing a specimen using pattern illumination
WO2018168137A1 (ja) * 2017-03-16 2018-09-20 ソニー株式会社 生体物質解析方法、生体物質解析装置、生体物質解析用プログラム及び生体物質解析システム
DE102017207013A1 (de) 2017-04-26 2018-10-31 Carl Zeiss Microscopy Gmbh Verfahren und Vorrichtung zur Regelung von in eine Lochblende eingestrahlten Intensitäten und/oder spektralen Anteilen einer Strahlung
US10712548B2 (en) 2017-06-08 2020-07-14 Microscope International, LLC Systems and methods for rapid scanning of images in digital microscopes
US10444486B2 (en) 2017-09-04 2019-10-15 Microscopes International, Llc Systems and methods for detection of blank fields in digital microscopes
DE102017121291A1 (de) * 2017-09-14 2019-03-14 Carl Zeiss Microscopy Gmbh Bestimmung von Aberrationen mittels Winkel-variabler Beleuchtung
JP7054266B2 (ja) * 2017-10-02 2022-04-13 ナノトロニクス イメージング インコーポレイテッド 顕微鏡撮像における口径食を低減するための装置および方法
WO2019157492A1 (en) 2018-02-12 2019-08-15 Intelligent Imaging Innovations, Inc. Tiling light sheet selective plane illumination microscopy using discontinuous light sheets
CN108519329B (zh) * 2018-03-26 2021-01-15 华中科技大学 一种多路扫描与探测的线共聚焦成像装置
US11112952B2 (en) 2018-03-26 2021-09-07 Microscopes International, Llc Interface for display of multi-layer images in digital microscopy
DE102019110869A1 (de) * 2018-12-21 2020-06-25 Leica Microsystems Cms Gmbh Mikroskop
WO2021008686A1 (en) * 2019-07-16 2021-01-21 Haag-Streit Ag Ophthalmologic slit lamp microscope with a spatial light modulator
CN110658708B (zh) * 2019-09-02 2021-09-07 杭州辰景光电科技有限公司 SLMs阵列拼接方法、拼接件及其拼接架
CN111474699B (zh) * 2020-04-09 2022-08-30 浙江未来技术研究院(嘉兴) 一种可编程孔径的手术显微镜
US11619586B2 (en) 2021-07-08 2023-04-04 X Development Llc System for imaging and selective illumination of targets within a sample

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS503355A (de) * 1973-05-11 1975-01-14
US4561731A (en) 1980-03-10 1985-12-31 Kley Victor B Electronic illumination control
JPS56137324A (en) * 1980-03-10 1981-10-27 Bii Kurei Bikutaa Microscope
US4806776A (en) 1980-03-10 1989-02-21 Kley Victor B Electrical illumination and detecting apparatus
JPH07122694B2 (ja) * 1986-10-16 1995-12-25 オリンパス光学工業株式会社 顕微鏡用照明装置
US5099363A (en) 1987-09-24 1992-03-24 Washington University Method and apparatus for slow aperture scanning in a single aperture confocal scanning EPI-illumination microscope
US4802748A (en) 1987-12-14 1989-02-07 Tracor Northern, Inc. Confocal tandem scanning reflected light microscope
DE3826317C1 (de) * 1988-08-03 1989-07-06 Ernst Leitz Wetzlar Gmbh, 6330 Wetzlar, De
DE3843876A1 (de) * 1988-12-24 1990-07-12 Leitz Wild Gmbh Spektralmikroskop mit einem photometer
JPH03132612A (ja) 1989-10-18 1991-06-06 Fuji Photo Film Co Ltd 共焦点走査型透過顕微鏡
JPH03134608A (ja) * 1989-10-20 1991-06-07 Fuji Photo Film Co Ltd 走査型顕微鏡
US5065008A (en) 1989-10-18 1991-11-12 Fuji Photo Film Co., Ltd. Scanning microscope and scanning mechanism for the same
GB9000740D0 (en) 1990-01-12 1990-03-14 Univ Salford Measurement of luminescence
US5067805A (en) 1990-02-27 1991-11-26 Prometrix Corporation Confocal scanning optical microscope
GB2248964A (en) * 1990-10-17 1992-04-22 Philips Electronic Associated Plural-wavelength infrared detector devices
US5299053A (en) * 1990-10-26 1994-03-29 American Cyanamid Company Variable shutter illumination system for microscope
US5239178A (en) 1990-11-10 1993-08-24 Carl Zeiss Optical device with an illuminating grid and detector grid arranged confocally to an object
FR2673718B1 (fr) * 1991-03-04 1993-05-14 Dilor Appareil de spectrometrie raman.
US5179276A (en) 1991-03-27 1993-01-12 Fuji Photo Film Co., Ltd. Optical scanning type image pickup apparatus and optical scanning type microscope
US5218195A (en) 1991-06-25 1993-06-08 Fuji Photo Film Co., Ltd. Scanning microscope, scanning width detecting device, and magnification indicating apparatus
US5162941A (en) 1991-07-23 1992-11-10 The Board Of Governors Of Wayne State University Confocal microscope
US5280169A (en) * 1992-12-22 1994-01-18 Honey Richard C Method and apparatus for limiting optical radiation intensity at an optical sensor using solid particles oscillating in an electric field
JP3647062B2 (ja) * 1993-05-17 2005-05-11 オリンパス株式会社 正立型顕微鏡
US5559214A (en) * 1993-05-28 1996-09-24 Sterling Winthrop Inc. Unsymmetrical complexing agents and targeting immunoreagents useful in thearpeutic and diagnostic compositions and methods
US5923466A (en) 1993-10-20 1999-07-13 Biophysica Technologies, Inc. Light modulated confocal optical instruments and method
US5587832A (en) 1993-10-20 1996-12-24 Biophysica Technologies, Inc. Spatially light modulated confocal microscope and method
WO1996039619A1 (en) 1995-06-06 1996-12-12 Kla Instruments Corporation Optical inspection of a specimen using multi-channel responses from the specimen
DE19528513A1 (de) 1995-08-03 1997-02-06 Haeusler Gerd Verfahren zur berührungslosen, schnellen und genauen Erfassung der Oberflächengestalt von Objekten
US5742419A (en) 1995-11-07 1998-04-21 The Board Of Trustees Of The Leland Stanford Junior Universtiy Miniature scanning confocal microscope
JPH09184984A (ja) * 1995-12-28 1997-07-15 Ishikawajima Harima Heavy Ind Co Ltd 顕微鏡
GB9603788D0 (en) * 1996-02-22 1996-04-24 Isis Innovation Confocal microscope
US5900949A (en) 1996-05-23 1999-05-04 Hewlett-Packard Company CCD imager for confocal scanning microscopy
US5866430A (en) 1996-06-13 1999-02-02 Grow; Ann E. Raman optrode processes and devices for detection of chemicals and microorganisms
US5812269A (en) 1996-07-29 1998-09-22 General Scanning, Inc. Triangulation-based 3-D imaging and processing method and system
IT1286838B1 (it) 1996-09-25 1998-07-17 Consiglio Nazionale Ricerche Metodo per la raccolta di immagini in microscopia confocale
DE19644662C2 (de) * 1996-10-25 2000-04-13 Leica Microsystems Beleuchtungseinrichtung für ein Mikroskop
US5867251A (en) 1997-05-02 1999-02-02 The General Hospital Corp. Scanning ophthalmoscope with spatial light modulators
US5887009A (en) 1997-05-22 1999-03-23 Optical Biopsy Technologies, Inc. Confocal optical scanning system employing a fiber laser
DE69720458T2 (de) 1997-10-22 2004-02-26 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Programmierbares räumlich lichtmoduliertes Mikroskop und Mikroskopieverfahren
EP1207415B1 (de) 1997-10-29 2006-08-30 MacAulay, Calum, E. Gerät und Verfahren zur Mikroskopie unter Verwendung räumlich modulierten Lichtes
DE69730030T2 (de) 1997-11-17 2005-07-21 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Konfokales Spektroskopiesystem und -verfahren

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US6483641B1 (en) 2002-11-19
ATE220465T1 (de) 2002-07-15
US20070188856A1 (en) 2007-08-16
JP4372996B2 (ja) 2009-11-25
DE69806496T2 (de) 2003-03-13
US20040047030A1 (en) 2004-03-11
CA2307315C (en) 2011-04-05
EP1207414A1 (de) 2002-05-22
WO1999022262A1 (en) 1999-05-06
EP1207415B1 (de) 2006-08-30
EP1207415A1 (de) 2002-05-22
EP1027624A1 (de) 2000-08-16
US7755832B2 (en) 2010-07-13
DE69835776T2 (de) 2007-08-30
AU9617598A (en) 1999-05-17
DE69806496D1 (de) 2002-08-14
JP2001521205A (ja) 2001-11-06
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US20080316571A1 (en) 2008-12-25
EP1027624B1 (de) 2002-07-10

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