DE69833455T2 - Verfahren und zusammensetzungen zur verstärkung der immunantwort und zur in-vitro herstellung von monoklonalen antikörpern (mabs) - Google Patents
Verfahren und zusammensetzungen zur verstärkung der immunantwort und zur in-vitro herstellung von monoklonalen antikörpern (mabs) Download PDFInfo
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- DE69833455T2 DE69833455T2 DE69833455T DE69833455T DE69833455T2 DE 69833455 T2 DE69833455 T2 DE 69833455T2 DE 69833455 T DE69833455 T DE 69833455T DE 69833455 T DE69833455 T DE 69833455T DE 69833455 T2 DE69833455 T2 DE 69833455T2
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Classifications
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6923—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
- A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Nanotechnology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Ceramic Engineering (AREA)
- Inorganic Chemistry (AREA)
- Biophysics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6515597P | 1997-11-10 | 1997-11-10 | |
| US65155P | 1997-11-10 | ||
| US7581198P | 1998-02-24 | 1998-02-24 | |
| US75811P | 1998-02-24 | ||
| US10745598P | 1998-11-06 | 1998-11-06 | |
| US107455P | 1998-11-06 | ||
| PCT/US1998/023957 WO1999024066A2 (en) | 1997-11-10 | 1998-11-10 | Methods and compositions for enhancing immune response and for the production of in vitro mabs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69833455D1 DE69833455D1 (de) | 2006-04-20 |
| DE69833455T2 true DE69833455T2 (de) | 2006-10-19 |
Family
ID=27370737
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69833455T Expired - Lifetime DE69833455T2 (de) | 1997-11-10 | 1998-11-10 | Verfahren und zusammensetzungen zur verstärkung der immunantwort und zur in-vitro herstellung von monoklonalen antikörpern (mabs) |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1039933B8 (enExample) |
| JP (3) | JP4588210B2 (enExample) |
| AT (1) | ATE317269T1 (enExample) |
| AU (3) | AU757357B2 (enExample) |
| CA (1) | CA2309602C (enExample) |
| DE (1) | DE69833455T2 (enExample) |
| NZ (1) | NZ504292A (enExample) |
| WO (1) | WO1999024066A2 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010055581A1 (en) | 1994-03-18 | 2001-12-27 | Lawrence Tamarkin | Composition and method for delivery of biologically-active factors |
| US6407218B1 (en) | 1997-11-10 | 2002-06-18 | Cytimmune Sciences, Inc. | Method and compositions for enhancing immune response and for the production of in vitro mabs |
| US7229841B2 (en) | 2001-04-30 | 2007-06-12 | Cytimmune Sciences, Inc. | Colloidal metal compositions and methods |
| EP1133994A1 (en) * | 2000-03-11 | 2001-09-19 | Biognostik Gesellschaft für biomolekulare Diagnostik mbH | A method for reversing the immunosuppressive effects of the Melanoma Inhibitory Activity "MIA" |
| CA2448607C (en) * | 2001-04-30 | 2013-01-22 | Cytimmune Sciences, Inc. | Colloidal metal compositions and methods |
| JP2008504216A (ja) * | 2003-12-02 | 2008-02-14 | サイトイミューン サイエンシズ インコーポレイテッド | モノクローナル抗体の生成のための方法および組成物 |
| AU2005209318B2 (en) * | 2004-01-28 | 2010-02-11 | Cytimmune Sciences, Inc. | Functionalized colloidal metal compositions and methods |
| KR100836745B1 (ko) * | 2007-01-31 | 2008-06-10 | (주)두비엘 | Ｈｂｖ 백신 및 그의 제조 방법 |
| US8877156B2 (en) | 2007-06-26 | 2014-11-04 | New York University | Contrast agents anchored by thiols on nanoparticles |
| CA2700378A1 (en) * | 2007-09-21 | 2009-03-29 | Cytimmune Sciences, Inc. | Nanotherapeutic colloidal metal compositions and methods |
| WO2009062151A1 (en) | 2007-11-08 | 2009-05-14 | Cytimmune Sciences, Inc. | Compositions and methods for generating antibodies |
| JP5364310B2 (ja) * | 2008-07-14 | 2013-12-11 | アルフレッサファーマ株式会社 | 反応性物質が結合した微小粒子の安定化方法および該微小粒子含有試薬 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1982001461A1 (en) * | 1980-07-18 | 1982-05-13 | Leland Stanford Junior Univ | Human hybridomas,precursors and products |
| CA1214123A (en) * | 1983-01-20 | 1986-11-18 | Masashi Matsui | Cell lines for use in the preparation of hybridoma cells |
| JPS61104796A (ja) * | 1984-10-26 | 1986-05-23 | Chemo Sero Therapeut Res Inst | モノクロ−ナル抗体の製造方法 |
| JPS62162963A (ja) * | 1986-01-10 | 1987-07-18 | Sadao Shiosaka | 金属コロイド粒子を担体とする低分子物質に対する特異抗体の作成法 |
| JP3880063B2 (ja) * | 1993-03-18 | 2007-02-14 | シティミューン サイエンシーズ，インコーポレイテッド | 生物学的に活性な因子の毒性を低減させる組成物および方法 |
| JPH07227299A (ja) * | 1994-02-14 | 1995-08-29 | Kyoto Daiichi Kagaku:Kk | Ｄｎａの特定塩基配列の検出方法及びその装置 |
| US5686578A (en) * | 1994-08-05 | 1997-11-11 | Immunomedics, Inc. | Polyspecific immunoconjugates and antibody composites for targeting the multidrug resistant phenotype |
| JPH09107980A (ja) * | 1995-08-17 | 1997-04-28 | Japan Tobacco Inc | 新規生理活性タンパク |
| DE69833876T2 (de) * | 1997-11-10 | 2007-05-24 | Cytimmune Sciences, Inc. | Zusammensetzungen und verfahren für die gezielte abgabe von faktoren |
| US6407218B1 (en) * | 1997-11-10 | 2002-06-18 | Cytimmune Sciences, Inc. | Method and compositions for enhancing immune response and for the production of in vitro mabs |
-
1998
- 1998-11-10 AU AU14548/99A patent/AU757357B2/en not_active Ceased
- 1998-11-10 EP EP98958518A patent/EP1039933B8/en not_active Expired - Lifetime
- 1998-11-10 WO PCT/US1998/023957 patent/WO1999024066A2/en not_active Ceased
- 1998-11-10 CA CA2309602A patent/CA2309602C/en not_active Expired - Fee Related
- 1998-11-10 NZ NZ504292A patent/NZ504292A/xx not_active IP Right Cessation
- 1998-11-10 JP JP2000520153A patent/JP4588210B2/ja not_active Expired - Fee Related
- 1998-11-10 DE DE69833455T patent/DE69833455T2/de not_active Expired - Lifetime
- 1998-11-10 AT AT98958518T patent/ATE317269T1/de active
-
2003
- 2003-05-23 AU AU2003204353A patent/AU2003204353B2/en not_active Ceased
-
2006
- 2006-11-10 AU AU2006235956A patent/AU2006235956B2/en not_active Ceased
-
2009
- 2009-06-17 JP JP2009144707A patent/JP2009292818A/ja active Pending
-
2012
- 2012-09-27 JP JP2012214639A patent/JP2013014616A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999024066A3 (en) | 1999-12-09 |
| EP1039933B1 (en) | 2006-02-08 |
| JP2013014616A (ja) | 2013-01-24 |
| WO1999024066A2 (en) | 1999-05-20 |
| AU757357B2 (en) | 2003-02-20 |
| NZ504292A (en) | 2003-03-28 |
| AU2006235956B2 (en) | 2010-02-11 |
| CA2309602C (en) | 2011-04-26 |
| DE69833455D1 (de) | 2006-04-20 |
| AU2006235956A1 (en) | 2006-11-30 |
| AU1454899A (en) | 1999-05-31 |
| AU2003204353B2 (en) | 2006-08-10 |
| CA2309602A1 (en) | 1999-05-20 |
| JP2002503639A (ja) | 2002-02-05 |
| JP4588210B2 (ja) | 2010-11-24 |
| EP1039933A2 (en) | 2000-10-04 |
| ATE317269T1 (de) | 2006-02-15 |
| EP1039933B8 (en) | 2006-12-20 |
| JP2009292818A (ja) | 2009-12-17 |
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