DE69831754D1 - Zelloberflächenglycoproteinen zusammenhang mit menschlicher b zell lymphomen - ulbp, dns und polypeptiden - Google Patents

Zelloberflächenglycoproteinen zusammenhang mit menschlicher b zell lymphomen - ulbp, dns und polypeptiden

Info

Publication number
DE69831754D1
DE69831754D1 DE69831754T DE69831754T DE69831754D1 DE 69831754 D1 DE69831754 D1 DE 69831754D1 DE 69831754 T DE69831754 T DE 69831754T DE 69831754 T DE69831754 T DE 69831754T DE 69831754 D1 DE69831754 D1 DE 69831754D1
Authority
DE
Germany
Prior art keywords
polypeptides
ulbp
cell
isolated
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69831754T
Other languages
English (en)
Other versions
DE69831754T2 (de
Inventor
John Cosman
H Mullberg
Cristian Fanslow
Marek Kubin
Richard J Armitage
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immunex Corp
Original Assignee
Immunex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunex Corp filed Critical Immunex Corp
Publication of DE69831754D1 publication Critical patent/DE69831754D1/de
Application granted granted Critical
Publication of DE69831754T2 publication Critical patent/DE69831754T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE69831754T 1997-12-17 1998-12-17 Zelloberflächenglycoproteinen zusammenhang mit menschlicher b zell lymphomen - ulbp, dns und polypeptiden Expired - Lifetime DE69831754T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6985797P 1997-12-17 1997-12-17
US69857P 1997-12-17
US9294698P 1998-07-15 1998-07-15
US92946P 1998-07-15
PCT/US1998/027048 WO1999031241A1 (en) 1997-12-17 1998-12-17 Cell surface glycoproteins associated with human b cell lymphomas - ulbp, dna and polypeptides

Publications (2)

Publication Number Publication Date
DE69831754D1 true DE69831754D1 (de) 2006-02-09
DE69831754T2 DE69831754T2 (de) 2006-06-29

Family

ID=26750491

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69831754T Expired - Lifetime DE69831754T2 (de) 1997-12-17 1998-12-17 Zelloberflächenglycoproteinen zusammenhang mit menschlicher b zell lymphomen - ulbp, dns und polypeptiden

Country Status (12)

Country Link
US (7) US6653447B1 (de)
EP (1) EP1037991B1 (de)
JP (1) JP4255211B2 (de)
AT (1) ATE305510T1 (de)
AU (1) AU742757C (de)
CA (1) CA2315251A1 (de)
DE (1) DE69831754T2 (de)
DK (1) DK1037991T3 (de)
ES (1) ES2251120T3 (de)
IL (2) IL136621A0 (de)
NZ (1) NZ505500A (de)
WO (1) WO1999031241A1 (de)

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WO2002062997A1 (fr) * 2001-02-05 2002-08-15 Takeda Chemical Industries, Ltd. Nouvelle proteine et son utilisation
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US7364890B2 (en) 2001-07-28 2008-04-29 Midwest Research Institute Thermal tolerant avicelase from Acidothermus cellulolyticus
ATE434624T1 (de) * 2001-10-04 2009-07-15 Immunex Corp Ul16-bindungsprotein 4
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WO2004022706A2 (en) * 2002-09-04 2004-03-18 The Trustees Of The University Of Pennsylvania Immune cell receptor ligand and immune cell receptor
US9809654B2 (en) 2002-09-27 2017-11-07 Vaccinex, Inc. Targeted CD1d molecules
EP1413316A1 (de) * 2002-09-27 2004-04-28 Bruno Robert Bifunktionelle Konjugate oder Fusionsproteine
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US7666417B2 (en) * 2003-04-22 2010-02-23 Fred Hutchinson Cancer Research Center Methods and compositions for treating autoimmune diseases or conditions
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MXPA06011553A (es) 2004-04-05 2007-01-26 Univ California Modulacion de nkg2d.
US7998481B2 (en) * 2004-04-05 2011-08-16 The Regents Of The University Of California Modulation of NKG2D for treating or preventing solid organ allograft rejection
CN102220412B (zh) 2004-11-29 2016-04-13 塞昆纳姆股份有限公司 用于检测甲基化dna的试剂盒和方法
WO2006056480A2 (en) 2004-11-29 2006-06-01 Klinikum Der Universität Regensburg Means and methods for detecting methylated dna
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US9611313B2 (en) 2007-06-26 2017-04-04 University Of Miami Antibody-endostatin fusion protein and its variants
EP2173377B1 (de) * 2007-06-26 2017-11-29 University of Miami Antikörper-endostatin-fusionsprotein und seine varianten
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US9539427B2 (en) 2010-11-08 2017-01-10 The Johns Hopkins University Methods for improving heart function
US10040853B2 (en) * 2011-09-09 2018-08-07 Fred Hutchinson Cancer Research Center Methods and compositions involving NKG2D inhibitors and cancer
US10093705B2 (en) 2011-09-13 2018-10-09 Dana-Farber Cancer Institute, Inc. Compositions and methods for brown fat induction and activity using FNDC5
US20130156808A1 (en) * 2011-11-22 2013-06-20 Stipan Jonjic Vaccine comprising beta-herpesvirus
AU2013292510A1 (en) 2012-07-19 2015-02-05 Amgen Inc. Human BTNL3 proteins, nucleic acids, and antibodies and uses thereof
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US9371352B2 (en) 2013-02-08 2016-06-21 Vaccinex, Inc. Modified glycolipids and methods of making and using the same
WO2014144817A2 (en) 2013-03-15 2014-09-18 Amgen Inc. Inhibitory polypeptides specific to wnt inhibitors
US20160175401A1 (en) 2013-07-31 2016-06-23 Dana-Farber Cancer Institute Inc. Compoitions and methods for modulating thermogenesis using pth-related and egf-related compounds
CA2923145C (en) 2013-09-05 2025-09-16 Amgen Inc. MOLECULES CONTAINING FCS AND EXHIBITING PREDICTABLE, UNIFORM AND REPRODUCIBLE GLYCOFORM PROFILES
KR102490462B1 (ko) 2013-10-28 2023-01-19 유니버시티 오브 피츠버그-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 종양분해성 hsv 벡터
AU2015206603B9 (en) 2014-01-14 2019-07-18 Dana-Farber Cancer Institute, Inc. Compositions and methods for identification, assessment, prevention, and treatment of melanoma using PD-L1 isoforms
MX377275B (es) 2014-05-16 2025-03-07 Amgen Inc Ensayo para detectar poblaciones celulares linfocitos t colaboradores 1 (th1) y linfocitos t colaboradores (th2).
DK3227311T3 (da) 2014-12-05 2022-03-07 Xyphos Biosciences Inc Indsættelige, variable fragmenter af antistoffer og modificerede A1- A2-domæner af NKG2D-ligander
US11117969B2 (en) * 2014-12-05 2021-09-14 Xyphos Biosciences Inc. Insertable variable fragments of antibodies and modified α1-α2 domains of NKG2D ligands
EP3368157B1 (de) 2015-10-29 2022-06-29 Dana-Farber Cancer Institute, Inc. Verfahren zur identifizierung, beurteilung, prävention und behandlung von stoffwechselerkrankungen mit verwendung von pm20d1 und n-lipidierten aminosäuren
ES2919953T3 (es) 2016-01-27 2022-07-29 Oncorus Inc Vectores víricos oncolíticos y usos de los mismos
WO2017218689A1 (en) 2016-06-14 2017-12-21 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Expression of nkg2d activating ligand proteins for sensitizing cancer cells to attack by cytotoxic immune cells
CN109983121A (zh) 2016-06-30 2019-07-05 昂克诺斯公司 治疗性多肽的假型化溶瘤病毒递送
BR112019013007A2 (pt) 2016-12-21 2019-10-08 Creatus Biosciences Inc organismo microbiano não natural, método de produção de um composto bioderivado, composto bioderivado e composição
CN110382684A (zh) 2016-12-21 2019-10-25 创新生物科学公司 产生木糖醇的梅奇酵母种
AU2018235928B2 (en) 2017-03-14 2023-09-21 Amgen Inc. Control of total afucosylated glycoforms of antibodies produced in cell culture
RU2771110C2 (ru) 2017-07-26 2022-04-26 Онкорус, Инк. Онколитические вирусные векторы и их применение
EP3731850A4 (de) 2017-12-29 2021-12-01 Oncorus, Inc. Onkolytische virale verabreichung von therapeutischen polypeptiden
CN119639849A (zh) 2018-03-26 2025-03-18 美国安进公司 细胞培养物中产生的抗体的总去岩藻糖基化糖型
KR102844238B1 (ko) 2018-03-27 2025-08-07 사이포스 바이오사이언시스 인코포레이티드 비천연 nkg2d 수용체를 결합하는 비천연 nkg2d 리간드의 변형된 a1-a2 도메인
WO2020051013A2 (en) * 2018-08-24 2020-03-12 The Trustees Of Columbia University In The City Of New York Anti-cd33 and nkg2d ligand chimeras for treatment of myeloid malignancies
AU2020355251A1 (en) 2019-09-26 2022-04-21 Amgen Inc. Methods of producing antibody compositions
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AU2021360897A1 (en) 2020-10-15 2023-05-25 Amgen Inc. Relative unpaired glycans in antibody production methods
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Also Published As

Publication number Publication date
WO1999031241A1 (en) 1999-06-24
US20040235058A1 (en) 2004-11-25
AU742757B2 (en) 2002-01-10
IL136621A (en) 2008-07-08
US20110281789A1 (en) 2011-11-17
US7193058B2 (en) 2007-03-20
AU2004599A (en) 1999-07-05
CA2315251A1 (en) 1999-06-24
EP1037991A1 (de) 2000-09-27
US20090324597A1 (en) 2009-12-31
DK1037991T3 (da) 2006-01-09
US6774224B2 (en) 2004-08-10
US7807796B2 (en) 2010-10-05
AU742757C (en) 2007-05-17
US20080008715A1 (en) 2008-01-10
US6458350B1 (en) 2002-10-01
US7427669B2 (en) 2008-09-23
ES2251120T3 (es) 2006-04-16
US20030147847A1 (en) 2003-08-07
US8410252B2 (en) 2013-04-02
US6653447B1 (en) 2003-11-25
EP1037991B1 (de) 2005-09-28
JP4255211B2 (ja) 2009-04-15
NZ505500A (en) 2002-12-20
ATE305510T1 (de) 2005-10-15
JP2002508183A (ja) 2002-03-19
DE69831754T2 (de) 2006-06-29
IL136621A0 (en) 2001-06-14

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