ES2080809T3 - Receptores de factor de necrosis tumoral alfa y beta. - Google Patents
Receptores de factor de necrosis tumoral alfa y beta.Info
- Publication number
- ES2080809T3 ES2080809T3 ES90309875T ES90309875T ES2080809T3 ES 2080809 T3 ES2080809 T3 ES 2080809T3 ES 90309875 T ES90309875 T ES 90309875T ES 90309875 T ES90309875 T ES 90309875T ES 2080809 T3 ES2080809 T3 ES 2080809T3
- Authority
- ES
- Spain
- Prior art keywords
- necrosis factor
- tumor necrosis
- alpha
- factor receptors
- beta tumor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Compounds Of Unknown Constitution (AREA)
Abstract
SE REVELAN PROTEINAS RECEPTORAS DEL FACTOR DE NECROSIS TUMORAL, DNAS Y VECTORES DE EXPRESION QUE CODIFICAN LOS RECEPTORES TNF, Y PROCESOS PARA LA PRODUCCION DE RECEPTORES TNF COMO PRODUCTOS DE CULTIVO DE CELDAS RECOMBINANTES
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40537089A | 1989-09-11 | 1989-09-11 | |
US405370 | 1989-09-11 | ||
US42141789A | 1989-10-13 | 1989-10-13 | |
US421417 | 1989-10-13 | ||
US07/523,635 US5395760A (en) | 1989-09-05 | 1990-05-10 | DNA encoding tumor necrosis factor-α and -β receptors |
US523635 | 1990-05-10 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2080809T3 true ES2080809T3 (es) | 1996-02-16 |
ES2080809T4 ES2080809T4 (es) | 2012-12-20 |
Family
ID=27410621
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90309875T Expired - Lifetime ES2080809T4 (es) | 1989-09-11 | 1990-09-10 | Receptores de factor de necrosis tumoral alfa y beta |
Country Status (9)
Country | Link |
---|---|
US (2) | US5395760A (es) |
EP (1) | EP0418014B1 (es) |
AT (1) | ATE131871T1 (es) |
DE (2) | DE10075011I2 (es) |
DK (1) | DK0418014T3 (es) |
ES (1) | ES2080809T4 (es) |
GR (1) | GR3019333T3 (es) |
LU (1) | LU90591I2 (es) |
NL (1) | NL300008I2 (es) |
Families Citing this family (166)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL83878A (en) * | 1987-09-13 | 1995-07-31 | Yeda Res & Dev | Soluble protein corresponding to tnf inhibitory protein its preparation and pharmaceutical compositions containing it |
US6479632B1 (en) | 1988-09-12 | 2002-11-12 | Yeda Research And Development Co. Ltd. | Tumor necrosis factor inhibitory protein and its purification |
US6406697B1 (en) | 1989-02-23 | 2002-06-18 | Genentech, Inc. | Hybrid immunoglobulins |
DK0393438T3 (da) * | 1989-04-21 | 2005-05-30 | Amgen Inc | TNF-receptor, TNF-bindende proteiner og DNAér, der koder herfor |
US7264944B1 (en) | 1989-04-21 | 2007-09-04 | Amgen Inc. | TNF receptors, TNF binding proteins and DNAs coding for them |
US6221675B1 (en) | 1989-04-21 | 2001-04-24 | Amgen, Inc. | TNF receptors, TNF binding proteins and DNAs coding for them |
US6232446B1 (en) | 1989-05-18 | 2001-05-15 | Yeda Research And Development Co. Ltd. | TNF ligands |
US6262239B1 (en) | 1989-05-18 | 2001-07-17 | Yeda Research And Development Co., Ltd. | TNF receptor-specific antibodies |
DE69017753T3 (de) * | 1989-05-18 | 2013-06-20 | Yeda Research And Development Co., Ltd. | Tumor-Nekrosefaktor-Bindungsprotein II, seine Reinigung und spezifische Antikörper |
US6143866A (en) * | 1989-07-18 | 2000-11-07 | Amgen, Inc. | Tumor necrosis factor (TNF) inhibitor and method for obtaining the same |
IL95031A (en) | 1989-07-18 | 2007-03-08 | Amgen Inc | A method of producing a recombinant human necrotic factor absorber |
EP0486526B2 (en) * | 1989-08-07 | 2001-03-07 | Peptech Limited | Tumour necrosis factor binding ligands |
US20030225254A1 (en) * | 1989-08-07 | 2003-12-04 | Rathjen Deborah Ann | Tumour necrosis factor binding ligands |
US5959087A (en) * | 1989-08-07 | 1999-09-28 | Peptide Technology, Ltd. | Tumour necrosis factor binding ligands |
US6451983B2 (en) | 1989-08-07 | 2002-09-17 | Peptech Limited | Tumor necrosis factor antibodies |
US6541610B1 (en) * | 1989-09-05 | 2003-04-01 | Immunex Corporation | Fusion proteins comprising tumor necrosis factor receptor |
US5395760A (en) * | 1989-09-05 | 1995-03-07 | Immunex Corporation | DNA encoding tumor necrosis factor-α and -β receptors |
NZ235148A (en) * | 1989-09-05 | 1991-12-23 | Immunex Corp | Tumour necrosis factor receptor protein and dna sequences |
US5945397A (en) * | 1989-09-05 | 1999-08-31 | Immunex Corporation | Purified p75 (type II) tumor necrosis factor receptor polypeptides |
EP1132471A3 (de) * | 1989-09-12 | 2001-11-28 | F. Hoffmann-La Roche Ag | TNF-bindende Proteine |
US6552170B1 (en) * | 1990-04-06 | 2003-04-22 | Amgen Inc. | PEGylation reagents and compounds formed therewith |
GB2246569A (en) * | 1990-06-15 | 1992-02-05 | Charing Cross Sunley Research | Tumour necrosis factor - alpha binding protein |
US20030064480A1 (en) * | 1990-06-28 | 2003-04-03 | Leander Lauffer | Fusion proteins with immunoglobulin portions, the preparation and use thereof |
US7253264B1 (en) | 1990-06-28 | 2007-08-07 | Sanofi-Arentideutschland GmbH | Immunoglobulin fusion proteins, their production and use |
DE59109032D1 (de) * | 1990-06-28 | 1998-09-03 | Hoechst Ag | Fusionsproteine mit immunglobulinanteilen, ihre Herstellung und Verwendung |
DK0604418T3 (da) * | 1991-03-29 | 1999-06-14 | Immunex Corp | Isolerede viralproteincytokinantagonister |
ATE181961T1 (de) * | 1991-04-17 | 1999-07-15 | Medisup Int Nv | Neue wasserlösliche polypeptide mit hoher affinität für alpha- und beta- interferone |
IL99120A0 (en) * | 1991-08-07 | 1992-07-15 | Yeda Res & Dev | Multimers of the soluble forms of tnf receptors,their preparation and pharmaceutical compositions containing them |
CA2121473C (en) * | 1991-10-15 | 2001-05-01 | Michael Mullarkey | Methods and compositions for treating allergic reactions |
NZ251820A (en) * | 1992-03-30 | 1996-07-26 | Immunex Corp | Fusion proteins with tnf-r (tumour necrosis factor-receptor) peptide linked to another tnf-r or an il-1r (interleukin-1-receptor) peptide |
WO1993021946A1 (en) * | 1992-04-30 | 1993-11-11 | Synergen, Inc. | Methods for treating interleukin-1 and tumor necrosis factor mediated diseases |
IL101769A (en) * | 1992-05-03 | 2007-02-11 | Yeda Res & Dev | Modulation of TNF receptor action |
US20050255104A1 (en) * | 1993-01-29 | 2005-11-17 | Centocor, Inc. | Methods of treating psoriasis using anti-TNF receptor fusion proteins |
CA2125763C (en) * | 1993-07-02 | 2007-08-28 | Maurice Kent Gately | P40 homodimer of interleukin-12 |
US6074642A (en) | 1994-05-02 | 2000-06-13 | Alexion Pharmaceuticals, Inc. | Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis |
IL111125A0 (en) * | 1994-05-11 | 1994-12-29 | Yeda Res & Dev | Soluble oligomeric tnf/ngf super family ligand receptors and their use |
US6579697B1 (en) * | 1995-05-11 | 2003-06-17 | Yeda Research And Development Co. Ltd. | Modulator of TNF/NGF superfamily receptors and soluble oligomeric TNF/NGF superfamily receptors |
US5708142A (en) | 1994-05-27 | 1998-01-13 | Genentech, Inc. | Tumor necrosis factor receptor-associated factors |
US5741667A (en) * | 1994-05-27 | 1998-04-21 | Genentech, Inc. | Tumor necrosis factor receptor-associated factors |
US7094564B1 (en) | 1995-03-15 | 2006-08-22 | Human Genome Sciences, Inc. | Human tumor necrosis factor receptor |
US7078493B1 (en) | 1995-03-15 | 2006-07-18 | Human Genome Sciences, Inc. | Antibodies to human tumor necrosis factor receptor-like genes |
US8110659B1 (en) | 1995-03-15 | 2012-02-07 | Human Genome Sciences, Inc. | Human tumor necrosis factor receptor-like genes |
US7427492B1 (en) | 1995-06-05 | 2008-09-23 | Human Genome Sciences, Inc. | Polynucleotides encoding human tumor necrosis factor receptor-like2 |
US7429646B1 (en) | 1995-06-05 | 2008-09-30 | Human Genome Sciences, Inc. | Antibodies to human tumor necrosis factor receptor-like 2 |
US7070783B1 (en) | 1995-05-09 | 2006-07-04 | The Mathilda And Terence Kennedy Institute Of Rheumatology | Small molecular weight TNF receptor multimeric molecule |
ZA966663B (en) * | 1995-08-17 | 1998-02-06 | Genentech Inc | Traf Inhibitors. |
US6369027B1 (en) * | 1995-12-22 | 2002-04-09 | Amgen Inc. | Osteoprotegerin |
US6410252B1 (en) | 1995-12-22 | 2002-06-25 | Case Western Reserve University | Methods for measuring T cell cytokines |
US6713061B1 (en) | 1996-03-12 | 2004-03-30 | Human Genome Sciences, Inc. | Death domain containing receptors |
WO1997033904A1 (en) | 1996-03-12 | 1997-09-18 | Human Genome Sciences, Inc. | Death domain containing receptors |
US7357927B2 (en) * | 1996-03-12 | 2008-04-15 | Human Genome Sciences, Inc. | Death domain containing receptors |
WO1997034616A1 (en) * | 1996-03-18 | 1997-09-25 | Medical Science Systems, Inc. | A method for periodontal disease treatment |
US5912141A (en) * | 1996-05-22 | 1999-06-15 | President & Fellows Of Harvard College | Nucleic acids encoding tumor virus susceptibility genes |
ATE347588T1 (de) | 1996-05-23 | 2006-12-15 | Scripps Research Inst | Systeme zur präsentation von mhc-antigenen der klasse ii und verfahren zur aktivierung von cd4?+-t-lymphozyten |
TW555765B (en) * | 1996-07-09 | 2003-10-01 | Amgen Inc | Low molecular weight soluble tumor necrosis factor type-I and type-II proteins |
US5939281A (en) * | 1996-09-16 | 1999-08-17 | Case Western Reserve University | Detecting alloreactivity |
EP0961782A4 (en) * | 1996-10-30 | 2003-07-16 | Human Genome Sciences Inc | TR2 RECEPTOR OF TUMOR NECROSIS FACTOR IN MAN |
US6593456B1 (en) * | 1996-11-06 | 2003-07-15 | The Regents Of The University Of California | Tumor necrosis factor receptor releasing enzyme |
NZ335864A (en) | 1996-11-06 | 2001-09-28 | Univ California | Isolated tumor necrosis factor receptor releasing enzyme (TRRE), compositions comprising the enzyme and methods of the use in modulation of TNF levels |
US20050191661A1 (en) * | 1996-11-06 | 2005-09-01 | Tetsuya Gatanaga | Treatment of inflammatory disease by cleaving TNF receptors |
US6930084B1 (en) | 1996-11-06 | 2005-08-16 | The Regents Of The University Of California | Treating arthritis with TNF receptor releasing enzyme |
DE69739375D1 (de) | 1996-11-27 | 2009-06-04 | Immunex Corp | Verfahren zur regulierung der stickstoffmonoxid-erzeugung |
EP2002846B1 (en) | 1996-12-06 | 2017-01-25 | Amgen Inc. | Combination therapy using an IL-1 inhibitor for treating IL-1 mediated diseases |
PT942740E (pt) | 1996-12-06 | 2004-01-30 | Amgen Inc | Terapia de combinacao utilizando uma proteina de ligacao de tnf para tratamento de doencas mediadas por tnf |
US20020137890A1 (en) * | 1997-03-31 | 2002-09-26 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
AU7705098A (en) * | 1997-05-29 | 1998-12-30 | Human Genome Sciences, Inc. | Human tumor necrosis factor receptor-like protein 8 |
EP1053351A4 (en) * | 1998-01-27 | 2002-09-25 | Millennium Pharm Inc | NOVEL TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMIL MOLECULES AND USES THEREOF |
US20030180310A1 (en) * | 1998-04-29 | 2003-09-25 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
US6620382B1 (en) | 1998-05-22 | 2003-09-16 | Biopheresis Technologies, Llc. | Method and compositions for treatment of cancers |
US8197430B1 (en) | 1998-05-22 | 2012-06-12 | Biopheresis Technologies, Inc. | Method and system to remove cytokine inhibitor in patients |
US7115557B2 (en) * | 1998-09-25 | 2006-10-03 | Sciaticon Ab | Use of certain drugs for treating nerve root injury |
US6660843B1 (en) * | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
US7294481B1 (en) * | 1999-01-05 | 2007-11-13 | Immunex Corporation | Method for producing recombinant proteins |
US7465785B2 (en) * | 1999-03-08 | 2008-12-16 | Genentech, Inc. | Polypeptide encoded by a nucleic acid over-expressed in melanoma |
EP1939300A1 (en) | 1999-05-28 | 2008-07-02 | Targeted Genetics Corporation | Methods and compositions for lowering the level of tumor necrosis factor (TNF) in TNF-associated disorders |
JP2003501043A (ja) * | 1999-05-28 | 2003-01-14 | ターゲティッド ジェネティクス コーポレイション | 腫瘍壊死因子(tnf)関連障害において、tnfのレベルを低下させるための方法および組成物 |
US6808902B1 (en) | 1999-11-12 | 2004-10-26 | Amgen Inc. | Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules |
US6379708B1 (en) * | 1999-11-20 | 2002-04-30 | Cytologic, Llc | Method for enhancing immune responses in mammals |
US7122631B2 (en) * | 2000-02-22 | 2006-10-17 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
CA2401683A1 (en) | 2000-03-02 | 2001-09-07 | Xencor | Design and discovery of protein based tnf-.alpha. variants for the treatment of tnf-.alpha. related disorders |
UA83458C2 (uk) | 2000-09-18 | 2008-07-25 | Байоджен Айдек Ма Інк. | Виділений поліпептид baff-r (рецептор фактора активації в-клітин сімейства tnf) |
MXPA03002443A (es) | 2000-09-22 | 2004-12-06 | Immunex Corp | Ensayos de clasificacion para agonistas o antagonistas del activador receptor de nf-kb. |
PL362414A1 (en) | 2001-02-19 | 2004-11-02 | Merck Patent Gmbh | Method for identification of t-cell epitopes and use for preparing molecules with reeduced immunogenicity |
US20030040119A1 (en) * | 2001-04-11 | 2003-02-27 | The Regents Of The University Of Michigan | Separation devices and methods for separating particles |
CN103232539B (zh) | 2001-06-26 | 2015-06-03 | 安姆根弗里蒙特公司 | 抗opgl抗体 |
WO2003026695A1 (en) * | 2001-09-21 | 2003-04-03 | Genset S.A. | Agonists and antagonists of cylixin for the treatment of metabolic disorders |
US7084257B2 (en) | 2001-10-05 | 2006-08-01 | Amgen Inc. | Fully human antibody Fab fragments with human interferon-gamma neutralizing activity |
AU2002359816B2 (en) * | 2001-12-21 | 2006-07-13 | Immunex Corporation | Methods for purifying protein |
ES2311094T3 (es) | 2002-02-27 | 2009-02-01 | Immunex Corporation | Composicion estabilizada de tnfr-fc que comprende arginina. |
ES2557741T3 (es) | 2002-03-27 | 2016-01-28 | Immunex Corporation | Procedimientos para incrementar la producción de polipéptidos |
US20060002935A1 (en) * | 2002-06-28 | 2006-01-05 | Domantis Limited | Tumor Necrosis Factor Receptor 1 antagonists and methods of use therefor |
US20080008713A1 (en) * | 2002-06-28 | 2008-01-10 | Domantis Limited | Single domain antibodies against tnfr1 and methods of use therefor |
US9028822B2 (en) | 2002-06-28 | 2015-05-12 | Domantis Limited | Antagonists against TNFR1 and methods of use therefor |
US7285269B2 (en) * | 2002-12-02 | 2007-10-23 | Amgen Fremont, Inc. | Antibodies directed to tumor necrosis factor |
PL378879A1 (pl) | 2002-12-30 | 2006-05-29 | Amgen Inc. | Terapia skojarzona z czynnikami kostymulującymi |
TWI353991B (en) | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
US20070172446A1 (en) | 2003-05-16 | 2007-07-26 | Intermune, Inc. | Synthetic chemokine receptor ligands and methods of use thereof |
US7892563B2 (en) * | 2003-05-20 | 2011-02-22 | Wyeth Holdings Corporation | Methods for treatment of severe acute respiratory syndrome (SARS) |
AU2004281780B2 (en) | 2003-10-14 | 2009-03-19 | F. Hoffmann-La Roche Ltd | Macrocyclic carboxylic acids and acylsulfonamides as inhibitors of HCV replication |
WO2005040758A2 (en) * | 2003-10-24 | 2005-05-06 | Intermune, Inc. | Use of pirfenidone in therapeutic regimens |
CN1980957A (zh) | 2004-03-23 | 2007-06-13 | 比奥根艾迪克Ma公司 | 受体偶联剂及其治疗用途 |
CA2565215C (en) * | 2004-04-30 | 2014-04-15 | Biopheresis Technologies, Inc. | Method and system to remove soluble tnfr1, tnfr2, and il2 in patients |
US7597884B2 (en) | 2004-08-09 | 2009-10-06 | Alios Biopharma, Inc. | Hyperglycosylated polypeptide variants and methods of use |
JP2008513356A (ja) * | 2004-08-09 | 2008-05-01 | アリオス バイオファーマ インク. | 合成高度糖鎖付加プロテアーゼ耐性ポリペプチド変異体、それを使用する経口製剤および方法 |
US7294484B2 (en) | 2004-08-27 | 2007-11-13 | Wyeth Research Ireland Limited | Production of polypeptides |
US7335491B2 (en) | 2004-08-27 | 2008-02-26 | Wyeth Research Ireland Limited | Production of anti-abeta |
TWI364458B (en) * | 2004-08-27 | 2012-05-21 | Wyeth Res Ireland Ltd | Production of tnfr-lg |
KR20080031684A (ko) | 2005-06-14 | 2008-04-10 | 암젠 인코포레이티드 | 자가 - 완충성 단백질 제형 |
US20070065514A1 (en) * | 2005-09-22 | 2007-03-22 | Howell Mark D | Method for enhancing immune responses in mammals |
KR101789603B1 (ko) * | 2005-11-10 | 2017-11-21 | 더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 | Tnf 수퍼패밀리 수용체에 대한 스플라이스 스위칭올리고머 및 염증성 질환 치료용 약제학적 조성물 |
US7785834B2 (en) * | 2005-11-10 | 2010-08-31 | Ercole Biotech, Inc. | Soluble TNF receptors and their use in treatment of disease |
US7504106B2 (en) * | 2006-03-14 | 2009-03-17 | Boris Skurkovich | Method and composition for treatment of renal failure with antibodies and their equivalents as partial or complete replacement for dialysis |
US8007790B2 (en) | 2006-04-03 | 2011-08-30 | Stowers Institute For Medical Research | Methods for treating polycystic kidney disease (PKD) or other cyst forming diseases |
CA2652858A1 (en) * | 2006-06-15 | 2007-12-27 | Targeted Genetics Corporation | Methods for treating target joints in inflammatory arthritis using aav vectors encoding a tnf antagonist |
CA2697784A1 (en) * | 2006-07-07 | 2008-01-10 | Bioassets Development Corporation | Novel regimens for treating diseases and disorders |
US20080075690A1 (en) * | 2006-09-22 | 2008-03-27 | Mark Douglas Howell | Method for enhancing immune responses in mammals |
US7833527B2 (en) | 2006-10-02 | 2010-11-16 | Amgen Inc. | Methods of treating psoriasis using IL-17 Receptor A antibodies |
US20090264353A1 (en) * | 2007-10-19 | 2009-10-22 | Santaris Pharma A/S | Splice Switching Oligomers for TNF Superfamily Receptors and their Use in Treatment of Disease |
ES2541546T3 (es) | 2006-11-03 | 2015-07-21 | Wyeth Llc | Sustancias que inhiben la glucólisis en cultivo celular |
PL2148691T3 (pl) | 2007-02-05 | 2015-12-31 | Apellis Pharmaceuticals Inc | Analogi kompstatyny do stosowania w leczeniu stanów zapalnych układu oddechowego |
CA2679941C (en) | 2007-03-02 | 2016-09-20 | Wyeth | Use of copper and glutamate in cell culture for production of polypeptides |
WO2009126564A1 (en) | 2008-04-07 | 2009-10-15 | Bayer Healthcare Llc | Methods of recombinant production of glycoproteins |
TW201117824A (en) | 2009-10-12 | 2011-06-01 | Amgen Inc | Use of IL-17 receptor a antigen binding proteins |
CA2782320A1 (en) * | 2009-12-02 | 2011-06-09 | Acceleron Pharma Inc. | Compositions and methods for increasing serum half-life of fc fusion proteins |
SI3295957T1 (sl) | 2010-01-15 | 2020-02-28 | Kirin-Amgen, Inc. | Formulacija protitelesa proti IL-17RA in terapevtski režim za zdravljenje luskavice |
TW201217526A (en) | 2010-07-09 | 2012-05-01 | Biogen Idec Hemophilia Inc | Chimeric clotting factors |
US9012178B2 (en) | 2010-08-05 | 2015-04-21 | Amgen Inc. | Dipeptides to enhance yield and viability from cell cultures |
CN105177032B (zh) * | 2010-09-01 | 2019-05-10 | 山东新时代药业有限公司 | 新型人肿瘤坏死因子受体-Fc融合基因及其产物蛋白 |
WO2012145682A1 (en) | 2011-04-21 | 2012-10-26 | Amgen Inc. | A method for culturing mammalian cells to improve recombinant protein production |
WO2012170938A1 (en) | 2011-06-08 | 2012-12-13 | Acceleron Pharma Inc. | Compositions and methods for increasing serum half-life |
IL310968A (en) | 2011-07-01 | 2024-04-01 | Amgen Inc | Mammalian cell culture |
WO2013012733A1 (en) | 2011-07-15 | 2013-01-24 | Biogen Idec Ma Inc. | Heterodimeric fc regions, binding molecules comprising same, and methods relating thereto |
US20140234330A1 (en) | 2011-07-22 | 2014-08-21 | Amgen Inc. | Il-17 receptor a is required for il-17c biology |
WO2013033600A1 (en) | 2011-09-02 | 2013-03-07 | Amgen Inc. | Pharmaceutical product and method of analysing light exposure of a pharmaceutical product |
US10350139B2 (en) | 2011-10-25 | 2019-07-16 | Corning Incorporated | Pharmaceutical glass packaging assuring pharmaceutical sterility |
WO2013063280A1 (en) | 2011-10-25 | 2013-05-02 | Corning Incorporated | Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients |
AR089231A1 (es) | 2011-12-15 | 2014-08-06 | Amgen Inc | Metodo de floculacion |
KR102133699B1 (ko) | 2012-09-11 | 2020-07-14 | 코히러스 바이오사이언시즈, 인코포레이티드 | 고순도 및 탁월한 수율의 정확하게 폴딩된 에타너셉트 |
US20140199728A1 (en) | 2013-01-14 | 2014-07-17 | Amgen Inc. | Methods of using cell-cycle inhibitors to modulate one or more properties of a cell culture |
TWI720289B (zh) | 2013-03-14 | 2021-03-01 | 美商安美基公司 | 用於增加重組蛋白質之甘露糖含量之方法 |
DK2969099T4 (da) | 2013-03-14 | 2022-03-14 | Amgen Inc | Fjernelse af lækket affinitetsoprensningsligand |
TWI788044B (zh) | 2013-03-15 | 2022-12-21 | 美商百歐維拉提夫治療公司 | 因子ix多肽調配物 |
US9603775B2 (en) | 2013-04-24 | 2017-03-28 | Corning Incorporated | Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients |
US9707155B2 (en) | 2013-04-24 | 2017-07-18 | Corning Incorporated | Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients |
US9717649B2 (en) | 2013-04-24 | 2017-08-01 | Corning Incorporated | Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients |
US9700485B2 (en) | 2013-04-24 | 2017-07-11 | Corning Incorporated | Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients |
US9707153B2 (en) | 2013-04-24 | 2017-07-18 | Corning Incorporated | Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients |
US9717648B2 (en) | 2013-04-24 | 2017-08-01 | Corning Incorporated | Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients |
US9849066B2 (en) | 2013-04-24 | 2017-12-26 | Corning Incorporated | Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients |
US9713572B2 (en) | 2013-04-24 | 2017-07-25 | Corning Incorporated | Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients |
US9839579B2 (en) | 2013-04-24 | 2017-12-12 | Corning Incorporated | Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients |
US9707154B2 (en) | 2013-04-24 | 2017-07-18 | Corning Incorporated | Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients |
US9700486B2 (en) | 2013-04-24 | 2017-07-11 | Corning Incorporated | Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients |
US9481901B2 (en) | 2013-05-30 | 2016-11-01 | Amgen Inc. | Methods for increasing mannose content of recombinant proteins |
WO2015066357A1 (en) | 2013-10-31 | 2015-05-07 | Amgen Inc. | Use of monensin to regulate glycosylation of recombinant proteins |
SG10201806643WA (en) | 2014-01-13 | 2018-09-27 | Amgen Inc | Regulating ornithine metabolism to manipulate the high mannose glycoform content of recombinant proteins |
US10106829B2 (en) | 2014-01-29 | 2018-10-23 | Amgen Inc. | Overexpression of N-glycosylation pathway regulators to modulate glycosylation of recombinant proteins |
CN113774084B (zh) | 2014-01-29 | 2024-04-16 | 美国安进公司 | 过表达n-糖基化途径调节基因以调节重组蛋白的糖基化 |
KR102530900B1 (ko) | 2014-03-31 | 2023-05-12 | 암젠 케이-에이, 인크. | 손발톱 및 두피 건선의 치료 방법 |
KR102598799B1 (ko) | 2014-06-04 | 2023-11-07 | 암젠 인크 | 포유류 세포 배양물을 회수하는 방법 |
AU2015349809B2 (en) | 2014-11-19 | 2022-02-10 | Amgen Inc. | Quantitation of glycan moiety in recombinant glycoproteins |
EP3680344A1 (en) | 2014-12-01 | 2020-07-15 | Amgen Inc. | Process for manipulating the level of glycan content of a glycoprotein |
WO2016149139A1 (en) | 2015-03-13 | 2016-09-22 | Samsung Bioepis Co., Ltd. | Anti-tnf-alpha polypeptide composition and use thereof |
CN109982685B (zh) | 2016-10-21 | 2022-03-11 | 美国安进公司 | 药物配制品及其制备方法 |
US11952399B2 (en) | 2018-12-18 | 2024-04-09 | Amgen Inc. | Methods for purifying proteins |
WO2023129974A1 (en) | 2021-12-29 | 2023-07-06 | Bristol-Myers Squibb Company | Generation of landing pad cell lines |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4675285A (en) * | 1984-09-19 | 1987-06-23 | Genetics Institute, Inc. | Method for identification and isolation of DNA encoding a desired protein |
JPS61293924A (ja) * | 1985-06-23 | 1986-12-24 | Asahi Chem Ind Co Ltd | 生理活性物質の受容タンパク |
US4935233A (en) * | 1985-12-02 | 1990-06-19 | G. D. Searle And Company | Covalently linked polypeptide cell modulators |
IL83878A (en) * | 1987-09-13 | 1995-07-31 | Yeda Res & Dev | Soluble protein corresponding to tnf inhibitory protein its preparation and pharmaceutical compositions containing it |
US5512544A (en) * | 1987-09-13 | 1996-04-30 | Yeda Research And Development Co. Ltd. | Pharmaceutical compositions comprising an anticytokine |
PT88641B (pt) * | 1987-10-02 | 1993-04-30 | Genentech Inc | Metodo para a preparacao de uma variante de adesao |
DE68926888T2 (de) * | 1988-01-22 | 1997-01-09 | Zymogenetics Inc | Verfahren zur Herstellung von sekretierten Rezeptoranalogen |
GB8806339D0 (en) * | 1988-03-17 | 1988-04-13 | Hoffmann La Roche | Monoclonal antibodies |
GB8807803D0 (en) * | 1988-03-31 | 1988-05-05 | Glaxo Group Ltd | Biochemical product |
US5116964A (en) * | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
EP0394827A1 (en) * | 1989-04-26 | 1990-10-31 | F. Hoffmann-La Roche Ag | Chimaeric CD4-immunoglobulin polypeptides |
DE3922089A1 (de) * | 1989-05-09 | 1990-12-13 | Basf Ag | Neue proteine und ihre herstellung |
DE69017753T3 (de) * | 1989-05-18 | 2013-06-20 | Yeda Research And Development Co., Ltd. | Tumor-Nekrosefaktor-Bindungsprotein II, seine Reinigung und spezifische Antikörper |
IL95031A (en) * | 1989-07-18 | 2007-03-08 | Amgen Inc | A method of producing a recombinant human necrotic factor absorber |
NZ235148A (en) * | 1989-09-05 | 1991-12-23 | Immunex Corp | Tumour necrosis factor receptor protein and dna sequences |
US5605690A (en) * | 1989-09-05 | 1997-02-25 | Immunex Corporation | Methods of lowering active TNF-α levels in mammals using tumor necrosis factor receptor |
US5395760A (en) * | 1989-09-05 | 1995-03-07 | Immunex Corporation | DNA encoding tumor necrosis factor-α and -β receptors |
EP1132471A3 (de) * | 1989-09-12 | 2001-11-28 | F. Hoffmann-La Roche Ag | TNF-bindende Proteine |
DE59109032D1 (de) * | 1990-06-28 | 1998-09-03 | Hoechst Ag | Fusionsproteine mit immunglobulinanteilen, ihre Herstellung und Verwendung |
GB9022648D0 (en) * | 1990-10-18 | 1990-11-28 | Charing Cross Sunley Research | Polypeptide and its use |
IL99120A0 (en) * | 1991-08-07 | 1992-07-15 | Yeda Res & Dev | Multimers of the soluble forms of tnf receptors,their preparation and pharmaceutical compositions containing them |
US5447851B1 (en) * | 1992-04-02 | 1999-07-06 | Univ Texas System Board Of | Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells |
-
1990
- 1990-05-10 US US07/523,635 patent/US5395760A/en not_active Expired - Lifetime
- 1990-09-10 DE DE2000175011 patent/DE10075011I2/de active Active
- 1990-09-10 EP EP90309875A patent/EP0418014B1/en not_active Expired - Lifetime
- 1990-09-10 ES ES90309875T patent/ES2080809T4/es not_active Expired - Lifetime
- 1990-09-10 AT AT90309875T patent/ATE131871T1/de active
- 1990-09-10 DE DE69024291T patent/DE69024291T2/de not_active Expired - Lifetime
- 1990-09-10 DK DK90309875.4T patent/DK0418014T3/da active
-
1996
- 1996-03-19 GR GR960400727T patent/GR3019333T3/el unknown
-
1998
- 1998-08-31 US US09/144,502 patent/USRE36755E/en not_active Expired - Lifetime
-
2000
- 2000-05-31 LU LU90591C patent/LU90591I2/fr unknown
- 2000-06-09 NL NL300008C patent/NL300008I2/nl unknown
Also Published As
Publication number | Publication date |
---|---|
ES2080809T4 (es) | 2012-12-20 |
EP0418014B1 (en) | 1995-12-20 |
DE10075011I2 (de) | 2004-08-12 |
EP0418014A1 (en) | 1991-03-20 |
DE69024291D1 (de) | 1996-02-01 |
US5395760A (en) | 1995-03-07 |
USRE36755E (en) | 2000-06-27 |
DK0418014T3 (da) | 1996-01-22 |
GR3019333T3 (en) | 1996-06-30 |
DE10075011I1 (de) | 2003-06-12 |
LU90591I2 (fr) | 2000-07-31 |
NL300008I1 (nl) | 2000-08-01 |
ATE131871T1 (de) | 1996-01-15 |
DE69024291T2 (de) | 1996-10-31 |
NL300008I2 (nl) | 2000-12-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2080809T3 (es) | Receptores de factor de necrosis tumoral alfa y beta. | |
CA2065346A1 (en) | Tumor necrosis factor-.alpha. and-.beta. receptors | |
ES2103706T3 (es) | Receptores de interleuquina-4. | |
DE69132937T2 (de) | Typ-II-Interleukin-1-Rezeptoren | |
EP0318296A3 (en) | Interleukin-1 receptors | |
NO872988D0 (no) | Pattedyr-interleukin-4. | |
DE69016508T2 (de) | Interleukin-7-Rezeptoren. | |
ATE109829T1 (de) | Interleukin-7. | |
DK0494260T3 (da) | Receptorer for granulocytkolonistimulerende faktor |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 418014 Country of ref document: ES |
|
SPCF | Request for supplementary protection certificate filed |
Free format text: ETANERCEPT (ENBREL) Spc suppl protection certif: C200000014 Filing date: 20000630 |
|
SPCG | Supplementary protection certificate granted |
Free format text: ETANERCEPT (ENBREL) Spc suppl protection certif: C200000014 Filing date: 20000630 Expiry date: 20150203 Effective date: 20040311 |