DE69825890T2 - Magnetische anordnung für zellen-trennung und verfahren zur trennung - Google Patents

Magnetische anordnung für zellen-trennung und verfahren zur trennung Download PDF

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Publication number
DE69825890T2
DE69825890T2 DE69825890T DE69825890T DE69825890T2 DE 69825890 T2 DE69825890 T2 DE 69825890T2 DE 69825890 T DE69825890 T DE 69825890T DE 69825890 T DE69825890 T DE 69825890T DE 69825890 T2 DE69825890 T2 DE 69825890T2
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DE
Germany
Prior art keywords
magnet
adjacent
magnets
interpolar
magnetized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69825890T
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German (de)
English (en)
Other versions
DE69825890D1 (de
Inventor
D. Martin STERMAN
Paul Lituri
E. Richard STELTER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PERMAG CORP WINDSOR LOCKS
Genzyme Corp
Permag Corp
Original Assignee
PERMAG CORP WINDSOR LOCKS
Genzyme Corp
Permag Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PERMAG CORP WINDSOR LOCKS, Genzyme Corp, Permag Corp filed Critical PERMAG CORP WINDSOR LOCKS
Publication of DE69825890D1 publication Critical patent/DE69825890D1/de
Application granted granted Critical
Publication of DE69825890T2 publication Critical patent/DE69825890T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/035—Open gradient magnetic separators, i.e. separators in which the gap is unobstructed, characterised by the configuration of the gap
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/025—High gradient magnetic separators
    • B03C1/031—Component parts; Auxiliary operations
    • B03C1/033—Component parts; Auxiliary operations characterised by the magnetic circuit
    • B03C1/0332—Component parts; Auxiliary operations characterised by the magnetic circuit using permanent magnets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/28—Magnetic plugs and dipsticks
    • B03C1/288—Magnetic plugs and dipsticks disposed at the outer circumference of a recipient
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F7/00—Magnets
    • H01F7/02—Permanent magnets [PM]
    • H01F7/0273—Magnetic circuits with PM for magnetic field generation
    • H01F7/0278—Magnetic circuits with PM for magnetic field generation for generating uniform fields, focusing, deflecting electrically charged particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/18—Magnetic separation whereby the particles are suspended in a liquid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/22—Details of magnetic or electrostatic separation characterised by the magnetic field, e.g. its shape or generation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/26—Details of magnetic or electrostatic separation for use in medical or biological applications

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  • Physics & Mathematics (AREA)
  • Electromagnetism (AREA)
  • Engineering & Computer Science (AREA)
  • Power Engineering (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Centrifugal Separators (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE69825890T 1997-06-04 1998-06-04 Magnetische anordnung für zellen-trennung und verfahren zur trennung Expired - Lifetime DE69825890T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/868,598 US6451207B1 (en) 1997-06-04 1997-06-04 Magnetic cell separation device
US868598 1997-06-04
PCT/US1998/011816 WO1998055236A1 (en) 1997-06-04 1998-06-04 Magnetic cell separation device

Publications (2)

Publication Number Publication Date
DE69825890D1 DE69825890D1 (de) 2004-09-30
DE69825890T2 true DE69825890T2 (de) 2005-09-08

Family

ID=25351973

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69825890T Expired - Lifetime DE69825890T2 (de) 1997-06-04 1998-06-04 Magnetische anordnung für zellen-trennung und verfahren zur trennung

Country Status (8)

Country Link
US (2) US6451207B1 (https=)
EP (1) EP0986436B1 (https=)
JP (1) JP4444377B2 (https=)
AT (1) ATE274376T1 (https=)
AU (1) AU753848B2 (https=)
CA (1) CA2292631C (https=)
DE (1) DE69825890T2 (https=)
WO (1) WO1998055236A1 (https=)

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US9597395B2 (en) 2001-12-07 2017-03-21 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions
JP4653952B2 (ja) 2001-12-07 2011-03-16 サイトリ セラピューティクス インコーポレイテッド 処理済み脂肪吸引細胞で患者を治療するためのシステムと方法
US20050095228A1 (en) 2001-12-07 2005-05-05 Fraser John K. Methods of using regenerative cells in the treatment of peripheral vascular disease and related disorders
US7651684B2 (en) 2001-12-07 2010-01-26 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in augmenting autologous fat transfer
US20050048035A1 (en) 2001-12-07 2005-03-03 Fraser John K. Methods of using regenerative cells in the treatment of stroke and related diseases and disorders
US7585670B2 (en) 2001-12-07 2009-09-08 Cytori Therapeutics, Inc. Automated methods for isolating and using clinically safe adipose derived regenerative cells
US7771716B2 (en) 2001-12-07 2010-08-10 Cytori Therapeutics, Inc. Methods of using regenerative cells in the treatment of musculoskeletal disorders
US6846985B2 (en) 2002-01-22 2005-01-25 Nanoset, Llc Magnetically shielded assembly
US20040225213A1 (en) 2002-01-22 2004-11-11 Xingwu Wang Magnetic resonance imaging coated assembly
US7162302B2 (en) 2002-03-04 2007-01-09 Nanoset Llc Magnetically shielded assembly
US7091412B2 (en) 2002-03-04 2006-08-15 Nanoset, Llc Magnetically shielded assembly
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CA2483868A1 (en) * 2002-05-03 2004-05-21 Molecular Probes, Inc. Compositions and methods for detection and isolation of phosphorylated molecules
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CA2516510C (en) 2003-02-20 2012-07-10 Macropore Biosurgery, Inc. Method of using adipose tissue-derived cells in the treatment of cardiovascular conditions
KR20060067974A (ko) * 2003-09-19 2006-06-20 뉴사우스 이노베이션즈 피티와이 리미티드 간세포의 분리 방법
JP2005128771A (ja) * 2003-10-23 2005-05-19 Fujitsu Ltd データファイルシステム、データアクセスサーバ、およびデータアクセスプログラム
WO2005065267A2 (en) * 2003-12-24 2005-07-21 Massachusetts Institute Of Technology Magnetophoretic cell clarification
US8211386B2 (en) 2004-06-08 2012-07-03 Biokit, S.A. Tapered cuvette and method of collecting magnetic particles
US20060051265A1 (en) * 2004-09-08 2006-03-09 Health Research, Inc. Apparatus and method for sorting microstructures in a fluid medium
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JP5763875B2 (ja) * 2005-06-24 2015-08-12 セプマグ、システムズ、ソシエダッド、リミターダＳｅｐｍａｇ Ｓｙｓｔｅｍｓ，Ｓ．Ｌ． 磁性粒子を分離するためのデバイス及び方法
US20070018764A1 (en) * 2005-07-19 2007-01-25 Analisi Tecnologica Innovadora Per A Processos Device and method for separating magnetic particles
NL1030761C2 (nl) * 2005-12-23 2007-06-29 Bakker Holding Son Bv Werkwijze en inrichting voor het scheiden van vaste deeltjes op basis van dichtheidsverschil.
EP1996931B1 (en) * 2005-12-28 2013-11-27 The General Hospital Corporation Blood cell sorting methods and systems
US20090304644A1 (en) * 2006-05-30 2009-12-10 Cytori Therapeutics, Inc. Systems and methods for manipulation of regenerative cells separated and concentrated from adipose tissue
US20100015104A1 (en) * 2006-07-26 2010-01-21 Cytori Therapeutics, Inc Generation of adipose tissue and adipocytes
US20090152176A1 (en) * 2006-12-23 2009-06-18 Baxter International Inc. Magnetic separation of fine particles from compositions
DE102007043281A1 (de) 2007-09-11 2009-05-28 Sebastian Dr. med. Chakrit Bhakdi Vorrichtung, Materialien und Verfahren zur Hochgradientenmagnetseparation biologischen Materials
WO2010006328A2 (en) * 2008-07-11 2010-01-14 The General Hospital Corporation Magnetic apparatus for blood separation
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US20100099076A1 (en) * 2008-10-16 2010-04-22 Kent State University Sensitive and rapid detection of viral particles in early viral infection by laser tweezers
KR101738324B1 (ko) * 2009-05-01 2017-05-19 비미니 테크놀로지스 엘엘씨 조직 및 세포 부유화 이식편의 최적화 시스템, 방법 및 조성물
US8845812B2 (en) * 2009-06-12 2014-09-30 Micron Technology, Inc. Method for contamination removal using magnetic particles
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EP2553686A4 (en) * 2010-03-29 2015-01-21 Glenn Lane Family Ltd Liability Ltd Partnership SPATIAL SEGREGATION OF PLASMA COMPONENTS
JP2014515694A (ja) 2011-03-11 2014-07-03 ギーシェン ヤン、 磁性粒子スカベンジング装置および方法
US20120262260A1 (en) * 2011-04-18 2012-10-18 Exact Sciences Corporation Magnetic microparticle localization device
US8708152B2 (en) 2011-04-20 2014-04-29 Magnetation, Inc. Iron ore separation device
HK1220287A1 (zh) 2013-03-15 2017-04-28 Glenn Lane Family Limited Liability Limited Partnership 可调节的质量分辨孔
DK3046417T3 (en) 2013-09-19 2017-10-09 Cytori Therapeutics Inc PROCEDURES FOR USING Oily Tissue Drained Cells To Treat RAYNAUD'S SYNDROME CONNECTED WITH SCLERODERMIA
WO2016002256A1 (ja) * 2014-07-03 2016-01-07 三菱電機株式会社 渦電流選別装置および渦電流選別方法
US9387486B2 (en) * 2014-09-30 2016-07-12 Ut-Battelle, Llc High-gradient permanent magnet apparatus and its use in particle collection
US11542463B2 (en) 2017-04-13 2023-01-03 Universiteit Antwerpen Micro algae harvesting methods and devices
US10449553B2 (en) * 2018-03-03 2019-10-22 Yuchen Zhou Magnetic biological entity separation device and method of use
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Also Published As

Publication number Publication date
DE69825890D1 (de) 2004-09-30
CA2292631C (en) 2008-01-15
US6451207B1 (en) 2002-09-17
CA2292631A1 (en) 1998-12-10
JP4444377B2 (ja) 2010-03-31
EP0986436B1 (en) 2004-08-25
US20030015474A1 (en) 2003-01-23
AU8061698A (en) 1998-12-21
US6572778B2 (en) 2003-06-03
JP2002504852A (ja) 2002-02-12
WO1998055236A1 (en) 1998-12-10
ATE274376T1 (de) 2004-09-15
EP0986436A1 (en) 2000-03-22
AU753848B2 (en) 2002-10-31

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