DE69825890T2 - Magnetische anordnung für zellen-trennung und verfahren zur trennung - Google Patents

Magnetische anordnung für zellen-trennung und verfahren zur trennung Download PDF

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Publication number
DE69825890T2
DE69825890T2 DE69825890T DE69825890T DE69825890T2 DE 69825890 T2 DE69825890 T2 DE 69825890T2 DE 69825890 T DE69825890 T DE 69825890T DE 69825890 T DE69825890 T DE 69825890T DE 69825890 T2 DE69825890 T2 DE 69825890T2
Authority
DE
Germany
Prior art keywords
magnet
adjacent
magnets
interpolar
magnetized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69825890T
Other languages
German (de)
English (en)
Other versions
DE69825890D1 (de
Inventor
D. Martin STERMAN
Paul Lituri
E. Richard STELTER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PERMAG CORP WINDSOR LOCKS
Genzyme Corp
Permag Corp
Original Assignee
PERMAG CORP WINDSOR LOCKS
Genzyme Corp
Permag Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PERMAG CORP WINDSOR LOCKS, Genzyme Corp, Permag Corp filed Critical PERMAG CORP WINDSOR LOCKS
Publication of DE69825890D1 publication Critical patent/DE69825890D1/de
Application granted granted Critical
Publication of DE69825890T2 publication Critical patent/DE69825890T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/035—Open gradient magnetic separators, i.e. separators in which the gap is unobstructed, characterised by the configuration of the gap
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/025—High gradient magnetic separators
    • B03C1/031—Component parts; Auxiliary operations
    • B03C1/033—Component parts; Auxiliary operations characterised by the magnetic circuit
    • B03C1/0332—Component parts; Auxiliary operations characterised by the magnetic circuit using permanent magnets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/28—Magnetic plugs and dipsticks
    • B03C1/288—Magnetic plugs and dipsticks disposed at the outer circumference of a recipient
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F7/00—Magnets
    • H01F7/02—Permanent magnets [PM]
    • H01F7/0273—Magnetic circuits with PM for magnetic field generation
    • H01F7/0278—Magnetic circuits with PM for magnetic field generation for generating uniform fields, focusing, deflecting electrically charged particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/18—Magnetic separation whereby the particles are suspended in a liquid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/22—Details of magnetic or electrostatic separation characterised by the magnetic field, e.g. its shape or generation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/26—Details of magnetic or electrostatic separation for use in medical or biological applications

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  • Physics & Mathematics (AREA)
  • Electromagnetism (AREA)
  • Engineering & Computer Science (AREA)
  • Power Engineering (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
  • Centrifugal Separators (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE69825890T 1997-06-04 1998-06-04 Magnetische anordnung für zellen-trennung und verfahren zur trennung Expired - Lifetime DE69825890T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US868598 1997-06-04
US08/868,598 US6451207B1 (en) 1997-06-04 1997-06-04 Magnetic cell separation device
PCT/US1998/011816 WO1998055236A1 (en) 1997-06-04 1998-06-04 Magnetic cell separation device

Publications (2)

Publication Number Publication Date
DE69825890D1 DE69825890D1 (de) 2004-09-30
DE69825890T2 true DE69825890T2 (de) 2005-09-08

Family

ID=25351973

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69825890T Expired - Lifetime DE69825890T2 (de) 1997-06-04 1998-06-04 Magnetische anordnung für zellen-trennung und verfahren zur trennung

Country Status (8)

Country Link
US (2) US6451207B1 (https=)
EP (1) EP0986436B1 (https=)
JP (1) JP4444377B2 (https=)
AT (1) ATE274376T1 (https=)
AU (1) AU753848B2 (https=)
CA (1) CA2292631C (https=)
DE (1) DE69825890T2 (https=)
WO (1) WO1998055236A1 (https=)

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US7585670B2 (en) 2001-12-07 2009-09-08 Cytori Therapeutics, Inc. Automated methods for isolating and using clinically safe adipose derived regenerative cells
US7651684B2 (en) 2001-12-07 2010-01-26 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in augmenting autologous fat transfer
US9597395B2 (en) 2001-12-07 2017-03-21 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions
KR100930139B1 (ko) 2001-12-07 2009-12-07 사이토리 테라퓨틱스, 인크. 처리된 리포애스퍼레이트 세포로 환자를 치료하기 위한시스템 및 방법
US20050048035A1 (en) 2001-12-07 2005-03-03 Fraser John K. Methods of using regenerative cells in the treatment of stroke and related diseases and disorders
US7771716B2 (en) 2001-12-07 2010-08-10 Cytori Therapeutics, Inc. Methods of using regenerative cells in the treatment of musculoskeletal disorders
US20050095228A1 (en) 2001-12-07 2005-05-05 Fraser John K. Methods of using regenerative cells in the treatment of peripheral vascular disease and related disorders
US6846985B2 (en) 2002-01-22 2005-01-25 Nanoset, Llc Magnetically shielded assembly
US7091412B2 (en) 2002-03-04 2006-08-15 Nanoset, Llc Magnetically shielded assembly
US20040225213A1 (en) 2002-01-22 2004-11-11 Xingwu Wang Magnetic resonance imaging coated assembly
US7162302B2 (en) 2002-03-04 2007-01-09 Nanoset Llc Magnetically shielded assembly
US7011758B2 (en) * 2002-02-11 2006-03-14 The Board Of Trustees Of The University Of Illinois Methods and systems for membrane testing
WO2003086637A1 (en) 2002-04-12 2003-10-23 Instrumentation Laboratory Company Immunoassay probe
CN1665790A (zh) * 2002-05-03 2005-09-07 莫莱丘莱尔探针公司 用于检测和分离磷酸化分子的组合物及方法
US20040140875A1 (en) * 2003-01-22 2004-07-22 Strom Carl H. Unipolar magnetic system
MXPA05009044A (es) 2003-02-20 2006-03-17 Macropore Biosurgery Inc Metodos para utilizar celulas derivadas de tejido adiposo en el tratamiento de condiciones cardiovasculares.
WO2005028640A1 (en) * 2003-09-19 2005-03-31 Newsouth Innovations Pty Limited Method for isolating hepatocytes
JP2005128771A (ja) * 2003-10-23 2005-05-19 Fujitsu Ltd データファイルシステム、データアクセスサーバ、およびデータアクセスプログラム
WO2005065267A2 (en) * 2003-12-24 2005-07-21 Massachusetts Institute Of Technology Magnetophoretic cell clarification
US8211386B2 (en) 2004-06-08 2012-07-03 Biokit, S.A. Tapered cuvette and method of collecting magnetic particles
US20060051265A1 (en) * 2004-09-08 2006-03-09 Health Research, Inc. Apparatus and method for sorting microstructures in a fluid medium
NL1028845C2 (nl) * 2005-04-22 2006-10-24 Rail Road Systems B V Inrichting voor het creeren van een substantieel magneetveld vrij gebied omgeven door een gebied met een magneetveld gradient.
EP1904237B1 (en) * 2005-06-24 2013-08-14 Sepmag Systems, S.L. Device and method for separating magnetic particles
US20070018764A1 (en) * 2005-07-19 2007-01-25 Analisi Tecnologica Innovadora Per A Processos Device and method for separating magnetic particles
NL1030761C2 (nl) * 2005-12-23 2007-06-29 Bakker Holding Son Bv Werkwijze en inrichting voor het scheiden van vaste deeltjes op basis van dichtheidsverschil.
US7867765B2 (en) * 2005-12-28 2011-01-11 The General Hospital Corporation Blood cell sorting methods and systems
WO2007139551A1 (en) * 2006-05-30 2007-12-06 Cytori Therapeutics, Inc. Systems and methods for manipulation of regenerative cells from adipose tissue
WO2008013863A2 (en) * 2006-07-26 2008-01-31 Cytori Therapeutics, Inc. Generation of adipose tissue and adipocytes
WO2008080047A2 (en) * 2006-12-23 2008-07-03 Baxter International Inc. Magnetic separation of fine particles from compositions
DE102007043281A1 (de) 2007-09-11 2009-05-28 Sebastian Dr. med. Chakrit Bhakdi Vorrichtung, Materialien und Verfahren zur Hochgradientenmagnetseparation biologischen Materials
US20110177592A1 (en) * 2008-07-11 2011-07-21 Faustman Denise L Magnetic apparatus for blood separation
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US8368033B2 (en) 2010-03-29 2013-02-05 Glenn Lane Spatial segregation of plasma components
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US20120262260A1 (en) * 2011-04-18 2012-10-18 Exact Sciences Corporation Magnetic microparticle localization device
US8708152B2 (en) 2011-04-20 2014-04-29 Magnetation, Inc. Iron ore separation device
HK1220287A1 (zh) 2013-03-15 2017-04-28 Glenn Lane Family Limited Liability Limited Partnership 可调节的质量分辨孔
JP6622189B2 (ja) 2013-09-19 2019-12-18 サイトリ・セラピューティクス株式会社 疼痛及び／又は線維症の調節において脂肪組織由来細胞を使用する方法
EP3165293B1 (en) * 2014-07-03 2020-01-08 Mitsubishi Electric Corporation Eddy current selection device and eddy current selection method
US9387486B2 (en) * 2014-09-30 2016-07-12 Ut-Battelle, Llc High-gradient permanent magnet apparatus and its use in particle collection
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US11278915B1 (en) 2018-07-20 2022-03-22 NeoGeneStar LLC Device for capturing and releasing magnetic particles
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CN110004062B (zh) * 2019-04-18 2022-07-01 中国人民解放军第四军医大学 分选富集数量极稀少循环肿瘤细胞的装置和方法
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Also Published As

Publication number Publication date
ATE274376T1 (de) 2004-09-15
CA2292631C (en) 2008-01-15
US20030015474A1 (en) 2003-01-23
DE69825890D1 (de) 2004-09-30
US6572778B2 (en) 2003-06-03
JP2002504852A (ja) 2002-02-12
AU8061698A (en) 1998-12-21
EP0986436B1 (en) 2004-08-25
AU753848B2 (en) 2002-10-31
CA2292631A1 (en) 1998-12-10
JP4444377B2 (ja) 2010-03-31
WO1998055236A1 (en) 1998-12-10
EP0986436A1 (en) 2000-03-22
US6451207B1 (en) 2002-09-17

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