AU753848B2 - Magnetic cell separation device - Google Patents

Magnetic cell separation device Download PDF

Info

Publication number
AU753848B2
AU753848B2 AU80616/98A AU8061698A AU753848B2 AU 753848 B2 AU753848 B2 AU 753848B2 AU 80616/98 A AU80616/98 A AU 80616/98A AU 8061698 A AU8061698 A AU 8061698A AU 753848 B2 AU753848 B2 AU 753848B2
Authority
AU
Australia
Prior art keywords
adjacent
magnets
magnet
interpolar
magnetic device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU80616/98A
Other languages
English (en)
Other versions
AU8061698A (en
Inventor
Paul Lituri
Richard E. Stelter
Martin D. Sterman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genzyme Corp
Permag Corp
Original Assignee
Genzyme Corp
Permag Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp, Permag Corp filed Critical Genzyme Corp
Publication of AU8061698A publication Critical patent/AU8061698A/en
Application granted granted Critical
Publication of AU753848B2 publication Critical patent/AU753848B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00Magnetic separation
    • B03C1/02Magnetic separation acting directly on the substance being separated
    • B03C1/035Open gradient magnetic separators, i.e. separators in which the gap is unobstructed, characterised by the configuration of the gap
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00Magnetic separation
    • B03C1/02Magnetic separation acting directly on the substance being separated
    • B03C1/025High gradient magnetic separators
    • B03C1/031Component parts; Auxiliary operations
    • B03C1/033Component parts; Auxiliary operations characterised by the magnetic circuit
    • B03C1/0332Component parts; Auxiliary operations characterised by the magnetic circuit using permanent magnets
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00Magnetic separation
    • B03C1/02Magnetic separation acting directly on the substance being separated
    • B03C1/28Magnetic plugs and dipsticks
    • B03C1/288Magnetic plugs and dipsticks disposed at the outer circumference of a recipient
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01FMAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F7/00Magnets
    • H01F7/02Permanent magnets [PM]
    • H01F7/0273Magnetic circuits with PM for magnetic field generation
    • H01F7/0278Magnetic circuits with PM for magnetic field generation for generating uniform fields, focusing, deflecting electrically charged particles
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00Details of magnetic or electrostatic separation
    • B03C2201/18Magnetic separation whereby the particles are suspended in a liquid
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00Details of magnetic or electrostatic separation
    • B03C2201/22Details of magnetic or electrostatic separation characterised by the magnetic field, e.g. its shape or generation
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00Details of magnetic or electrostatic separation
    • B03C2201/26Details of magnetic or electrostatic separation for use in medical or biological applications

Landscapes

  • Physics & Mathematics (AREA)
  • Electromagnetism (AREA)
  • Engineering & Computer Science (AREA)
  • Power Engineering (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
  • Centrifugal Separators (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AU80616/98A 1997-06-04 1998-06-04 Magnetic cell separation device Expired AU753848B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/868,598 US6451207B1 (en) 1997-06-04 1997-06-04 Magnetic cell separation device
US08/868598 1997-06-04
PCT/US1998/011816 WO1998055236A1 (en) 1997-06-04 1998-06-04 Magnetic cell separation device

Publications (2)

Publication Number Publication Date
AU8061698A AU8061698A (en) 1998-12-21
AU753848B2 true AU753848B2 (en) 2002-10-31

Family

ID=25351973

Family Applications (1)

Application Number Title Priority Date Filing Date
AU80616/98A Expired AU753848B2 (en) 1997-06-04 1998-06-04 Magnetic cell separation device

Country Status (8)

Country Link
US (2) US6451207B1 (https=)
EP (1) EP0986436B1 (https=)
JP (1) JP4444377B2 (https=)
AT (1) ATE274376T1 (https=)
AU (1) AU753848B2 (https=)
CA (1) CA2292631C (https=)
DE (1) DE69825890T2 (https=)
WO (1) WO1998055236A1 (https=)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6413420B1 (en) * 2000-03-17 2002-07-02 Dexter Magnetic Technologies, Inc. Magnetic separation device
FR2826592B1 (fr) 2001-06-27 2003-08-15 Bio Merieux Procede, dispositif, et equipement de separation par voie humide de micro particules magnetiques
DE10136060A1 (de) * 2001-07-25 2003-02-13 Roche Diagnostics Gmbh System zur Separation von magnetisch anziehbaren Partikeln
US7585670B2 (en) 2001-12-07 2009-09-08 Cytori Therapeutics, Inc. Automated methods for isolating and using clinically safe adipose derived regenerative cells
US7651684B2 (en) 2001-12-07 2010-01-26 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in augmenting autologous fat transfer
US9597395B2 (en) 2001-12-07 2017-03-21 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions
KR100930139B1 (ko) 2001-12-07 2009-12-07 사이토리 테라퓨틱스, 인크. 처리된 리포애스퍼레이트 세포로 환자를 치료하기 위한시스템 및 방법
US20050048035A1 (en) 2001-12-07 2005-03-03 Fraser John K. Methods of using regenerative cells in the treatment of stroke and related diseases and disorders
US7771716B2 (en) 2001-12-07 2010-08-10 Cytori Therapeutics, Inc. Methods of using regenerative cells in the treatment of musculoskeletal disorders
US20050095228A1 (en) 2001-12-07 2005-05-05 Fraser John K. Methods of using regenerative cells in the treatment of peripheral vascular disease and related disorders
US6846985B2 (en) 2002-01-22 2005-01-25 Nanoset, Llc Magnetically shielded assembly
US7091412B2 (en) 2002-03-04 2006-08-15 Nanoset, Llc Magnetically shielded assembly
US20040225213A1 (en) 2002-01-22 2004-11-11 Xingwu Wang Magnetic resonance imaging coated assembly
US7162302B2 (en) 2002-03-04 2007-01-09 Nanoset Llc Magnetically shielded assembly
US7011758B2 (en) * 2002-02-11 2006-03-14 The Board Of Trustees Of The University Of Illinois Methods and systems for membrane testing
WO2003086637A1 (en) 2002-04-12 2003-10-23 Instrumentation Laboratory Company Immunoassay probe
CN1665790A (zh) * 2002-05-03 2005-09-07 莫莱丘莱尔探针公司 用于检测和分离磷酸化分子的组合物及方法
US20040140875A1 (en) * 2003-01-22 2004-07-22 Strom Carl H. Unipolar magnetic system
MXPA05009044A (es) 2003-02-20 2006-03-17 Macropore Biosurgery Inc Metodos para utilizar celulas derivadas de tejido adiposo en el tratamiento de condiciones cardiovasculares.
WO2005028640A1 (en) * 2003-09-19 2005-03-31 Newsouth Innovations Pty Limited Method for isolating hepatocytes
JP2005128771A (ja) * 2003-10-23 2005-05-19 Fujitsu Ltd データファイルシステム、データアクセスサーバ、およびデータアクセスプログラム
WO2005065267A2 (en) * 2003-12-24 2005-07-21 Massachusetts Institute Of Technology Magnetophoretic cell clarification
US8211386B2 (en) 2004-06-08 2012-07-03 Biokit, S.A. Tapered cuvette and method of collecting magnetic particles
US20060051265A1 (en) * 2004-09-08 2006-03-09 Health Research, Inc. Apparatus and method for sorting microstructures in a fluid medium
NL1028845C2 (nl) * 2005-04-22 2006-10-24 Rail Road Systems B V Inrichting voor het creeren van een substantieel magneetveld vrij gebied omgeven door een gebied met een magneetveld gradient.
EP1904237B1 (en) * 2005-06-24 2013-08-14 Sepmag Systems, S.L. Device and method for separating magnetic particles
US20070018764A1 (en) * 2005-07-19 2007-01-25 Analisi Tecnologica Innovadora Per A Processos Device and method for separating magnetic particles
NL1030761C2 (nl) * 2005-12-23 2007-06-29 Bakker Holding Son Bv Werkwijze en inrichting voor het scheiden van vaste deeltjes op basis van dichtheidsverschil.
US7867765B2 (en) * 2005-12-28 2011-01-11 The General Hospital Corporation Blood cell sorting methods and systems
WO2007139551A1 (en) * 2006-05-30 2007-12-06 Cytori Therapeutics, Inc. Systems and methods for manipulation of regenerative cells from adipose tissue
WO2008013863A2 (en) * 2006-07-26 2008-01-31 Cytori Therapeutics, Inc. Generation of adipose tissue and adipocytes
WO2008080047A2 (en) * 2006-12-23 2008-07-03 Baxter International Inc. Magnetic separation of fine particles from compositions
DE102007043281A1 (de) 2007-09-11 2009-05-28 Sebastian Dr. med. Chakrit Bhakdi Vorrichtung, Materialien und Verfahren zur Hochgradientenmagnetseparation biologischen Materials
US20110177592A1 (en) * 2008-07-11 2011-07-21 Faustman Denise L Magnetic apparatus for blood separation
WO2010021993A1 (en) 2008-08-19 2010-02-25 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in the treatment of the lymphatic system and malignant disease
US20100099076A1 (en) * 2008-10-16 2010-04-22 Kent State University Sensitive and rapid detection of viral particles in early viral infection by laser tweezers
AU2010242780B2 (en) * 2009-05-01 2016-04-21 Puregraft Llc Systems, methods and compositions for optimizing tissue and cell enriched grafts
US8845812B2 (en) * 2009-06-12 2014-09-30 Micron Technology, Inc. Method for contamination removal using magnetic particles
IN2012DN03194A (https=) 2009-10-28 2015-10-09 Magnetation Inc
TWI362964B (en) * 2009-12-23 2012-05-01 Ind Tech Res Inst Magnetic separation device and method for separating magnetic substances in bio-samples
US8368033B2 (en) 2010-03-29 2013-02-05 Glenn Lane Spatial segregation of plasma components
CA2829405A1 (en) 2011-03-11 2012-09-20 Guisheng Yang Magnetic particle scavenging device and method
US20120262260A1 (en) * 2011-04-18 2012-10-18 Exact Sciences Corporation Magnetic microparticle localization device
US8708152B2 (en) 2011-04-20 2014-04-29 Magnetation, Inc. Iron ore separation device
HK1220287A1 (zh) 2013-03-15 2017-04-28 Glenn Lane Family Limited Liability Limited Partnership 可调节的质量分辨孔
JP6622189B2 (ja) 2013-09-19 2019-12-18 サイトリ・セラピューティクス株式会社 疼痛及び/又は線維症の調節において脂肪組織由来細胞を使用する方法
EP3165293B1 (en) * 2014-07-03 2020-01-08 Mitsubishi Electric Corporation Eddy current selection device and eddy current selection method
US9387486B2 (en) * 2014-09-30 2016-07-12 Ut-Battelle, Llc High-gradient permanent magnet apparatus and its use in particle collection
US11542463B2 (en) 2017-04-13 2023-01-03 Universiteit Antwerpen Micro algae harvesting methods and devices
US12145151B2 (en) * 2018-03-03 2024-11-19 Applied Cells Inc. Methods and apparatus to separate biological entities
US11278915B1 (en) 2018-07-20 2022-03-22 NeoGeneStar LLC Device for capturing and releasing magnetic particles
WO2020174005A1 (en) 2019-02-28 2020-09-03 The Regenerative Group Ltd. Regenerative combination of plasma and adipose tissue
CN110004062B (zh) * 2019-04-18 2022-07-01 中国人民解放军第四军医大学 分选富集数量极稀少循环肿瘤细胞的装置和方法
DE102021125870A1 (de) * 2021-10-05 2023-04-06 Sekels Gmbh Vorrichtung zur Bewegung eines magnetischen Objekts in einem Behältnis
EP4344786A1 (en) 2022-09-27 2024-04-03 Sepmag Systems, S.L. Biomagnetic separation system with double ring profile
CN117839863B (zh) * 2024-01-04 2025-02-25 北京麦戈龙科技有限公司 磁性粒子分离装置
CN117884254B (zh) * 2024-01-04 2025-02-25 北京麦戈龙科技有限公司 磁性粒子分离装置
WO2025145622A1 (zh) * 2024-01-04 2025-07-10 北京麦戈龙生物科技有限公司 磁性粒子分离装置

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1202100A (en) * 1967-10-18 1970-08-12 Bethlehem Steel Corp Magnetic separator method and apparatus
US5466574A (en) * 1991-03-25 1995-11-14 Immunivest Corporation Apparatus and methods for magnetic separation featuring external magnetic means

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3365599A (en) 1965-03-17 1968-01-23 Wehr Corp Magnetic circuit
US5622831A (en) 1990-09-26 1997-04-22 Immunivest Corporation Methods and devices for manipulation of magnetically collected material
US5269915A (en) 1993-04-08 1993-12-14 Colonel Clair Magnetic source and condenser for producing flux perpendicular to gas and liquid flow in ferrous and nonferrous pipes
JP2788861B2 (ja) * 1994-11-30 1998-08-20 株式会社チップトン 磁気選別装置及びそれに用いられる払拭ブラシ

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1202100A (en) * 1967-10-18 1970-08-12 Bethlehem Steel Corp Magnetic separator method and apparatus
US5466574A (en) * 1991-03-25 1995-11-14 Immunivest Corporation Apparatus and methods for magnetic separation featuring external magnetic means

Also Published As

Publication number Publication date
ATE274376T1 (de) 2004-09-15
CA2292631C (en) 2008-01-15
US20030015474A1 (en) 2003-01-23
DE69825890D1 (de) 2004-09-30
US6572778B2 (en) 2003-06-03
JP2002504852A (ja) 2002-02-12
AU8061698A (en) 1998-12-21
DE69825890T2 (de) 2005-09-08
EP0986436B1 (en) 2004-08-25
CA2292631A1 (en) 1998-12-10
JP4444377B2 (ja) 2010-03-31
WO1998055236A1 (en) 1998-12-10
EP0986436A1 (en) 2000-03-22
US6451207B1 (en) 2002-09-17

Similar Documents

Publication Publication Date Title
AU753848B2 (en) Magnetic cell separation device
US6562239B2 (en) Magnetic separation device
US5622831A (en) Methods and devices for manipulation of magnetically collected material
US5567326A (en) Multisample magnetic separation device
US6361749B1 (en) Apparatus and methods for magnetic separation
CA2453110A1 (en) System for the separation of magnetically attractable particles
JP2004535591A5 (https=)
WO1999019071A1 (en) High gradient magnetic device and method for cell separation or purification
JPH0829425A (ja) 液体中の被検成分を磁気的に分離する方法
WO2008080047A2 (en) Magnetic separation of fine particles from compositions
US7985340B2 (en) Magnetic separator
CN106999890A (zh) 颗粒操作方法和颗粒操作用装置
US20110147278A1 (en) Magnetic separation device and method for separating magnetic substance in bio-samples
JP4826704B2 (ja) 極集中型磁気回路および磁気分離装置
US20210170423A1 (en) Magnetic separation system and devices
JPH02151767A (ja) 磁性微粒子を免疫反応の標識に用いる検体調整法及び検体調整器具
KR101934671B1 (ko) 자성 입자 분리 장치
Gooneratne et al. A micro-pillar array to trap magnetic beads in microfluidic systems
CA3162947A1 (en) Method and apparatus for processing material
EP1954396B1 (en) Magnetic separator and method
RU2198919C1 (ru) Устройство для сбора иммуномагнитных частиц, связанных при помощи специфических антител с бактериальными или вирусными инфекционными агентами, из инфицированной биологической жидкости
Owen Magnetic sorting of leukocytes
WO2021086443A1 (en) Biological component separators
US20230191412A1 (en) Two-Stage Magnetic Device for Sorting Biological Objects
US20230102744A1 (en) Magnetic Device for Sorting Biological Objects

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired