DE69824958D1 - Enantioselektive additions-reaktion mit hilfe eines organozink reagenzes - Google Patents

Enantioselektive additions-reaktion mit hilfe eines organozink reagenzes

Info

Publication number
DE69824958D1
DE69824958D1 DE69824958T DE69824958T DE69824958D1 DE 69824958 D1 DE69824958 D1 DE 69824958D1 DE 69824958 T DE69824958 T DE 69824958T DE 69824958 T DE69824958 T DE 69824958T DE 69824958 D1 DE69824958 D1 DE 69824958D1
Authority
DE
Germany
Prior art keywords
organozink
reagent
help
addition reaction
enantioselective addition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69824958T
Other languages
English (en)
Other versions
DE69824958T2 (de
Inventor
Yi Chen
D Tillyer
Lushi Tan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9711599A external-priority patent/GB9711599D0/en
Priority claimed from GB9727129A external-priority patent/GB9727129D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE69824958D1 publication Critical patent/DE69824958D1/de
Publication of DE69824958T2 publication Critical patent/DE69824958T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/68—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
DE69824958T 1997-05-16 1998-05-12 Enantioselektive additions-reaktion mit hilfe eines organozink reagenzes Expired - Lifetime DE69824958T2 (de)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US4671397P 1997-05-16 1997-05-16
US46713P 1997-05-16
GB9711599A GB9711599D0 (en) 1997-06-05 1997-06-05 Efficient enatioselective addition reation using an organozinc reagent
GB9711599 1997-06-05
US5788497P 1997-09-03 1997-09-03
US57884P 1997-09-03
GB9727129A GB9727129D0 (en) 1997-12-22 1997-12-22 Efficient enantioselective addition reaction using an organozinc reagent
GB9727129 1997-12-22
US8352598P 1998-04-29 1998-04-29
US83525P 1998-04-29
PCT/US1998/008888 WO1998051676A1 (en) 1997-05-16 1998-05-12 Efficient enantioselective addition reaction using an organozinc reagent

Publications (2)

Publication Number Publication Date
DE69824958D1 true DE69824958D1 (de) 2004-08-12
DE69824958T2 DE69824958T2 (de) 2005-07-14

Family

ID=27547294

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69824958T Expired - Lifetime DE69824958T2 (de) 1997-05-16 1998-05-12 Enantioselektive additions-reaktion mit hilfe eines organozink reagenzes

Country Status (26)

Country Link
US (1) US6015926A (de)
EP (1) EP0981520B1 (de)
JP (1) JP3273615B2 (de)
KR (1) KR100566683B1 (de)
CN (1) CN1106389C (de)
AR (1) AR011731A1 (de)
AT (1) ATE270666T1 (de)
AU (1) AU739250B2 (de)
BR (1) BR9809628A (de)
CA (1) CA2289206C (de)
CZ (1) CZ297968B6 (de)
DE (1) DE69824958T2 (de)
DK (1) DK0981520T3 (de)
EA (1) EA002192B1 (de)
ES (1) ES2224396T3 (de)
HR (1) HRP980266B1 (de)
HU (1) HU226881B1 (de)
NZ (1) NZ500526A (de)
PL (1) PL193448B1 (de)
PT (1) PT981520E (de)
RS (1) RS49860B (de)
SI (1) SI0981520T1 (de)
SK (1) SK285446B6 (de)
TW (1) TWI221833B (de)
UA (1) UA59396C2 (de)
WO (1) WO1998051676A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6201158B1 (en) * 1998-06-22 2001-03-13 Merck & Co., Inc. Process for making intermediate aldehydes
US7514466B2 (en) 2004-04-27 2009-04-07 Wyeth Purification of progesterone receptor modulators
US20090163601A1 (en) * 2007-12-21 2009-06-25 The Regents Of The University Of California (r)-2-methyl-(2,5-dimethylphenyl)propanol and (s)-(2-methyl-2,5-dimethylphenyl)propanol
ZA200806473B (en) 2008-01-31 2009-04-29 Aptuit Laurus Pvt Ltd An efficient process to induce enantioselectivity in procarbonyl compounds
US9073817B2 (en) 2008-01-31 2015-07-07 Laurus Labs Private Limited Efficient process to induce enantioselectivity in procarbonyl compounds
US20110071287A1 (en) * 2008-05-01 2011-03-24 Ranbaxy Laboratories Limited Process for the preparation of efavirenz
WO2010032259A2 (en) 2008-05-30 2010-03-25 Emcure Pharmaceuticals Limited Novel process
KR100878436B1 (ko) * 2008-08-18 2009-01-13 주식회사 지씨에이치앤피 금은화 추출물을 포함하는 소화성 궤양 치료 또는 예방용 약학조성물
EP2417114A1 (de) * 2009-04-09 2012-02-15 Lonza Ltd. Verfahren zur synthese chiraler cyclischer carbamate
US8115032B2 (en) * 2009-04-09 2012-02-14 Lonza Ltd. Process for the synthesis of a propargylic alcohol
US20110172419A1 (en) * 2009-04-09 2011-07-14 Aleksander Warm Process for the synthesis of cyclic carbamates
WO2010115638A2 (en) * 2009-04-09 2010-10-14 Lonza Ltd. Autocatalytic process for the synthesis of chiral propargylic alcohols
EP2448917A2 (de) 2009-07-03 2012-05-09 Archimica GmbH Verfahren zur enantioselektiven addition von organometallischen kohlenstoffnukleophilen an trifluormethylketone und verwendung des verfahrens in der synthese von hiv reverse transcriptase inhibitoren
US8080655B2 (en) * 2009-07-20 2011-12-20 Apotex Pharmachem Inc. Methods of making efavirenz and intermediates thereof
EP2447247A1 (de) 2010-10-14 2012-05-02 Lonza Ltd. Prozess zur Synthese von chiralen Propargylalkoholen
EP2441759A1 (de) * 2010-10-14 2012-04-18 Lonza Ltd. Verfahren zur Synthese von zyklischen Carbamaten
EP2447255A1 (de) 2010-10-14 2012-05-02 Lonza Ltd. Verfahren zur Synthese von zyklischen Carbamaten
WO2012079235A1 (en) * 2010-12-16 2012-06-21 Lonza Ltd Process for preparing efavirenz
CN103254087B (zh) * 2013-06-07 2015-03-18 郑州大学 依非韦伦中间体的制备方法
CN105330554B (zh) 2015-02-15 2017-07-11 上海迪赛诺药业股份有限公司 手性环丙基乙炔基叔醇类化合物的合成方法
DE202015104551U1 (de) 2015-08-27 2015-12-03 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Reaktoren für die Herstellung von Efavirenz sowie Zwischenprodukte
NL2018412B1 (en) * 2017-02-23 2018-09-17 Univ Nelson Mandela Metropolitan Method for the manufacture of efavirenz
CN106946718A (zh) * 2017-04-27 2017-07-14 武汉工程大学 一种合成依非韦伦中间体的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5665720A (en) * 1992-08-07 1997-09-09 Merck & Co., Inc. Benzoxazinones as inhibitors of HIV reverse transcriptase
WO1995020389A1 (en) * 1994-01-28 1995-08-03 Merck & Co., Inc. Benzoxazinones as inhibitors of hiv reverse transcriptase
US5663467A (en) * 1995-01-23 1997-09-02 Merck & Co., Inc. Synthesis of cyclopropylacetylene
US5633405A (en) * 1995-05-25 1997-05-27 Merck & Co., Inc. Asymmetric synthesis of (-)-6-chloro-4-cyclopropyl-ethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxanzin-2-one
CA2276074A1 (en) * 1997-01-10 1998-07-16 Merck & Co., Inc. Efficient synthesis of a chiral mediator
PL197740B1 (pl) * 1997-02-05 2008-04-30 Merck & Co Inc Postać krystaliczna I (-)-6-chloro-4-cyklopropyloetynylo-4-trifluorometylo-1,4-dihydro-2H-3,1-benzoksazyn-2-onu i sposób krystalizacji postaci I (-)-6-chloro-4-cyklopropylo-etynylo-4-trifluorometylo-1,4-dihydro-2H-3,1-benzoksazyn-2-onu
TW480253B (en) * 1997-02-12 2002-03-21 Merck & Co Inc Efficient synthesis of a 1,4-dihydro-2H-3,1-benzoxazin-2-one

Also Published As

Publication number Publication date
SI0981520T1 (en) 2004-10-31
CN1255919A (zh) 2000-06-07
RS49860B (sr) 2008-08-07
HRP980266A2 (en) 1999-02-28
AR011731A1 (es) 2000-08-30
EA002192B1 (ru) 2002-02-28
HUP0003404A2 (hu) 2000-12-28
AU7470798A (en) 1998-12-08
PT981520E (pt) 2004-10-29
KR20010012650A (ko) 2001-02-26
UA59396C2 (uk) 2003-09-15
AU739250B2 (en) 2001-10-04
DE69824958T2 (de) 2005-07-14
EP0981520A1 (de) 2000-03-01
EP0981520B1 (de) 2004-07-07
NZ500526A (en) 2001-07-27
CZ404699A3 (cs) 2000-07-12
CZ297968B6 (cs) 2007-05-09
SK156299A3 (en) 2000-07-11
CN1106389C (zh) 2003-04-23
PL193448B1 (pl) 2007-02-28
DK0981520T3 (da) 2004-11-01
JP2000513746A (ja) 2000-10-17
PL336717A1 (en) 2000-07-03
JP3273615B2 (ja) 2002-04-08
US6015926A (en) 2000-01-18
CA2289206A1 (en) 1998-11-19
SK285446B6 (sk) 2007-01-04
ATE270666T1 (de) 2004-07-15
WO1998051676A1 (en) 1998-11-19
HRP980266B1 (en) 2002-10-31
YU58299A (sh) 2001-12-26
ES2224396T3 (es) 2005-03-01
CA2289206C (en) 2008-02-05
BR9809628A (pt) 2000-07-04
EA199901040A1 (ru) 2000-04-24
HU226881B1 (en) 2010-01-28
TWI221833B (en) 2004-10-11
HUP0003404A3 (en) 2003-06-30
KR100566683B1 (ko) 2006-04-03

Similar Documents

Publication Publication Date Title
DE69824958D1 (de) Enantioselektive additions-reaktion mit hilfe eines organozink reagenzes
EE200000283A (et) Keemilised ühendid
EE200000284A (et) Keemilised ühendid
EE200000285A (et) Keemilised ühendid
DE59609222D1 (de) Amperometrischer Biosensor
DE69629805D1 (de) Biologische reagenzienkugel
DE69729672D1 (de) Biosensor
ID15985A (id) Senyawa kimia
DE69835501D1 (de) Handbetätigter zerstäuber für flüssigkeiten
DK128697A (da) Katalyseproces
DE69840196D1 (de) Probenröhrchen
ID21466A (id) Pelapisan ganda
FI955587A0 (fi) Kemialliset yhdisteet
DE69807283D1 (de) Beschichtungsverfahren
DE69820935D1 (de) Fluidmischsystem
BR9800254B1 (pt) reagente de coloração para a determinação de células sanguìneas.
AU5916399A (en) Nucleic acid ligand interaction assays
FI941867A0 (fi) Reagenssiallas
FI963863A (fi) Analyyttinen toteaminen
ID24181A (id) Proses kimia
ZA9810857B (en) Measurement of the emission of pollutants.
DE69821296D1 (de) Mischen von flüssigen Gasen
DE69817539D1 (de) Pc-chipanordnungverbindungsbus
DE29703943U1 (de) Universalwinkelmesser
EP0977988A4 (de) Homogener fluoreszenztest zur messung des effektes von verbindungen auf die genexpression

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: MERCK SHARP & DOHME CORP., NEW JERSEY, N.J., US

R081 Change of applicant/patentee

Ref document number: 981520

Country of ref document: EP

Owner name: SCHERING CORPORATION, US

Free format text: FORMER OWNER: MERCK SHARP & DOHME CORP., 07065-0900 RAHWAY, US

Effective date: 20121213

R082 Change of representative

Ref document number: 981520

Country of ref document: EP

Representative=s name: ABITZ & PARTNER, DE

Effective date: 20121213