DE69822830D1 - Verfahren und vorrichtung zur bestimmung und charakterisierung von teilchen - Google Patents
Verfahren und vorrichtung zur bestimmung und charakterisierung von teilchenInfo
- Publication number
- DE69822830D1 DE69822830D1 DE69822830T DE69822830T DE69822830D1 DE 69822830 D1 DE69822830 D1 DE 69822830D1 DE 69822830 T DE69822830 T DE 69822830T DE 69822830 T DE69822830 T DE 69822830T DE 69822830 D1 DE69822830 D1 DE 69822830D1
- Authority
- DE
- Germany
- Prior art keywords
- determining
- characterizing particles
- characterizing
- particles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002245 particle Substances 0.000 title 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects
- G01N15/12—Investigating individual particles by measuring electrical or magnetic effects by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle
- G01N15/13—Details pertaining to apertures
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1019—Associating Coulter-counter and optical flow cytometer [OFC]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects
- G01N15/12—Investigating individual particles by measuring electrical or magnetic effects by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle
- G01N2015/135—Electrodes
Landscapes
- Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Dispersion Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/887,588 US6111398A (en) | 1997-07-03 | 1997-07-03 | Method and apparatus for sensing and characterizing particles |
US887588 | 1997-07-03 | ||
US09/108,997 US6175227B1 (en) | 1997-07-03 | 1998-07-01 | Potential-sensing method and apparatus for sensing and characterizing particles by the Coulter principle |
US108997 | 1998-07-01 | ||
PCT/US1998/013911 WO1999001743A1 (en) | 1997-07-03 | 1998-07-02 | Method and apparatus for sensing and characterizing particles |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69822830D1 true DE69822830D1 (de) | 2004-05-06 |
DE69822830T2 DE69822830T2 (de) | 2005-03-24 |
Family
ID=26806530
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69822830T Expired - Lifetime DE69822830T2 (de) | 1997-07-03 | 1998-07-02 | Verfahren und vorrichtung zur bestimmung und charakterisierung von teilchen |
Country Status (6)
Country | Link |
---|---|
US (1) | US6175227B1 (de) |
EP (1) | EP0993600B1 (de) |
JP (1) | JP4112637B2 (de) |
CN (1) | CN1160549C (de) |
DE (1) | DE69822830T2 (de) |
WO (1) | WO1999001743A1 (de) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6259242B1 (en) * | 1999-05-26 | 2001-07-10 | Coulter International Corp. | Apparatus incorporating a sensing conduit in conductive material and method of use thereof for sensing and characterizing particles |
US6624621B2 (en) * | 2000-04-03 | 2003-09-23 | Howard L. North, Jr. | Particle counter volume sensor |
KR100338346B1 (ko) * | 2000-05-24 | 2002-05-30 | 박호군 | 막여과 시간에 따른 막오염 진행 추이를 동시에연속적으로 모니터링하기 위한 막여과 장치 및 방법 |
US20030015045A1 (en) * | 2001-07-23 | 2003-01-23 | Takehito Yoshida | Particle counting method and particle counter |
JP4704036B2 (ja) * | 2002-06-11 | 2011-06-15 | ケムパック エイ/エス | 液体中に懸濁された粒子を特徴付けるための使い捨てカートリッジ |
CA2489099C (en) * | 2002-06-11 | 2012-12-18 | Chempaq A/S | A disposable cartridge for characterizing particles suspended in a liquid |
US20040069638A1 (en) * | 2002-09-30 | 2004-04-15 | The Regents Of The University Of California | Electrophoretic/electrochemical devices with nanometer-scale metallic components |
EP1565873B1 (de) * | 2002-11-18 | 2013-06-05 | International Remote Imaging Systems, Inc. | Teilchenextraktion für ein automatisches strömungsmikroskop |
US7405562B2 (en) | 2004-07-23 | 2008-07-29 | Yehya Ghallab | Magnetic field imaging detection apparatus |
WO2006019242A1 (en) * | 2004-08-17 | 2006-02-23 | Korea Advanced Institute Of Science And Technology | Device and method for measuring fine particle concentration |
US7397232B2 (en) * | 2005-10-21 | 2008-07-08 | The University Of Akron | Coulter counter having a plurality of channels |
US20070202495A1 (en) * | 2006-02-06 | 2007-08-30 | Michael Mayer | Use of resistive-pulse sensing with submicrometer pores or nanopores for the detection of the assembly of submicrometer or nanometer sized objects |
CN101750477A (zh) * | 2008-12-05 | 2010-06-23 | 深圳迈瑞生物医疗电子股份有限公司 | 微孔排堵装置、方法和粒子分析装置 |
JP2012524908A (ja) * | 2009-04-24 | 2012-10-18 | ベックマン コールター, インコーポレイテッド | 粒子を特徴づける方法 |
JP5456653B2 (ja) * | 2010-12-13 | 2014-04-02 | 日本光電工業株式会社 | 血液測定装置 |
FR2971337B1 (fr) * | 2011-02-04 | 2013-03-01 | Horiba Abx Sas | Dispositif et procede de mesures multiparametriques de microparticules dans un fluide |
US9423336B2 (en) | 2013-01-24 | 2016-08-23 | Beckman Coulter, Inc. | Systems and methods for particle sensing and characterization |
CN103163375B (zh) * | 2013-02-19 | 2015-04-22 | 中国科学院电工研究所 | 一种固液导体接触电阻测量方法 |
WO2016139809A1 (ja) * | 2015-03-05 | 2016-09-09 | 株式会社日立製作所 | 粒子分析装置及び粒子分析方法 |
CN106769698B (zh) * | 2016-12-29 | 2019-08-06 | 迪瑞医疗科技股份有限公司 | 一种基于电阻抗原理的血细胞异常脉冲信号识别处理方法 |
JP6925040B2 (ja) * | 2018-08-27 | 2021-08-25 | アイポア株式会社 | 分析装置、及び、分析方法 |
WO2021079598A1 (ja) * | 2019-10-25 | 2021-04-29 | 株式会社朝日Fr研究所 | 粒子測定モジュール及びそれの使用方法、並びに粒子測定モジュールの製造方法 |
CN113433038B (zh) * | 2021-05-31 | 2022-11-01 | 昆明理工大学 | 一种新的混合纳米流体粒子组合的选择方法 |
Family Cites Families (81)
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US2656508A (en) | 1949-08-27 | 1953-10-20 | Wallace H Coulter | Means for counting particles suspended in a fluid |
BE562451A (de) | 1956-05-09 | |||
NL127771C (de) | 1958-12-29 | |||
US3122431A (en) | 1958-12-29 | 1964-02-25 | Coulter Electronics | Method of making a scanner element for particle analyzers |
US3259842A (en) | 1959-08-19 | 1966-07-05 | Coulter Electronics | Particle analyzing device |
US3299354A (en) | 1962-07-05 | 1967-01-17 | Coulter Electronics | Aperture tube structure for particle study apparatus |
NL137000C (de) | 1964-03-26 | |||
US3444464A (en) | 1965-11-26 | 1969-05-13 | Coulter Electronics | Multiple aperture fittings for particle analyzing apparatus |
US3668531A (en) | 1966-02-23 | 1972-06-06 | Coulter Electronics | Pulse analyzing apparatus |
US3502974A (en) | 1966-05-23 | 1970-03-24 | Coulter Electronics | Signal modulated apparatus for generating and detecting resistive and reactive changes in a modulated current path for particle classification and analysis |
US3502973A (en) | 1966-05-23 | 1970-03-24 | Coulter Electronics | Collating apparatus for pairs of electrical pulses produced by particle analyzing apparatus |
US3810010A (en) | 1968-11-02 | 1974-05-07 | Telefunken Patent | Particle analysis method and apparatus wherein liquid containing particles is sucked into a constricted flow path |
US3603875A (en) | 1969-05-12 | 1971-09-07 | Coulter Electronics | Particle analyzing method and apparatus employing multiple apertures and multiple channels per aperture |
BE758383A (nl) | 1969-11-06 | 1971-04-16 | Coulter Electronics | Aftastelement en doorboord plaatje voor het electronisch tellenen sorteren van deeltjes |
US3701029A (en) | 1970-10-27 | 1972-10-24 | Coulter Electronics | Axial trajectory sensor having gating means controlled by pulse duration measuring for electronic particle study apparatus and method |
US3700867A (en) | 1970-12-24 | 1972-10-24 | Coulter Electronics | Axial trajectory sensor for electronic particle study apparatus and method |
US3783391A (en) | 1971-02-08 | 1974-01-01 | Coulter Electronics | Axial trajectory sensor having gating means controlled by pulse duration measuring for electronic particle study apparatus and method |
US3793587A (en) | 1971-03-10 | 1974-02-19 | Licentia Gmbh | Particle volume and cross-section measurement |
US3714565A (en) | 1971-03-26 | 1973-01-30 | Coulter Electronics | Electronic particle analyzing apparatus with improved aperture tube |
US3771058A (en) | 1971-04-05 | 1973-11-06 | Coulter Electronics | Scanner element for coulter particle apparatus |
US3746976A (en) | 1971-04-07 | 1973-07-17 | Coulter Electronics | Self-cleaning aperture tube for coulter study apparatus |
US3710263A (en) | 1971-04-09 | 1973-01-09 | Coulter Electronics | Axial trajectory sensor having gating means controlled by pulse duration measuring for electronic particle study apparatus and method |
US3710264A (en) | 1971-04-09 | 1973-01-09 | Coulter Electronics | Axial trajectory sensor having gating means controlled by pulse duration measuring for electronic particle study apparatus and method |
US3781674A (en) | 1971-07-22 | 1973-12-25 | Coulter Electronics | Noise discriminating circuitry and method for electronic particle study apparatus |
US3739268A (en) | 1971-08-20 | 1973-06-12 | Iit Res Inst | Particle sensing apparatus, method and flow direction collar therefor |
US3949198A (en) | 1972-03-27 | 1976-04-06 | Coulter Electronics, Inc. | Methods and apparatuses for correcting coincidence count inaccuracies in a coulter type of particle analyzer |
US3949197A (en) | 1972-09-26 | 1976-04-06 | Coulter Electronics, Inc. | Methods and apparatuses for correcting coincidence count errors in a particle analyzer having a sensing zone through which the particles flow |
US3790883A (en) | 1972-05-09 | 1974-02-05 | Coulter Electronics | Particle study apparatus having improved particle resolution means |
US3863159A (en) | 1973-05-07 | 1975-01-28 | Coulter Electronics | Particle analyzing method and apparatus having pulse amplitude modification for particle volume linearization |
US3863160A (en) | 1973-05-07 | 1975-01-28 | Edward Neal Doty | Method and apparatus for finding the center amplitude of each pulse of a train of random amplitude asymmetric pulses |
US3871770A (en) | 1973-06-04 | 1975-03-18 | Nuclear Data Inc | Hydrodynamic focusing method and apparatus |
US4019134A (en) | 1973-08-13 | 1977-04-19 | Coulter Electronics, Inc. | Particle detector independent of errors caused by changes of electrolyte conductivity and electrode polarization |
US3944917A (en) | 1973-08-13 | 1976-03-16 | Coulter Electronics, Inc. | Electrical sensing circuitry for particle analyzing device |
US3979669A (en) | 1973-09-26 | 1976-09-07 | Coulter Electronics, Inc. | Particle analyzing system |
US3902115A (en) | 1973-09-26 | 1975-08-26 | Coulter Electronics | Self-cleaning aperture tube for coulter study apparatus and electrolyte supply system therefor |
US3924180A (en) | 1973-10-12 | 1975-12-02 | Us Energy | Potential sensing cell analyzer |
US3961249A (en) | 1973-10-15 | 1976-06-01 | Coulter Electronics, Inc. | Particle size distribution analyzation employing trailing edge differentiation |
US3936739A (en) | 1974-02-12 | 1976-02-03 | Coulter Electronics, Inc. | Method and apparatus for generating error corrected signals |
US3940691A (en) | 1974-02-19 | 1976-02-24 | Coulter Electronics, Inc. | Particle analyzer of the coulter type including coincidence error correction circuitry |
US4009443A (en) | 1974-07-02 | 1977-02-22 | Coulter Electronics, Inc. | Method and apparatus for providing primary coincidence correction during particle analysis utilizing time generation techniques |
US3963984A (en) | 1974-11-04 | 1976-06-15 | Coulter Electronics, Inc. | Method and system for cleaning an aperture in a particle study device |
US3987391A (en) | 1974-12-02 | 1976-10-19 | Coulter Electronics, Inc. | Method and apparatus for correcting total particle volume error due to particle coincidence |
US4014611A (en) | 1975-04-30 | 1977-03-29 | Coulter Electronics, Inc. | Aperture module for use in particle testing apparatus |
US4184766A (en) | 1976-10-28 | 1980-01-22 | Coulter Electronics, Inc. | Method and apparatus for correlating measurements of tandem sensing zones |
US4165484A (en) | 1977-03-23 | 1979-08-21 | Becton, Dickinson And Company | Particle counting apparatus utilizing various fluid resistors to maintain proper pressure differentials |
CH614781A5 (de) | 1977-06-27 | 1979-12-14 | Contraves Ag | |
US4157498A (en) | 1977-08-01 | 1979-06-05 | Miles Laboratories, Inc. | Flow-through type particle analyzing apparatus |
DE2750447C2 (de) | 1977-11-11 | 1986-04-17 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen | Vorrichtung zur Messung bestimmter Eigenschaften in einer Partikelsuspension suspendierter Partikel |
US4434398A (en) | 1978-05-18 | 1984-02-28 | Particle Data, Inc. | Porous passage means and method for particle analyzing systems |
US4290011A (en) | 1978-05-18 | 1981-09-15 | Particle Data, Inc. | Particle length and volume comeasurement with controlled orientation |
DE2828232C2 (de) | 1978-06-28 | 1986-04-17 | Kernforschungsanlage Jülich GmbH, 5170 Jülich | Vorrichtung zur Bestimmung des dielektrischen Durchbruches und der Größe von als Umhüllung eine Membran aufweisenden Partikeln |
US4491786A (en) | 1978-09-13 | 1985-01-01 | Coulter Electronics, Inc. | Transducer for measuring particles suspended in a fluid |
US4224567A (en) | 1978-11-03 | 1980-09-23 | The United States Of America As Represented By The United States Department Of Energy | Apparatus for measuring resistance change only in a cell analyzer and method for calibrating it |
US4395676A (en) | 1980-11-24 | 1983-07-26 | Coulter Electronics, Inc. | Focused aperture module |
US4438390A (en) | 1981-03-23 | 1984-03-20 | Coulter Electronics, Inc. | Tandem sensing zones for improved signal-to-noise ratio in particle analyzer |
US4412175A (en) | 1981-04-30 | 1983-10-25 | Coulter Electronics, Inc. | Debris alarm |
US4420720A (en) * | 1981-06-29 | 1983-12-13 | Coulter Electronics, Inc. | Field focused particle sensing zone |
US4484134A (en) | 1981-08-31 | 1984-11-20 | Coulter Electrnonics, Inc. | Elongate particle sensing aperture |
US4450435A (en) | 1981-11-30 | 1984-05-22 | Bobby Dencil James | Analog debris alarm |
US4515274A (en) | 1981-12-02 | 1985-05-07 | Coulter Corporation | Particle analyzing and sorting apparatus |
US4510438A (en) | 1982-02-16 | 1985-04-09 | Coulter Electronics, Inc. | Coincidence correction in particle analysis system |
US4525666A (en) | 1982-05-03 | 1985-06-25 | Coulter Electronics, Inc. | Cell breakdown |
DD212588A1 (de) * | 1982-12-20 | 1984-08-15 | Norbert Lenk | Messduese zur erfassung der in einem elektrolyten suspendierten teilchen |
US4710021A (en) | 1983-10-14 | 1987-12-01 | Sequoia-Turner Corporation | Particulate matter analyzing apparatus and method |
JPS61160038A (ja) * | 1985-01-08 | 1986-07-19 | Sumitomo Electric Ind Ltd | 粒子検出器 |
GB2177804A (en) | 1985-05-31 | 1987-01-28 | Coulter Electronics | Analysing and editing electrical pulses |
US4778657A (en) * | 1985-09-10 | 1988-10-18 | Kernforschungszentrum Karlsruhe Gmbh | Apparatus for determining the characteristics of particles suspended in liquids |
US4760328A (en) | 1986-05-05 | 1988-07-26 | Integrated Ionics, Inc. | Particle counter having electrodes and circuitry mounted on the pane of the orifice |
US4775833A (en) | 1986-10-03 | 1988-10-04 | Coulter Electronics, Inc. | Lodged debris detector for a particle analyzer |
US4791355A (en) | 1986-10-21 | 1988-12-13 | Coulter Electronics Inc. | Particle analyzer for measuring the resistance and reactance of a particle |
KR970007077B1 (ko) | 1987-03-13 | 1997-05-02 | 코울터 일렉트로닉스 인커퍼레이티드 | 광산란 기술을 이용한 다중-부분식별 분석 방법 |
CS272965B1 (en) * | 1987-06-18 | 1991-02-12 | Rudolf Ing Butas | Conducting sensor for measuring lenght and number of fibres in water suspension |
CA1328679C (en) * | 1989-05-18 | 1994-04-19 | Raynald Hachey | Apparatus for particle determination in liquid metals |
US4972137A (en) | 1989-05-31 | 1990-11-20 | Coulter Electronics, Inc. | Isolation circuit for blood cell counter |
JP2965688B2 (ja) | 1990-11-30 | 1999-10-18 | シスメックス株式会社 | 粒子検出装置 |
DE69432410T2 (de) | 1993-05-14 | 2004-03-04 | Coulter International Corp., Miami | Retikulozyt bestimmungsverfahren und geraet, das lichtstreuungstechniken verwendet |
US5402062A (en) | 1993-12-23 | 1995-03-28 | Abbott Laboratories | Mechanical capture of count wafer for particle analysis |
US5432992A (en) | 1993-12-23 | 1995-07-18 | Abbott Laboratories | Method of making count probe with removable count wafer |
JPH07301595A (ja) | 1994-05-09 | 1995-11-14 | Toa Medical Electronics Co Ltd | 粒子測定装置およびその粒子測定方法 |
DE19601054C1 (de) * | 1996-01-05 | 1997-04-10 | Inst Bioprozess Analysenmesst | Verfahren und Vorrichtung zur Bestimmung von Parametern von Partikeln in Elektrolyten |
SE507956C2 (sv) * | 1996-11-20 | 1998-08-03 | Medonic Ab | Utspädnings- och mätanordning för partikelräkning |
-
1998
- 1998-07-01 US US09/108,997 patent/US6175227B1/en not_active Expired - Lifetime
- 1998-07-02 DE DE69822830T patent/DE69822830T2/de not_active Expired - Lifetime
- 1998-07-02 EP EP98933154A patent/EP0993600B1/de not_active Expired - Lifetime
- 1998-07-02 WO PCT/US1998/013911 patent/WO1999001743A1/en active IP Right Grant
- 1998-07-02 CN CNB988067870A patent/CN1160549C/zh not_active Expired - Lifetime
- 1998-07-02 JP JP50743999A patent/JP4112637B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0993600B1 (de) | 2004-03-31 |
CN1261957A (zh) | 2000-08-02 |
US6175227B1 (en) | 2001-01-16 |
CN1160549C (zh) | 2004-08-04 |
JP2002508077A (ja) | 2002-03-12 |
DE69822830T2 (de) | 2005-03-24 |
EP0993600A1 (de) | 2000-04-19 |
WO1999001743A1 (en) | 1999-01-14 |
JP4112637B2 (ja) | 2008-07-02 |
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Legal Events
Date | Code | Title | Description |
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8364 | No opposition during term of opposition |