DE69814918T2 - Vorrichtung und verfahren zur erzeugung von aerosolen für arzneimittelverabreichung - Google Patents

Vorrichtung und verfahren zur erzeugung von aerosolen für arzneimittelverabreichung Download PDF

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Publication number
DE69814918T2
DE69814918T2 DE69814918T DE69814918T DE69814918T2 DE 69814918 T2 DE69814918 T2 DE 69814918T2 DE 69814918 T DE69814918 T DE 69814918T DE 69814918 T DE69814918 T DE 69814918T DE 69814918 T2 DE69814918 T2 DE 69814918T2
Authority
DE
Germany
Prior art keywords
liquid
fluid
gas
diameter
flow
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69814918T
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German (de)
English (en)
Other versions
DE69814918D1 (de
Inventor
Alfonso Ganan Calvo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universidad de Sevilla
Original Assignee
Universidad de Sevilla
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ES9702654A external-priority patent/ES2158741B1/es
Priority claimed from US09/191,592 external-priority patent/US6174469B1/en
Application filed by Universidad de Sevilla filed Critical Universidad de Sevilla
Application granted granted Critical
Publication of DE69814918D1 publication Critical patent/DE69814918D1/de
Publication of DE69814918T2 publication Critical patent/DE69814918T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/02—Inhalators with activated or ionised fluids, e.g. electrohydrodynamic [EHD] or electrostatic devices; Ozone-inhalators with radioactive tagged particles
    • A61M15/025—Bubble jet droplet ejection devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/20—Mixing gases with liquids
    • B01F23/23—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids
    • B01F23/232—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids using flow-mixing means for introducing the gases, e.g. baffles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/30—Injector mixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
    • B05B7/02—Spray pistols; Apparatus for discharge
    • B05B7/04—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge
    • B05B7/0416—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge with arrangements for mixing one gas and one liquid
    • B05B7/0441—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge with arrangements for mixing one gas and one liquid with one inner conduit of liquid surrounded by an external conduit of gas upstream the mixing chamber
    • B05B7/0475—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge with arrangements for mixing one gas and one liquid with one inner conduit of liquid surrounded by an external conduit of gas upstream the mixing chamber with means for deflecting the peripheral gas flow towards the central liquid flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
    • B05B7/02—Spray pistols; Apparatus for discharge
    • B05B7/06—Spray pistols; Apparatus for discharge with at least one outlet orifice surrounding another approximately in the same plane
    • B05B7/061—Spray pistols; Apparatus for discharge with at least one outlet orifice surrounding another approximately in the same plane with several liquid outlets discharging one or several liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
    • B05B7/02—Spray pistols; Apparatus for discharge
    • B05B7/06—Spray pistols; Apparatus for discharge with at least one outlet orifice surrounding another approximately in the same plane
    • B05B7/062—Spray pistols; Apparatus for discharge with at least one outlet orifice surrounding another approximately in the same plane with only one liquid outlet and at least one gas outlet
    • B05B7/065—Spray pistols; Apparatus for discharge with at least one outlet orifice surrounding another approximately in the same plane with only one liquid outlet and at least one gas outlet an inner gas outlet being surrounded by an annular adjacent liquid outlet
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
    • B05B7/02—Spray pistols; Apparatus for discharge
    • B05B7/06—Spray pistols; Apparatus for discharge with at least one outlet orifice surrounding another approximately in the same plane
    • B05B7/062—Spray pistols; Apparatus for discharge with at least one outlet orifice surrounding another approximately in the same plane with only one liquid outlet and at least one gas outlet
    • B05B7/066—Spray pistols; Apparatus for discharge with at least one outlet orifice surrounding another approximately in the same plane with only one liquid outlet and at least one gas outlet with an inner liquid outlet surrounded by at least one annular gas outlet
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
    • B05B7/02—Spray pistols; Apparatus for discharge
    • B05B7/08—Spray pistols; Apparatus for discharge with separate outlet orifices, e.g. to form parallel jets, i.e. the axis of the jets being parallel, to form intersecting jets, i.e. the axis of the jets converging but not necessarily intersecting at a point
    • B05B7/0884—Spray pistols; Apparatus for discharge with separate outlet orifices, e.g. to form parallel jets, i.e. the axis of the jets being parallel, to form intersecting jets, i.e. the axis of the jets converging but not necessarily intersecting at a point the outlet orifices for jets constituted by a liquid or a mixture containing a liquid being aligned
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F02—COMBUSTION ENGINES; HOT-GAS OR COMBUSTION-PRODUCT ENGINE PLANTS
    • F02M—SUPPLYING COMBUSTION ENGINES IN GENERAL WITH COMBUSTIBLE MIXTURES OR CONSTITUENTS THEREOF
    • F02M43/00—Fuel-injection apparatus operating simultaneously on two or more fuels, or on a liquid fuel and another liquid, e.g. the other liquid being an anti-knock additive
    • F02M43/04—Injectors peculiar thereto
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F02—COMBUSTION ENGINES; HOT-GAS OR COMBUSTION-PRODUCT ENGINE PLANTS
    • F02M—SUPPLYING COMBUSTION ENGINES IN GENERAL WITH COMBUSTIBLE MIXTURES OR CONSTITUENTS THEREOF
    • F02M67/00—Apparatus in which fuel-injection is effected by means of high-pressure gas, the gas carrying the fuel into working cylinders of the engine, e.g. air-injection type
    • F02M67/10—Injectors peculiar thereto, e.g. valve less type
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F02—COMBUSTION ENGINES; HOT-GAS OR COMBUSTION-PRODUCT ENGINE PLANTS
    • F02M—SUPPLYING COMBUSTION ENGINES IN GENERAL WITH COMBUSTIBLE MIXTURES OR CONSTITUENTS THEREOF
    • F02M69/00—Low-pressure fuel-injection apparatus ; Apparatus with both continuous and intermittent injection; Apparatus injecting different types of fuel
    • F02M69/04—Injectors peculiar thereto
    • F02M69/047—Injectors peculiar thereto injectors with air chambers, e.g. communicating with atmosphere for aerating the nozzles
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F02—COMBUSTION ENGINES; HOT-GAS OR COMBUSTION-PRODUCT ENGINE PLANTS
    • F02M—SUPPLYING COMBUSTION ENGINES IN GENERAL WITH COMBUSTIBLE MIXTURES OR CONSTITUENTS THEREOF
    • F02M69/00—Low-pressure fuel-injection apparatus ; Apparatus with both continuous and intermittent injection; Apparatus injecting different types of fuel
    • F02M69/08—Low-pressure fuel-injection apparatus ; Apparatus with both continuous and intermittent injection; Apparatus injecting different types of fuel characterised by the fuel being carried by compressed air into main stream of combustion-air
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F23—COMBUSTION APPARATUS; COMBUSTION PROCESSES
    • F23D—BURNERS
    • F23D11/00—Burners using a direct spraying action of liquid droplets or vaporised liquid into the combustion space
    • F23D11/10—Burners using a direct spraying action of liquid droplets or vaporised liquid into the combustion space the spraying being induced by a gaseous medium, e.g. water vapour
    • F23D11/106—Burners using a direct spraying action of liquid droplets or vaporised liquid into the combustion space the spraying being induced by a gaseous medium, e.g. water vapour medium and fuel meeting at the burner outlet
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00378—Piezoelectric or ink jet dispensers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B1/00—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means
    • B05B1/02—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to produce a jet, spray, or other discharge of particular shape or nature, e.g. in single drops, or having an outlet of particular shape
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • G01N15/1409—Handling samples, e.g. injecting samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • G01N2015/1406—Control of droplet point

Landscapes

  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Combustion & Propulsion (AREA)
  • General Health & Medical Sciences (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nanotechnology (AREA)
  • Pulmonology (AREA)
  • Materials Engineering (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Composite Materials (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Nozzles (AREA)
  • Glanulating (AREA)
  • Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
DE69814918T 1997-12-17 1998-12-16 Vorrichtung und verfahren zur erzeugung von aerosolen für arzneimittelverabreichung Expired - Lifetime DE69814918T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
ES9702654A ES2158741B1 (es) 1997-12-17 1997-12-17 Dispositivo de sipersion de un fluido en otro inmiscible en forma de microgotas o microburbujas de tamaño uniforme.
ES9702654 1997-12-17
US09/191,592 US6174469B1 (en) 1996-05-13 1998-11-13 Device and method for creating dry particles
US191592 1998-11-13
PCT/IB1998/002055 WO1999030834A1 (en) 1997-12-17 1998-12-16 Device and method for creating aerosols for drug delivery

Publications (2)

Publication Number Publication Date
DE69814918D1 DE69814918D1 (de) 2003-06-26
DE69814918T2 true DE69814918T2 (de) 2004-03-11

Family

ID=26155105

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69806504T Expired - Lifetime DE69806504T2 (de) 1997-12-17 1998-12-16 Verfahren zur erzeugung von hohlen tröpfchen
DE69814918T Expired - Lifetime DE69814918T2 (de) 1997-12-17 1998-12-16 Vorrichtung und verfahren zur erzeugung von aerosolen für arzneimittelverabreichung

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69806504T Expired - Lifetime DE69806504T2 (de) 1997-12-17 1998-12-16 Verfahren zur erzeugung von hohlen tröpfchen

Country Status (7)

Country Link
EP (3) EP1039971B1 (enExample)
JP (2) JP2002508244A (enExample)
AU (2) AU743440B2 (enExample)
CA (2) CA2314918A1 (enExample)
DE (2) DE69806504T2 (enExample)
ES (1) ES2175828T3 (enExample)
WO (2) WO1999030833A1 (enExample)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6595202B2 (en) 1996-05-13 2003-07-22 Universidad De Sevilla Device and method for creating aerosols for drug delivery
US6248378B1 (en) * 1998-12-16 2001-06-19 Universidad De Sevilla Enhanced food products
JP2001063917A (ja) * 1999-07-29 2001-03-13 Barmag Ag 管巻き装置
DE10015109A1 (de) * 2000-03-28 2001-10-04 Peter Walzel Verfahren und Vorrichtungen zur Herstellung gleich großer Tropfen
US7575761B2 (en) 2000-06-30 2009-08-18 Novartis Pharma Ag Spray drying process control of drying kinetics
GB0027357D0 (en) 2000-11-09 2000-12-27 Bradford Particle Design Plc Particle formation methods and their products
US7193084B2 (en) 2000-12-22 2007-03-20 Baxter International Inc. Polymorphic form of itraconazole
US6607784B2 (en) 2000-12-22 2003-08-19 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US6977085B2 (en) 2000-12-22 2005-12-20 Baxter International Inc. Method for preparing submicron suspensions with polymorph control
US8067032B2 (en) 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
US6951656B2 (en) 2000-12-22 2005-10-04 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US9700866B2 (en) 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
US6884436B2 (en) 2000-12-22 2005-04-26 Baxter International Inc. Method for preparing submicron particle suspensions
CA2445516C (en) 2001-04-26 2007-11-20 New England Pharmaceuticals, Inc. Metered dose delivery device for liquid and powder agents
US20060003012A9 (en) 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
WO2003026611A2 (en) 2001-09-26 2003-04-03 Baxter International Inc. Preparation of submicron sized nanoparticles via dispersion and solvent or liquid phase removal
US7112340B2 (en) 2001-10-19 2006-09-26 Baxter International Inc. Compositions of and method for preparing stable particles in a frozen aqueous matrix
WO2003037303A1 (en) 2001-11-01 2003-05-08 Nektar Therapeutics Spray drying methods and compositions thereof
US9339459B2 (en) 2003-04-24 2016-05-17 Nektar Therapeutics Particulate materials
US6958848B2 (en) 2002-05-23 2005-10-25 E Ink Corporation Capsules, materials for use therein and electrophoretic media and displays containing such capsules
US7511079B2 (en) 2003-03-24 2009-03-31 Baxter International Inc. Methods and apparatuses for the comminution and stabilization of small particles
US7380550B2 (en) 2004-01-30 2008-06-03 Hewlett-Packard Development Company, L.P. Systems and methods for particle detection
ES2264608B2 (es) * 2004-09-30 2007-08-16 Universidad De Sevilla Dispositivo y procedimiento para la atomizacion neumatica de liquidos mediante flujo implosivo de gas.
WO2006089984A1 (es) * 2005-01-17 2006-08-31 Universidad De Sevilla Procedimiento y dispositivo para micro-mezclado de fluidos mediante célula de reflujo
ES2257968B1 (es) * 2005-01-28 2007-07-01 Universidad De Sevilla Procedimiento y dispositivo para la obtencion de particulas de tamaño micro y nanometrico.
ES2272168B1 (es) * 2005-06-30 2008-04-16 Universidad De Sevilla Procedimiento y dispositivo para impresion por micro-gotas de espuma.
JP2011507676A (ja) * 2007-12-07 2011-03-10 エクスプレイ ミクロパーティクルズ アクティエボラーグ 粒子を生成する方法と構造
WO2009129547A1 (en) 2008-04-18 2009-10-22 The Board Of Trustees Of The University Of Alabama Meso-scaled combustion system
EP2576078B1 (en) 2010-05-28 2018-04-25 Arizona Board of Regents acting for and on behalf of Arizona State University Apparatus and methods for a gas dynamic virtual nozzle
MX350838B (es) 2011-02-11 2017-09-18 Grain Proc Corporation * Composicion de sal.
CN102500489A (zh) * 2011-11-06 2012-06-20 中国科学技术大学 一种可实现微细雾化的喷枪喷头
BR112014026212A8 (pt) * 2012-04-23 2019-12-24 Chiesi Farm Spa equipamento para administração de medicamento, processo para administração de um medicamento e uso de um equipamento para administração de medicamento
EP2777818A1 (en) 2013-03-15 2014-09-17 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Method and device of producing an intermittent liquid jet
WO2014179193A1 (en) 2013-04-30 2014-11-06 Uwe Weierstall Apparatus and methods for lipidic cubic phase (lcp) injection for membrane protein investigations
EP3058208B1 (en) * 2013-10-15 2019-06-19 Nostrum Energy Pte. Ltd. Gas-assisted fluid atomizing injector
EP2962751B1 (en) 2014-07-03 2017-04-05 Helmholtz-Zentrum Geesthacht Zentrum für Material- und Küstenforschung GmbH Method of forming droplets in a multiple-phase system
ES2606957B1 (es) 2015-09-28 2018-01-15 Ingeniatrics Tecnologías, S.L. Dispositivos y métodos para microencapsulación basados en capilares concéntricos
DE102017207870A1 (de) * 2017-05-10 2018-11-15 Robert Bosch Gmbh Verfahren und Vorrichtung zur Herstellung monodisperser Mikropartikel
CN107376063B (zh) * 2017-07-04 2020-08-21 浙江医尔仁医疗科技有限公司 中西药靶向雾化装置
CN107715789B (zh) * 2017-10-23 2023-10-03 中国石油大学(北京) 一种制备聚合物颗粒的新方法及装置
CN108553929B (zh) * 2018-06-15 2023-10-03 四川大学 一种气流式喷雾干燥器用雾化喷嘴
CN108852848B (zh) * 2018-08-02 2024-01-16 合肥中科力一科技有限公司 一种用于中药及儿童用药的药物微包裹仪的制备喷头结构
CN108852847A (zh) * 2018-08-02 2018-11-23 合肥中科力科技有限公司 一种药物微包裹仪及其系统
US10369579B1 (en) 2018-09-04 2019-08-06 Zyxogen, Llc Multi-orifice nozzle for droplet atomization
EP3930493A2 (en) * 2019-02-28 2022-01-05 Juul Labs, Inc. Vaporizer device with vaporizer cartridge
JP7665646B2 (ja) * 2020-03-24 2025-04-21 ボストン サイエンティフィック サイムド，インコーポレイテッド 薬剤送達システム及びその使用方法
CN111642561B (zh) * 2020-07-07 2024-03-29 蚌埠市江淮米业有限公司 一种大米的保鲜加工方法
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CN114414441B (zh) * 2022-03-29 2022-06-07 广东禾康精细化工有限公司 一种克菌丹生产用的装置及其控制方法
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CN117065375B (zh) * 2023-10-17 2023-12-22 山东源邦新材料股份有限公司 一种基于喷雾干燥法制备asa粉末的方法
CN119717021A (zh) * 2025-02-26 2025-03-28 常州市凯迪电器股份有限公司 一种信号转换电路、遇阻判定方法及电动升降桌

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3810010A (en) * 1968-11-02 1974-05-07 Telefunken Patent Particle analysis method and apparatus wherein liquid containing particles is sucked into a constricted flow path
CS153231B1 (enExample) * 1970-11-18 1974-02-25
CH563807A5 (en) * 1973-02-14 1975-07-15 Battelle Memorial Institute Fine granules and microcapsules mfrd. from liquid droplets - partic. of high viscosity requiring forced sepn. of droplets
US4019983A (en) * 1974-10-10 1977-04-26 Houdaille Industries, Inc. Disinfection system and method
US4162282A (en) * 1976-04-22 1979-07-24 Coulter Electronics, Inc. Method for producing uniform particles
US4352789A (en) * 1980-03-17 1982-10-05 Minnesota Mining And Manufacturing Company Aerosol compositions containing finely divided solid materials
US4484577A (en) 1981-07-23 1984-11-27 Key Pharmaceuticals, Inc. Drug delivery method and inhalation device therefor
US4462543A (en) * 1981-12-24 1984-07-31 The Procter & Gamble Company Nozzle
DE3219316A1 (de) * 1982-05-22 1983-11-24 Ruhrchemie Ag, 4200 Oberhausen Verfahren und vorrichtung zur herstellung von synthesegas durch partielle oxidation von kohle-wasser-suspensionen
CA1235367A (en) * 1984-04-05 1988-04-19 Gary J. Green Method and apparatus for producing uniform liquid droplets
GB8614566D0 (en) 1986-06-16 1986-07-23 Ici Plc Spraying
US5514646A (en) 1989-02-09 1996-05-07 Chance; Ronald E. Insulin analogs modified at position 29 of the B chain
JPH05507439A (ja) * 1990-05-30 1993-10-28 ワイヤーハウザー　カンパニー 材料を気体に被覆する装置
US5235969A (en) * 1990-08-20 1993-08-17 Intersurgical (Guernsey) Limited Nebulizer having combined structure for removing particles over two microns
US5404871A (en) 1991-03-05 1995-04-11 Aradigm Delivery of aerosol medications for inspiration
EP0940154B1 (en) 1991-07-02 2007-04-18 Nektar Therapeutics Device for delivering aerosolized medicaments
JP2582557Y2 (ja) * 1991-07-17 1998-10-08 森永乳業 株式会社 噴霧装置
US5554646A (en) 1992-04-29 1996-09-10 Wisconsin Alumni Research Foundation Method for reducing body fat in animals
US5785049A (en) 1994-09-21 1998-07-28 Inhale Therapeutic Systems Method and apparatus for dispersion of dry powder medicaments
WO1994011116A1 (en) * 1992-11-06 1994-05-26 Patrick Sundholm Method and apparatus for coating paper or the like
US5364838A (en) 1993-01-29 1994-11-15 Miris Medical Corporation Method of administration of insulin
JPH07213961A (ja) * 1994-02-01 1995-08-15 Kyowa Hakko Kogyo Co Ltd スプレー装置とそれを用いたコーティング装置及び造粒装置
GB9403702D0 (en) * 1994-02-25 1994-04-13 Flow Research Evaluation Diagn Improvements relating to spray generators
US5522385A (en) 1994-09-27 1996-06-04 Aradigm Corporation Dynamic particle size control for aerosolized drug delivery
US5829436A (en) 1996-02-05 1998-11-03 Aradigm Corporation Ventilation imaging using a fine particle aerosol generator
ES2140998B1 (es) * 1996-05-13 2000-10-16 Univ Sevilla Procedimiento de atomizacion de liquidos.
GB9610821D0 (en) * 1996-05-23 1996-07-31 Glaxo Wellcome Inc Metering apparatus
WO2006038652A1 (ja) 2004-10-06 2006-04-13 Zeon Corporation 電極組成物、電極および電池

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EP1037713A1 (en) 2000-09-27
AU743440B2 (en) 2002-01-24
ES2175828T3 (es) 2002-11-16
AU737688B2 (en) 2001-08-30
CA2314920A1 (en) 1999-06-24
EP1293259A2 (en) 2003-03-19
DE69806504D1 (de) 2002-08-14
WO1999030833A1 (en) 1999-06-24
WO1999030834A1 (en) 1999-06-24
AU1572999A (en) 1999-07-05
CA2314920C (en) 2009-04-14
DE69806504T2 (de) 2003-02-27
AU1573099A (en) 1999-07-05
EP1039971A1 (en) 2000-10-04
DE69814918D1 (de) 2003-06-26
EP1039971B1 (en) 2003-05-21
CA2314918A1 (en) 1999-06-24
EP1037713B1 (en) 2002-07-10
JP2002508232A (ja) 2002-03-19
JP2002508244A (ja) 2002-03-19
EP1293259A3 (en) 2004-01-07

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