DE69812599D1 - Imino-aza-anthracyclonderivate zur behandlung von amyloidosis - Google Patents

Imino-aza-anthracyclonderivate zur behandlung von amyloidosis

Info

Publication number
DE69812599D1
DE69812599D1 DE69812599T DE69812599T DE69812599D1 DE 69812599 D1 DE69812599 D1 DE 69812599D1 DE 69812599 T DE69812599 T DE 69812599T DE 69812599 T DE69812599 T DE 69812599T DE 69812599 D1 DE69812599 D1 DE 69812599D1
Authority
DE
Germany
Prior art keywords
anthracyclone
aza
imino
derivatives
treating amyloidosis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69812599T
Other languages
English (en)
Other versions
DE69812599T2 (de
Inventor
Michele Caruso
Daniela Faiardi
Tiziano Bandiera
Jacqueline Lansen
Antonino Suarato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Pharmacia Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Italia SpA filed Critical Pharmacia Italia SpA
Application granted granted Critical
Publication of DE69812599D1 publication Critical patent/DE69812599D1/de
Publication of DE69812599T2 publication Critical patent/DE69812599T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyridine Compounds (AREA)
DE69812599T 1997-01-27 1998-01-09 Imino-aza-anthracyclonderivate zur behandlung von amyloidosis Expired - Fee Related DE69812599T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9701628 1997-01-27
GBGB9701628.1A GB9701628D0 (en) 1997-01-27 1997-01-27 Imino-aza-anthracyclinone derivatives
PCT/EP1998/000152 WO1998032754A1 (en) 1997-01-27 1998-01-09 Imino-aza-anthracyclinone derivatives for the treatment of amyloidosis

Publications (2)

Publication Number Publication Date
DE69812599D1 true DE69812599D1 (de) 2003-04-30
DE69812599T2 DE69812599T2 (de) 2004-01-08

Family

ID=10806639

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69812599T Expired - Fee Related DE69812599T2 (de) 1997-01-27 1998-01-09 Imino-aza-anthracyclonderivate zur behandlung von amyloidosis

Country Status (25)

Country Link
US (1) US6194422B1 (de)
EP (1) EP0970080B1 (de)
JP (1) JP2001511123A (de)
KR (1) KR20000070483A (de)
CN (1) CN1103774C (de)
AR (1) AR011572A1 (de)
AT (1) ATE235494T1 (de)
AU (1) AU745981B2 (de)
BR (1) BR9815448A (de)
CA (1) CA2277951C (de)
DE (1) DE69812599T2 (de)
DK (1) DK0970080T3 (de)
EA (1) EA001887B1 (de)
ES (1) ES2195313T3 (de)
GB (1) GB9701628D0 (de)
HU (1) HUP0001222A3 (de)
IL (1) IL130831A (de)
NO (1) NO313198B1 (de)
NZ (1) NZ337221A (de)
PL (1) PL190304B1 (de)
PT (1) PT970080E (de)
TW (1) TW519544B (de)
UA (1) UA57063C2 (de)
WO (1) WO1998032754A1 (de)
ZA (1) ZA98611B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9902938D0 (en) * 1999-02-10 1999-03-31 Novartis Ag Organic compounds
GB9911804D0 (en) * 1999-05-20 1999-07-21 Merck Sharp & Dohme Therapeutic combination
US7053191B2 (en) * 2003-05-21 2006-05-30 Solux Corporation Method of preparing 4-R-substituted 4-demethoxydaunorubicin
US8357785B2 (en) * 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
US9376406B2 (en) 2011-03-03 2016-06-28 Indiana University Research And Technology Corporation uPAR-uPA interaction inhibitors and methods for treating cancer
US8846882B2 (en) 2011-04-29 2014-09-30 Synbias Pharma Ag Method of producing 4-demethoxydaunorubicin

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2258652A (en) * 1991-08-15 1993-02-17 Merck Sharp & Dohme Pharmaceutically useful azabicyclic oxime ethers
GB9416007D0 (en) * 1994-08-08 1994-09-28 Erba Carlo Spa Anthracyclinone derivatives
GB9418260D0 (en) * 1994-09-09 1994-10-26 Erba Carlo Spa Anthracycline derivatives
GB9516349D0 (en) * 1995-08-09 1995-10-11 Pharmacia Spa Aza-anthracyclinone derivatives

Also Published As

Publication number Publication date
PL334803A1 (en) 2000-03-13
DE69812599T2 (de) 2004-01-08
UA57063C2 (uk) 2003-06-16
IL130831A0 (en) 2001-01-28
HUP0001222A2 (hu) 2000-10-28
NZ337221A (en) 2001-01-26
BR9815448A (pt) 2001-10-16
EP0970080B1 (de) 2003-03-26
ES2195313T3 (es) 2003-12-01
NO993549L (no) 1999-09-21
EA199900684A1 (ru) 2000-04-24
KR20000070483A (ko) 2000-11-25
CN1103774C (zh) 2003-03-26
AR011572A1 (es) 2000-08-30
CA2277951A1 (en) 1998-07-30
ATE235494T1 (de) 2003-04-15
WO1998032754A1 (en) 1998-07-30
DK0970080T3 (da) 2003-07-21
HUP0001222A3 (en) 2001-01-29
IL130831A (en) 2005-08-31
JP2001511123A (ja) 2001-08-07
CA2277951C (en) 2006-06-06
AU745981B2 (en) 2002-04-11
ZA98611B (en) 1998-08-17
AU5863398A (en) 1998-08-18
PT970080E (pt) 2003-07-31
EP0970080A1 (de) 2000-01-12
PL190304B1 (pl) 2005-11-30
US6194422B1 (en) 2001-02-27
EA001887B1 (ru) 2001-10-22
GB9701628D0 (en) 1997-03-19
TW519544B (en) 2003-02-01
NO993549D0 (no) 1999-07-20
NO313198B1 (no) 2002-08-26
CN1244866A (zh) 2000-02-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee