DE69809902T2 - Verbesserte vorrichtung zum fluoreszenznachweis - Google Patents
Verbesserte vorrichtung zum fluoreszenznachweisInfo
- Publication number
- DE69809902T2 DE69809902T2 DE69809902T DE69809902T DE69809902T2 DE 69809902 T2 DE69809902 T2 DE 69809902T2 DE 69809902 T DE69809902 T DE 69809902T DE 69809902 T DE69809902 T DE 69809902T DE 69809902 T2 DE69809902 T2 DE 69809902T2
- Authority
- DE
- Germany
- Prior art keywords
- led
- detection device
- fluorescent
- fluorescence detection
- hole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000001917 fluorescence detection Methods 0.000 title claims description 24
- 239000011159 matrix material Substances 0.000 claims abstract description 43
- 239000012491 analyte Substances 0.000 claims abstract description 27
- 239000003269 fluorescent indicator Substances 0.000 claims abstract description 23
- 239000007788 liquid Substances 0.000 claims abstract description 13
- 230000002238 attenuated effect Effects 0.000 claims abstract description 9
- 239000004065 semiconductor Substances 0.000 claims description 46
- 239000000758 substrate Substances 0.000 claims description 29
- 238000001514 detection method Methods 0.000 claims description 18
- 230000003287 optical effect Effects 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 14
- 229920000642 polymer Polymers 0.000 claims description 11
- 230000000903 blocking effect Effects 0.000 claims description 9
- 239000011248 coating agent Substances 0.000 claims description 7
- 238000000576 coating method Methods 0.000 claims description 7
- 230000004044 response Effects 0.000 claims description 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 4
- 229910052760 oxygen Inorganic materials 0.000 claims description 4
- 239000001301 oxygen Substances 0.000 claims description 4
- 238000005530 etching Methods 0.000 claims description 3
- MOBZIKDAUJCZDU-UHFFFAOYSA-L 4,7-diphenyl-1,10-phenanthroline;ruthenium(2+);diperchlorate Chemical compound [Ru+2].[O-]Cl(=O)(=O)=O.[O-]Cl(=O)(=O)=O.C1=CC=CC=C1C1=CC=NC2=C1C=CC1=C(C=3C=CC=CC=3)C=CN=C21.C1=CC=CC=C1C1=CC=NC2=C1C=CC1=C(C=3C=CC=CC=3)C=CN=C21.C1=CC=CC=C1C1=CC=NC2=C1C=CC1=C(C=3C=CC=CC=3)C=CN=C21 MOBZIKDAUJCZDU-UHFFFAOYSA-L 0.000 claims description 2
- 230000005284 excitation Effects 0.000 claims description 2
- 230000002596 correlated effect Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 description 18
- 230000003321 amplification Effects 0.000 description 4
- 230000008021 deposition Effects 0.000 description 4
- 238000001802 infusion Methods 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 238000003199 nucleic acid amplification method Methods 0.000 description 4
- 239000000853 adhesive Substances 0.000 description 3
- 230000001070 adhesive effect Effects 0.000 description 3
- 239000003822 epoxy resin Substances 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 230000000873 masking effect Effects 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 229920000647 polyepoxide Polymers 0.000 description 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 235000011449 Rosa Nutrition 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- 239000004020 conductor Substances 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 239000004593 Epoxy Substances 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 239000012327 Ruthenium complex Substances 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 229910052681 coesite Inorganic materials 0.000 description 1
- 229910052906 cristobalite Inorganic materials 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000027734 detection of oxygen Effects 0.000 description 1
- 238000010894 electron beam technology Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 238000000608 laser ablation Methods 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 239000012811 non-conductive material Substances 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 229920005573 silicon-containing polymer Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 229910052682 stishovite Inorganic materials 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 229910052905 tridymite Inorganic materials 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
- G01N21/6454—Individual samples arranged in a regular 2D-array, e.g. multiwell plates using an integrated detector array
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N2021/7769—Measurement method of reaction-produced change in sensor
- G01N2021/7786—Fluorescence
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Plasma & Fusion (AREA)
- Optics & Photonics (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Luminescent Compositions (AREA)
- Dental Preparations (AREA)
- Geophysics And Detection Of Objects (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/855,234 US5894351A (en) | 1997-05-13 | 1997-05-13 | Fluorescence sensing device |
| PCT/US1998/009588 WO1998052024A1 (en) | 1997-05-13 | 1998-05-12 | Improved fluorescence sensing device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69809902D1 DE69809902D1 (de) | 2003-01-16 |
| DE69809902T2 true DE69809902T2 (de) | 2003-05-28 |
Family
ID=25320700
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69809902T Expired - Lifetime DE69809902T2 (de) | 1997-05-13 | 1998-05-12 | Verbesserte vorrichtung zum fluoreszenznachweis |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5894351A (enExample) |
| EP (1) | EP0981736B1 (enExample) |
| JP (1) | JP4088352B2 (enExample) |
| KR (1) | KR100508666B1 (enExample) |
| CN (1) | CN1146726C (enExample) |
| AT (1) | ATE229178T1 (enExample) |
| AU (1) | AU723849B2 (enExample) |
| CA (1) | CA2287307C (enExample) |
| DE (1) | DE69809902T2 (enExample) |
| DK (1) | DK0981736T3 (enExample) |
| ES (1) | ES2187968T3 (enExample) |
| NO (1) | NO328830B1 (enExample) |
| PT (1) | PT981736E (enExample) |
| TW (1) | TW385365B (enExample) |
| WO (1) | WO1998052024A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102015211909A1 (de) * | 2015-06-26 | 2016-12-29 | Robert Bosch Gmbh | Kostengünstiges Pulsoxymeter |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070225612A1 (en) * | 1996-07-15 | 2007-09-27 | Mace Leslie E | Metabolic measurements system including a multiple function airway adapter |
| US7335164B2 (en) | 1996-07-15 | 2008-02-26 | Ntc Technology, Inc. | Multiple function airway adapter |
| DE19725050C2 (de) * | 1997-06-13 | 1999-06-24 | Fraunhofer Ges Forschung | Anordnung zur Detektion biochemischer oder chemischer Substanzen mittels Fluoreszenzlichtanregung und Verfahren zu deren Herstellung |
| US6572561B2 (en) | 1998-01-16 | 2003-06-03 | Healthetech, Inc. | Respiratory calorimeter |
| JP4238390B2 (ja) * | 1998-02-27 | 2009-03-18 | 株式会社ニコン | 照明装置、該照明装置を備えた露光装置および該露光装置を用いて半導体デバイスを製造する方法 |
| US6922576B2 (en) * | 1998-06-19 | 2005-07-26 | Becton, Dickinson And Company | Micro optical sensor device |
| US6535753B1 (en) * | 1998-08-20 | 2003-03-18 | Microsense International, Llc | Micro-invasive method for painless detection of analytes in extra-cellular space |
| US20090011945A1 (en) * | 1999-07-28 | 2009-01-08 | Bright Frank V | Method For Making Microsensor Arrays For Detecting Analytes |
| WO2001009604A1 (en) * | 1999-07-28 | 2001-02-08 | The Research Foundation Of State University Of New York | Microsensor arrays and method of using same for detecting analytes |
| US6612306B1 (en) | 1999-10-13 | 2003-09-02 | Healthetech, Inc. | Respiratory nitric oxide meter |
| EP2264439A3 (en) * | 1999-11-12 | 2011-01-19 | E.I. Du Pont De Nemours And Company | Fluorometer with low heat-generating light source |
| CN1446222A (zh) | 2000-08-04 | 2003-10-01 | 医药及科学传感器公司 | 水环境中分析物的检测 |
| US6620106B2 (en) | 2000-09-29 | 2003-09-16 | Healthetech, Inc. | Indirect calorimetry system |
| US7470420B2 (en) | 2000-12-05 | 2008-12-30 | The Regents Of The University Of California | Optical determination of glucose utilizing boronic acid adducts |
| US6653141B2 (en) | 2000-12-05 | 2003-11-25 | The Regents Of The University Of California | Polyhydroxyl-substituted organic molecule sensing method and device |
| US6627177B2 (en) * | 2000-12-05 | 2003-09-30 | The Regents Of The University Of California | Polyhydroxyl-substituted organic molecule sensing optical in vivo method utilizing a boronic acid adduct and the device thereof |
| US20020119581A1 (en) * | 2001-01-05 | 2002-08-29 | Daniloff George Y. | Detection of analytes |
| US6844563B2 (en) * | 2001-05-22 | 2005-01-18 | Matsushita Electric Industrial Co., Ltd. | Fluorescence detecting device with integrated circuit and photodiode, and detection method |
| TWI293363B (en) | 2001-12-11 | 2008-02-11 | Sensors For Med & Science Inc | High performance fluorescent optical sensor |
| US20030153026A1 (en) * | 2002-01-04 | 2003-08-14 | Javier Alarcon | Entrapped binding protein as biosensors |
| US6855556B2 (en) | 2002-01-04 | 2005-02-15 | Becton, Dickinson And Company | Binding protein as biosensors |
| US6867420B2 (en) * | 2002-06-03 | 2005-03-15 | The Regents Of The University Of California | Solid-state detector and optical system for microchip analyzers |
| US7108659B2 (en) * | 2002-08-01 | 2006-09-19 | Healthetech, Inc. | Respiratory analyzer for exercise use |
| US20040161853A1 (en) | 2003-02-13 | 2004-08-19 | Zhongping Yang | Implantable chemical sensor with rugged optical coupler |
| US20040175821A1 (en) * | 2003-03-07 | 2004-09-09 | Ehman Michael F. | Integrated photodetector for heavy metals and biological activity analysis |
| CN1806475B (zh) * | 2003-04-15 | 2013-07-03 | 医药及科学传感器公司 | 具有集成天线的印刷电路装置和具有集成印刷电路板天线的可植入传感器处理系统 |
| US20040234962A1 (en) * | 2003-05-02 | 2004-11-25 | Javier Alarcon | Multicoated or multilayer entrapment matrix for protein biosensor |
| US7713745B2 (en) * | 2004-04-13 | 2010-05-11 | Sensors For Medicine And Science, Inc. | Non-covalent immobilization of indicator molecules |
| US20050234316A1 (en) | 2004-04-16 | 2005-10-20 | Sensors For Medicine And Science, Inc. | Housing for a circuit that is to be implanted in-vivo and process of making the same |
| WO2005124348A1 (en) * | 2004-06-09 | 2005-12-29 | Becton, Dickinson And Company | Multianalyte sensor |
| JP5011650B2 (ja) * | 2005-04-01 | 2012-08-29 | パナソニック株式会社 | 光検知方法 |
| JP5041714B2 (ja) * | 2006-03-13 | 2012-10-03 | 信越化学工業株式会社 | マイクロチップ及びマイクロチップ製造用ｓｏｉ基板 |
| AU2007240316A1 (en) | 2006-04-20 | 2007-11-01 | Becton, Dickinson And Company | Thermostable proteins and methods of making and using thereof |
| JP5638343B2 (ja) * | 2010-10-25 | 2014-12-10 | テルモ株式会社 | 蛍光センサ |
| JP6084172B2 (ja) | 2011-03-15 | 2017-02-22 | センセオニクス，インコーポレーテッド | 酸化感受性材料の統合的な触媒による保護 |
| WO2012169230A1 (ja) * | 2011-06-08 | 2012-12-13 | オリンパス株式会社 | 蛍光センサ |
| WO2012169236A1 (ja) * | 2011-06-08 | 2012-12-13 | オリンパス株式会社 | 蛍光センサおよび蛍光センサの製造方法 |
| JP2014224680A (ja) * | 2011-09-12 | 2014-12-04 | テルモ株式会社 | 蛍光センサーおよびアナライト成分測定方法 |
| JP6087337B2 (ja) * | 2012-02-16 | 2017-03-01 | テルモ株式会社 | 蛍光センサおよびセンサシステム |
| US8906320B1 (en) | 2012-04-16 | 2014-12-09 | Illumina, Inc. | Biosensors for biological or chemical analysis and systems and methods for same |
| WO2014045388A1 (ja) * | 2012-09-21 | 2014-03-27 | テルモ株式会社 | 蛍光センサ |
| WO2014045387A1 (ja) * | 2012-09-21 | 2014-03-27 | テルモ株式会社 | 蛍光センサ |
| US9963556B2 (en) | 2013-09-18 | 2018-05-08 | Senseonics, Incorporated | Critical point drying of hydrogels in analyte sensors |
| BR112016013353B1 (pt) | 2013-12-10 | 2020-11-24 | Illumina, Inc | Biossensor e metodo para produzir um biossensor |
| KR101569515B1 (ko) | 2014-08-13 | 2015-11-27 | (주)옵토레인 | 측광형 발광소자가 내장된 바이오칩 및 그 제조방법 |
| US10861829B2 (en) | 2017-12-26 | 2020-12-08 | Illumina, Inc. | Sensor system |
| JP2018141790A (ja) * | 2018-03-26 | 2018-09-13 | 株式会社ジャパンディスプレイ | 検体検出チップ |
| US10782236B2 (en) | 2018-06-11 | 2020-09-22 | Semiconductor Components Industries, Llc | Methods and apparatus for a biosensor |
| EP3767276A1 (en) * | 2019-07-19 | 2021-01-20 | Sensirion AG | Total organic carbon sensor with uv-sensitive photodetector comprising a down-converting layer |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0725269A3 (en) * | 1995-02-03 | 1997-12-17 | Motorola, Inc. | Optical sensor and method therefor |
| US5517313A (en) * | 1995-02-21 | 1996-05-14 | Colvin, Jr.; Arthur E. | Fluorescent optical sensor |
| US5591407A (en) * | 1995-04-21 | 1997-01-07 | American Research Corporation Of Virginia | Laser diode sensor |
-
1997
- 1997-05-13 US US08/855,234 patent/US5894351A/en not_active Expired - Lifetime
-
1998
- 1998-05-12 DK DK98922204T patent/DK0981736T3/da active
- 1998-05-12 ES ES98922204T patent/ES2187968T3/es not_active Expired - Lifetime
- 1998-05-12 PT PT98922204T patent/PT981736E/pt unknown
- 1998-05-12 CA CA002287307A patent/CA2287307C/en not_active Expired - Fee Related
- 1998-05-12 AU AU74803/98A patent/AU723849B2/en not_active Ceased
- 1998-05-12 KR KR10-1999-7010500A patent/KR100508666B1/ko not_active Expired - Fee Related
- 1998-05-12 EP EP98922204A patent/EP0981736B1/en not_active Expired - Lifetime
- 1998-05-12 WO PCT/US1998/009588 patent/WO1998052024A1/en not_active Ceased
- 1998-05-12 AT AT98922204T patent/ATE229178T1/de active
- 1998-05-12 JP JP54938198A patent/JP4088352B2/ja not_active Expired - Fee Related
- 1998-05-12 DE DE69809902T patent/DE69809902T2/de not_active Expired - Lifetime
- 1998-05-12 CN CNB988050242A patent/CN1146726C/zh not_active Expired - Fee Related
- 1998-05-13 TW TW087107405A patent/TW385365B/zh not_active IP Right Cessation
-
1999
- 1999-10-28 NO NO19995282A patent/NO328830B1/no not_active IP Right Cessation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102015211909A1 (de) * | 2015-06-26 | 2016-12-29 | Robert Bosch Gmbh | Kostengünstiges Pulsoxymeter |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1146726C (zh) | 2004-04-21 |
| JP4088352B2 (ja) | 2008-05-21 |
| US5894351A (en) | 1999-04-13 |
| HK1023401A1 (en) | 2000-09-08 |
| AU723849B2 (en) | 2000-09-07 |
| JP2001525930A (ja) | 2001-12-11 |
| KR100508666B1 (ko) | 2005-08-17 |
| PT981736E (pt) | 2003-04-30 |
| DE69809902D1 (de) | 2003-01-16 |
| TW385365B (en) | 2000-03-21 |
| AU7480398A (en) | 1998-12-08 |
| DK0981736T3 (da) | 2003-03-31 |
| NO995282D0 (no) | 1999-10-28 |
| KR20010012545A (ko) | 2001-02-15 |
| EP0981736A1 (en) | 2000-03-01 |
| EP0981736B1 (en) | 2002-12-04 |
| CA2287307C (en) | 2007-07-10 |
| NO995282L (no) | 2000-01-10 |
| NO328830B1 (no) | 2010-05-25 |
| ES2187968T3 (es) | 2003-06-16 |
| WO1998052024A1 (en) | 1998-11-19 |
| CA2287307A1 (en) | 1998-11-19 |
| ATE229178T1 (de) | 2002-12-15 |
| CN1255973A (zh) | 2000-06-07 |
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