DE69736860T2 - Verbindungen zur hemmung der angiogenese durch gentherapie - Google Patents

Verbindungen zur hemmung der angiogenese durch gentherapie Download PDF

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Publication number
DE69736860T2
DE69736860T2 DE69736860T DE69736860T DE69736860T2 DE 69736860 T2 DE69736860 T2 DE 69736860T2 DE 69736860 T DE69736860 T DE 69736860T DE 69736860 T DE69736860 T DE 69736860T DE 69736860 T2 DE69736860 T2 DE 69736860T2
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DE
Germany
Prior art keywords
cells
vegf
tumor
sflt
use according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69736860T
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German (de)
English (en)
Other versions
DE69736860D1 (de
Inventor
A. Kenneth Rahway THOMAS
K. Corey Birmingham GOLDMAN
L. Richard Rahway KENDALL
R. William Rahway HUCKLE
J. Andrew Rahway BETT
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Merck and Co Inc
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Merck and Co Inc
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Publication of DE69736860D1 publication Critical patent/DE69736860D1/de
Publication of DE69736860T2 publication Critical patent/DE69736860T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
DE69736860T 1996-09-24 1997-09-24 Verbindungen zur hemmung der angiogenese durch gentherapie Expired - Fee Related DE69736860T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2664196P 1996-09-24 1996-09-24
US26641P 1996-09-24
PCT/US1997/017044 WO1998013071A1 (en) 1996-09-24 1997-09-24 Gene therapy for inhibition of angiogenesis

Publications (2)

Publication Number Publication Date
DE69736860D1 DE69736860D1 (de) 2006-12-07
DE69736860T2 true DE69736860T2 (de) 2007-05-16

Family

ID=21833003

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69736860T Expired - Fee Related DE69736860T2 (de) 1996-09-24 1997-09-24 Verbindungen zur hemmung der angiogenese durch gentherapie

Country Status (9)

Country Link
US (1) US6375929B1 (enExample)
EP (1) EP0928203B1 (enExample)
JP (1) JP2001501471A (enExample)
AT (1) ATE343400T1 (enExample)
AU (1) AU738806B2 (enExample)
CA (1) CA2266419A1 (enExample)
DE (1) DE69736860T2 (enExample)
ES (1) ES2274549T3 (enExample)
WO (1) WO1998013071A1 (enExample)

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US7306799B2 (en) 1999-06-08 2007-12-11 Regeneron Pharmaceuticals, Inc. Use of VEGF inhibitors for treatment of eye disorders
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Also Published As

Publication number Publication date
ATE343400T1 (de) 2006-11-15
CA2266419A1 (en) 1998-04-02
JP2001501471A (ja) 2001-02-06
WO1998013071A1 (en) 1998-04-02
US6375929B1 (en) 2002-04-23
ES2274549T3 (es) 2007-05-16
AU4650397A (en) 1998-04-17
AU738806B2 (en) 2001-09-27
DE69736860D1 (de) 2006-12-07
EP0928203B1 (en) 2006-10-25
EP0928203A4 (en) 2003-01-22
EP0928203A1 (en) 1999-07-14

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