DE69734607T2 - Langwirkende arzneistoffe und diese enthaltende arzneimittel - Google Patents
Langwirkende arzneistoffe und diese enthaltende arzneimittel Download PDFInfo
- Publication number
- DE69734607T2 DE69734607T2 DE69734607T DE69734607T DE69734607T2 DE 69734607 T2 DE69734607 T2 DE 69734607T2 DE 69734607 T DE69734607 T DE 69734607T DE 69734607 T DE69734607 T DE 69734607T DE 69734607 T2 DE69734607 T2 DE 69734607T2
- Authority
- DE
- Germany
- Prior art keywords
- insulin
- fmoc
- lys
- phe
- gly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 239000003814 drug Substances 0.000 title claims description 66
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- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 28
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- ZAIPMKNFIOOWCQ-UEKVPHQBSA-N cephalexin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C)C(O)=O)=CC=CC=C1 ZAIPMKNFIOOWCQ-UEKVPHQBSA-N 0.000 claims description 17
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- PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 claims description 9
- 101000976075 Homo sapiens Insulin Proteins 0.000 claims description 8
- 125000000524 functional group Chemical group 0.000 claims description 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 7
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- 239000007929 subcutaneous injection Substances 0.000 claims description 6
- 125000000217 alkyl group Chemical group 0.000 claims description 5
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- 125000003118 aryl group Chemical group 0.000 claims description 5
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- 150000002431 hydrogen Chemical class 0.000 claims description 4
- 108010051696 Growth Hormone Proteins 0.000 claims description 3
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- 125000004183 alkoxy alkyl group Chemical group 0.000 claims description 3
- 125000003545 alkoxy group Chemical group 0.000 claims description 3
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- 239000002246 antineoplastic agent Substances 0.000 claims description 3
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- 125000003710 aryl alkyl group Chemical group 0.000 claims description 3
- 239000000122 growth hormone Substances 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims description 3
- 150000003839 salts Chemical class 0.000 claims description 3
- 241000283690 Bos taurus Species 0.000 claims description 2
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- 239000000854 Human Growth Hormone Substances 0.000 claims description 2
- VRKCDEWVVXAWCZ-UHFFFAOYSA-N amino(nitro)sulfamic acid Chemical compound [O-][N+](=O)N(N)S(O)(=O)=O VRKCDEWVVXAWCZ-UHFFFAOYSA-N 0.000 claims description 2
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- 229940127003 anti-diabetic drug Drugs 0.000 claims description 2
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- 229940124599 anti-inflammatory drug Drugs 0.000 claims description 2
- 239000000043 antiallergic agent Substances 0.000 claims description 2
- 239000000924 antiasthmatic agent Substances 0.000 claims description 2
- 108010006025 bovine growth hormone Proteins 0.000 claims description 2
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 claims description 2
- 125000002233 tyrosyl group Chemical group 0.000 claims description 2
- 101000993800 Sus scrofa Insulin Proteins 0.000 claims 1
- 239000000730 antalgic agent Substances 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical class O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 claims 1
- PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 claims 1
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Classifications
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- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/555—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound pre-targeting systems involving an organic compound, other than a peptide, protein or antibody, for targeting specific cells
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Landscapes
- Health & Medical Sciences (AREA)
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- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
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- Animal Behavior & Ethology (AREA)
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- Medicinal Preparation (AREA)
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL11902996 | 1996-08-07 | ||
| IL11902996A IL119029A0 (en) | 1996-08-07 | 1996-08-07 | Long-acting drugs and pharamaceutical compositions comprising them |
| PCT/IL1997/000265 WO1998005361A2 (en) | 1996-08-07 | 1997-08-05 | Long-acting drugs and pharmaceutical compositions comprising them |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69734607D1 DE69734607D1 (de) | 2005-12-15 |
| DE69734607T2 true DE69734607T2 (de) | 2006-08-03 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69734607T Expired - Lifetime DE69734607T2 (de) | 1996-08-07 | 1997-08-05 | Langwirkende arzneistoffe und diese enthaltende arzneimittel |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6504005B1 (Direct) |
| EP (1) | EP1019089B1 (Direct) |
| JP (1) | JP4416184B2 (Direct) |
| KR (1) | KR20000029806A (Direct) |
| CN (1) | CN1227501A (Direct) |
| AT (1) | ATE308998T1 (Direct) |
| AU (1) | AU725468B2 (Direct) |
| BR (1) | BR9711045A (Direct) |
| CA (1) | CA2261835C (Direct) |
| CZ (1) | CZ36999A3 (Direct) |
| DE (1) | DE69734607T2 (Direct) |
| DK (1) | DK1019089T3 (Direct) |
| ES (1) | ES2252787T3 (Direct) |
| HU (1) | HUP0000809A2 (Direct) |
| IL (3) | IL119029A0 (Direct) |
| NO (1) | NO990518L (Direct) |
| NZ (1) | NZ333845A (Direct) |
| WO (1) | WO1998005361A2 (Direct) |
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| IL139400A0 (en) * | 2000-11-01 | 2001-11-25 | Yeda Res & Dev | Long-acting cytokine derivatives and pharmaceutical compositions comprising them |
| US7259233B2 (en) * | 2000-12-13 | 2007-08-21 | Eli Lilly And Company | Chronic treatment regimen using glucagon-like insulinotropic peptides |
| US6946137B2 (en) * | 2001-10-19 | 2005-09-20 | Idexx Laboratories, Inc. | Methods for the controlled delivery of pharmacologically active compounds |
| ES2561108T3 (es) * | 2001-10-19 | 2016-02-24 | Idexx Laboratories, Inc. | Composiciones inyectables para la liberación controlada de compuesto farmacológicamente activo |
| US20030171285A1 (en) * | 2001-11-20 | 2003-09-11 | Finn Rory F. | Chemically-modified human growth hormone conjugates |
| BE1015608A6 (fr) * | 2003-07-15 | 2005-06-07 | Messadek Jallal | Traitement des arterites. |
| JP4033382B2 (ja) * | 2002-04-08 | 2008-01-16 | 久光製薬株式会社 | インスリン投与装置 |
| DE602004030212D1 (de) * | 2003-01-16 | 2011-01-05 | Caprotec Bioanalytics Gmbh | Verfahren zur identifizierung von auf arzneimittel nicht-zielgerichteten proteinen |
| WO2004089280A2 (en) | 2003-04-08 | 2004-10-21 | Yeda Research And Development Co. Ltd. | Reversible pegylated drugs |
| EP1615632B1 (fr) * | 2003-04-17 | 2006-12-06 | Jallal Messadek | Formulations orales flottantes pour la liberation controlee de la betaine |
| EP2107069B1 (en) * | 2003-08-05 | 2013-01-16 | Novo Nordisk A/S | Novel insulin derivatives |
| BE1016128A6 (fr) * | 2004-07-22 | 2006-03-07 | Messadek Jallal | Combinaisons therapeutiques |
| US7282487B2 (en) * | 2004-10-28 | 2007-10-16 | Idexx Laboratories | Method for treating bacterial infections in horses or pigs with tilmicosin |
| WO2006050581A2 (en) * | 2004-11-10 | 2006-05-18 | Jallal Messadek | Betaine as agent against arthropod - or mosquito -borne diseases |
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-
1996
- 1996-08-07 IL IL11902996A patent/IL119029A0/xx unknown
-
1997
- 1997-08-05 DE DE69734607T patent/DE69734607T2/de not_active Expired - Lifetime
- 1997-08-05 NZ NZ333845A patent/NZ333845A/xx unknown
- 1997-08-05 KR KR1019997000941A patent/KR20000029806A/ko not_active Withdrawn
- 1997-08-05 HU HU0000809A patent/HUP0000809A2/hu unknown
- 1997-08-05 EP EP97933828A patent/EP1019089B1/en not_active Expired - Lifetime
- 1997-08-05 CN CN97197122A patent/CN1227501A/zh active Pending
- 1997-08-05 IL IL12827497A patent/IL128274A0/xx active IP Right Grant
- 1997-08-05 US US09/242,026 patent/US6504005B1/en not_active Expired - Lifetime
- 1997-08-05 AT AT97933828T patent/ATE308998T1/de active
- 1997-08-05 BR BR9711045A patent/BR9711045A/pt not_active IP Right Cessation
- 1997-08-05 CZ CZ99369A patent/CZ36999A3/cs unknown
- 1997-08-05 WO PCT/IL1997/000265 patent/WO1998005361A2/en not_active Ceased
- 1997-08-05 AU AU37060/97A patent/AU725468B2/en not_active Ceased
- 1997-08-05 JP JP50777098A patent/JP4416184B2/ja not_active Expired - Lifetime
- 1997-08-05 ES ES97933828T patent/ES2252787T3/es not_active Expired - Lifetime
- 1997-08-05 DK DK97933828T patent/DK1019089T3/da active
- 1997-08-05 CA CA002261835A patent/CA2261835C/en not_active Expired - Lifetime
-
1999
- 1999-01-28 IL IL128274A patent/IL128274A/en not_active IP Right Cessation
- 1999-02-04 NO NO990518A patent/NO990518L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU725468B2 (en) | 2000-10-12 |
| ATE308998T1 (de) | 2005-11-15 |
| DK1019089T3 (da) | 2006-03-13 |
| AU3706097A (en) | 1998-02-25 |
| NZ333845A (en) | 2000-09-29 |
| US6504005B1 (en) | 2003-01-07 |
| WO1998005361A3 (en) | 1998-06-18 |
| JP4416184B2 (ja) | 2010-02-17 |
| ES2252787T3 (es) | 2006-05-16 |
| IL119029A0 (en) | 1996-11-14 |
| IL128274A (en) | 2006-08-01 |
| KR20000029806A (ko) | 2000-05-25 |
| CN1227501A (zh) | 1999-09-01 |
| WO1998005361A2 (en) | 1998-02-12 |
| HUP0000809A2 (hu) | 2000-11-28 |
| EP1019089B1 (en) | 2005-11-09 |
| JP2000515542A (ja) | 2000-11-21 |
| CA2261835A1 (en) | 1998-02-12 |
| EP1019089A2 (en) | 2000-07-19 |
| NO990518D0 (no) | 1999-02-04 |
| DE69734607D1 (de) | 2005-12-15 |
| CZ36999A3 (cs) | 1999-07-14 |
| NO990518L (no) | 1999-04-06 |
| CA2261835C (en) | 2008-07-29 |
| IL128274A0 (en) | 1999-11-30 |
| BR9711045A (pt) | 1999-08-17 |
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