DE69731317D1 - Neue carbonyl-reduktase, gene welche diese kodieren und methoden zu deren verwendung - Google Patents

Neue carbonyl-reduktase, gene welche diese kodieren und methoden zu deren verwendung

Info

Publication number
DE69731317D1
DE69731317D1 DE69731317T DE69731317T DE69731317D1 DE 69731317 D1 DE69731317 D1 DE 69731317D1 DE 69731317 T DE69731317 T DE 69731317T DE 69731317 T DE69731317 T DE 69731317T DE 69731317 D1 DE69731317 D1 DE 69731317D1
Authority
DE
Germany
Prior art keywords
encode
genes
methods
carbonyl reductase
enzyme
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69731317T
Other languages
English (en)
Other versions
DE69731317T2 (de
Inventor
Yoshihiko Yasohara
Noriyuki Kizaki
Junzo Hasegawa
Masaru Wada
Sakayu Shimizu
Michihiko Kataoka
K Yamamoto
Hiroshi Kawabata
Keiko Kita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kaneka Corp
Original Assignee
Kaneka Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaneka Corp filed Critical Kaneka Corp
Publication of DE69731317D1 publication Critical patent/DE69731317D1/de
Application granted granted Critical
Publication of DE69731317T2 publication Critical patent/DE69731317T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
DE69731317T 1997-02-07 1997-09-01 Neue carbonyl-reduktase, gene welche diese kodieren und methoden zu deren verwendung Expired - Lifetime DE69731317T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2566797 1997-02-07
JP2566797 1997-02-07
JP11305297 1997-04-30
JP11305297 1997-04-30
PCT/JP1997/003051 WO1998035025A1 (fr) 1997-02-07 1997-09-01 Nouvelle carbonyle reductase, gene codant celle-ci et procede d'utilisation

Publications (2)

Publication Number Publication Date
DE69731317D1 true DE69731317D1 (de) 2004-11-25
DE69731317T2 DE69731317T2 (de) 2006-02-23

Family

ID=26363321

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69731317T Expired - Lifetime DE69731317T2 (de) 1997-02-07 1997-09-01 Neue carbonyl-reduktase, gene welche diese kodieren und methoden zu deren verwendung

Country Status (14)

Country Link
US (2) US6218156B1 (de)
EP (1) EP0967271B1 (de)
JP (1) JP4012257B2 (de)
KR (1) KR100506134B1 (de)
AT (1) ATE280218T1 (de)
AU (1) AU4032997A (de)
CA (1) CA2280502A1 (de)
CZ (1) CZ298236B6 (de)
DE (1) DE69731317T2 (de)
ES (1) ES2235246T3 (de)
IL (2) IL131241A0 (de)
SI (1) SI20120A (de)
SK (1) SK105699A3 (de)
WO (1) WO1998035025A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6242253B1 (en) 1997-10-09 2001-06-05 Regents Of The University Of California IkB kinase, subunits thereof, and methods of using same
JP2000189170A (ja) 1998-05-08 2000-07-11 Daicel Chem Ind Ltd 光学活性４―ハロ―３―ヒドロキシ酪酸エステルの製造方法
JP2000175693A (ja) * 1998-12-18 2000-06-27 Kanegafuchi Chem Ind Co Ltd （ｒ）−２−ヒドロキシ−１−フェノキシプロパン誘導体の製造方法
JP2000236883A (ja) 1998-12-21 2000-09-05 Daicel Chem Ind Ltd 新規なカルボニル還元酵素、該酵素の製造方法、該酵素をコードするｄｎａおよびこれを利用したアルコールの製造方法
KR20010103017A (ko) * 1999-02-19 2001-11-17 플레믹 크리스티안 글루코스 데히드로게나제 융합 단백질 및 발현계에서의그의 용도
TWI275645B (en) * 2000-02-16 2007-03-11 Daicel Chemical Industries Ltd. (R)-2-octanol dehydrogenases, methods for producing the enzymes, DNA encoding the enzymes, and methods for producing alcohols using the enzymes
US6682916B2 (en) * 2000-06-27 2004-01-27 Kaneka Corporation Chlorohydroxyacetone derivative and process for producing optically active chloropropanediol derivative from the same
US6884607B2 (en) * 2000-12-07 2005-04-26 Sumitomo Chemical Company, Limited Process for producing optically active 4-halo-3-hydroxybutanoate
JP4493333B2 (ja) * 2001-07-02 2010-06-30 株式会社カネカ 酵素改変方法および酸化還元酵素変異体
US20050014818A1 (en) * 2001-11-09 2005-01-20 Masaru Mitsuda Process for producing optically active chroman derivative and intermediate
KR100522133B1 (ko) * 2002-01-26 2005-10-18 한국과학기술연구원 클루이베로마이세스 마르시아누스로부터 분리 및 정제된 카르보닐 환원효소 및 그 제조 방법
CA2479705C (en) * 2002-03-19 2011-02-01 Mitsubishi Chemical Corporation Novel carbonyl reductase, gene encoding the same, and process for producing optically active alcohols using the same
JP4228605B2 (ja) * 2002-07-02 2009-02-25 住友化学株式会社 改変型還元酵素、その遺伝子及びそれらの利用
JP4228606B2 (ja) * 2002-07-03 2009-02-25 住友化学株式会社 改変型還元酵素、その遺伝子及びそれらの利用
US20050272136A1 (en) * 2002-07-15 2005-12-08 Sumitomo Chemical Company, Limited Process for producing 3-hydroxycyclohexanone
EP1537222B1 (de) * 2002-08-09 2011-03-09 Codexis, Inc. Enzymatische verfahren zur herstellung 4-substituierter 3-hydroxybuttersäure-derivate
JP2007502111A (ja) * 2003-08-11 2007-02-08 コデクシス， インコーポレイテッド ４−置換３−ヒドロキシ酪酸誘導体およびビシナルなシアノ，ヒドロキシ置換カルボン酸エステルの生成のための酵素的プロセス
EP1654354A1 (de) * 2003-08-11 2006-05-10 Codexis, Inc. Verbesserte ketoreduktase polypeptide und entsprechende polynukleotide
EP1811021A4 (de) * 2004-10-27 2008-05-28 Kaneka Corp Neue carbonylreduktase, gen dafür und verwendung davon
US20100003732A1 (en) 2005-05-31 2010-01-07 Kaneka Corporation Process for production of optically active 2-substituted propanal derivative
JP2009114065A (ja) * 2006-02-21 2009-05-28 Kaneka Corp （２ｒ，３ｒ）および（２ｓ，３ｓ）−３−フェニルイソセリン誘導体の製造法
US7834190B2 (en) * 2006-05-26 2010-11-16 Kaneka Corporation Process for production of optically active-3-amino-2-hydroxypropionic cyclopropylamide derivatives and salts thereof
CN101528917B (zh) 2006-10-02 2015-07-29 科德克希思公司 用于制备立体异构纯的他汀类及其合成中间体的组合物和方法
JP5265513B2 (ja) 2007-02-19 2013-08-14 株式会社カネカ 光学活性３−アミノピペリジン又はその塩の製造方法
EP2202303B1 (de) 2007-09-26 2016-10-26 Kaneka Corporation Neue glucose-dehydrogenase
CN102803233B (zh) * 2009-06-22 2017-03-01 爱思开生物制药株式会社 制备氨基甲酸(r)‑1‑芳基‑2‑四唑基‑乙酯的方法
US8404461B2 (en) 2009-10-15 2013-03-26 SK Biopharmaceutical Co. Ltd. Method for preparation of carbamic acid (R)-1-aryl-2-tetrazolyl-ethyl ester
WO2011078172A1 (ja) 2009-12-25 2011-06-30 株式会社カネカ 光学活性３－置換グルタル酸モノアミドの製造法
CN111172124B (zh) * 2020-02-26 2022-07-22 复旦大学 一种羰基还原酶突变体及其在制备(r)-4-氯-3-羟基-丁酸酯中的应用
CN115433721B (zh) * 2022-06-24 2024-01-23 山东理工大学 一种羰基还原酶突变体及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61146191A (ja) * 1984-12-20 1986-07-03 Kanegafuchi Chem Ind Co Ltd （Ｓ）−γ−ハロ−β−ヒドロキシ酪酸エステルの製造法
JP2566960B2 (ja) 1987-06-08 1996-12-25 電気化学工業株式会社 （Ｒ）−ｒ−置換−β−ハイドロキシ酪酸エステルの製造法
JP3163338B2 (ja) 1992-05-28 2001-05-08 味の素株式会社 （Ｓ）−γ−ハロゲン化−β−ハイドロキシ酪酸エステルの製造方法
JP3155107B2 (ja) 1993-01-12 2001-04-09 ダイセル化学工業株式会社 光学活性４−ハロ−３−ヒドロキシ酪酸エステルの製造方法
JPH08336393A (ja) 1995-04-13 1996-12-24 Mitsubishi Chem Corp 光学活性なγ−置換−β−ヒドロキシ酪酸エステルの製造法

Also Published As

Publication number Publication date
US6218156B1 (en) 2001-04-17
SK105699A3 (en) 2000-06-12
KR100506134B1 (ko) 2005-08-08
EP0967271A1 (de) 1999-12-29
ATE280218T1 (de) 2004-11-15
EP0967271B1 (de) 2004-10-20
IL131241A0 (en) 2001-01-28
KR20000070896A (ko) 2000-11-25
JP4012257B2 (ja) 2007-11-21
CA2280502A1 (en) 1998-08-13
WO1998035025A1 (fr) 1998-08-13
IL131241A (en) 2006-12-31
US6448052B2 (en) 2002-09-10
CZ298236B6 (cs) 2007-08-01
CZ276199A3 (cs) 2000-03-15
ES2235246T3 (es) 2005-07-01
AU4032997A (en) 1998-08-26
EP0967271A4 (de) 2002-09-25
SI20120A (sl) 2000-06-30
US20020006651A1 (en) 2002-01-17
DE69731317T2 (de) 2006-02-23

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