DE69434148D1 - Alkoholdehydrogenase, dafür kodierende DNA, Herstellung und Verfahren zur Herstellung von optisch aktiven Alkoholen - Google Patents

Alkoholdehydrogenase, dafür kodierende DNA, Herstellung und Verfahren zur Herstellung von optisch aktiven Alkoholen

Info

Publication number
DE69434148D1
DE69434148D1 DE69434148T DE69434148T DE69434148D1 DE 69434148 D1 DE69434148 D1 DE 69434148D1 DE 69434148 T DE69434148 T DE 69434148T DE 69434148 T DE69434148 T DE 69434148T DE 69434148 D1 DE69434148 D1 DE 69434148D1
Authority
DE
Germany
Prior art keywords
production
optically active
alcohol dehydrogenase
dna coding
coding therefor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69434148T
Other languages
English (en)
Other versions
DE69434148T2 (de
Inventor
Tomoko Kojima
Hiroaki Yamamoto
Naoki Kawada
Akinobu Matsuyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daicel Corp
Original Assignee
Daicel Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27324995&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69434148(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Daicel Chemical Industries Ltd filed Critical Daicel Chemical Industries Ltd
Publication of DE69434148D1 publication Critical patent/DE69434148D1/de
Application granted granted Critical
Publication of DE69434148T2 publication Critical patent/DE69434148T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69434148T 1993-09-24 1994-09-26 Alkoholdehydrogenase, dafür kodierende DNA, Herstellung und Verfahren zur Herstellung von optisch aktiven Alkoholen Expired - Lifetime DE69434148T2 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP26164993 1993-09-24
JP26164993 1993-09-24
JP33719193 1993-12-28
JP33719193 1993-12-28
JP18130894A JP3574682B2 (ja) 1993-09-24 1994-08-02 新規な酵素、該酵素を製造する方法、該酵素をコードするｄｎａ、該ｄｎａを含む形質転換体、該酵素による光学活性アルコール等の製造方法
JP18130894 1994-08-02

Publications (2)

Publication Number Publication Date
DE69434148D1 true DE69434148D1 (de) 2004-12-30
DE69434148T2 DE69434148T2 (de) 2006-02-16

Family

ID=27324995

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69434148T Expired - Lifetime DE69434148T2 (de) 1993-09-24 1994-09-26 Alkoholdehydrogenase, dafür kodierende DNA, Herstellung und Verfahren zur Herstellung von optisch aktiven Alkoholen

Country Status (4)

Country Link
US (2) US5763236A (de)
EP (1) EP0645453B1 (de)
JP (1) JP3574682B2 (de)
DE (1) DE69434148T2 (de)

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DE19610984A1 (de) * 1996-03-21 1997-09-25 Boehringer Mannheim Gmbh Alkohol-Dehydrogenase und deren Verwendung zur enzymatischen Herstellung chiraler Hydroxyverbindungen
US6730503B1 (en) 1996-09-19 2004-05-04 Roche Vitamins Inc. Alcohol/aldehyde dehydrogenase
US5807926A (en) * 1996-10-11 1998-09-15 Mcgill University Immobilized cofactor-dependent enzymes
WO1998017788A1 (fr) * 1996-10-22 1998-04-30 Daicel Chemical Industries, Ltd. Nouvelle alcool-deshydrogenase secondaire, procede pour preparer cette enzyme et procede pour preparer des alcools et des cetones en utilisant cette enzyme
US6218581B1 (en) * 1997-12-29 2001-04-17 Sanyo Shokuhin Co., Ltd. Process of producing optically active alcohol
EP1054974B1 (de) * 1998-02-18 2007-03-28 Lonza AG Verfahren zur herstellung von trifluor-3(r)-hydroxybuttersäurederivaten
JP4012299B2 (ja) 1998-02-25 2007-11-21 ダイセル化学工業株式会社 ハロゲン置換を含む光学活性アルコールの製造方法
JP2000197485A (ja) * 1999-01-07 2000-07-18 Daicel Chem Ind Ltd 酸化還元酵素の生産能を有する微生物において酸化還元酵素の電子受容体再生活性を高める方法、および該方法により調製された微生物の利用
US7202070B2 (en) * 2000-10-31 2007-04-10 Biocatalytics, Inc. Method for reductive amination of a ketone using a mutated enzyme
DE60315958D1 (de) * 2002-03-18 2007-10-11 Biocatalytics Inc Alkohol-dehydrogenase mit hoher stabilität gegenüber lösungsmittel und temperatur
DE10327454A1 (de) * 2003-06-18 2005-01-20 Juelich Enzyme Products Gmbh Oxidoreduktase aus Pichia capsulata
EP1715054A4 (de) * 2004-01-30 2010-10-06 Kaneka Corp Verfahren zur produktion von optisch aktivem 1-substituiertem 2-methylpyrrolidin und zwischenstufe dafür
DE112005000772B4 (de) * 2004-04-07 2017-12-28 Waters Technologies Corp. (N.D.Ges.D. Staates Delaware) Flüssigchromatographiereagenz und Verfahren zum Auftrennen von Enantiomeren
AT413541B (de) * 2004-05-10 2006-03-15 Iep Gmbh Verfahren zur herstellung von 2-butanol
DE102004038054A1 (de) * 2004-08-05 2006-03-16 Maxens Gmbh Verfahren zur Herstellung primärer Alkohole
DE102004055508A1 (de) * 2004-11-17 2006-06-01 Basf Ag Verfahren zur Herstellung optisch aktiver Alkohole
DE102005010804A1 (de) * 2005-03-07 2006-09-14 Basf Ag Verfahren zur Herstellung optisch aktiver Alkohole
AT502395B1 (de) * 2005-07-27 2007-03-15 Iep Gmbh Oxidoreduktasen zur stereoselektiven reduktion von ketoverbindungen
DE102005043152A1 (de) * 2005-09-10 2007-03-15 Degussa Ag Alkoholdehydrogenase aus Nocardia globerula und deren Verwendung
AT502185B1 (de) * 2005-09-23 2007-02-15 Iep Gmbh Verfahren zur enantioselektiven enzymatischen reduktion von ketoverbindungen
DE102006009744A1 (de) * 2006-03-02 2007-09-06 Wacker Chemie Ag Herstellung von (S)-2-Butanol durch oxidative Racematspaltung
AT503486B1 (de) 2006-04-11 2008-05-15 Iep Gmbh Verfahren zur enantioselektiven reduktion von steroiden
US8206970B2 (en) 2006-05-02 2012-06-26 Butamax(Tm) Advanced Biofuels Llc Production of 2-butanol and 2-butanone employing aminobutanol phosphate phospholyase
US8828704B2 (en) 2006-05-02 2014-09-09 Butamax Advanced Biofuels Llc Fermentive production of four carbon alcohols
US7659104B2 (en) 2006-05-05 2010-02-09 E.I. Du Pont De Nemours And Company Solvent tolerant microorganisms and methods of isolation
US8129163B2 (en) 2006-11-29 2012-03-06 Kaneka Corporation Gene suitable for alcohol dehydrogenase, vector and transformant
AT504542B1 (de) 2006-12-07 2008-09-15 Iep Gmbh Verfahren zur enantioselektiven enzymatischen reduktion von secodionderivaten
US20080274522A1 (en) * 2007-05-02 2008-11-06 Bramucci Michael G Method for the production of 2-butanone
US8426174B2 (en) 2007-05-02 2013-04-23 Butamax(Tm) Advanced Biofuels Llc Method for the production of 2-butanol
TWI601825B (zh) * 2007-09-27 2017-10-11 Ｉｅｐ有限公司 對映異構選擇性酶催化還原中間產物之方法
US8188250B2 (en) * 2008-04-28 2012-05-29 Butamax(Tm) Advanced Biofuels Llc Butanol dehydrogenase enzyme from the bacterium Achromobacter xylosoxidans
DE102008038326B4 (de) 2008-08-19 2011-03-17 Jeromin, Günter E., Prof. Dr. Immobilisierung von Alkoholdehydrogenasen und deren Coenzyme sowie Verwendung des Immobilisats
EP2226386A1 (de) 2009-03-05 2010-09-08 IEP GmbH Verfahren zur stereoselektiven enzymatischen Reduktion von Ketoverbindungen
EP2427559A4 (de) * 2009-05-06 2013-09-18 Dna Twopointo Inc Biotransformation mithilfe genetisch modifizierter candida
JP5683580B2 (ja) * 2009-06-22 2015-03-11 エスケー バイオファーマシューティカル カンパニー リミテッド カルバミン酸（ｒ）−１−アリール−２−テトラゾリル−エチルエステルの製造方法
WO2011009849A2 (en) 2009-07-21 2011-01-27 Basf Se Method for preparing optically active hydroxy acid esters
US8404461B2 (en) * 2009-10-15 2013-03-26 SK Biopharmaceutical Co. Ltd. Method for preparation of carbamic acid (R)-1-aryl-2-tetrazolyl-ethyl ester
EP2504302A1 (de) * 2009-11-24 2012-10-03 Basf Se Verfahren zum isolieren eines alkanols aus einer wässrigen biotransformationsbrühe
CA2784903A1 (en) 2009-12-29 2011-07-28 Butamax(Tm) Advanced Biofuels Llc Alcohol dehydrogenases (adh) useful for fermentive production of lower alkyl alcohols
WO2011090054A1 (ja) 2010-01-20 2011-07-28 株式会社カネカ 安定性が向上したｎａｄｈオキシダーゼ変異体とその利用法
NZ603816A (en) 2010-05-27 2014-06-27 Pharmazell Gmbh Novel 7alpha-hydroxysteroid dehydrogenase knockout mutants and use thereof
CN103889997B (zh) 2011-01-18 2017-08-25 通用原子公司 水解酶酶底物及其应用
WO2013002277A1 (ja) 2011-06-28 2013-01-03 株式会社カネカ 酵素機能改変方法及びその変異体
DE102013104418B4 (de) 2013-04-30 2018-09-27 Cambrex Iep Gmbh Biokatalytisches Verfahren für die Herstellung von (R)-3-Chinuclidinol
CN105319316B (zh) * 2014-07-16 2019-04-02 中国科学院天津工业生物技术研究所 一种快速检测发酵液中苏氨酸含量的方法
CN117511890A (zh) * 2017-04-27 2024-02-06 科德克希思公司 酮还原酶多肽及多核苷酸
CN110914446B (zh) 2017-07-14 2024-02-06 C-乐克塔股份有限公司 酮还原酶

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5157782A (ja) * 1974-11-15 1976-05-20 Hitachi Condenser Keshoban
JPS5157882A (en) 1974-11-16 1976-05-20 Rikagaku Kenkyusho Datsusuisokosono seizoho
CA1211728A (en) * 1982-06-28 1986-09-23 Exxon Research And Engineering Company Primary and secondary alcohol dehydrogenase enzymes and use thereof
DE4009676A1 (de) * 1990-03-26 1991-10-02 Rhein Biotech Proz & Prod Gmbh Dna-sequenz, umfassend ein fuer xylosereduktase und/oder xylitoldehydrogenase codierendes strukturgen
DE4014573C1 (de) * 1990-05-07 1991-10-10 Forschungszentrum Juelich Gmbh, 5170 Juelich, De
US5225339A (en) * 1992-02-26 1993-07-06 The Scripps Research Institute Lactobacillus kefir alcohol dehydrogenase
US5523223A (en) * 1992-03-13 1996-06-04 Forschungszentrum Julich Gmbh Ketoester reductase for conversion of keto acid esters to optically active hydroxy acid esters

Also Published As

Publication number Publication date
US5763236A (en) 1998-06-09
US6255092B1 (en) 2001-07-03
JPH07231785A (ja) 1995-09-05
JP3574682B2 (ja) 2004-10-06
EP0645453B1 (de) 2004-11-24
DE69434148T2 (de) 2006-02-16
EP0645453A3 (de) 1997-03-26
EP0645453A2 (de) 1995-03-29

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