DE69726720D1 - Vorrichtung zur hyperpolarisation von spin-polarisiertem edelgas mit hoher kapazität - Google Patents

Vorrichtung zur hyperpolarisation von spin-polarisiertem edelgas mit hoher kapazität

Info

Publication number
DE69726720D1
DE69726720D1 DE69726720T DE69726720T DE69726720D1 DE 69726720 D1 DE69726720 D1 DE 69726720D1 DE 69726720 T DE69726720 T DE 69726720T DE 69726720 T DE69726720 T DE 69726720T DE 69726720 D1 DE69726720 D1 DE 69726720D1
Authority
DE
Germany
Prior art keywords
gas
hyperpolarization
spin
polarized
high capacity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69726720T
Other languages
English (en)
Other versions
DE69726720T2 (de
Inventor
D Cates
Bastian Driehuys
William Happer
Eli Miron
Brian Saam
Daniel Walter
Hunter Middleton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Princeton University
Original Assignee
Princeton University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Princeton University filed Critical Princeton University
Application granted granted Critical
Publication of DE69726720D1 publication Critical patent/DE69726720D1/de
Publication of DE69726720T2 publication Critical patent/DE69726720T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/282—Means specially adapted for hyperpolarisation or for hyperpolarised contrast agents, e.g. for the generation of hyperpolarised gases using optical pumping cells, for storing hyperpolarised contrast agents or for the determination of the polarisation of a hyperpolarised contrast agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A61K49/1815—Suspensions, emulsions, colloids, dispersions compo-inhalant, e.g. breath tests
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S62/00—Refrigeration
    • Y10S62/919—Isotope
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S62/00—Refrigeration
    • Y10S62/923—Inert gas
    • Y10S62/925—Xenon or krypton

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Separation By Low-Temperature Treatments (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
  • Inorganic Insulating Materials (AREA)
DE69726720T 1996-03-29 1997-03-27 Vorrichtung zur hyperpolarisation von spin-polarisiertem edelgas mit hoher kapazität Expired - Lifetime DE69726720T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US622863 1996-03-29
US08/622,863 US5642625A (en) 1996-03-29 1996-03-29 High volume hyperpolarizer for spin-polarized noble gas
PCT/US1997/005084 WO1997037178A1 (en) 1996-03-29 1997-03-27 High volume hyperpolarizer for spin-polarized noble gas

Publications (2)

Publication Number Publication Date
DE69726720D1 true DE69726720D1 (de) 2004-01-22
DE69726720T2 DE69726720T2 (de) 2004-10-28

Family

ID=24495796

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69726720T Expired - Lifetime DE69726720T2 (de) 1996-03-29 1997-03-27 Vorrichtung zur hyperpolarisation von spin-polarisiertem edelgas mit hoher kapazität

Country Status (11)

Country Link
US (1) US5642625A (de)
EP (3) EP1816423A3 (de)
JP (2) JP4040095B2 (de)
AT (1) ATE256274T1 (de)
AU (1) AU709623B2 (de)
CA (1) CA2250168C (de)
DE (1) DE69726720T2 (de)
DK (1) DK0896655T3 (de)
ES (1) ES2212092T3 (de)
PT (1) PT896655E (de)
WO (1) WO1997037178A1 (de)

Families Citing this family (93)

* Cited by examiner, † Cited by third party
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DE69838030T2 (de) 1997-08-18 2008-03-13 The Trustees Of Princeton University Spin-polarisation eines edelgases über spinaustausch mit optisch gepumpten alkalimetallen
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US6307204B1 (en) * 1997-11-14 2001-10-23 Jasco Corporation UV detector for liquid chromatography
WO1999025243A1 (en) 1997-11-14 1999-05-27 Norbert Weiler Apparatus for fluid administration
WO1999034189A2 (en) * 1997-12-12 1999-07-08 Magnetic Imaging Technologies, Inc. Process and device to solidify and thaw a polarized gas comprising xenon
US6079213A (en) * 1997-12-12 2000-06-27 Magnetic Imaging Technologies Incorporated Methods of collecting, thawing, and extending the useful life of polarized gases and associated accumulators and heating jackets
AU2003203796B2 (en) * 1997-12-12 2006-10-12 Medi-Physics, Inc. Polarized gas accumulators and heating jackets and associated gas collection and thaw methods and polarized gas products
ATE238540T1 (de) * 1997-12-12 2003-05-15 Medi Physics Inc Verfahren zum sägen und auftauen eines xenon enthaltenden polarisierten gases
EP1279912B1 (de) * 1997-12-12 2005-03-02 Medi-Physics, Inc. Verfahren zum Sammeln und Auftauen polarisierter Gase, dessen Sammler und Heizmanschette
EP1066537A1 (de) 1998-03-18 2001-01-10 Magnetic Imaging Technologies Inc. Magnetresonanzverfahren zur abbildung von lungen- und herzgefässen und zur beurteilung des blutflusses unter verwendung von gelöstem 129xe
US6051208A (en) * 1998-04-13 2000-04-18 Duke University In vivo magnetic resonance vascular imaging using laser-polarized gas microbubbles
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JP2004515263A (ja) * 2000-07-13 2004-05-27 メディ−フィジックス・インコーポレイテッド １２９Ｘｅスペクトル法特有の化学シフトを用いて、病変をインビボで検出する診断法
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JP5699725B2 (ja) * 2011-03-23 2015-04-15 セイコーエプソン株式会社 ガスセル製造装置およびガスセルの製造方法
US8698493B2 (en) * 2011-08-05 2014-04-15 Wisconsin Alumni Research Foundation Noble gas magnetic resonator
CN102981190B (zh) * 2012-12-13 2016-08-10 吉林大学 光泵磁力仪吸收室吸收比的测试装置及测试方法
WO2014132651A1 (ja) * 2013-02-28 2014-09-04 国立大学法人京都大学 アルカリ金属セルの製造方法、アルカリ金属の製造方法、およびアルカリ金属ガス含有セル
DE102013013197A1 (de) 2013-08-09 2015-02-12 Bundesrepublik Deutschland, vertreten durch das Bundesministerium für Wirtschaft und Arbeit, dieses vertreten durch den Präsidenten der Physikalisch-Technischen Bundesanstalt Braunschweig und Berlin Verfahren und Vorrichtung zum kryogenfreien Aufkonzentrieren eines hyperpolarisierten Gases in einem kontinuierlich fließenden Gasstrom und Verwendung
EP3107583B1 (de) 2014-02-21 2019-05-29 Duke University Systeme zur herstellung von hyperpolarisiertem edelgas mit nanoclusterunterdrückung, -detektion und/oder -filtrierung und zugehörige verfahren und vorrichtungen
US10126438B2 (en) 2014-09-19 2018-11-13 University Of Virginia Patent Foundation Systems and methods for polarized nuclear imaging and spectroscopy
CN104913798B (zh) * 2015-05-13 2017-11-07 北京航天控制仪器研究所 一种制备原子气室的原子分装器及原子气室的制备方法
US11754652B2 (en) 2016-09-15 2023-09-12 University Of Virginia Patent Foundation Systems and methods for polarized nuclear imaging and spectroscopy
US10520561B2 (en) * 2017-09-27 2019-12-31 General Electric Company System and method for hyperpolarizing a substance and quenching radicals therein
CN108051220B (zh) * 2017-12-08 2019-12-13 北京卫星环境工程研究所 电推进航天器点火试验用圆柱筒体型氙泵、冷板及抽气系统
US11944424B2 (en) 2018-05-18 2024-04-02 Duke University Dynamic 129Xe gas exchange spectroscopy
WO2023224674A2 (en) * 2021-12-09 2023-11-23 The Regents Of The University Of California Rapidly enhanced spin polarization injection in an optically pumped spin ratchet
WO2023234979A2 (en) * 2021-12-20 2023-12-07 The Regents Of The University Of California High field magnetometry with hyperpolarized nuclear spins
CN114644322B (zh) * 2022-04-15 2024-02-06 宁波诺丁汉大学 超极化稀有气体生产设备

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Also Published As

Publication number Publication date
DE69726720T2 (de) 2004-10-28
EP1386618A2 (de) 2004-02-04
JP4350775B2 (ja) 2009-10-21
WO1997037178A1 (en) 1997-10-09
EP1386618A3 (de) 2004-03-24
EP0896655B1 (de) 2003-12-10
AU709623B2 (en) 1999-09-02
CA2250168C (en) 2002-05-28
EP0896655A1 (de) 1999-02-17
DK0896655T3 (da) 2004-04-13
CA2250168A1 (en) 1997-10-09
PT896655E (pt) 2004-04-30
US5642625A (en) 1997-07-01
EP1816423A3 (de) 2011-12-21
EP0896655A4 (de) 2000-07-12
AU2594397A (en) 1997-10-22
ATE256274T1 (de) 2003-12-15
JP2008055157A (ja) 2008-03-13
EP1816423A2 (de) 2007-08-08
JP2000507689A (ja) 2000-06-20
JP4040095B2 (ja) 2008-01-30
ES2212092T3 (es) 2004-07-16

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