DE69722766D1 - Verbesserte fermentative Herstellung von Carotenoide - Google Patents

Verbesserte fermentative Herstellung von Carotenoide

Info

Publication number
DE69722766D1
DE69722766D1 DE69722766T DE69722766T DE69722766D1 DE 69722766 D1 DE69722766 D1 DE 69722766D1 DE 69722766 T DE69722766 T DE 69722766T DE 69722766 T DE69722766 T DE 69722766T DE 69722766 D1 DE69722766 D1 DE 69722766D1
Authority
DE
Germany
Prior art keywords
carotenoids
fermentative production
adonixanthin
astaxanthin
directed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69722766T
Other languages
English (en)
Other versions
DE69722766T2 (de
Inventor
Luis Pasamontes
Yuri Tsygankov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM IP Assets BV
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of DE69722766D1 publication Critical patent/DE69722766D1/de
Publication of DE69722766T2 publication Critical patent/DE69722766T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P23/00—Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes

Landscapes

  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
DE69722766T 1996-12-02 1997-11-20 Verbesserte fermentative Herstellung von Carotenoide Expired - Fee Related DE69722766T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96810839 1996-12-02
EP96810839 1996-12-02

Publications (2)

Publication Number Publication Date
DE69722766D1 true DE69722766D1 (de) 2003-07-17
DE69722766T2 DE69722766T2 (de) 2004-04-22

Family

ID=8225762

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69722766T Expired - Fee Related DE69722766T2 (de) 1996-12-02 1997-11-20 Verbesserte fermentative Herstellung von Carotenoide

Country Status (11)

Country Link
US (3) US6291204B1 (de)
EP (1) EP0872554B1 (de)
JP (1) JPH10155497A (de)
CN (1) CN1325648C (de)
AT (1) ATE242812T1 (de)
BR (1) BR9705676A (de)
DE (1) DE69722766T2 (de)
DK (1) DK0872554T3 (de)
ES (1) ES2200110T3 (de)
ID (1) ID17683A (de)
IN (1) IN190903B (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19909637A1 (de) * 1999-03-05 2000-09-07 Peter Beyer Verfahren zur Verbesserung des agronomischen Wertes und der ernährungsphysiologischen Eigenschaften von Pflanzen
FR2792335A1 (fr) * 1999-04-19 2000-10-20 Thallia Pharmaceuticals Cyanobacteries sur-exprimant un gene implique dans la voie de biosynthese des carotenoides
US20050005310A1 (en) * 1999-07-12 2005-01-06 Genentech, Inc. Expression vectors and methods
DE60038032T2 (de) * 1999-07-27 2009-02-05 Food Industry Research And Development Institute Technische handhabung der metabolischen kontrolle
US6660507B2 (en) 2000-09-01 2003-12-09 E. I. Du Pont De Nemours And Company Genes involved in isoprenoid compound production
US6818424B2 (en) * 2000-09-01 2004-11-16 E. I. Du Pont De Nemours And Company Production of cyclic terpenoids
ES2311613T3 (es) 2001-06-06 2009-02-16 Dsm Ip Assets B.V. Produccion mejorada de isoprenoides.
JP2003304875A (ja) * 2002-04-15 2003-10-28 Nippon Oil Corp カンタキサンチンの製造方法
WO2004029275A1 (en) * 2002-09-27 2004-04-08 Dsm Ip Assets B.V. Production of zeaxanthin by phaffia
JP2006500046A (ja) * 2002-09-27 2006-01-05 ディーエスエム アイピー アセッツ ビー．ブイ． ファフィアによるカンタキサンチンの製造方法
US7091031B2 (en) * 2004-08-16 2006-08-15 E. I. Du Pont De Nemours And Company Carotenoid hydroxylase enzymes
US7074604B1 (en) 2004-12-29 2006-07-11 E. I. Du Pont De Nemours And Company Bioproduction of astaxanthin using mutant carotenoid ketolase and carotenoid hydroxylase genes
GB0501365D0 (en) * 2005-01-21 2005-03-02 Promar As Compositions
WO2006102342A2 (en) 2005-03-18 2006-09-28 Microbia, Inc. Production of carotenoids in oleaginous yeast and fungi
CN100387726C (zh) * 2005-03-28 2008-05-14 浙江省农业科学院 一种β-胡萝卜素的生产方法
JP2006280297A (ja) * 2005-04-01 2006-10-19 Tosoh Corp ゲラニルゲラニル２リン酸合成酵素及びその遺伝子等
DE102005049072A1 (de) * 2005-10-13 2007-04-19 Peter und Traudl Engelhorn-Stiftung zur Förderung der Biotechnologie und Gentechnik Astaxanthinbiosynthese in Eukaryoten
JP5023474B2 (ja) * 2005-10-28 2012-09-12 東ソー株式会社 カロテノイド合成微生物の作製方法およびカロテノイドの製造方法
EP2471919A1 (de) * 2005-10-28 2012-07-04 Tosoh Corporation Verfahren zur Herstellung eines carotinoidsynthetisierenden Mikroorganismus und Verfahren zur Herstellung von Carotinoiden
US7393671B2 (en) * 2006-03-30 2008-07-01 E.I. Du Pont De Nemours And Company Mutant carotenoid ketolases
US7422873B2 (en) * 2006-03-31 2008-09-09 E.I. Du Pont De Nemours And Company Mutant carotenoid ketolase
EP2078092A2 (de) 2006-09-28 2009-07-15 Microbia, Inc. Herstellung von carotenoiden in öliger hefe und pilzen
US7629823B2 (en) * 2006-10-04 2009-12-08 Power Integrations, Inc. Method and apparatus for pulse width modulation
KR100832584B1 (ko) * 2007-04-05 2008-05-27 에스케이에너지 주식회사 라이코펜의 생합성에 관여하는 유전자, 그 유전자를포함하는 재조합 벡터, 및 그 재조합 벡터로 형질전환된미생물
KR101441613B1 (ko) * 2007-05-04 2014-09-26 아미코젠주식회사 재조합 대장균을 이용한 라이코펜 생산 방법
JP4969370B2 (ja) * 2007-08-29 2012-07-04 Ｊｘ日鉱日石エネルギー株式会社 カロテノイドの製造方法
TW200934872A (en) 2008-02-05 2009-08-16 Echem Hightech Co Ltd A strain of genetically reengineered escherichia coli for biosynthesis of high yield carotenoids after mutation screening
US8313659B2 (en) * 2009-07-10 2012-11-20 Seagate Technology Llc Fabrication of multi-dimensional microstructures
US20140248668A1 (en) * 2011-08-08 2014-09-04 Evolva Sa Methods and Materials for Recombinant Production of Saffron Compounds
CN106801028B (zh) * 2017-01-17 2019-12-31 中山大学 产高含量玉米黄素或虾青素工程菌及其应用
CN111032855A (zh) * 2017-06-01 2020-04-17 尼普生物股份有限公司 微生物体中异源类胡萝卜素的产生
CN108148763A (zh) * 2018-03-08 2018-06-12 青岛旭能生物工程有限责任公司 一种通过流加方法提高摇瓶发酵纤细裸藻产量的方法
CN109536518A (zh) * 2018-10-31 2019-03-29 昆明理工大学 一种八氢番茄红素脱氢酶基因RKcrtI及其应用
CN109609519A (zh) * 2018-10-31 2019-04-12 昆明理工大学 一种基因RKcrtYB及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0393690B1 (de) 1989-04-21 1995-03-29 Kirin Beer Kabushiki Kaisha Zur Synthese von Karotinoiden verwendbare DNA-Sequenzen
CA2055447C (en) * 1990-03-02 2006-12-19 Rodney Lee Ausich Biosynthesis of carotenoids in genetically engineered hosts
US5607839A (en) 1993-07-22 1997-03-04 Nippon Oil Company, Ltd. Bacteria belonging to new genus process for production of carotenoids using same
EP1203818A3 (de) 1993-12-27 2002-06-12 Kirin Beer Kabushiki Kaisha DNA-Kette zur Synthese von Xanthophyllen, und Prozess zur Herstellung von Xanthophyllen
ES2216027T3 (es) * 1995-06-09 2004-10-16 Dsm Ip Assets B.V. Produccion de carotenoides fermentativos.

Also Published As

Publication number Publication date
ES2200110T3 (es) 2004-03-01
US20030022273A1 (en) 2003-01-30
DE69722766T2 (de) 2004-04-22
CN1184159A (zh) 1998-06-10
US6291204B1 (en) 2001-09-18
CN1325648C (zh) 2007-07-11
ID17683A (id) 1998-01-22
ATE242812T1 (de) 2003-06-15
JPH10155497A (ja) 1998-06-16
US6677134B2 (en) 2004-01-13
EP0872554A2 (de) 1998-10-21
DK0872554T3 (da) 2003-08-25
BR9705676A (pt) 1999-05-25
EP0872554B1 (de) 2003-06-11
IN190903B (de) 2003-08-30
US20040058410A1 (en) 2004-03-25
US7063956B2 (en) 2006-06-20
EP0872554A3 (de) 2000-06-07

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: DSM IP ASSETS B.V., HEERLEN, NL

8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee