DE69720458T2 - Programmierbares räumlich lichtmoduliertes Mikroskop und Mikroskopieverfahren - Google Patents
Programmierbares räumlich lichtmoduliertes Mikroskop und Mikroskopieverfahren Download PDFInfo
- Publication number
- DE69720458T2 DE69720458T2 DE69720458T DE69720458T DE69720458T2 DE 69720458 T2 DE69720458 T2 DE 69720458T2 DE 69720458 T DE69720458 T DE 69720458T DE 69720458 T DE69720458 T DE 69720458T DE 69720458 T2 DE69720458 T2 DE 69720458T2
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- DE
- Germany
- Prior art keywords
- image
- confocal
- optical imaging
- light
- confocal optical
- Prior art date
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- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title claims abstract description 24
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Classifications
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
- G02B21/008—Details of detection or image processing, including general computer control
- G02B21/0084—Details of detection or image processing, including general computer control time-scale detection, e.g. strobed, ultra-fast, heterodyne detection
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
- G02B21/0032—Optical details of illumination, e.g. light-sources, pinholes, beam splitters, slits, fibers
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
- G02B21/0036—Scanning details, e.g. scanning stages
- G02B21/004—Scanning details, e.g. scanning stages fixed arrays, e.g. switchable aperture arrays
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
- G02B21/0036—Scanning details, e.g. scanning stages
- G02B21/0048—Scanning details, e.g. scanning stages scanning mirrors, e.g. rotating or galvanomirrors, MEMS mirrors
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
- G02B21/0052—Optical details of the image generation
- G02B21/0076—Optical details of the image generation arrangements using fluorescence or luminescence
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
- G02B21/008—Details of detection or image processing, including general computer control
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B26/00—Optical devices or arrangements for the control of light using movable or deformable optical elements
- G02B26/08—Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light
- G02B26/0816—Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light by means of one or more reflecting elements
- G02B26/0833—Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light by means of one or more reflecting elements the reflecting element being a micromechanical device, e.g. a MEMS mirror, DMD
- G02B26/0841—Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light by means of one or more reflecting elements the reflecting element being a micromechanical device, e.g. a MEMS mirror, DMD the reflecting element being moved or deformed by electrostatic means
Landscapes
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Computer Vision & Pattern Recognition (AREA)
- General Engineering & Computer Science (AREA)
- Microscoopes, Condenser (AREA)
- Liquid Crystal (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP97118354A EP0911667B1 (en) | 1997-10-22 | 1997-10-22 | Programmable spatially light modulated microscope and microscopy method |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69720458D1 DE69720458D1 (de) | 2003-05-08 |
DE69720458T2 true DE69720458T2 (de) | 2004-02-26 |
Family
ID=8227511
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69720458T Expired - Lifetime DE69720458T2 (de) | 1997-10-22 | 1997-10-22 | Programmierbares räumlich lichtmoduliertes Mikroskop und Mikroskopieverfahren |
Country Status (5)
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102005040471A1 (de) * | 2005-08-26 | 2007-03-15 | Leica Microsystems (Schweiz) Ag | Mikroskop |
DE102006040636B3 (de) * | 2006-05-15 | 2007-12-20 | Leica Microsystems (Schweiz) Ag | Autofokus-System und Verfahren zum Autofokussieren |
DE102018127281A1 (de) * | 2018-10-31 | 2020-04-30 | Carl Zeiss Microscopy Gmbh | Mikroskop und Verfahren zur Mikroskopie |
Families Citing this family (97)
Publication number | Priority date | Publication date | Assignee | Title |
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CA2307315C (en) | 1997-10-29 | 2011-04-05 | Calum Eric Macaulay | Apparatus and methods relating to spatially light modulated microscopy |
US6388809B1 (en) | 1997-10-29 | 2002-05-14 | Digital Optical Imaging Corporation | Methods and apparatus for improved depth resolution use of out-of-focus information in microscopy |
GB9901365D0 (en) * | 1999-01-22 | 1999-03-10 | Isis Innovations Ltd | Confocal microscopy apparatus and method |
JP3544892B2 (ja) * | 1999-05-12 | 2004-07-21 | 株式会社東京精密 | 外観検査方法及び装置 |
US6700606B1 (en) * | 1999-06-09 | 2004-03-02 | Activcard Ireland Limited | Micromirror optical imager |
DE19932487A1 (de) * | 1999-07-09 | 2001-02-08 | Epigenomics Gmbh | Vorrichtung und Verfahren zur photolithographischen Belichtung von biologischen Stoffen |
DE19960583A1 (de) * | 1999-12-15 | 2001-07-05 | Evotec Biosystems Ag | Verfahren und Vorrichtung zur Mikroskopie |
US6663560B2 (en) * | 1999-12-17 | 2003-12-16 | Digital Optical Imaging Corporation | Methods and apparatus for imaging using a light guide bundle and a spatial light modulator |
US6530882B1 (en) * | 2000-06-30 | 2003-03-11 | Inner Vision Imaging, L.L.C. | Endoscope having microscopic and macroscopic magnification |
JP4610713B2 (ja) * | 2000-10-13 | 2011-01-12 | オリンパス株式会社 | 内視鏡装置 |
JP4932076B2 (ja) * | 2000-10-30 | 2012-05-16 | オリンパス株式会社 | 走査型レーザ顕微鏡 |
JP4153675B2 (ja) * | 2001-04-10 | 2008-09-24 | 三菱重工業株式会社 | 材料寿命の評価システム、及び、その評価方法 |
CA2452693A1 (en) * | 2001-06-06 | 2002-12-12 | Digital Optical Imaging Corporation | Light modulated microarray reader and methods relating thereto |
WO2003025656A1 (fr) * | 2001-09-03 | 2003-03-27 | Kabushiki Kaisha Hayashi Soken | Procede et dispositif de balayage a commande numerique |
US6885492B2 (en) * | 2001-11-08 | 2005-04-26 | Imaginative Optics, Inc. | Spatial light modulator apparatus |
US7180660B2 (en) * | 2002-02-04 | 2007-02-20 | Carl-Zeiss-Stiftung Trading As Carl Zeiss | Stereo-examination systems and stereo-image generation apparatus as well as a method for operating the same |
US6996292B1 (en) * | 2002-04-18 | 2006-02-07 | Sandia Corporation | Staring 2-D hadamard transform spectral imager |
US7193775B2 (en) * | 2002-05-30 | 2007-03-20 | Dmetrix, Inc. | EPI-illumination system for an array microscope |
JP3691837B2 (ja) * | 2002-08-16 | 2005-09-07 | 株式会社林創研 | バイオチップ分析装置 |
US7901630B2 (en) | 2002-08-20 | 2011-03-08 | Illumina, Inc. | Diffraction grating-based encoded microparticle assay stick |
US7872804B2 (en) | 2002-08-20 | 2011-01-18 | Illumina, Inc. | Encoded particle having a grating with variations in the refractive index |
US7923260B2 (en) | 2002-08-20 | 2011-04-12 | Illumina, Inc. | Method of reading encoded particles |
US7900836B2 (en) | 2002-08-20 | 2011-03-08 | Illumina, Inc. | Optical reader system for substrates having an optically readable code |
US7164533B2 (en) | 2003-01-22 | 2007-01-16 | Cyvera Corporation | Hybrid random bead/chip based microarray |
US7508608B2 (en) | 2004-11-17 | 2009-03-24 | Illumina, Inc. | Lithographically fabricated holographic optical identification element |
US7092160B2 (en) | 2002-09-12 | 2006-08-15 | Illumina, Inc. | Method of manufacturing of diffraction grating-based optical identification element |
US20100255603A9 (en) | 2002-09-12 | 2010-10-07 | Putnam Martin A | Method and apparatus for aligning microbeads in order to interrogate the same |
WO2004038461A2 (en) * | 2002-10-22 | 2004-05-06 | William Marsh Rice University | Random access high-speed confocal microscope |
FR2848682B1 (fr) | 2002-12-13 | 2005-02-18 | Commissariat Energie Atomique | Microscope optique a eclairage structure modifiable |
US7339148B2 (en) * | 2002-12-16 | 2008-03-04 | Olympus America Inc. | Confocal microscope |
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JP4031716B2 (ja) * | 2003-02-06 | 2008-01-09 | 株式会社コーナン・メディカル | 眼科用撮影装置 |
DE10327987A1 (de) * | 2003-06-21 | 2005-01-20 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Konfokales optisches System |
US7881502B2 (en) * | 2003-06-30 | 2011-02-01 | Weyerhaeuser Nr Company | Method and system for three-dimensionally imaging an apical dome of a plant embryo |
EP1972983B1 (fr) * | 2003-07-04 | 2009-12-02 | Vincent Lauer | Dispositif d`imagerie à balayage pour microscopie confocale à soustraction d`images |
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JP2006133499A (ja) * | 2004-11-05 | 2006-05-25 | Shimadzu Corp | 共焦点スキャナ及び共焦点顕微鏡 |
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JP2006154290A (ja) * | 2004-11-29 | 2006-06-15 | Hamamatsu Univ School Of Medicine | 蛍光顕微鏡システム |
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JP6795624B2 (ja) | 2016-05-27 | 2020-12-02 | ヴェリリー ライフ サイエンシズ エルエルシー | 空間光変調器ベースのハイパースペクトル共焦点顕微鏡および使用方法 |
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KR101907782B1 (ko) | 2017-04-12 | 2018-10-12 | 한국과학기술원 | 광학 현미경 장치 및 시편의 영상 측정 방법 |
JP2019066706A (ja) | 2017-10-02 | 2019-04-25 | ソニー株式会社 | 蛍光顕微鏡装置及び蛍光顕微鏡システム |
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EP0485803B1 (de) * | 1990-11-10 | 1996-05-01 | Grosskopf, Rudolf, Dr.-Ing. | Optische Abtastvorrichtung mit konfokalem Strahlengang, in der Lichtquellen- und Detektormatrix verwendet werden |
US5532873A (en) * | 1993-09-08 | 1996-07-02 | Dixon; Arthur E. | Scanning beam laser microscope with wide range of magnification |
US5587832A (en) * | 1993-10-20 | 1996-12-24 | Biophysica Technologies, Inc. | Spatially light modulated confocal microscope and method |
GB9603788D0 (en) * | 1996-02-22 | 1996-04-24 | Isis Innovation | Confocal microscope |
JP2001500628A (ja) * | 1996-02-28 | 2001-01-16 | ケニス シー ジョンソン | マイクロリトグラフィ用マイクロレンズスキャナ及び広フィールド共焦顕微鏡 |
US6038067A (en) * | 1996-05-23 | 2000-03-14 | The Regents Of The University Of California | Scanning computed confocal imager |
-
1997
- 1997-10-22 DE DE69720458T patent/DE69720458T2/de not_active Expired - Lifetime
- 1997-10-22 EP EP97118354A patent/EP0911667B1/en not_active Expired - Lifetime
- 1997-10-22 AT AT97118354T patent/ATE236412T1/de not_active IP Right Cessation
-
1998
- 1998-10-21 US US09/176,240 patent/US6399935B1/en not_active Expired - Lifetime
- 1998-10-22 JP JP30100398A patent/JP4064550B2/ja not_active Expired - Lifetime
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102005040471A1 (de) * | 2005-08-26 | 2007-03-15 | Leica Microsystems (Schweiz) Ag | Mikroskop |
DE102005040471B4 (de) * | 2005-08-26 | 2007-06-21 | Leica Microsystems (Schweiz) Ag | Mikroskop |
DE102006040636B3 (de) * | 2006-05-15 | 2007-12-20 | Leica Microsystems (Schweiz) Ag | Autofokus-System und Verfahren zum Autofokussieren |
DE102018127281A1 (de) * | 2018-10-31 | 2020-04-30 | Carl Zeiss Microscopy Gmbh | Mikroskop und Verfahren zur Mikroskopie |
Also Published As
Publication number | Publication date |
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EP0911667A1 (en) | 1999-04-28 |
DE69720458D1 (de) | 2003-05-08 |
JPH11194275A (ja) | 1999-07-21 |
US6399935B1 (en) | 2002-06-04 |
ATE236412T1 (de) | 2003-04-15 |
JP4064550B2 (ja) | 2008-03-19 |
EP0911667B1 (en) | 2003-04-02 |
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