DE69714600T2 - Verfahren zur markierung von nukleotiden, markierte nukleotide und nuetzliche zwischenprodukte - Google Patents

Verfahren zur markierung von nukleotiden, markierte nukleotide und nuetzliche zwischenprodukte

Info

Publication number
DE69714600T2
DE69714600T2 DE69714600T DE69714600T DE69714600T2 DE 69714600 T2 DE69714600 T2 DE 69714600T2 DE 69714600 T DE69714600 T DE 69714600T DE 69714600 T DE69714600 T DE 69714600T DE 69714600 T2 DE69714600 T2 DE 69714600T2
Authority
DE
Germany
Prior art keywords
nucleotides
chain
spacer
moiety
linker
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69714600T
Other languages
English (en)
Other versions
DE69714600D1 (de
Inventor
Jan Houthoff
Jan Reedijk
Tinka Jelsma
Jochem Heetebrij
Hendricus Volkers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kreatech Biotechnology BV
Original Assignee
Kreatech Biotechnology BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kreatech Biotechnology BV filed Critical Kreatech Biotechnology BV
Application granted granted Critical
Publication of DE69714600D1 publication Critical patent/DE69714600D1/de
Publication of DE69714600T2 publication Critical patent/DE69714600T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/80—Fluorescent dyes, e.g. rhodamine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cold Cathode And The Manufacture (AREA)
  • Inorganic Insulating Materials (AREA)
  • Medicinal Preparation (AREA)
DE69714600T 1996-10-08 1997-10-08 Verfahren zur markierung von nukleotiden, markierte nukleotide und nuetzliche zwischenprodukte Expired - Lifetime DE69714600T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96202792 1996-10-08
PCT/NL1997/000559 WO1998015564A1 (en) 1996-10-08 1997-10-08 Methods for labeling nucleotides, labeled nucleotides and useful intermediates

Publications (2)

Publication Number Publication Date
DE69714600D1 DE69714600D1 (de) 2002-09-12
DE69714600T2 true DE69714600T2 (de) 2003-03-27

Family

ID=8224469

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69714600T Expired - Lifetime DE69714600T2 (de) 1996-10-08 1997-10-08 Verfahren zur markierung von nukleotiden, markierte nukleotide und nuetzliche zwischenprodukte

Country Status (12)

Country Link
US (4) USRE40557E1 (de)
EP (1) EP0937090B1 (de)
JP (2) JP4981197B2 (de)
AT (1) ATE221894T1 (de)
AU (1) AU726692B2 (de)
CA (1) CA2267133C (de)
DE (1) DE69714600T2 (de)
DK (1) DK0937090T3 (de)
ES (1) ES2182121T3 (de)
NZ (1) NZ334803A (de)
PT (1) PT937090E (de)
WO (1) WO1998015564A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0937090T3 (da) * 1996-10-08 2002-12-02 Kreatech Biotech Bv Fremgangsmåder til mærkning af nucleotider, mærkede nucleotider og nyttige mellemprodukter
US6458373B1 (en) 1997-01-07 2002-10-01 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
EP1006199A1 (de) 1998-12-03 2000-06-07 Kreatech Biotechnology B.V. Verfahren zur Herstellung von Verknüpfungen an ausgewählten Positionen von Nukleinsäuresträngen und deren Verwendung
EP1218547A4 (de) * 1999-10-15 2005-04-20 Ventana Med Syst Inc Methode zum in-situ-nachweis einzelner genkopien
US6376669B1 (en) * 1999-11-05 2002-04-23 3M Innovative Properties Company Dye labeled imidazoquinoline compounds
GB0016836D0 (en) 2000-07-07 2000-08-30 Lee Helen Improved dipstick assays (1)
WO2002069898A2 (en) 2001-03-02 2002-09-12 Stratagene Compositions and methods using platinum compounds for nucleic acid labeling
DK1262778T3 (da) * 2001-05-28 2008-02-18 Kreatech Biotech Bv Fremgangsmåde til differentieret mærkning ved anvendelse af platinkomplekser
US7166478B2 (en) * 2002-03-12 2007-01-23 Enzo Life Sciences, Inc., C/O Enzo Biochem, Inc. Labeling reagents and labeled targets, target labeling processes and other processes for using same in nucleic acid determinations and analyses
US20050208495A1 (en) * 2002-09-17 2005-09-22 Joseph Richard A Real-time detection of nucleic acid reactions
US20050028450A1 (en) * 2003-08-07 2005-02-10 Wen-Qing Xu CMP slurry
US20060281100A1 (en) * 2005-06-14 2006-12-14 Shen Gene G Thiotriphosphate nucleotide dye terminators
EP1745802A1 (de) 2005-07-20 2007-01-24 Kreatech Biotechnology B.V. Verfahren zur Konjugierung therapeutischer Verbindungen an zellgezielten Gruppen über Metallkomplexen
WO2007126078A1 (ja) * 2006-04-27 2007-11-08 Onecell Inc. ヌクレオチド－遷移金属錯体触媒
WO2009015359A2 (en) 2007-07-26 2009-01-29 Cellay, Llc Highly visible chromosome-specific probes and related methods
KR101072900B1 (ko) * 2007-12-04 2011-10-17 주식회사 파나진 고정화된 펩티드핵산 프로브를 사용한 표적핵산의 선택적 표지 및 검출 방법
JP6120416B2 (ja) 2012-01-06 2017-04-26 リンクシス ビー．ヴイ． 細胞標的コンジュゲートを調製するための方法、及び得られる錯体
CN109030698B (zh) * 2018-08-06 2020-09-04 泰山医学院 一种液相色谱法检测固体福美钠纯度的方法
CN108760961B (zh) * 2018-08-06 2020-09-22 青岛中科荣达新材料有限公司 一种液相色谱法检测固体福美钾纯度的方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4207416A (en) * 1974-09-05 1980-06-10 Engelhard Minerals & Chemicals Corporation Ethylenediamineplatinum(II) 2,4-dioxopyrimidine complexes
JPS6087295A (ja) * 1983-10-19 1985-05-16 Nippon Kayaku Co Ltd 新規白金錯体
DE3568063D1 (en) * 1985-01-10 1989-03-09 Molecular Diagnostics Inc Photochemical method of labelling nucleic acids for detection in hybridization assays
JPS63203692A (ja) * 1987-02-19 1988-08-23 Nippon Kayaku Co Ltd 新規白金錯体
WO1989004317A1 (en) * 1987-11-06 1989-05-18 Sagami Chemical Research Center Platinum (ii) complexes
US5552541A (en) * 1990-06-20 1996-09-03 Beckman Instruments, Inc. Haptenic probes for detecting capture polynucleotides
NL9001639A (nl) * 1990-07-19 1992-02-17 Amc Amsterdam Pt-houdende verbinding, werkwijze voor de bereiding ervan, alsmede toepassing van dergelijke verbindingen.
US5714327A (en) * 1990-07-19 1998-02-03 Kreatech Diagnostics Platinum-containing compounds, methods for their preparation and applications thereof
EP0646019B9 (de) * 1992-06-09 2002-12-18 Neorx Corporation Biotin-DOTA Konjugate und deren Verwendung in "Pretargeting" Verfahren
JPH0698797A (ja) * 1992-09-22 1994-04-12 Toyobo Co Ltd 核酸検出法
DE4344742A1 (de) * 1993-06-09 1994-12-15 Boehringer Mannheim Gmbh Verfahren zur Immobilisierung von Nukleinsäuren
DE4326466A1 (de) * 1993-08-06 1995-02-09 Boehringer Mannheim Gmbh Infrarot-Farbstoff-markierte Nucleotide und ihre Verwendung in der Nucleinsäure-Detektion
EP1019420B1 (de) * 1995-05-09 2003-08-06 Kreatech Biotechnology B.V. Verfahren zur herstellung von linkern zwischen markierungsgruppen und bio-organischen molekülen auf der basis von platin für die markierung von bio-organischen molekülen zur entdeckung interessanter biologischer substanzen
DK0937090T3 (da) * 1996-10-08 2002-12-02 Kreatech Biotech Bv Fremgangsmåder til mærkning af nucleotider, mærkede nucleotider og nyttige mellemprodukter

Also Published As

Publication number Publication date
US7217813B2 (en) 2007-05-15
US20050118621A1 (en) 2005-06-02
JP2010166914A (ja) 2010-08-05
DK0937090T3 (da) 2002-12-02
AU4474697A (en) 1998-05-05
AU726692B2 (en) 2000-11-16
US6797818B2 (en) 2004-09-28
WO1998015564A1 (en) 1998-04-16
ATE221894T1 (de) 2002-08-15
EP0937090A1 (de) 1999-08-25
USRE40557E1 (en) 2008-10-28
ES2182121T3 (es) 2003-03-01
NZ334803A (en) 2000-05-26
DE69714600D1 (de) 2002-09-12
CA2267133C (en) 2006-07-18
PT937090E (pt) 2002-12-31
US6338943B1 (en) 2002-01-15
JP4981197B2 (ja) 2012-07-18
CA2267133A1 (en) 1998-04-16
JP2001503742A (ja) 2001-03-21
EP0937090B1 (de) 2002-08-07
US20020160396A1 (en) 2002-10-31

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