ES2182121T3 - Metodos para marcar nucleotidos, nucleotidos marcados e intermediarios utiles. - Google Patents
Metodos para marcar nucleotidos, nucleotidos marcados e intermediarios utiles.Info
- Publication number
- ES2182121T3 ES2182121T3 ES97943223T ES97943223T ES2182121T3 ES 2182121 T3 ES2182121 T3 ES 2182121T3 ES 97943223 T ES97943223 T ES 97943223T ES 97943223 T ES97943223 T ES 97943223T ES 2182121 T3 ES2182121 T3 ES 2182121T3
- Authority
- ES
- Spain
- Prior art keywords
- nucleotides
- chain
- spacer
- moiety
- linker
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/80—Fluorescent dyes, e.g. rhodamine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Inorganic Insulating Materials (AREA)
- Medicinal Preparation (AREA)
- Cold Cathode And The Manufacture (AREA)
Abstract
EN LA PRESENTE INVENCION SE PRESENTAN PROCEDIMIENTOS MEJORADOS PARA ETIQUETAR NUCLEOTIDOS. EL PROCEDIMIENTO DE LA INVENCION DE ETIQUETADO DE NUCLEOTIDOS CONSISTE EN LOS PASOS SIGUIENTES: SE HACE REACCIONAR UNA FRACCION REACTIVA DE UN LINKER, SIENDO EL LINKER UN COMPUESTO DE PLATINO QUE TIENE UN PUENTE DE ESTABILIZACION Y DOS FRACCIONES REACTIVAS, CON UNA FRACCION DONADORA DE ELECTRONES DE UN SEPARADOR, COMPRENDIENDO EL SEPARADOR UNA CADENA QUE TIENE AL MENOS CUATRO ATOMOS Y AL MENOS UN HETEROATOMO EN LA CADENA, Y COMPRENDIENDO ADEMAS EL SEPARADOR DICHA FRACCION DONADORA DE ELECTRONES EN UN EXTREMO DE LA CADENA Y UNA FRACCION REACTIVA EN EL OTRO EXTREMO DE LA CADENA; SE HACE REACCIONAR LA FRACCION REACTIVA DE DICHO SEPARADOR CON UNA ETIQUETA; Y SE HACE REACCIONAR LA OTRA UNIDAD REACTIVA DEL LINKER ANTEDICHO CON UN NUCLEOTIDO. UNA GRAN VENTAJA DE LA INVENCION ES QUE SEGUN EL PROCEDIMIENTO DE LA INVENCION SE PUEDE ETIQUETAR TODO TIPO DE NUCLEOTIDOS CUANDO HASTA LA FECHA LA APLICACION DE UNA ETIQUETA QUEDABA SOBRE TODO RESTRINGIDA A UN NUCLEOTIDO O A CIERTO TIPO DE NUCLEOTIDOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP96202792 | 1996-10-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2182121T3 true ES2182121T3 (es) | 2003-03-01 |
Family
ID=8224469
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES97943223T Expired - Lifetime ES2182121T3 (es) | 1996-10-08 | 1997-10-08 | Metodos para marcar nucleotidos, nucleotidos marcados e intermediarios utiles. |
Country Status (12)
Country | Link |
---|---|
US (4) | USRE40557E1 (es) |
EP (1) | EP0937090B1 (es) |
JP (2) | JP4981197B2 (es) |
AT (1) | ATE221894T1 (es) |
AU (1) | AU726692B2 (es) |
CA (1) | CA2267133C (es) |
DE (1) | DE69714600T2 (es) |
DK (1) | DK0937090T3 (es) |
ES (1) | ES2182121T3 (es) |
NZ (1) | NZ334803A (es) |
PT (1) | PT937090E (es) |
WO (1) | WO1998015564A1 (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE221894T1 (de) * | 1996-10-08 | 2002-08-15 | Kreatech Biotech Bv | Verfahren zur markierung von nukleotiden, markierte nukleotide und nuetzliche zwischenprodukte |
US6458373B1 (en) | 1997-01-07 | 2002-10-01 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
EP1006199A1 (en) | 1998-12-03 | 2000-06-07 | Kreatech Biotechnology B.V. | Applications with and methods for producing selected interstrand crosslinks in nucleic acid |
EP1218547A4 (en) * | 1999-10-15 | 2005-04-20 | Ventana Med Syst Inc | METHOD FOR DETECTING UNIQUE GENE IN SITU COPIES |
US6376669B1 (en) * | 1999-11-05 | 2002-04-23 | 3M Innovative Properties Company | Dye labeled imidazoquinoline compounds |
GB0016836D0 (en) | 2000-07-07 | 2000-08-30 | Lee Helen | Improved dipstick assays (1) |
WO2002069898A2 (en) | 2001-03-02 | 2002-09-12 | Stratagene | Compositions and methods using platinum compounds for nucleic acid labeling |
ATE376675T1 (de) * | 2001-05-28 | 2007-11-15 | Kreatech Biotech Bv | Ein verfahren zur differentiellen markierung mittels platin-komplexen |
US7166478B2 (en) * | 2002-03-12 | 2007-01-23 | Enzo Life Sciences, Inc., C/O Enzo Biochem, Inc. | Labeling reagents and labeled targets, target labeling processes and other processes for using same in nucleic acid determinations and analyses |
WO2004027384A2 (en) * | 2002-09-17 | 2004-04-01 | Perkinelmer Life Sciences, Inc. | Real-time detection of nucleic acid reactions |
US20050028450A1 (en) * | 2003-08-07 | 2005-02-10 | Wen-Qing Xu | CMP slurry |
US20060281100A1 (en) * | 2005-06-14 | 2006-12-14 | Shen Gene G | Thiotriphosphate nucleotide dye terminators |
EP1745802A1 (en) | 2005-07-20 | 2007-01-24 | Kreatech Biotechnology B.V. | Method of conjugating therapeutic compounds to cell targeting moieties via metal complexes |
WO2007126078A1 (ja) * | 2006-04-27 | 2007-11-08 | Onecell Inc. | ヌクレオチド-遷移金属錯体触媒 |
EP2185573A4 (en) | 2007-07-26 | 2011-12-07 | Cellay Inc | SPECIFIC PROBES OF HIGHLY VISIBLE CHROMOSOMES AND ASSOCIATED METHODS |
KR101072900B1 (ko) * | 2007-12-04 | 2011-10-17 | 주식회사 파나진 | 고정화된 펩티드핵산 프로브를 사용한 표적핵산의 선택적 표지 및 검출 방법 |
JP6120416B2 (ja) | 2012-01-06 | 2017-04-26 | リンクシス ビー.ヴイ. | 細胞標的コンジュゲートを調製するための方法、及び得られる錯体 |
CN108760961B (zh) * | 2018-08-06 | 2020-09-22 | 青岛中科荣达新材料有限公司 | 一种液相色谱法检测固体福美钾纯度的方法 |
CN109030698B (zh) * | 2018-08-06 | 2020-09-04 | 泰山医学院 | 一种液相色谱法检测固体福美钠纯度的方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4207416A (en) * | 1974-09-05 | 1980-06-10 | Engelhard Minerals & Chemicals Corporation | Ethylenediamineplatinum(II) 2,4-dioxopyrimidine complexes |
JPS6087295A (ja) * | 1983-10-19 | 1985-05-16 | Nippon Kayaku Co Ltd | 新規白金錯体 |
DE3568063D1 (en) * | 1985-01-10 | 1989-03-09 | Molecular Diagnostics Inc | Photochemical method of labelling nucleic acids for detection in hybridization assays |
JPS63203692A (ja) * | 1987-02-19 | 1988-08-23 | Nippon Kayaku Co Ltd | 新規白金錯体 |
EP0386243A4 (en) * | 1987-11-06 | 1990-10-10 | Sagami Chemical Research Center | Platinum (ii) complexes |
US5552541A (en) * | 1990-06-20 | 1996-09-03 | Beckman Instruments, Inc. | Haptenic probes for detecting capture polynucleotides |
US5714327A (en) * | 1990-07-19 | 1998-02-03 | Kreatech Diagnostics | Platinum-containing compounds, methods for their preparation and applications thereof |
NL9001639A (nl) * | 1990-07-19 | 1992-02-17 | Amc Amsterdam | Pt-houdende verbinding, werkwijze voor de bereiding ervan, alsmede toepassing van dergelijke verbindingen. |
EP1138334A3 (en) * | 1992-06-09 | 2002-04-03 | Neorx Corporation | Pretargeting methods and compounds |
JPH0698797A (ja) * | 1992-09-22 | 1994-04-12 | Toyobo Co Ltd | 核酸検出法 |
DE4344742A1 (de) * | 1993-06-09 | 1994-12-15 | Boehringer Mannheim Gmbh | Verfahren zur Immobilisierung von Nukleinsäuren |
DE4326466A1 (de) * | 1993-08-06 | 1995-02-09 | Boehringer Mannheim Gmbh | Infrarot-Farbstoff-markierte Nucleotide und ihre Verwendung in der Nucleinsäure-Detektion |
ATE246696T1 (de) * | 1995-05-09 | 2003-08-15 | Kreatech Biotech Bv | Verfahren zur herstellung von linkern zwischen markierungsgruppen und bio-organischen molekülen auf der basis von platin für die markierung von bio-organischen molekülen zur entdeckung interessanter biologischer substanzen |
ATE221894T1 (de) * | 1996-10-08 | 2002-08-15 | Kreatech Biotech Bv | Verfahren zur markierung von nukleotiden, markierte nukleotide und nuetzliche zwischenprodukte |
-
1997
- 1997-10-08 AT AT97943223T patent/ATE221894T1/de active
- 1997-10-08 EP EP97943223A patent/EP0937090B1/en not_active Expired - Lifetime
- 1997-10-08 DK DK97943223T patent/DK0937090T3/da active
- 1997-10-08 JP JP51741498A patent/JP4981197B2/ja not_active Expired - Lifetime
- 1997-10-08 US US10/900,902 patent/USRE40557E1/en not_active Expired - Lifetime
- 1997-10-08 PT PT97943223T patent/PT937090E/pt unknown
- 1997-10-08 NZ NZ334803A patent/NZ334803A/xx not_active IP Right Cessation
- 1997-10-08 DE DE69714600T patent/DE69714600T2/de not_active Expired - Lifetime
- 1997-10-08 US US09/402,707 patent/US6338943B1/en not_active Ceased
- 1997-10-08 AU AU44746/97A patent/AU726692B2/en not_active Expired
- 1997-10-08 ES ES97943223T patent/ES2182121T3/es not_active Expired - Lifetime
- 1997-10-08 CA CA002267133A patent/CA2267133C/en not_active Expired - Lifetime
- 1997-10-08 WO PCT/NL1997/000559 patent/WO1998015564A1/en active IP Right Grant
-
2002
- 2002-01-14 US US10/047,874 patent/US6797818B2/en not_active Expired - Lifetime
-
2004
- 2004-09-27 US US10/950,985 patent/US7217813B2/en not_active Expired - Fee Related
-
2010
- 2010-01-29 JP JP2010019643A patent/JP2010166914A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP0937090A1 (en) | 1999-08-25 |
US6797818B2 (en) | 2004-09-28 |
USRE40557E1 (en) | 2008-10-28 |
DE69714600D1 (de) | 2002-09-12 |
JP2010166914A (ja) | 2010-08-05 |
NZ334803A (en) | 2000-05-26 |
JP2001503742A (ja) | 2001-03-21 |
EP0937090B1 (en) | 2002-08-07 |
US7217813B2 (en) | 2007-05-15 |
PT937090E (pt) | 2002-12-31 |
AU4474697A (en) | 1998-05-05 |
CA2267133C (en) | 2006-07-18 |
US20050118621A1 (en) | 2005-06-02 |
ATE221894T1 (de) | 2002-08-15 |
DK0937090T3 (da) | 2002-12-02 |
US6338943B1 (en) | 2002-01-15 |
CA2267133A1 (en) | 1998-04-16 |
DE69714600T2 (de) | 2003-03-27 |
AU726692B2 (en) | 2000-11-16 |
WO1998015564A1 (en) | 1998-04-16 |
JP4981197B2 (ja) | 2012-07-18 |
US20020160396A1 (en) | 2002-10-31 |
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