DE69713109T2 - Verbindungen mit wachstumshormon freisetzenden eigenschaften - Google Patents
Verbindungen mit wachstumshormon freisetzenden eigenschaftenInfo
- Publication number
- DE69713109T2 DE69713109T2 DE69713109T DE69713109T DE69713109T2 DE 69713109 T2 DE69713109 T2 DE 69713109T2 DE 69713109 T DE69713109 T DE 69713109T DE 69713109 T DE69713109 T DE 69713109T DE 69713109 T2 DE69713109 T2 DE 69713109T2
- Authority
- DE
- Germany
- Prior art keywords
- ethyl
- methyl
- naphthyl
- mmol
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000018997 Growth Hormone Human genes 0.000 title claims abstract description 39
- 108010051696 Growth Hormone Proteins 0.000 title claims abstract description 39
- 239000000122 growth hormone Substances 0.000 title claims abstract description 39
- 230000003578 releasing effect Effects 0.000 title description 5
- 150000001875 compounds Chemical class 0.000 claims abstract description 114
- 241001465754 Metazoa Species 0.000 claims abstract description 14
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- 239000008267 milk Substances 0.000 claims abstract description 4
- 210000004080 milk Anatomy 0.000 claims abstract description 4
- 239000000203 mixture Substances 0.000 claims description 37
- 229910052739 hydrogen Inorganic materials 0.000 claims description 28
- 239000001257 hydrogen Substances 0.000 claims description 28
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 27
- -1 amino, hydroxyl Chemical group 0.000 claims description 27
- 150000003839 salts Chemical class 0.000 claims description 19
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 14
- 125000003118 aryl group Chemical group 0.000 claims description 14
- 159000000021 acetate salts Chemical class 0.000 claims description 13
- 229910052736 halogen Inorganic materials 0.000 claims description 13
- 150000002367 halogens Chemical group 0.000 claims description 13
- 206010062767 Hypophysitis Diseases 0.000 claims description 12
- 210000003635 pituitary gland Anatomy 0.000 claims description 12
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 11
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 9
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- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims description 7
- 230000015556 catabolic process Effects 0.000 claims description 7
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- 230000000694 effects Effects 0.000 claims description 7
- 150000002431 hydrogen Chemical class 0.000 claims description 7
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 7
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- PKVGEUCCBFDWEF-YBLZLUOVSA-N (e)-5-[[(2r)-2-hydroxypropyl]amino]-n,5-dimethyl-n-[(2r)-1-[methyl(2-phenylethyl)amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]hex-2-enamide Chemical compound O=C([C@@H](CC=1C=C2C=CC=CC2=CC=1)N(C)C(=O)/C=C/CC(C)(C)NC[C@H](O)C)N(C)CCC1=CC=CC=C1 PKVGEUCCBFDWEF-YBLZLUOVSA-N 0.000 claims description 3
- IEEUKABHJLYTDI-UDKPXMKSSA-N (e)-5-amino-n,5-dimethyl-n-[(2r)-1-[methyl(2-phenylethyl)amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]hex-2-enamide Chemical compound O=C([C@@H](CC=1C=C2C=CC=CC2=CC=1)N(C)C(=O)\C=C\CC(C)(C)N)N(C)CCC1=CC=CC=C1 IEEUKABHJLYTDI-UDKPXMKSSA-N 0.000 claims description 3
- NKTMLMJWHNDQDF-VISBSAOHSA-N (e)-5-amino-n,5-dimethyl-n-[(2r)-1-[methyl(2-thiophen-2-ylethyl)amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]hex-2-enamide Chemical compound O=C([C@@H](CC=1C=C2C=CC=CC2=CC=1)N(C)C(=O)\C=C\CC(C)(C)N)N(C)CCC1=CC=CS1 NKTMLMJWHNDQDF-VISBSAOHSA-N 0.000 claims description 3
- WAMMBZKCAXKZKW-LZZUIANGSA-N (e)-5-amino-n-[(2r)-1-[2-[2-(2-hydroxyethoxy)phenyl]ethyl-methylamino]-3-naphthalen-2-yl-1-oxopropan-2-yl]-n,5-dimethylhex-2-enamide Chemical compound O=C([C@@H](CC=1C=C2C=CC=CC2=CC=1)N(C)C(=O)\C=C\CC(C)(C)N)N(C)CCC1=CC=CC=C1OCCO WAMMBZKCAXKZKW-LZZUIANGSA-N 0.000 claims description 3
- QUDVOSPQRDYTCI-BYFPVTHSSA-N (e)-5-amino-n-[(2r)-1-[2-[2-(benzenesulfonamido)phenyl]ethyl-methylamino]-3-naphthalen-2-yl-1-oxopropan-2-yl]-n,5-dimethylhex-2-enamide Chemical compound O=C([C@@H](CC=1C=C2C=CC=CC2=CC=1)N(C)C(=O)\C=C\CC(C)(C)N)N(C)CCC1=CC=CC=C1NS(=O)(=O)C1=CC=CC=C1 QUDVOSPQRDYTCI-BYFPVTHSSA-N 0.000 claims description 3
- BOSXPQNYNMINOQ-MGUPHCMFSA-N (e)-5-amino-n-[(2r)-1-[2-[2-(methanesulfonamido)phenyl]ethyl-methylamino]-3-naphthalen-2-yl-1-oxopropan-2-yl]-n,5-dimethylhex-2-enamide Chemical compound O=C([C@@H](CC=1C=C2C=CC=CC2=CC=1)N(C)C(=O)\C=C\CC(C)(C)N)N(C)CCC1=CC=CC=C1NS(C)(=O)=O BOSXPQNYNMINOQ-MGUPHCMFSA-N 0.000 claims description 3
- ITQNUYSUYRVNQP-LZZUIANGSA-N (e)-5-amino-n-[(2r)-1-[2-[2-[(2-aminoacetyl)amino]phenyl]ethyl-methylamino]-3-naphthalen-2-yl-1-oxopropan-2-yl]-n,5-dimethylhex-2-enamide Chemical compound O=C([C@@H](CC=1C=C2C=CC=CC2=CC=1)N(C)C(=O)\C=C\CC(C)(C)N)N(C)CCC1=CC=CC=C1NC(=O)CN ITQNUYSUYRVNQP-LZZUIANGSA-N 0.000 claims description 3
- COPOOZYPAUETCC-FEBJRPPSSA-N (e)-n,5-dimethyl-5-(methylamino)-n-[(2r)-1-[methyl(2-phenylethyl)amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]hex-2-enamide Chemical compound O=C([C@@H](CC=1C=C2C=CC=CC2=CC=1)N(C)C(=O)/C=C/CC(C)(C)NC)N(C)CCC1=CC=CC=C1 COPOOZYPAUETCC-FEBJRPPSSA-N 0.000 claims description 3
- GYIPHGRIGGSXCL-BVEXFFHSSA-N (e)-n-[(2r)-1-[2-[2-(2-hydroxyethoxy)phenyl]ethyl-methylamino]-3-naphthalen-2-yl-1-oxopropan-2-yl]-n,5-dimethyl-5-(methylamino)hex-2-enamide Chemical compound O=C([C@@H](CC=1C=C2C=CC=CC2=CC=1)N(C)C(=O)/C=C/CC(C)(C)NC)N(C)CCC1=CC=CC=C1OCCO GYIPHGRIGGSXCL-BVEXFFHSSA-N 0.000 claims description 3
- YEJLGCGPEJEPLW-ZSTWXAJCSA-N 3-(1-aminoethyl)-n-methyl-n-[(2r)-1-[methyl(2-thiophen-2-ylethyl)amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]benzamide Chemical compound CC(N)C1=CC=CC(C(=O)N(C)[C@H](CC=2C=C3C=CC=CC3=CC=2)C(=O)N(C)CCC=2SC=CC=2)=C1 YEJLGCGPEJEPLW-ZSTWXAJCSA-N 0.000 claims description 3
- 241001494479 Pecora Species 0.000 claims description 3
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- XYTIFQRQPIRQKL-LNFHGXOESA-N (e)-5-amino-n,5-dimethyl-n-[(2r)-1-[methyl(2-thiophen-2-ylethyl)amino]-1-oxo-3-(4-phenylphenyl)propan-2-yl]hex-2-enamide Chemical compound O=C([C@@H](CC=1C=CC(=CC=1)C=1C=CC=CC=1)N(C)C(=O)\C=C\CC(C)(C)N)N(C)CCC1=CC=CS1 XYTIFQRQPIRQKL-LNFHGXOESA-N 0.000 claims description 2
- LRHAXAVCVRWWKU-PVBLUSGHSA-N (e)-n,5-dimethyl-5-(methylamino)-n-[(2r)-1-[methyl(2-thiophen-2-ylethyl)amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]hex-2-enamide Chemical compound O=C([C@@H](CC=1C=C2C=CC=CC2=CC=1)N(C)C(=O)/C=C/CC(C)(C)NC)N(C)CCC1=CC=CS1 LRHAXAVCVRWWKU-PVBLUSGHSA-N 0.000 claims description 2
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- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims 2
- VFRSADQPWYCXDG-LEUCUCNGSA-N ethyl (2s,5s)-5-methylpyrrolidine-2-carboxylate;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.CCOC(=O)[C@@H]1CC[C@H](C)N1 VFRSADQPWYCXDG-LEUCUCNGSA-N 0.000 claims 2
- VIMOBOVSUKYOAI-LNFHGXOESA-N (e)-5-amino-n-[(2r)-1-[2-[2-(2-hydroxyethoxy)phenyl]ethyl-methylamino]-3-naphthalen-2-yl-1-oxopropan-2-yl]-5-methylhex-2-enamide Chemical compound O=C([C@@H](CC=1C=C2C=CC=CC2=CC=1)NC(=O)\C=C\CC(C)(C)N)N(C)CCC1=CC=CC=C1OCCO VIMOBOVSUKYOAI-LNFHGXOESA-N 0.000 claims 1
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- GGUBFICZYGKNTD-UHFFFAOYSA-N triethyl phosphonoacetate Chemical compound CCOC(=O)CP(=O)(OCC)OCC GGUBFICZYGKNTD-UHFFFAOYSA-N 0.000 description 1
- MBYLVOKEDDQJDY-UHFFFAOYSA-N tris(2-aminoethyl)amine Chemical compound NCCN(CCN)CCN MBYLVOKEDDQJDY-UHFFFAOYSA-N 0.000 description 1
- 239000002753 trypsin inhibitor Substances 0.000 description 1
- 229960003726 vasopressin Drugs 0.000 description 1
- 239000003039 volatile agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/06—Compounds containing any of the groups, e.g. semicarbazides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK80396 | 1996-07-22 | ||
| PCT/DK1997/000314 WO1998003473A1 (en) | 1996-07-22 | 1997-07-17 | Compounds with growth hormone releasing properties |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69713109D1 DE69713109D1 (de) | 2002-07-11 |
| DE69713109T2 true DE69713109T2 (de) | 2003-01-02 |
Family
ID=8097747
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69713109T Expired - Lifetime DE69713109T2 (de) | 1996-07-22 | 1997-07-17 | Verbindungen mit wachstumshormon freisetzenden eigenschaften |
| DE69734215T Expired - Lifetime DE69734215T2 (de) | 1996-07-22 | 1997-07-17 | Verbindungen mit Wachstumshormon-freisetzenden Eigenschaften |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69734215T Expired - Lifetime DE69734215T2 (de) | 1996-07-22 | 1997-07-17 | Verbindungen mit Wachstumshormon-freisetzenden Eigenschaften |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US5922770A (enExample) |
| EP (2) | EP0923539B1 (enExample) |
| JP (1) | JP4425992B2 (enExample) |
| AT (2) | ATE218537T1 (enExample) |
| AU (1) | AU3434697A (enExample) |
| DE (2) | DE69713109T2 (enExample) |
| WO (1) | WO1998003473A1 (enExample) |
| ZA (1) | ZA976371B (enExample) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6127341A (en) * | 1997-06-20 | 2000-10-03 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| JP4116097B2 (ja) * | 1997-06-20 | 2008-07-09 | ノボ ノルディスク アクティーゼルスカブ | 成長ホルモン放出特性をもつ化合物 |
| DE69941255D1 (de) * | 1998-05-11 | 2009-09-24 | Novo Nordisk As | Verbindungen mit wachstumshormon freisetzenden eigenschaften |
| TW450954B (en) * | 1998-05-14 | 2001-08-21 | Pharmacia & Amp Upjohn Company | Phenylsulfonamide-phenylethylamines useful as dopamine receptors |
| DE69943239D1 (de) * | 1998-06-30 | 2011-04-14 | Novo Nordisk As | Verbindungen mit wachstumshormon-freisetzenden eigenschaften |
| US6919315B1 (en) | 1998-06-30 | 2005-07-19 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| US6358951B1 (en) * | 1998-08-21 | 2002-03-19 | Pfizer Inc. | Growth hormone secretagogues |
| EP1930021A3 (en) | 1999-02-18 | 2008-06-18 | Kaken Pharmaceutical Co., Ltd. | Novel amide derivatives as growth hormone secretagogues |
| UA73530C2 (uk) * | 1999-11-10 | 2005-08-15 | Ново Нордіск А/С | Сполука з властивостями вивільнювати гормон росту |
| DE60124080T2 (de) | 2000-03-23 | 2007-03-01 | Elan Pharmaceuticals, Inc., San Francisco | Verbindungen und verfahren zur behandlung der alzheimerschen krankheit |
| US6992081B2 (en) | 2000-03-23 | 2006-01-31 | Elan Pharmaceuticals, Inc. | Compounds to treat Alzheimer's disease |
| US6613801B2 (en) * | 2000-05-30 | 2003-09-02 | Transtech Pharma, Inc. | Method for the synthesis of compounds of formula I and their uses thereof |
| US7087632B2 (en) * | 2001-03-05 | 2006-08-08 | Transtech Pharma, Inc. | Benzimidazole derivatives as therapeutic agents |
| ES2333097T3 (es) | 2000-05-31 | 2010-02-17 | Raqualia Pharma Inc | Uso de secretagogos de la hormona de crecimiento para estimular la motilidad gastrointestinal. |
| EP1666452A2 (en) | 2000-06-30 | 2006-06-07 | Elan Pharmaceuticals, Inc. | Compounds to treat Alzheimer's disease |
| US20030096864A1 (en) * | 2000-06-30 | 2003-05-22 | Fang Lawrence Y. | Compounds to treat alzheimer's disease |
| US6846813B2 (en) * | 2000-06-30 | 2005-01-25 | Pharmacia & Upjohn Company | Compounds to treat alzheimer's disease |
| US7034182B2 (en) * | 2000-06-30 | 2006-04-25 | Elan Pharmaceuticals, Inc. | Compounds to treat Alzheimer's disease |
| PE20020276A1 (es) | 2000-06-30 | 2002-04-06 | Elan Pharm Inc | COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER |
| KR100900020B1 (ko) * | 2001-02-16 | 2009-06-01 | 알레릭스 뉴로사이언스, 인크. | Ｇｌｙｔ-1 저해제로서의 티오펜 치환 아민 유도체 |
| EP1377295A4 (en) * | 2001-03-05 | 2007-05-09 | Transtech Pharma Inc | CARBOXYL ACID DERIVATIVES THERAPEUTIC AGENTS |
| BR0210721A (pt) * | 2001-06-27 | 2004-07-20 | Elan Pharm Inc | Composto, sal ou éster farmaceuticamente aceitável, método para fabricar um composto, e, método para tratar um paciente que tem, ou para evitar que o paciente adquira uma doença ou condição |
| US20070213407A1 (en) * | 2001-06-29 | 2007-09-13 | Elan Pharmaceuticals And Pharmacia & Upjohn Company Llc | Compounds to treat Alzheimer's disease |
| WO2003059880A1 (en) * | 2002-01-11 | 2003-07-24 | Sankyo Company, Limited | Amino alcohol derivative or phosphonic acid derivative and medicinal composition containing these |
| US7230133B2 (en) | 2003-05-01 | 2007-06-12 | Bristol-Myers Squibb Company | Malonamides and malonamide derivatives as modulators of chemokine receptor activity |
| WO2005000295A1 (en) * | 2003-05-20 | 2005-01-06 | Transtech Pharma, Inc. | Rage antagonists as agents to reverse amyloidosis and diseases associated therewith |
| US7476653B2 (en) | 2003-06-18 | 2009-01-13 | Tranzyme Pharma, Inc. | Macrocyclic modulators of the ghrelin receptor |
| WO2005027913A1 (en) * | 2003-09-19 | 2005-03-31 | Pfizer Products Inc. | Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and a growth hormone secretagogue |
| EP1733724A4 (en) | 2004-02-24 | 2010-07-07 | Sankyo Co | Aminoalcohol compound |
| EP1735055A1 (en) * | 2004-03-30 | 2006-12-27 | Sapphire Therapeutics, Inc. | Method of reducing c-reactive protein using growth hormone secretagogues |
| CN103772483A (zh) * | 2004-06-29 | 2014-05-07 | 赫尔辛医疗股份公司 | （3r）－1－（2－甲基丙氨酰－d－色氨酰）－3－（苯甲基）－3－哌啶羧酸1,2,2－三甲基酰肼的晶形 |
| AU2005272598B2 (en) * | 2004-08-12 | 2011-11-17 | Helsinn Therapeutics (U.S.), Inc. | Method of stimulating the motility of the gastrointestinal system using growth hormone secretagogues |
| CN101248184B (zh) | 2005-08-25 | 2013-01-16 | 宇部兴产株式会社 | 光学活性（S或R）-α-氨基酸及光学活性（S或R）-α-氨基酸酯的制造方法 |
| CU23558A1 (es) | 2006-02-28 | 2010-07-20 | Ct Ingenieria Genetica Biotech | Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento |
| US8889632B2 (en) | 2007-01-31 | 2014-11-18 | Dana-Farber Cancer Institute, Inc. | Stabilized p53 peptides and uses thereof |
| EA200901077A1 (ru) | 2007-02-09 | 2010-04-30 | Транзим Фарма, Инк. | Макроциклические модуляторы грелинового рецептора и их применение |
| MX2009008561A (es) * | 2007-02-13 | 2010-01-15 | Helsinn Therapeutics Us Inc | Metodo para tratar trastornos proliferativos celulares utilizando secretagogos. |
| JP5631201B2 (ja) | 2007-03-28 | 2014-11-26 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ステッチングされたポリペプチド |
| TWI429436B (zh) * | 2007-04-10 | 2014-03-11 | Helsinn Therapeutics Us Inc | 使用生長激素促泌素治療或預防嘔吐之方法 |
| UA105657C2 (uk) | 2009-02-27 | 2014-06-10 | Хелсінн Терапьютікс (Ю.Ес.), Інк. | Поліпшені способи лікування мігрені на основі анамореліну |
| CA2772797C (en) | 2009-09-30 | 2018-09-25 | Transtech Pharma, Inc. | Substituted imidazole derivatives |
| KR20180058866A (ko) | 2010-08-13 | 2018-06-01 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티도미메틱 거대고리 |
| BR112014009418A2 (pt) | 2011-10-18 | 2017-04-18 | Aileron Therapeutics Inc | macrociclos peptidomiméticos |
| CN112500466B (zh) | 2012-02-15 | 2022-05-03 | 艾瑞朗医疗公司 | 拟肽大环化合物 |
| WO2013123267A1 (en) | 2012-02-15 | 2013-08-22 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
| US9717710B2 (en) | 2012-10-05 | 2017-08-01 | Vtv Therapeutics Llc | Treatment of mild and moderate Alzheimer's disease |
| MX2015005244A (es) | 2012-11-01 | 2015-07-14 | Aileron Therapeutics Inc | Aminoacidos disustituidos y metodos de preparacion y el uso de los mismos. |
| US9119832B2 (en) | 2014-02-05 | 2015-09-01 | The Regents Of The University Of California | Methods of treating mild brain injury |
| AU2015320549A1 (en) | 2014-09-24 | 2017-04-13 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| SG11201707750YA (en) | 2015-03-20 | 2017-10-30 | Aileron Therapeutics Inc | Peptidomimetic macrocycles and uses thereof |
| US20170121385A1 (en) | 2015-10-28 | 2017-05-04 | Oxeia Biopharmaceuticals, Inc. | Methods of treating neurodegenerative conditions |
| EP3414783B1 (en) | 2016-02-09 | 2021-08-18 | Lumeova, Inc | Ultra-wideband, wireless optical high speed communication devices and systems |
| WO2019190822A1 (en) | 2018-03-28 | 2019-10-03 | Vtv Therapeutics Llc | Crystalline forms of [3-(4- {2-butyl-1-[4-(4-chloro-phenoxy)-phenyl]-1h-imidazol-4-yl} -phenoxy)-propyl]-diethyl-amine |
| WO2019190823A1 (en) | 2018-03-28 | 2019-10-03 | Vtv Therapeutics Llc | Pharmaceutically acceptable salts of [3-(4- {2-butyl-1-[4-(4-chlorophenoxy)-phenyl]-1h-imidazol-4-yl} -phenoxy)-propyl]-diethyl-amine |
| WO2020076668A1 (en) | 2018-10-10 | 2020-04-16 | Vtv Therapeutics Llc | Metabolites of [3-(4-{2-butyl-l-[4-(4-chloro-phenoxy)-phenyl]-lh-imidazol-4-yl } -phen ox y)-prop yl] -diethyl-amine |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI962584A0 (fi) * | 1993-12-23 | 1996-06-20 | Novo Nordisk As | Kasvuhormonia vapauttavia ominaisuuksia sisältäviä yhdisteitä |
| DE69633003T2 (de) * | 1995-01-27 | 2005-08-18 | Novo Nordisk A/S | Verbindungen mit wachstumshormon-freisetzenden eigenschaften |
| CA2239711A1 (en) * | 1995-12-22 | 1997-07-03 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
-
1997
- 1997-07-17 WO PCT/DK1997/000314 patent/WO1998003473A1/en not_active Ceased
- 1997-07-17 AT AT97930368T patent/ATE218537T1/de not_active IP Right Cessation
- 1997-07-17 DE DE69713109T patent/DE69713109T2/de not_active Expired - Lifetime
- 1997-07-17 EP EP97930368A patent/EP0923539B1/en not_active Expired - Lifetime
- 1997-07-17 AT AT01123155T patent/ATE304528T1/de not_active IP Right Cessation
- 1997-07-17 US US08/896,550 patent/US5922770A/en not_active Expired - Lifetime
- 1997-07-17 DE DE69734215T patent/DE69734215T2/de not_active Expired - Lifetime
- 1997-07-17 EP EP01123155A patent/EP1184370B1/en not_active Expired - Lifetime
- 1997-07-17 JP JP50646598A patent/JP4425992B2/ja not_active Expired - Lifetime
- 1997-07-17 AU AU34346/97A patent/AU3434697A/en not_active Abandoned
- 1997-07-18 ZA ZA9706371A patent/ZA976371B/xx unknown
-
1999
- 1999-03-17 US US09/270,862 patent/US6127354A/en not_active Expired - Lifetime
-
2000
- 2000-07-19 US US09/619,227 patent/US6274584B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO1998003473A1 (en) | 1998-01-29 |
| DE69734215D1 (de) | 2005-10-20 |
| AU3434697A (en) | 1998-02-10 |
| EP1184370A3 (en) | 2002-03-27 |
| US6274584B1 (en) | 2001-08-14 |
| US5922770A (en) | 1999-07-13 |
| US6127354A (en) | 2000-10-03 |
| EP0923539A1 (en) | 1999-06-23 |
| ATE218537T1 (de) | 2002-06-15 |
| JP2000515517A (ja) | 2000-11-21 |
| ZA976371B (en) | 1998-01-22 |
| EP1184370B1 (en) | 2005-09-14 |
| EP0923539B1 (en) | 2002-06-05 |
| EP1184370A2 (en) | 2002-03-06 |
| ATE304528T1 (de) | 2005-09-15 |
| JP4425992B2 (ja) | 2010-03-03 |
| DE69734215T2 (de) | 2006-06-29 |
| DE69713109D1 (de) | 2002-07-11 |
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| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: SAPPHIRE THERAPEUTICS, INC., BRIDGEWATER, N.J., US |