ATE218537T1 - Verbindungen mit wachstumshormon freisetzenden eigenschaften - Google Patents
Verbindungen mit wachstumshormon freisetzenden eigenschaftenInfo
- Publication number
- ATE218537T1 ATE218537T1 AT97930368T AT97930368T ATE218537T1 AT E218537 T1 ATE218537 T1 AT E218537T1 AT 97930368 T AT97930368 T AT 97930368T AT 97930368 T AT97930368 T AT 97930368T AT E218537 T1 ATE218537 T1 AT E218537T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- growth hormone
- hormone releasing
- releasing properties
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/06—Compounds containing any of the groups, e.g. semicarbazides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK80396 | 1996-07-22 | ||
PCT/DK1997/000314 WO1998003473A1 (en) | 1996-07-22 | 1997-07-17 | Compounds with growth hormone releasing properties |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE218537T1 true ATE218537T1 (de) | 2002-06-15 |
Family
ID=8097747
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT01123155T ATE304528T1 (de) | 1996-07-22 | 1997-07-17 | Verbindungen mit wachstumshormon-freisetzenden eigenschaften |
AT97930368T ATE218537T1 (de) | 1996-07-22 | 1997-07-17 | Verbindungen mit wachstumshormon freisetzenden eigenschaften |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT01123155T ATE304528T1 (de) | 1996-07-22 | 1997-07-17 | Verbindungen mit wachstumshormon-freisetzenden eigenschaften |
Country Status (8)
Country | Link |
---|---|
US (3) | US5922770A (de) |
EP (2) | EP1184370B1 (de) |
JP (1) | JP4425992B2 (de) |
AT (2) | ATE304528T1 (de) |
AU (1) | AU3434697A (de) |
DE (2) | DE69713109T2 (de) |
WO (1) | WO1998003473A1 (de) |
ZA (1) | ZA976371B (de) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1005484A1 (de) * | 1997-06-20 | 2000-06-07 | Novo Nordisk A/S | Verbindungen mit wachstumshormon freisetzenden eigenschaften |
US6127341A (en) * | 1997-06-20 | 2000-10-03 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
AU757217B2 (en) * | 1998-05-11 | 2003-02-06 | Helsinn Healthcare Sa | Compounds with growth hormone releasing properties |
TW450954B (en) * | 1998-05-14 | 2001-08-21 | Pharmacia & Amp Upjohn Company | Phenylsulfonamide-phenylethylamines useful as dopamine receptors |
WO2000001726A1 (en) * | 1998-06-30 | 2000-01-13 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
US6919315B1 (en) | 1998-06-30 | 2005-07-19 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
US6358951B1 (en) | 1998-08-21 | 2002-03-19 | Pfizer Inc. | Growth hormone secretagogues |
KR100699404B1 (ko) | 1999-02-18 | 2007-03-23 | 가켄 세야쿠 가부시키가이샤 | 성장 호르몬 분비촉진제로서의 신규 아미드 유도체 |
UA73530C2 (uk) * | 1999-11-10 | 2005-08-15 | Ново Нордіск А/С | Сполука з властивостями вивільнювати гормон росту |
AU2001252958A1 (en) | 2000-03-23 | 2001-10-03 | Elan Pharmaceuticals, Inc. | Compounds and methods to treat alzheimer's disease |
US6992081B2 (en) | 2000-03-23 | 2006-01-31 | Elan Pharmaceuticals, Inc. | Compounds to treat Alzheimer's disease |
US6613801B2 (en) * | 2000-05-30 | 2003-09-02 | Transtech Pharma, Inc. | Method for the synthesis of compounds of formula I and their uses thereof |
EP1159964B1 (de) | 2000-05-31 | 2009-10-28 | Pfizer Products Inc. | Verwendung von Wachstumshormonsekretagoga zur Förderung der Beweglichkeit des Verdauungstrakts |
WO2002002506A2 (en) * | 2000-06-30 | 2002-01-10 | Elan Pharmaceuticals, Inc. | Compounds to treat alzheimer's disease |
PE20020276A1 (es) | 2000-06-30 | 2002-04-06 | Elan Pharm Inc | COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER |
US6846813B2 (en) * | 2000-06-30 | 2005-01-25 | Pharmacia & Upjohn Company | Compounds to treat alzheimer's disease |
US20030096864A1 (en) * | 2000-06-30 | 2003-05-22 | Fang Lawrence Y. | Compounds to treat alzheimer's disease |
EP1666452A2 (de) | 2000-06-30 | 2006-06-07 | Elan Pharmaceuticals, Inc. | Verbindungen zur Behandlung der Alzheimerischen Krankheit |
SK287304B6 (sk) * | 2001-02-16 | 2010-06-07 | Nps Pharmaceuticals, Inc. | Substituované amínové deriváty ako inhibítory GlyT-1, farmaceutické prostriedky s ich obsahom, ich použitie, spôsob ich prípravy, ich medziprodukty a spôsob ich prípravy |
CN1494425B (zh) * | 2001-03-05 | 2011-12-07 | 特兰斯泰克制药公司 | 用作治疗剂的羧酰胺衍生物 |
WO2002069965A1 (en) * | 2001-03-05 | 2002-09-12 | Transtech Pharma, Inc. | Benzimidazole derivatives as therapeutic agents |
MXPA04000140A (es) * | 2001-06-27 | 2004-06-03 | Elan Pharm Inc | Derivados de beta-hidroxiamina utiles en el tratamiento de enfermedad de alzheimer. |
US20070213407A1 (en) * | 2001-06-29 | 2007-09-13 | Elan Pharmaceuticals And Pharmacia & Upjohn Company Llc | Compounds to treat Alzheimer's disease |
BR0306811A (pt) * | 2002-01-11 | 2004-10-26 | Sankyo Co | Composto, éster farmacologicamente aceitável do mesmo, composição farmacêutica e métodos para prevenção ou tratamento de doenças autoimunes, da artrite reumatóide e da rejeição causada pelo transplante de vários órgãos em um mamìfero |
US7230133B2 (en) | 2003-05-01 | 2007-06-12 | Bristol-Myers Squibb Company | Malonamides and malonamide derivatives as modulators of chemokine receptor activity |
WO2005000295A1 (en) * | 2003-05-20 | 2005-01-06 | Transtech Pharma, Inc. | Rage antagonists as agents to reverse amyloidosis and diseases associated therewith |
US7476653B2 (en) | 2003-06-18 | 2009-01-13 | Tranzyme Pharma, Inc. | Macrocyclic modulators of the ghrelin receptor |
WO2005027913A1 (en) * | 2003-09-19 | 2005-03-31 | Pfizer Products Inc. | Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and a growth hormone secretagogue |
NZ549162A (en) | 2004-02-24 | 2009-12-24 | Sankyo Co | Amino-pyrrol alcohol compounds |
KR20070010151A (ko) * | 2004-03-30 | 2007-01-22 | 사파이어 세라퓨틱스, 인크. | 성장 호르몬 분비촉진제를 이용하여 c-반응성 단백질을감소시키는 방법 |
EP1768976B1 (de) * | 2004-06-29 | 2017-04-26 | Helsinn Healthcare S.A. | Kristalline formen von (3r)-1-(2-methylalanyl-d-tryptophyl)-3-(phenylmethyl)-3-piperidincarbonsäure-1,2,2-trimethylhydrazid |
KR20130048793A (ko) * | 2004-08-12 | 2013-05-10 | 헬신 세라퓨틱스 (유.에스.) 인크. | 성장 호르몬 분비촉진제를 이용하여 위장관계의 운동성을 촉진하는 방법 |
CN101248184B (zh) | 2005-08-25 | 2013-01-16 | 宇部兴产株式会社 | 光学活性(S或R)-α-氨基酸及光学活性(S或R)-α-氨基酸酯的制造方法 |
CU23558A1 (es) | 2006-02-28 | 2010-07-20 | Ct Ingenieria Genetica Biotech | Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento |
PT2118123E (pt) | 2007-01-31 | 2016-02-10 | Harvard College | Péptidos de p53 estabilizados e suas utilizações |
BRPI0807046A2 (pt) | 2007-02-09 | 2015-05-26 | Tranzyme Pharma Inc | Composto, composição farmacêutica, métodos de tratar um distúrbio, uma doença cardiovascular e um paciente que sofre de motilidade gastrointestinal reduzida ou disfuncional e, kit. |
JP2010518158A (ja) * | 2007-02-13 | 2010-05-27 | ヘルシン セラピューティクス(ユー.エス.),インコーポレイティド | 成長ホルモン分泌促進物質を用いた細胞増殖性障害の治療方法 |
KR101623985B1 (ko) | 2007-03-28 | 2016-05-25 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 스티칭된 폴리펩티드 |
TWI429436B (zh) * | 2007-04-10 | 2014-03-11 | Helsinn Therapeutics Us Inc | 使用生長激素促泌素治療或預防嘔吐之方法 |
UA105657C2 (uk) | 2009-02-27 | 2014-06-10 | Хелсінн Терапьютікс (Ю.Ес.), Інк. | Поліпшені способи лікування мігрені на основі анамореліну |
US8580833B2 (en) | 2009-09-30 | 2013-11-12 | Transtech Pharma, Inc. | Substituted imidazole derivatives and methods of use thereof |
PT2603600T (pt) | 2010-08-13 | 2019-02-27 | Aileron Therapeutics Inc | Macrociclos peptidomiméticos |
CN104039342A (zh) | 2011-10-18 | 2014-09-10 | 爱勒让治疗公司 | 拟肽大环化合物 |
EP2822572B1 (de) | 2012-02-15 | 2020-06-10 | Aileron Therapeutics, Inc. | Peptidomimetische makrozyklen |
EP2819688A4 (de) | 2012-02-15 | 2015-10-28 | Aileron Therapeutics Inc | Triazol- und thioethervernetzte peptidomimetische makrozyklen |
US9717710B2 (en) | 2012-10-05 | 2017-08-01 | Vtv Therapeutics Llc | Treatment of mild and moderate Alzheimer's disease |
BR112015009470A2 (pt) | 2012-11-01 | 2019-12-17 | Aileron Therapeutics Inc | aminoácidos dissubstituídos e seus métodos de preparação e uso |
US9119832B2 (en) | 2014-02-05 | 2015-09-01 | The Regents Of The University Of California | Methods of treating mild brain injury |
EP3197478A4 (de) | 2014-09-24 | 2018-05-30 | Aileron Therapeutics, Inc. | Peptidomimetische makrozyklen und verwendungen davon |
US10253067B2 (en) | 2015-03-20 | 2019-04-09 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
US20170121385A1 (en) | 2015-10-28 | 2017-05-04 | Oxeia Biopharmaceuticals, Inc. | Methods of treating neurodegenerative conditions |
EP3414783B1 (de) | 2016-02-09 | 2021-08-18 | Lumeova, Inc | Vorrichtungen und systeme zur ultrabreitbandigen, drahtlosen optischen hochgeschwindigkeitsübertragung |
WO2019190822A1 (en) | 2018-03-28 | 2019-10-03 | Vtv Therapeutics Llc | Crystalline forms of [3-(4- {2-butyl-1-[4-(4-chloro-phenoxy)-phenyl]-1h-imidazol-4-yl} -phenoxy)-propyl]-diethyl-amine |
WO2019190823A1 (en) | 2018-03-28 | 2019-10-03 | Vtv Therapeutics Llc | Pharmaceutically acceptable salts of [3-(4- {2-butyl-1-[4-(4-chlorophenoxy)-phenyl]-1h-imidazol-4-yl} -phenoxy)-propyl]-diethyl-amine |
WO2020076668A1 (en) | 2018-10-10 | 2020-04-16 | Vtv Therapeutics Llc | Metabolites of [3-(4-{2-butyl-l-[4-(4-chloro-phenoxy)-phenyl]-lh-imidazol-4-yl } -phen ox y)-prop yl] -diethyl-amine |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2179597A1 (en) * | 1993-12-23 | 1995-06-29 | Nils Langeland Johansen | Compounds with growth hormone releasing properties |
PL186511B1 (pl) * | 1995-01-27 | 2004-01-30 | Novo Nordisk As | Nowe związki peptydowe, kompozycje farmaceutycznedo pobudzania uwalniania hormonu wzrostu i zastosowanie tych związków do wytwarzania leku do pobudzania uwalniania hormonu wzrostu |
WO1997023508A1 (en) * | 1995-12-22 | 1997-07-03 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
-
1997
- 1997-07-17 EP EP01123155A patent/EP1184370B1/de not_active Expired - Lifetime
- 1997-07-17 DE DE69713109T patent/DE69713109T2/de not_active Expired - Lifetime
- 1997-07-17 AT AT01123155T patent/ATE304528T1/de not_active IP Right Cessation
- 1997-07-17 AU AU34346/97A patent/AU3434697A/en not_active Abandoned
- 1997-07-17 JP JP50646598A patent/JP4425992B2/ja not_active Expired - Lifetime
- 1997-07-17 US US08/896,550 patent/US5922770A/en not_active Expired - Lifetime
- 1997-07-17 DE DE69734215T patent/DE69734215T2/de not_active Expired - Lifetime
- 1997-07-17 WO PCT/DK1997/000314 patent/WO1998003473A1/en active IP Right Grant
- 1997-07-17 AT AT97930368T patent/ATE218537T1/de not_active IP Right Cessation
- 1997-07-17 EP EP97930368A patent/EP0923539B1/de not_active Expired - Lifetime
- 1997-07-18 ZA ZA9706371A patent/ZA976371B/xx unknown
-
1999
- 1999-03-17 US US09/270,862 patent/US6127354A/en not_active Expired - Lifetime
-
2000
- 2000-07-19 US US09/619,227 patent/US6274584B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE69713109D1 (de) | 2002-07-11 |
EP0923539B1 (de) | 2002-06-05 |
EP0923539A1 (de) | 1999-06-23 |
EP1184370A3 (de) | 2002-03-27 |
ATE304528T1 (de) | 2005-09-15 |
DE69713109T2 (de) | 2003-01-02 |
AU3434697A (en) | 1998-02-10 |
US6127354A (en) | 2000-10-03 |
DE69734215D1 (de) | 2005-10-20 |
ZA976371B (en) | 1998-01-22 |
DE69734215T2 (de) | 2006-06-29 |
US6274584B1 (en) | 2001-08-14 |
EP1184370A2 (de) | 2002-03-06 |
JP4425992B2 (ja) | 2010-03-03 |
WO1998003473A1 (en) | 1998-01-29 |
US5922770A (en) | 1999-07-13 |
JP2000515517A (ja) | 2000-11-21 |
EP1184370B1 (de) | 2005-09-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |