DE69710573T2 - Morpholinyl-anthracyclinderivate - Google Patents

Morpholinyl-anthracyclinderivate

Info

Publication number
DE69710573T2
DE69710573T2 DE69710573T DE69710573T DE69710573T2 DE 69710573 T2 DE69710573 T2 DE 69710573T2 DE 69710573 T DE69710573 T DE 69710573T DE 69710573 T DE69710573 T DE 69710573T DE 69710573 T2 DE69710573 T2 DE 69710573T2
Authority
DE
Germany
Prior art keywords
anthracycline
morpholinyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69710573T
Other languages
English (en)
Other versions
DE69710573D1 (en
Inventor
Michele Caruso
Pierpaolo Lovisolo
Cristina Geroni
Antonino Suarato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nerviano Medical Sciences SRL
Original Assignee
Pharmacia Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Italia SpA filed Critical Pharmacia Italia SpA
Application granted granted Critical
Publication of DE69710573D1 publication Critical patent/DE69710573D1/de
Publication of DE69710573T2 publication Critical patent/DE69710573T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69710573T 1996-07-11 1997-06-20 Morpholinyl-anthracyclinderivate Expired - Lifetime DE69710573T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9614621A GB2315067B (en) 1996-07-11 1996-07-11 Morpholinyl anthracycline derivatives
PCT/EP1997/003252 WO1998002446A1 (en) 1996-07-11 1997-06-20 Morpholinyl anthracycline derivatives

Publications (2)

Publication Number Publication Date
DE69710573D1 DE69710573D1 (en) 2002-03-28
DE69710573T2 true DE69710573T2 (de) 2002-10-31

Family

ID=10796770

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69710573T Expired - Lifetime DE69710573T2 (de) 1996-07-11 1997-06-20 Morpholinyl-anthracyclinderivate

Country Status (5)

Country Link
EP (1) EP0889898B1 (de)
JP (1) JP4066389B2 (de)
DE (1) DE69710573T2 (de)
GB (1) GB2315067B (de)
WO (1) WO1998002446A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004082579A2 (en) * 2003-03-18 2004-09-30 Pharmacia Italia S.P.A. Nemorubicin as radiosensitizer in combination with radiation therapy against tumors
WO2009099741A1 (en) * 2008-02-01 2009-08-13 Genentech, Inc. Nemorubicin metabolite and analog reagents, antibody-drug conjugates and methods
KR101328315B1 (ko) * 2008-04-11 2013-11-11 티안진 헤메이 바이오-텍 컴퍼니 리미티드 고활성의 안트라사이클린 항생물질 유도체, 이의 제조방법 및 사용
EP2303332B1 (de) * 2008-07-15 2014-12-31 Genentech, Inc. Anthracyclinkonjugate, verfahren zu deren herstellung und deren verwendung als antitumormittel
EP2646456B1 (de) * 2010-12-02 2015-01-21 Nerviano Medical Sciences S.r.l. Verfahren zur herstellung von morpholinylanthracyclin-derivaten
DK2991993T3 (en) * 2013-04-29 2018-07-30 Nerviano Medical Sciences Srl NEW MORPHOLINYLANTHRACYCLINE DERIVATIVES
MX2016004285A (es) 2013-10-04 2016-07-08 Engeneic Molecular Delivery Pty Ltd Tratamiento de tumor por combinacion con minicelulas dirigidas a ligando, biespecificas, cargadas con farmacos e interferon-gamma.
CA2958479A1 (en) 2014-09-12 2016-03-17 Genentech, Inc. Anti-cll-1 antibodies and immunoconjugates
SI3191135T1 (sl) 2014-09-12 2021-01-29 Genentech, Inc. Anti-HER2 protitelesa in imunokonjugati
CN106714844B (zh) 2014-09-12 2022-08-05 基因泰克公司 蒽环类二硫化物中间体、抗体-药物缀合物和方法
WO2016051389A1 (en) 2014-10-03 2016-04-07 Engeneic Molecular Delivery Pty Ltd Enhanced loading of intact, bacterially derived vesicles with small molecule compounds
CN107001384A (zh) 2014-11-05 2017-08-01 内尔维阿诺医学科学有限公司 官能化的吗啉基蒽环类衍生物
MA43354A (fr) 2015-10-16 2018-08-22 Genentech Inc Conjugués médicamenteux à pont disulfure encombré
CN110776501B (zh) * 2019-08-22 2021-04-02 联宁（苏州）生物制药有限公司 一种用于抗体药物偶联物的药物毒素pnu-159682的制备方法及其中间体
EP4180061A1 (de) 2021-11-10 2023-05-17 Nerviano Medical Sciences S.r.l. Linker-reagenzien für anthracyclinderivate, antikörper-arznemittelkonjugate und verfahren
CN115043895A (zh) * 2022-07-15 2022-09-13 戊言医药科技（上海）有限公司 一种pnu-159682及其中间体的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826964A (en) * 1982-07-20 1989-05-02 Sri International Bridged oxygen analogs of daunorubcin and doxorubicin
US4585859A (en) * 1983-05-24 1986-04-29 Sri International Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin
JPS6297A (ja) * 1985-06-24 1987-01-06 Microbial Chem Res Found アントラサイクリン化合物
GB8606204D0 (en) * 1986-03-13 1986-04-16 Erba Farmitalia Biosynthetic anthracyclines
JP2779652B2 (ja) * 1988-12-27 1998-07-23 武田薬品工業株式会社 生理活性物質ｔａｎ―１１２０，その還元体，それらの製造法および用途ならびに微生物
GB2296495B (en) * 1994-12-23 1998-04-15 Erba Carlo Spa Anthracycline derivatives

Also Published As

Publication number Publication date
WO1998002446A1 (en) 1998-01-22
GB2315067A (en) 1998-01-21
GB9614621D0 (en) 1996-09-04
EP0889898A1 (de) 1999-01-13
EP0889898B1 (de) 2002-02-20
GB2315067B (en) 2000-02-16
JP4066389B2 (ja) 2008-03-26
DE69710573D1 (en) 2002-03-28
JPH11513040A (ja) 1999-11-09

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: PHARMACIA ITALIA S.P.A., MAILAND/MILANO, IT

8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: NERVIANO MEDICAL SCIENCES S.R.L., NERVIANO, MI, IT