DE69637140D1 - Verfahren zur herstellung einer epoxyverbindung - Google Patents

Verfahren zur herstellung einer epoxyverbindung

Info

Publication number
DE69637140D1
DE69637140D1 DE69637140T DE69637140T DE69637140D1 DE 69637140 D1 DE69637140 D1 DE 69637140D1 DE 69637140 T DE69637140 T DE 69637140T DE 69637140 T DE69637140 T DE 69637140T DE 69637140 D1 DE69637140 D1 DE 69637140D1
Authority
DE
Germany
Prior art keywords
sup
group
chr
hydroxyalkyl
hydroxycarbonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69637140T
Other languages
English (en)
Other versions
DE69637140T2 (de
Inventor
John S Ng
Ping T Wang
Julio A Baez
Chin Liu
Dennis K Anderson
Jon P Lawson
Dernhard Erb
Joseph Wieczorek
Gennaro Mucciariello
Fortunato Vanzanella
Sastry A Kunda
Leo J Letendre
Mark J Pozzo
Yuen-Lung L Sing
Edward E Yonan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Publication of DE69637140D1 publication Critical patent/DE69637140D1/de
Application granted granted Critical
Publication of DE69637140T2 publication Critical patent/DE69637140T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/001—Lactones
    • C07J21/003—Lactones at position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/005—Degradation of the lateral chains at position 17
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/06—Hydroxylating
    • C12P33/08—Hydroxylating at 11 position
    • C12P33/10—Hydroxylating at 11 position at 11 alpha-position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69637140T 1995-12-11 1996-12-11 Verfahren zur herstellung einer epoxy-verbindung Expired - Fee Related DE69637140T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US845595P 1995-12-11 1995-12-11
US8455P 1995-12-11
US08/763,910 US5981744A (en) 1995-12-11 1996-12-11 Processes for preparation of 9,11-epoxy steroids and intermediates useful therein
PCT/US1996/020780 WO1997021720A2 (en) 1995-12-11 1996-12-11 Processes for preparation of 7 alpha-carboxyl 9,11-epoxy steroids and intermediates useful therein and a general process for the epoxidation of olifinic double bonds
US763910 1996-12-11

Publications (2)

Publication Number Publication Date
DE69637140D1 true DE69637140D1 (de) 2007-08-02
DE69637140T2 DE69637140T2 (de) 2008-04-10

Family

ID=26678218

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69637140T Expired - Fee Related DE69637140T2 (de) 1995-12-11 1996-12-11 Verfahren zur herstellung einer epoxy-verbindung

Country Status (12)

Country Link
US (13) US5981744A (de)
EP (1) EP0973791B1 (de)
JP (2) JP4146897B2 (de)
CN (1) CN100384866C (de)
AT (1) ATE365171T1 (de)
DE (1) DE69637140T2 (de)
DK (1) DK0973791T3 (de)
EA (1) EA009176B1 (de)
ES (1) ES2287943T3 (de)
IL (2) IL124631A (de)
PT (1) PT973791E (de)
WO (1) WO1997021720A2 (de)

Families Citing this family (41)

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US20050267302A1 (en) * 1995-12-11 2005-12-01 G.D. Searle & Co. Eplerenone crystalline form exhibiting enhanced dissolution rate
US20020038021A1 (en) * 1995-12-11 2002-03-28 Barton Kathleen P. Eplerenone crystalline form exhibiting enhanced dissolution rate
US20020045746A1 (en) * 1995-12-11 2002-04-18 Barton Kathleen P. Eplerenone crystalline form
ATE365171T1 (de) 1995-12-11 2007-07-15 Searle Llc Verfahren zur herstellung einer epoxyverbindung
EP1223174A3 (de) * 1996-12-11 2005-03-16 G.D. Searle & Co. Verfahren zur Herstellung von 3-Keto-7alpha-alkoxycarbonyl- Delta4,5-steroiden sowie Zwischenprodukte davon
US6887991B1 (en) 1996-12-11 2005-05-03 G. D. Searle & Company Processes for preparation of 9, 11-epoxy steroids and intermediates useful therein
NZ336004A (en) 1996-12-11 2001-04-27 G Process for preparation of 3-keto-7-alpha-alkoxycarbonyl substituted delta-4,5-steroid by reacting 4,5-dihydro-5,7-lactone steroid substrate in the presence of a base
EP1832598A3 (de) * 1999-09-30 2008-01-02 Hollis-Eden Pharmaceuticals Inc. Therapeutische Behandlung von androgenrezeptorbedingten Leiden
US20030083493A1 (en) * 1999-12-08 2003-05-01 Barton Kathleen P. Eplerenone drug substance having high phase purity
CA2362845A1 (en) * 1999-12-08 2001-06-14 Pharmacia Corporation Eplerenone crystalline form
US6716829B2 (en) 2000-07-27 2004-04-06 Pharmacia Corporation Aldosterone antagonist and cyclooxygenase-2 inhibitor combination therapy to prevent or treat inflammation-related cardiovascular disorders
US7235655B2 (en) * 2002-03-22 2007-06-26 Pharmacia & Upjohn Company Processes to prepare eplerenone
PL372460A1 (en) * 2002-03-22 2005-07-25 Pharmacia Corporation C-17 spirolactonization and 6,7 oxidation of steroids
JP2006507369A (ja) * 2002-08-16 2006-03-02 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー ５−アンドロステン−３β−オールステロイド中間体およびそれらの製法
US20070066579A1 (en) * 2002-08-16 2007-03-22 White Michael J 5-androsten-3beta-ol steroid intermediates and processs for their preparation
AU2003213807A1 (en) * 2002-11-06 2004-06-03 Pharmacia & Upjohn Company Llc Processes for preparing 7-carboxy substituted steroids
ATE354583T1 (de) * 2002-11-07 2007-03-15 Pharmacia & Upjohn Co Llc Verfahren zur herstellung c-7 substituierter 5- androstene
CL2004000574A1 (es) * 2003-03-21 2005-02-11 Pharmacia Corp Sa Organizada B Proceso para preparar un compuesto 17-espirolactona o la sal de lactona abierta por carbonilacion del correspondiente 17-alquenil o alquinil derivado, los intermediarios que se usan y su proceso de obtencion.
US20040265948A1 (en) * 2003-06-27 2004-12-30 White Michael Jon Microbial method for hydrolysis and oxidation of androst-5-ene and pregn-5-ene steroid esters
WO2005016912A1 (en) * 2003-08-19 2005-02-24 Pfizer Inc. An efficient microbial preparation of capravirine metabolites m4 and m5
TW200602352A (en) * 2004-03-22 2006-01-16 Upjohn Co Improved process for the preparation of 9,11 epoxy steroids
CN1321128C (zh) * 2005-07-15 2007-06-13 浙江医药股份有限公司新昌制药厂 孕甾－4－烯－7，21－二甲酸，9，11－环氧－17－羟基－3－氧代，γ－内酯，甲酯，(7α,11α,17α)－的制备方法
WO2007025780A2 (en) * 2005-09-02 2007-03-08 Recordati Ireland Limited Aldosterone receptor antagonists
WO2008045323A2 (en) * 2006-10-06 2008-04-17 Health Research Inc. Method for determination of dht levels in tissue samples
US20080242856A1 (en) * 2007-04-02 2008-10-02 Funci Biotechnology Co., Ltd. Extracts of taiwanofungus camphoratus with a capacity for inhibiting the activity of matrix metalloproteinases and method for preparing the same
HU227304B1 (en) * 2007-07-04 2011-02-28 Richter Gedeon Nyrt Process for producing 9alpha-hydroxy-steroids
WO2010068500A2 (en) * 2008-11-25 2010-06-17 Evestra, Inc. PROGESTATIONAL 3-(6,6-ETHYLENE-17b-HYDROXY-3-OXO-17a-PREGNA-4-ENE-17a -YL) PROPIONIC ACID g-LACTONES
ES2641144T3 (es) 2010-05-10 2017-11-07 Inserm (Institut National De La Santé Et De La Recherche Medicale) Métodos y composiciones para el tratamiento de la acumulación de líquido en y/o bajo la retina
US9241944B2 (en) 2010-06-16 2016-01-26 Institut National De La Santé Et De La Recherche Médicale (Inserm) Methods and compositions for stimulating reepithelialisation during wound healing
CN104262450A (zh) * 2014-09-19 2015-01-07 江苏嘉逸医药有限公司 依普利酮的制备及精制方法
ES2699923T3 (es) 2014-10-17 2019-02-13 Ind Chimica Srl Proceso para la preparación de 7alfa-(metoxicarbonil)-3-oxo-17alfa-pregn-4,9(11)-dien-21,17-carbolactona, un intermedio útil para la síntesis de moléculas con actividad farmacológica
WO2016063269A1 (en) 2014-10-20 2016-04-28 Prendergast Patrick T Use of antagonists to the nuclear steroid receptor alone or in combination as direct antiviral agents to inhibit alphavirus, togaviridae, arenaviridae, filoviridae, bunyaviridae, flaviviridae and rhabdoviridae
WO2017055248A1 (en) 2015-09-28 2017-04-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of heart failure
ES2846835T3 (es) 2015-10-13 2021-07-29 Inst Nat Sante Rech Med Métodos y composiciones farmacéuticas para el tratamiento de la neovascularización coroidea
CN105753930A (zh) * 2016-03-30 2016-07-13 北京万全德众医药生物技术有限公司 依普利酮的一种合成方法
WO2018019843A1 (en) 2016-07-26 2018-02-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Antagonist of mineralocorticoid receptor for the treatment of osteoarthritis
CN106501388A (zh) * 2016-09-22 2017-03-15 北京万全德众医药生物技术有限公司 一种用气相色谱法分离测定依普利酮中三氯乙酰胺的方法
CN108085359B (zh) * 2016-11-22 2020-07-24 保定九孚生化有限公司 一种11α-羟基-4-烯-3,17-雄甾二酮的生产方法
CN110698529A (zh) * 2019-11-19 2020-01-17 湖南新合新生物医药有限公司 一种依普利酮中间体△9,11烯酯的制备方法
WO2023031277A1 (en) 2021-08-31 2023-03-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the treatment of ocular rosacea
CN114235976B (zh) * 2021-11-09 2023-11-03 暨南大学 一种含氮杂环有机化合物中间产物的合成和分析方法

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ATE365171T1 (de) 1995-12-11 2007-07-15 Searle Llc Verfahren zur herstellung einer epoxyverbindung

Also Published As

Publication number Publication date
IL175299A0 (en) 2006-09-05
JP2002504077A (ja) 2002-02-05
US20040191874A1 (en) 2004-09-30
US20020016455A1 (en) 2002-02-07
EA009176B1 (ru) 2007-12-28
US6630587B2 (en) 2003-10-07
ATE365171T1 (de) 2007-07-15
CN100384866C (zh) 2008-04-30
CN1209136A (zh) 1999-02-24
US6953851B2 (en) 2005-10-11
WO1997021720A3 (en) 1997-10-30
JP2008100996A (ja) 2008-05-01
EP0973791B1 (de) 2007-06-20
US20040067917A1 (en) 2004-04-08
US6180780B1 (en) 2001-01-30
PT973791E (pt) 2007-09-26
IL124631A (en) 2004-03-28
DE69637140T2 (de) 2008-04-10
DK0973791T3 (da) 2007-09-17
ES2287943T3 (es) 2007-12-16
US6335441B1 (en) 2002-01-01
US20020019522A1 (en) 2002-02-14
US6331622B1 (en) 2001-12-18
EA199800449A1 (ru) 1999-02-25
US20050239761A1 (en) 2005-10-27
US20070060746A1 (en) 2007-03-15
US5981744A (en) 1999-11-09
JP4146897B2 (ja) 2008-09-10
US6258946B1 (en) 2001-07-10
EP0973791A2 (de) 2000-01-26
WO1997021720A2 (en) 1997-06-19
US20030100541A1 (en) 2003-05-29
IL124631A0 (en) 1999-01-26
US20020042507A1 (en) 2002-04-11
US7129345B2 (en) 2006-10-31
US7038040B2 (en) 2006-05-02
US6586591B2 (en) 2003-07-01

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