DE69637136D1 - Screening von kombinatorischen Peptidbibliotheken zur Selektion von Peptidliganden zur Verwendung in der Affinitätsreinigung von Zielproteinen - Google Patents
Screening von kombinatorischen Peptidbibliotheken zur Selektion von Peptidliganden zur Verwendung in der Affinitätsreinigung von ZielproteinenInfo
- Publication number
- DE69637136D1 DE69637136D1 DE69637136T DE69637136T DE69637136D1 DE 69637136 D1 DE69637136 D1 DE 69637136D1 DE 69637136 T DE69637136 T DE 69637136T DE 69637136 T DE69637136 T DE 69637136T DE 69637136 D1 DE69637136 D1 DE 69637136D1
- Authority
- DE
- Germany
- Prior art keywords
- peptide
- target protein
- target
- peptides
- support material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B30/00—Methods of screening libraries
- C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/962—Prevention or removal of interfering materials or reactants or other treatment to enhance results, e.g. determining or preventing nonspecific binding
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/967—Standards, controls, materials, e.g. validation studies, buffer systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/807—Apparatus included in process claim, e.g. physical support structures
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/807—Apparatus included in process claim, e.g. physical support structures
- Y10S436/808—Automated or kit
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/815—Test for named compound or class of compounds
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/438,331 US5834318A (en) | 1995-05-10 | 1995-05-10 | Screening of combinatorial peptide libraries for selection of peptide ligand useful in affinity purification of target proteins |
US438331 | 1999-11-13 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69637136D1 true DE69637136D1 (de) | 2007-08-02 |
DE69637136T2 DE69637136T2 (de) | 2008-02-21 |
Family
ID=23740236
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69637136T Expired - Lifetime DE69637136T2 (de) | 1995-05-10 | 1996-04-29 | Screening von kombinatorischen Peptidbibliotheken zur Selektion von Peptidliganden zur Verwendung in der Affinitätsreinigung von Zielproteinen |
Country Status (10)
Country | Link |
---|---|
US (1) | US5834318A (de) |
EP (1) | EP0742438B1 (de) |
JP (1) | JPH09101306A (de) |
AT (1) | ATE365325T1 (de) |
AU (1) | AU716309B2 (de) |
CA (1) | CA2175868A1 (de) |
DE (1) | DE69637136T2 (de) |
DK (1) | DK0742438T3 (de) |
ES (1) | ES2289746T3 (de) |
PT (1) | PT742438E (de) |
Families Citing this family (75)
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US6277583B1 (en) * | 1996-02-07 | 2001-08-21 | Conjuchem, Inc. | Affinity labeling libraries and applications thereof |
WO1997033169A1 (en) * | 1996-03-08 | 1997-09-12 | Smithkline Beecham Corporation | A method for determining the affinity of proteins for chemical agents during screening of combinatorial libraries |
WO1998011437A1 (en) | 1996-09-16 | 1998-03-19 | Conjuchem, Inc. | Affinity labeling libraries with tagged leaving groups |
GB9800378D0 (en) * | 1998-01-08 | 1998-03-04 | Univ Liverpool | Proteome analysis |
US6287874B1 (en) | 1998-02-02 | 2001-09-11 | Signature Bioscience, Inc. | Methods for analyzing protein binding events |
CA2240325A1 (en) | 1998-03-27 | 1998-11-14 | Synsorb Biotech, Inc. | Methods for screening compound libraries |
US6613575B1 (en) | 1998-03-27 | 2003-09-02 | Ole Hindsgaul | Methods for screening compound libraries |
US6054047A (en) | 1998-03-27 | 2000-04-25 | Synsorb Biotech, Inc. | Apparatus for screening compound libraries |
US6720190B1 (en) | 1998-03-27 | 2004-04-13 | Ole Hindsgaul | Methods for screening compound libraries |
US6261848B1 (en) * | 1998-05-08 | 2001-07-17 | The Johns Hopkins University | Miniature immuno-optical rapid analyte sensor platform |
US6908770B1 (en) | 1998-07-16 | 2005-06-21 | Board Of Regents, The University Of Texas System | Fluid based analysis of multiple analytes by a sensor array |
US5994310A (en) * | 1998-09-03 | 1999-11-30 | Bayer Corporation | Peptide ligands for affinity purification of human Factor VIII |
US6864359B1 (en) | 1999-02-11 | 2005-03-08 | Xencor | Structure-based screening techniques for drug discovery |
CA2362541A1 (en) * | 1999-02-11 | 2000-08-17 | Xencor, Inc. | Structure-based screening techniques for drug discovery |
ATE376183T1 (de) * | 1999-04-15 | 2007-11-15 | Univ Virginia | Proteomabbau |
AU1429701A (en) | 1999-07-16 | 2001-02-05 | Board Of Regents, The University Of Texas System | General signaling protocols for chemical receptors in immobilized matrices |
DE19943743C2 (de) * | 1999-09-03 | 2002-02-07 | Jerini Biotools Gmbh | Verfahren zur Identifizierung von Bindungspartnern mit positions-spezifischen Arrays |
AU4309201A (en) * | 1999-12-02 | 2001-06-12 | V.I. Technologies, Inc. | Method of identifying a ligand for a target molecule |
AU2001247195A1 (en) | 2000-01-31 | 2001-08-07 | Board Of Regents, The University Of Texas System | Method and system for collecting and transmitting chemical information |
US6365355B1 (en) | 2000-03-28 | 2002-04-02 | The Regents Of The University Of California | Chimeric proteins for detection and quantitation of DNA mutations, DNA sequence variations, DNA damage and DNA mismatches |
EP1272509A2 (de) * | 2000-04-05 | 2003-01-08 | V.I. Technologies, Inc. | Peptidische bindstoffe für prione und verfahren zu deren verwendung |
EP2336166A1 (de) | 2000-10-12 | 2011-06-22 | University Of Rochester | Zusammensetzungen die die Proliferation von Krebszellen hemmen |
JP2004534519A (ja) * | 2000-11-17 | 2004-11-18 | アルフレッド イー. スランツ | 標的分子機能の決定と薬物リード化合物の同定に関する方法 |
CA2440582A1 (en) * | 2001-03-09 | 2002-10-03 | Dyax Corp. | Serum albumin binding moieties |
ATE434936T1 (de) | 2001-03-14 | 2009-07-15 | Myriad Genetics Inc | Tsg101-gag-wechselwirkung und ihre verwendung |
US7291456B2 (en) * | 2002-01-24 | 2007-11-06 | The Regents Of The University Of California | Method for determining differences in molecular interactions and for screening a combinatorial library |
WO2003062831A1 (en) * | 2002-01-24 | 2003-07-31 | The Regents Of The University Of California | Method for determining differences in molecular interactions and for screening a combinatorial library |
JP2005532263A (ja) | 2002-02-06 | 2005-10-27 | ヴァイコー テクノロジーズ, インコーポレイテッド | 抗梗塞分子 |
AU2003225008A1 (en) * | 2002-04-15 | 2003-11-03 | American National Red Cross | Plasma protein-binding ligands |
US20070015230A1 (en) * | 2002-04-15 | 2007-01-18 | Hammond David J | Identification and characterization of analytes from whole blood |
CA2523626A1 (en) | 2002-04-26 | 2003-11-06 | Board Of Regents, The University Of Texas System | Method and system for the detection of cardiac risk factors |
JP2006506058A (ja) * | 2002-05-17 | 2006-02-23 | アルフレッド イー. スラネッズ, | 標的機能を決定して薬物リードを同定するためのプロセス |
CA2490009A1 (en) * | 2002-06-21 | 2003-12-31 | Dyax Corporation | Serum protein-associated target-specific ligands and identification method therefor |
AU2003257181A1 (en) | 2002-08-05 | 2004-02-23 | University Of Rochester | Protein transducing domain/deaminase chimeric proteins, related compounds, and uses thereof |
NZ572892A (en) * | 2002-12-03 | 2010-03-26 | Univ North Carolina State | Prion protein ligands with the sequence YVHEA |
US20040142379A1 (en) | 2003-01-16 | 2004-07-22 | Carlsberg Research Laboratory | Affinity fishing for ligands and proteins receptors |
US7510848B2 (en) * | 2003-04-04 | 2009-03-31 | North Carolina State University | Prion protein binding materials and methods of use |
PT1615992E (pt) | 2003-04-04 | 2013-11-29 | Pathogen Removal & Diagnostic Technologies Inc | Materiais de ligação à proteína prião e métodos de utilização |
AU2004229535A1 (en) * | 2003-04-14 | 2004-10-28 | Pathogen Removal And Diagnostic Technologies, Inc. | Method for identifying ligands specific for structural isoforms of proteins |
WO2004097371A2 (en) * | 2003-04-25 | 2004-11-11 | Board Of Regents, The University Of Texas System | System and method for the detection of analytes |
US7651850B2 (en) | 2003-05-16 | 2010-01-26 | Board Of Regents, The University Of Texas System | Image and part recognition technology |
US9317922B2 (en) | 2003-05-16 | 2016-04-19 | Board Of Regents The University Of Texas System | Image and part recognition technology |
US20050059083A1 (en) * | 2003-09-15 | 2005-03-17 | Becton Dickinson And Company | High throughput method to identify ligands for cell attachment |
US8101431B2 (en) | 2004-02-27 | 2012-01-24 | Board Of Regents, The University Of Texas System | Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems |
US8105849B2 (en) | 2004-02-27 | 2012-01-31 | Board Of Regents, The University Of Texas System | Integration of fluids and reagents into self-contained cartridges containing sensor elements |
GB0416699D0 (en) * | 2004-07-27 | 2004-09-01 | Prometic Biosciences Ltd | Prion protein ligands and methods of use |
US7408030B2 (en) * | 2005-01-13 | 2008-08-05 | North Carolina State University | Purification of immunoglobulins using affinity chromatography and peptide ligands |
US7338775B1 (en) | 2005-02-09 | 2008-03-04 | Myriad Genetics, Inc. | Enzyme assay and use thereof |
JP4841618B2 (ja) * | 2005-03-23 | 2011-12-21 | バイオ−ラッド ラボラトリーズ インコーポレーティッド | タンパク質を精製するための方法 |
JP5129119B2 (ja) | 2005-04-05 | 2013-01-23 | コーニング インコーポレイテッド | 標識フリーバイオセンサおよび細胞 |
ES2431315T3 (es) | 2005-05-19 | 2013-11-26 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Epítopos funcionales del antígeno PsaA de Streptococcus pneumoniae y usos de los mismos |
US8377398B2 (en) | 2005-05-31 | 2013-02-19 | The Board Of Regents Of The University Of Texas System | Methods and compositions related to determination and use of white blood cell counts |
US8501939B2 (en) * | 2005-06-10 | 2013-08-06 | Prometic Biosciences Limited | Triazines and pyrimidines as protein binding ligands |
US8080534B2 (en) | 2005-10-14 | 2011-12-20 | Phigenix, Inc | Targeting PAX2 for the treatment of breast cancer |
EP2189522A1 (de) | 2005-10-14 | 2010-05-26 | MUSC Foundation For Research Development | PAX2 als Ziel zur Induktion einer Immunität gegen DEFB1-vermittelte Tumore und bei der Krebstherapie |
JP5926475B2 (ja) | 2006-09-21 | 2016-05-25 | ユニバーシティー オブ ロチェスター | 筋緊張性ジストロフィーのためのタンパク質置換治療に関する組成物および方法 |
WO2008136852A2 (en) | 2006-11-01 | 2008-11-13 | University Of Rochester | Methods and compositions related to the structure and function of apobec3g |
EP2099957A1 (de) * | 2007-01-10 | 2009-09-16 | GE Healthcare Bio-Sciences AB | Multimodale ionenaustausch-chromotographie-harze |
CA2677665C (en) | 2007-02-08 | 2019-11-05 | University Of Utah Research Foundation | Methods and compositions related to inhibition of viral entry |
WO2010027641A2 (en) | 2008-08-15 | 2010-03-11 | Georgetown University | Na channels, disease, and related assays and compositions |
WO2010065617A1 (en) | 2008-12-02 | 2010-06-10 | University Of Utah Research Foundation | Pde1 as a target therapeutic in heart disease |
KR101183159B1 (ko) * | 2008-12-22 | 2012-09-17 | 한국전자통신연구원 | 바이오 칩 및 이를 이용한 바이오 물질 검출 장치 |
US20120149663A1 (en) | 2009-08-18 | 2012-06-14 | Georgetown University | Boronic acid compositions and methods related to cancer |
WO2011043980A1 (en) | 2009-10-07 | 2011-04-14 | Sanford Burnham Medical Research Institute | Methods and compositions related to clot-binding lipid compounds |
US20130224730A1 (en) * | 2009-11-18 | 2013-08-29 | Arizona Board Of Regents Acting For And On Behalf Of Arizona State University | Peptide ligands |
US8912136B2 (en) | 2009-12-18 | 2014-12-16 | Sanford-Burnham Medical Research Institute | Methods and compositions related to clot-binding compounds |
US20130224116A1 (en) | 2010-11-05 | 2013-08-29 | TransBio Ltd. | Markers of Endothelial Progenitor Cells and Uses Thereof |
EP2688911B1 (de) | 2011-03-24 | 2017-08-02 | OPKO Pharmaceuticals, LLC | Biomarkerermittlung in komplexen biologischen Flüssigkeiten mittels auf Kügelchen oder Partikeln basierenden Bibliotheken |
JP6205345B2 (ja) | 2011-03-28 | 2017-09-27 | ユニヴァーシティー オブ ユタ リサーチ ファウンデーション | ウイルス侵入の阻害に関する方法および組成物 |
CA2873511A1 (en) | 2012-05-17 | 2013-11-21 | Ra Pharmaceuticals, Inc. | Peptide and peptidomimetic inhibitors |
CN103513039B (zh) * | 2013-07-10 | 2015-12-23 | 广州美格生物科技有限公司 | 一种利用定向肽库检测蛋白质与其他分子相互作用的方法 |
PT3628680T (pt) | 2014-06-12 | 2021-10-07 | Ra Pharmaceuticals Inc | Modulação da atividade do complemento |
JP6640229B2 (ja) | 2015-01-28 | 2020-02-05 | ラ ファーマシューティカルズ インコーポレイテッドRa Pharmaceuticals,Inc. | 補体活性の変調剤 |
MX2018007352A (es) | 2015-12-16 | 2019-05-16 | Ra Pharmaceuticals Inc | Moduladores de la actividad del complemento. |
MX2019006527A (es) | 2016-12-07 | 2019-08-01 | Ra Pharmaceuticals Inc | Moduladores de la actividad del complemento. |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5133866A (en) * | 1988-03-24 | 1992-07-28 | Terrapin Technologies, Inc. | Method to identify analyte-bending ligands |
US5650489A (en) * | 1990-07-02 | 1997-07-22 | The Arizona Board Of Regents | Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof |
EP0473065A3 (en) * | 1990-08-29 | 1992-08-26 | Abbott Laboratories | Simultaneous assay for detecting two or more analytes |
-
1995
- 1995-05-10 US US08/438,331 patent/US5834318A/en not_active Expired - Lifetime
-
1996
- 1996-04-29 DK DK96106717T patent/DK0742438T3/da active
- 1996-04-29 AT AT96106717T patent/ATE365325T1/de active
- 1996-04-29 PT PT96106717T patent/PT742438E/pt unknown
- 1996-04-29 DE DE69637136T patent/DE69637136T2/de not_active Expired - Lifetime
- 1996-04-29 ES ES96106717T patent/ES2289746T3/es not_active Expired - Lifetime
- 1996-04-29 EP EP96106717A patent/EP0742438B1/de not_active Expired - Lifetime
- 1996-05-06 CA CA002175868A patent/CA2175868A1/en not_active Abandoned
- 1996-05-06 AU AU52087/96A patent/AU716309B2/en not_active Ceased
- 1996-05-07 JP JP8135710A patent/JPH09101306A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP0742438B1 (de) | 2007-06-20 |
PT742438E (pt) | 2007-09-21 |
ES2289746T3 (es) | 2008-02-01 |
DE69637136T2 (de) | 2008-02-21 |
JPH09101306A (ja) | 1997-04-15 |
ATE365325T1 (de) | 2007-07-15 |
EP0742438A3 (de) | 1998-04-08 |
CA2175868A1 (en) | 1996-11-11 |
EP0742438A2 (de) | 1996-11-13 |
US5834318A (en) | 1998-11-10 |
DK0742438T3 (da) | 2007-10-29 |
AU716309B2 (en) | 2000-02-24 |
AU5208796A (en) | 1996-11-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |