DE69635447D1 - Plasma-kallikrein inhibitoren vom kunitz-typ - Google Patents

Plasma-kallikrein inhibitoren vom kunitz-typ

Info

Publication number
DE69635447D1
DE69635447D1 DE69635447A DE69635447A DE69635447D1 DE 69635447 D1 DE69635447 D1 DE 69635447D1 DE 69635447 A DE69635447 A DE 69635447A DE 69635447 A DE69635447 A DE 69635447A DE 69635447 D1 DE69635447 D1 DE 69635447D1
Authority
DE
Germany
Prior art keywords
plasma kallikrein
kallikrein inhibitors
kunitz type
inhibitors
kunitz
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69635447A
Other languages
English (en)
Other versions
DE69635447T4 (de
DE69635447T2 (de
Inventor
S Dennis
A Lazarus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of DE69635447D1 publication Critical patent/DE69635447D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE69635447A 1995-06-05 1996-06-04 Plasma-kallikrein inhibitoren vom kunitz-typ Expired - Fee Related DE69635447D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/463,155 US5780265A (en) 1995-06-05 1995-06-05 Kunitz type plasma kallikrein inhibitors
PCT/US1996/009059 WO1996039519A1 (en) 1995-06-05 1996-06-04 Kunitz type plasma kallikrein inhibitors

Publications (1)

Publication Number Publication Date
DE69635447D1 true DE69635447D1 (de) 2005-12-22

Family

ID=23839061

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69635447T Expired - Lifetime DE69635447T4 (de) 1995-06-05 1996-06-04 Plasma-kallikrein inhibitoren vom kunitz-typ
DE69635447A Expired - Fee Related DE69635447D1 (de) 1995-06-05 1996-06-04 Plasma-kallikrein inhibitoren vom kunitz-typ

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69635447T Expired - Lifetime DE69635447T4 (de) 1995-06-05 1996-06-04 Plasma-kallikrein inhibitoren vom kunitz-typ

Country Status (10)

Country Link
US (1) US5780265A (de)
EP (1) EP0832232B9 (de)
JP (1) JPH11511963A (de)
AT (1) ATE310087T1 (de)
AU (1) AU6048296A (de)
CA (1) CA2220130A1 (de)
DE (2) DE69635447T4 (de)
IL (1) IL122116A0 (de)
WO (1) WO1996039519A1 (de)
ZA (1) ZA964608B (de)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060134087A1 (en) * 1988-09-02 2006-06-22 Dyax Corp. ITI-D1 Kunitz domain mutants as hNE inhibitors
US6057287A (en) * 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
ATE277081T1 (de) * 1994-01-11 2004-10-15 Dyax Corp Inhibitoren des humanplasmins, die sich von den kunitz domänen ableiten
ZA963619B (en) 1995-05-08 1996-11-22 Scios Inc Protease inhibitor peptides
JP2001515044A (ja) 1997-08-14 2001-09-18 ザ・レジェンツ・オブ・ザ・ユニバーシティー・オブ・カリフォルニア 蛍光アミロイドＡβペプチドとその使用
JP3626982B2 (ja) * 1997-08-29 2005-03-09 アークレイ株式会社 タンパク質分解酵素阻害物質の測定方法およびそれに用いる測定キット
US6087473A (en) * 1999-05-26 2000-07-11 Zymogenetics, Inc. Kunitz domain polypeptide and materials and methods for making it
US6380354B1 (en) 1998-09-03 2002-04-30 Zymogenetics, Inc. Kunitz domain polypeptide zkun6
CN1550235A (zh) * 1999-04-29 2004-12-01 ŵ��Ų�ڿ˹�˾ 结合肝素的拮抗剂在缓激肽释放的抑制中的应用
EP1674110A1 (de) * 1999-04-29 2006-06-28 Novo Nordisk A/S Inhibierung der Freisetzung von Bradykinin
US20060154319A1 (en) * 1999-04-29 2006-07-13 Flodgaard Hans J Inhibition of bradykinin release
JP2002346015A (ja) * 2001-05-28 2002-12-03 Hiroaki Yoshiike スイング診断装置
WO2003012450A1 (en) * 2001-08-02 2003-02-13 The Scripps Research Institute Diagnostic markers of liver dysfunction
PT2311432E (pt) 2002-06-07 2015-02-09 Dyax Corp Polipeptídeos de domínio kunitz modificado e sua utilização para a redução de isquemia ou aparecimento de uma resposta inflamatória sistémica associada a um procedimento cirúrgico
US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
ES2395014T3 (es) * 2002-08-28 2013-02-07 Dyax Corp. Métodos para conservar órganos y tejidos
DK1583562T3 (da) * 2003-01-06 2011-09-19 Angiochem Inc Angiopep-1, beslægtede forbindelser og anvendelser deraf
US6989369B2 (en) * 2003-02-07 2006-01-24 Dyax Corp. Kunitz domain peptides
JP4739207B2 (ja) * 2003-08-29 2011-08-03 ダイアックス コーポレーション ポリペグ化されたプロテアーゼインヒビター
US7235530B2 (en) * 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
DK1859041T4 (en) * 2005-02-18 2015-02-09 Angiochem Inc APROTINE POLYPEPTIDES FOR TRANSPORTING A BLOOD-BRAIN BARRIER CONNECTION
US20090016959A1 (en) * 2005-02-18 2009-01-15 Richard Beliveau Delivery of antibodies to the central nervous system
US8841259B2 (en) * 2005-02-24 2014-09-23 Joslin Diabetes Center Compositions and methods for treating vascular permeability
PT2233156E (pt) 2005-07-15 2013-07-31 Angiochem Inc Uso de polipéptidos de aprotinina como transportadores em conjugados farmacêuticos
WO2007079096A2 (en) 2005-12-29 2007-07-12 Dyax Corp. Protease inhibition
JP2009529542A (ja) * 2006-03-10 2009-08-20 ダイアックス コーポレーション エカランチドに関する配合物
WO2008091692A2 (en) * 2007-01-25 2008-07-31 Joslin Diabetes Center, Inc. Methods of diagnosing, treating, and preventing increased vascular permeability
US9365634B2 (en) * 2007-05-29 2016-06-14 Angiochem Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
PL2164866T3 (pl) 2007-05-29 2014-10-31 Angiochem Inc Polipeptydy podobne do aprotyniny do dostarczania skoniugowanych z nimi środków do tkanek
EP2279008B1 (de) 2008-04-18 2019-03-06 Angiochem Inc. Pharmazeutische zusammensetzungen von paclitaxel, paclitaxel-analoga oder paclitaxel-konjugaten und relevante herstellungs- und anwendungsverfahren
JP2012505637A (ja) 2008-10-15 2012-03-08 アンジオケム，インコーポレーテッド Ｇｌｐ−１アゴニストのコンジュゲート及びその使用
AU2009304505A1 (en) 2008-10-15 2010-04-22 Angiochem Inc. Etoposide and doxorubicin conjugates for drug delivery
CN102307904A (zh) * 2008-12-05 2012-01-04 安吉奥开米公司 神经降压素或神经降压素类似物的缀合物及其用途
MX2011006685A (es) 2008-12-17 2011-09-27 Angiochem Inc Inhibidores de metaloproteinas de matriz de membrana tipo-1 y sus usos.
WO2010080833A1 (en) * 2009-01-06 2010-07-15 Dyax Corp. Treatment of mucositis with kallikrein inhibitors
EP2421562B1 (de) 2009-04-20 2019-03-13 Angiochem Inc. Behandlung von ovarialkarzinom mit einem an ein angiopep-2-analogon konjugierten antitumorwirkstoff
IN2012DN00248A (de) 2009-07-02 2015-05-01 Angiochem Inc
CA3021759A1 (en) * 2010-01-06 2011-07-14 Dyax Corp. Plasma kallikrein binding proteins
WO2011153642A1 (en) * 2010-06-10 2011-12-15 Angiochem Inc. Leptin and leptin analog conjugates and fusion proteins and uses thereof
KR102320178B1 (ko) 2011-01-06 2021-11-02 다케다 파머수티컬 컴패니 리미티드 혈장 칼리크레인 결합 단백질
IL295414A (en) 2014-03-27 2022-10-01 Takeda Pharmaceuticals Co Compositions and methods for treating macular edema as a result of diabetes
CA2989400A1 (en) 2015-06-15 2016-12-22 Angiochem Inc. Ang1005 for the treatment of leptomeningeal carcinomatosis
JP7003354B2 (ja) 2015-12-11 2022-03-04 武田薬品工業株式会社 遺伝性血管性浮腫の発作を治療するための血漿カリクレイン阻害薬およびその用途
WO2021217053A1 (en) * 2020-04-24 2021-10-28 Rezolute, Inc. Plasma kallikrein inhibitors for the treatment of ards and related conditions

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2188322A (en) * 1986-03-26 1987-09-30 Bayer Ag Aprotinin and analogues thereof produced by a recombinant host
IT1214523B (it) * 1986-09-15 1990-01-18 Montedison Spa Copolieteri liquido cristallini.
US5223482A (en) * 1986-11-17 1993-06-29 Scios Nova Inc. Recombinant Alzheimer's protease inhibitory amyloid protein and method of use
GB2208511A (en) * 1987-08-07 1989-04-05 Bayer Ag Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology
DK225488D0 (da) * 1988-04-26 1988-04-26 Novo Industri As Polypeptid
US5663143A (en) * 1988-09-02 1997-09-02 Dyax Corp. Engineered human-derived kunitz domains that inhibit human neutrophil elastase
DE3912638A1 (de) * 1989-04-18 1990-10-31 Bayer Ag Gentechnologisch hergestellte homologe des alzheimer protease inhibitors, wirtstaemme sowie expressionsvektoren fuer ihre herstellung und ihre verwendung als arzneimittel
DE3930522A1 (de) * 1989-09-13 1991-03-21 Bayer Ag Rekombinante aprotinin-varianten - gentechnisches verfahren zur mikrobiellen herstellung von homogen prozessierten aprotinin-varianten sowie die therapeutische anwendung derselben
JPH04166087A (ja) * 1990-10-26 1992-06-11 Asahi Chem Ind Co Ltd 新規な蛋白
IL104314A0 (en) * 1992-01-07 1993-05-13 Novo Nordisk As Human kunitz-type protease inhibitor and variants thereof,their production and pharmaceutical compositions containing them
IL104326A0 (en) * 1992-01-07 1993-05-13 Novo Nordisk As Variant of human kunitz-type protease inhibitor
IL104324A0 (en) * 1992-01-07 1993-05-13 Novo Nordisk As Variant of human kunitz-type protease inhibitor
IL104327A0 (en) * 1992-01-07 1993-05-13 Novo Nordisk As Variant of human kunitz-type protease inhibitor
IL104325A (en) * 1992-01-07 2000-10-31 Novo Nordisk As Variants of human kunitz-type protease inhibitor domain II of tissue factor pathway inhibitor (TFPI) pharmaceutical compositions containing them a DNA construct encoding them their expression vectors a cell containing said DNA constructs and methods for the production of all the above
WO1993014199A1 (en) * 1992-01-13 1993-07-22 Abbott Laboratories A pump-1 catalyzed method of making low molecular weight urokinase-type plasminogen activator
US5455338A (en) * 1993-11-05 1995-10-03 Zymogenetics, Inc. DNA encoding novel human kunitz-type inhibitors and methods relating thereto
DK0739355T3 (da) * 1994-01-11 2005-01-24 Dyax Corp Kallikrein-inhiberende "Kunitz-domæne"-proteiner og analoger deraf
US5795954A (en) * 1994-03-04 1998-08-18 Genentech, Inc. Factor VIIa inhibitors from Kunitz domain proteins

Also Published As

Publication number Publication date
DE69635447T4 (de) 2007-05-10
CA2220130A1 (en) 1996-12-12
JPH11511963A (ja) 1999-10-19
DE69635447T2 (de) 2006-08-10
WO1996039519A1 (en) 1996-12-12
ATE310087T1 (de) 2005-12-15
IL122116A0 (en) 1998-04-05
EP0832232B1 (de) 2005-11-16
EP0832232A1 (de) 1998-04-01
EP0832232B9 (de) 2006-09-06
US5780265A (en) 1998-07-14
AU6048296A (en) 1996-12-24
ZA964608B (en) 1997-12-04

Similar Documents

Publication Publication Date Title
ATE310087T1 (de) Plasma-kallikrein inhibitoren vom kunitz-typ
MX9603775A (es) Proteinas inhibidoras del dominio de kunitz, derivadas del inhibidor del precursor de la beta-proteina amiloide de alzheimer.
TR199801151T2 (xx) Trombin inhibit�r� �n ila�lar.
ES2191102T3 (es) Heterociclos de peptidilo utiles en el tratamiento de las afecciones relacionadas con la trombina.
SI1509232T1 (sl) Kombinacija antagonista nmda in zaviralcev acetilholinesteraze za zdravljenje alzheimerjeve bolezni
ES2066033T3 (es) Inhibidores de las proteinasas, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
NO20032254D0 (no) Forbindelser for inhibering av ekspresjon av VACM-I
NO20061736L (no) Krystallform av epotilon B
BR0207961A (pt) Combinação de análogos da epotilona e agentes quimioterápicos para o tratamento de doenças proliferativas
ATE226636T1 (de) Serpin-resistenter t-pa; mutanten; gene
HUP0100669A3 (en) Peptide derivatives as serine protease inhibitors, their use and pharmaceutical compositions comprising thereof
NO996578L (no) Urokinase-inhibitorer
TR200101120T2 (tr) Serin proteaz inhibitörü
BR9815469A (pt) Inibidores de protease
DK0662948T3 (da) 2-amino-4-phenyl-4-oxosmørsyrederivater med kynureninase- og/eller kynurenin-3-hydroxylaseinhiberende virkning
HK1016495A1 (en) Phosphorous-containing cysteine and serine protease inhibitors
PT831826E (pt) Composicao farmaceutica que inclui um inibidor de proteinase e um monoglicerideo
HK1029936A1 (en) Quinoline-containing alpha-ketoamide cysteine and serine protease inhibitors
ZA923602B (en) Inhibitors of cathepsin g and elastase for preventing connective tissue degradation
ATE282607T1 (de) Tryptase-inhibitoren
HUP0401854A2 (hu) COX-2 inhibitorokat és aszpirint tartalmazó kombinációk
ES2195025T3 (es) Proteinas de fusion de un dominio de factor tisular-dominio de kunitz como inhibidores del factor viia.
TR200000954T2 (tr) Mikrodolaşım hastalıklarının tedavisi ve önlenmesi için madde.
FI951078A0 (fi) Retrovirusinfektion inhibitio
WO2003028621A3 (de) Proteinaseinhibitoren zur therapie und diagnose von neurodegenerativen erkrankungen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee