DE69635447D1 - PLASMA KALLIKREIN INHIBITORS OF KUNITZ TYPE - Google Patents

PLASMA KALLIKREIN INHIBITORS OF KUNITZ TYPE

Info

Publication number
DE69635447D1
DE69635447D1 DE69635447A DE69635447A DE69635447D1 DE 69635447 D1 DE69635447 D1 DE 69635447D1 DE 69635447 A DE69635447 A DE 69635447A DE 69635447 A DE69635447 A DE 69635447A DE 69635447 D1 DE69635447 D1 DE 69635447D1
Authority
DE
Germany
Prior art keywords
plasma kallikrein
kallikrein inhibitors
kunitz type
inhibitors
kunitz
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69635447A
Other languages
German (de)
Other versions
DE69635447T2 (en
DE69635447T4 (en
Inventor
S Dennis
A Lazarus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of DE69635447D1 publication Critical patent/DE69635447D1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Potent and specific serine protease inhibitors are provided that are capable of inhibiting plasma kallikrein. The inhibitors are provided in pharmaceutical compositions for the treatment of diseases and disorders where inhibition of plasma kallikrein in indicated.
DE69635447A 1995-06-05 1996-06-04 PLASMA KALLIKREIN INHIBITORS OF KUNITZ TYPE Expired - Fee Related DE69635447D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/463,155 US5780265A (en) 1995-06-05 1995-06-05 Kunitz type plasma kallikrein inhibitors
PCT/US1996/009059 WO1996039519A1 (en) 1995-06-05 1996-06-04 Kunitz type plasma kallikrein inhibitors

Publications (1)

Publication Number Publication Date
DE69635447D1 true DE69635447D1 (en) 2005-12-22

Family

ID=23839061

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69635447A Expired - Fee Related DE69635447D1 (en) 1995-06-05 1996-06-04 PLASMA KALLIKREIN INHIBITORS OF KUNITZ TYPE
DE69635447T Expired - Lifetime DE69635447T4 (en) 1995-06-05 1996-06-04 PLASMA KALLIKREIN INHIBITORS OF KUNITZ TYPE

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69635447T Expired - Lifetime DE69635447T4 (en) 1995-06-05 1996-06-04 PLASMA KALLIKREIN INHIBITORS OF KUNITZ TYPE

Country Status (10)

Country Link
US (1) US5780265A (en)
EP (1) EP0832232B9 (en)
JP (1) JPH11511963A (en)
AT (1) ATE310087T1 (en)
AU (1) AU6048296A (en)
CA (1) CA2220130A1 (en)
DE (2) DE69635447D1 (en)
IL (1) IL122116A0 (en)
WO (1) WO1996039519A1 (en)
ZA (1) ZA964608B (en)

Families Citing this family (44)

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US20060134087A1 (en) * 1988-09-02 2006-06-22 Dyax Corp. ITI-D1 Kunitz domain mutants as hNE inhibitors
US6057287A (en) * 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
PT737207E (en) * 1994-01-11 2005-02-28 Dyax Corp HUMAN PLASMA INHIBITORS DERIVED FROM KUNITZ DOMAINS
ZA963619B (en) 1995-05-08 1996-11-22 Scios Inc Protease inhibitor peptides
EP1003539A4 (en) 1997-08-14 2002-09-11 Univ California FLUORESCENT AMYLOID A beta PEPTIDES AND USES THEREOF
JP3626982B2 (en) * 1997-08-29 2005-03-09 アークレイ株式会社 Method for measuring proteolytic enzyme inhibitor and measurement kit used therefor
US6087473A (en) 1999-05-26 2000-07-11 Zymogenetics, Inc. Kunitz domain polypeptide and materials and methods for making it
US6380354B1 (en) 1998-09-03 2002-04-30 Zymogenetics, Inc. Kunitz domain polypeptide zkun6
IL145894A0 (en) * 1999-04-29 2002-07-25 Novo Nordisk As Use of heparin-binding antagonists in the inhibition of bradykinin release
EP1674110A1 (en) * 1999-04-29 2006-06-28 Novo Nordisk A/S Inhibition of bradykinin release
US20060154319A1 (en) * 1999-04-29 2006-07-13 Flodgaard Hans J Inhibition of bradykinin release
JP2002346015A (en) * 2001-05-28 2002-12-03 Hiroaki Yoshiike Swing diagnostic device
WO2003012450A1 (en) * 2001-08-02 2003-02-13 The Scripps Research Institute Diagnostic markers of liver dysfunction
US7153829B2 (en) * 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
JP2005534647A (en) 2002-06-07 2005-11-17 ダイアックス、コープ Prevention and reduction of blood loss
US7166576B2 (en) * 2002-08-28 2007-01-23 Dyax Corp. Methods for preserving organs and tissues
EP1583562B1 (en) * 2003-01-06 2011-06-15 Angiochem Inc. Angiopep-1, related compounds, and uses thereof
US6989369B2 (en) * 2003-02-07 2006-01-24 Dyax Corp. Kunitz domain peptides
CA2536873C (en) * 2003-08-29 2019-09-10 Dyax Corp. Poly-pegylated protease inhibitors
US7235530B2 (en) * 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
US20090016959A1 (en) * 2005-02-18 2009-01-15 Richard Beliveau Delivery of antibodies to the central nervous system
PT2360258E (en) * 2005-02-18 2015-01-13 Angiochem Inc Aprotinin polypeptides for transporting a compound across the blood-brain barrier
WO2006091459A2 (en) 2005-02-24 2006-08-31 Joslin Diabetes Center, Inc. Compositions and methods for treating vascular permeability
DK2433653T3 (en) 2005-07-15 2019-08-19 Angiochem Inc Use of aprotinin polypeptides as carriers in pharmaceutical conjugates
SI1981519T1 (en) 2005-12-29 2018-05-31 Dyax Corp. Protease inhibition
EP2001500A4 (en) * 2006-03-10 2010-07-28 Dyax Corp Formulations for ecallantide
US20100119512A1 (en) * 2007-01-25 2010-05-13 Joslin Diabetes Center Methods of diagnosing, treating, and preventing increased vascular permeability
US9365634B2 (en) * 2007-05-29 2016-06-14 Angiochem Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
CA2688344C (en) 2007-05-29 2019-09-03 Angiochem, Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
TR201905480T4 (en) * 2008-04-18 2019-05-21 Angiochem Inc Pharmaceutical compositions of paclitaxel, paclitaxel analogs or paclitaxel conjugates and their respective preparation and use methods.
EP2346896A4 (en) 2008-10-15 2014-06-25 Angiochem Inc Etoposide and doxorubicin conjugates for drug delivery
CA2740316A1 (en) 2008-10-15 2010-04-22 Angiochem Inc. Conjugates of glp-1 agonists and uses thereof
BRPI0922689A2 (en) * 2008-12-05 2018-11-06 Angiochem Inc. neurotensin conjugates or neurotensin analogs and uses thereof
CN102300987A (en) 2008-12-17 2011-12-28 安吉奥开米公司 Membrane Type-1 Matrix Metalloprotein Inhibitors And Uses Thereof
AU2010203712A1 (en) * 2009-01-06 2010-07-15 Dyax Corp. Treatment of mucositis with kallikrein inhibitors
RU2011146654A (en) 2009-04-20 2013-05-27 Ангиокем Инк. METHODS FOR TREATING OVARIAN CANCER USING CONJUGATED PRODUCT
IN2012DN00248A (en) 2009-07-02 2015-05-01 Angiochem Inc
SI2521568T1 (en) * 2010-01-06 2019-01-31 Dyax Corp. Plasma kallikrein binding proteins
WO2011153642A1 (en) * 2010-06-10 2011-12-15 Angiochem Inc. Leptin and leptin analog conjugates and fusion proteins and uses thereof
CN103635489B (en) 2011-01-06 2016-04-13 戴埃克斯有限公司 Blood plasma prekallikrein associated proteins
CN106459210A (en) 2014-03-27 2017-02-22 戴埃克斯有限公司 Compositions and methods for treatment of diabetic macular edema
CA2989400A1 (en) 2015-06-15 2016-12-22 Angiochem Inc. Ang1005 for the treatment of leptomeningeal carcinomatosis
EA201891388A1 (en) 2015-12-11 2018-11-30 Дайэкс Корп. PLASMA KALLIKREIN INHIBITORS AND THEIR APPLICATION FOR THE TREATMENT OF THE EXPOSURE OF HEREDITARY ANGIONEUROTIC DOMESTIC
WO2021217053A1 (en) * 2020-04-24 2021-10-28 Rezolute, Inc. Plasma kallikrein inhibitors for the treatment of ards and related conditions

Family Cites Families (18)

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Publication number Priority date Publication date Assignee Title
GB2188322A (en) * 1986-03-26 1987-09-30 Bayer Ag Aprotinin and analogues thereof produced by a recombinant host
IT1214523B (en) * 1986-09-15 1990-01-18 Montedison Spa CRYSTALLINE LIQUID COPOLERS.
US5223482A (en) * 1986-11-17 1993-06-29 Scios Nova Inc. Recombinant Alzheimer's protease inhibitory amyloid protein and method of use
GB2208511A (en) * 1987-08-07 1989-04-05 Bayer Ag Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology
DK225488D0 (en) * 1988-04-26 1988-04-26 Novo Industri As POLYPEPTIDE
US5663143A (en) * 1988-09-02 1997-09-02 Dyax Corp. Engineered human-derived kunitz domains that inhibit human neutrophil elastase
DE3912638A1 (en) * 1989-04-18 1990-10-31 Bayer Ag GENETICALLY MANUFACTURED HOMOLOGE OF THE ALZHEIMER PROTEASE INHIBITOR, WIRSTSTAEMME AND EXPRESSION VECTORS FOR THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS
DE3930522A1 (en) * 1989-09-13 1991-03-21 Bayer Ag RECOMBINANT APROTININ VARIANTS - GENETIC METHOD FOR MICROBIAL PRODUCTION OF HOMOGENEOUS APROTININ VARIANTS, AND THE THERAPEUTIC APPLICATION THEREOF
JPH04166087A (en) * 1990-10-26 1992-06-11 Asahi Chem Ind Co Ltd New protein
IL104325A (en) * 1992-01-07 2000-10-31 Novo Nordisk As Variants of human kunitz-type protease inhibitor domain II of tissue factor pathway inhibitor (TFPI) pharmaceutical compositions containing them a DNA construct encoding them their expression vectors a cell containing said DNA constructs and methods for the production of all the above
IL104324A0 (en) * 1992-01-07 1993-05-13 Novo Nordisk As Variant of human kunitz-type protease inhibitor
IL104314A0 (en) * 1992-01-07 1993-05-13 Novo Nordisk As Human kunitz-type protease inhibitor and variants thereof,their production and pharmaceutical compositions containing them
IL104326A0 (en) * 1992-01-07 1993-05-13 Novo Nordisk As Variant of human kunitz-type protease inhibitor
IL104327A0 (en) * 1992-01-07 1993-05-13 Novo Nordisk As Variant of human kunitz-type protease inhibitor
WO1993014199A1 (en) * 1992-01-13 1993-07-22 Abbott Laboratories A pump-1 catalyzed method of making low molecular weight urokinase-type plasminogen activator
US5455338A (en) * 1993-11-05 1995-10-03 Zymogenetics, Inc. DNA encoding novel human kunitz-type inhibitors and methods relating thereto
DK0739355T3 (en) * 1994-01-11 2005-01-24 Dyax Corp Kallikrein-inhibiting "Kunitz domain" proteins and analogs thereof
US5795954A (en) * 1994-03-04 1998-08-18 Genentech, Inc. Factor VIIa inhibitors from Kunitz domain proteins

Also Published As

Publication number Publication date
EP0832232B1 (en) 2005-11-16
US5780265A (en) 1998-07-14
ATE310087T1 (en) 2005-12-15
DE69635447T2 (en) 2006-08-10
WO1996039519A1 (en) 1996-12-12
ZA964608B (en) 1997-12-04
EP0832232A1 (en) 1998-04-01
CA2220130A1 (en) 1996-12-12
IL122116A0 (en) 1998-04-05
JPH11511963A (en) 1999-10-19
EP0832232B9 (en) 2006-09-06
DE69635447T4 (en) 2007-05-10
AU6048296A (en) 1996-12-24

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee