DE69626862T2 - Imidazolderivate mit alpha2-rezeptor aktivität - Google Patents

Imidazolderivate mit alpha2-rezeptor aktivität

Info

Publication number
DE69626862T2
DE69626862T2 DE69626862T DE69626862T DE69626862T2 DE 69626862 T2 DE69626862 T2 DE 69626862T2 DE 69626862 T DE69626862 T DE 69626862T DE 69626862 T DE69626862 T DE 69626862T DE 69626862 T2 DE69626862 T2 DE 69626862T2
Authority
DE
Germany
Prior art keywords
alkyl
hydrogen
different
imidazole derivatives
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69626862T
Other languages
English (en)
Other versions
DE69626862D1 (de
Inventor
Arto Karjalainen
Paavo Huhtala
Juha-Matti Savola
Siegfried Wurster
Maire Eloranta
Maarit Hillilae
Raimo Saxlund
Victor Cockcroft
Arja Karjalainen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orion Oyj
Original Assignee
Orion Oyj
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Oyj filed Critical Orion Oyj
Application granted granted Critical
Publication of DE69626862D1 publication Critical patent/DE69626862D1/de
Publication of DE69626862T2 publication Critical patent/DE69626862T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Otolaryngology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Resins (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69626862T 1995-10-03 1996-10-02 Imidazolderivate mit alpha2-rezeptor aktivität Expired - Lifetime DE69626862T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9520150.5A GB9520150D0 (en) 1995-10-03 1995-10-03 New imidazole derivatives
PCT/FI1996/000518 WO1997012874A1 (en) 1995-10-03 1996-10-02 Imidazole derivatives having affinity for alpha2 receptors activity

Publications (2)

Publication Number Publication Date
DE69626862D1 DE69626862D1 (de) 2003-04-24
DE69626862T2 true DE69626862T2 (de) 2003-12-24

Family

ID=10781676

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69626862T Expired - Lifetime DE69626862T2 (de) 1995-10-03 1996-10-02 Imidazolderivate mit alpha2-rezeptor aktivität

Country Status (30)

Country Link
US (2) US6313311B1 (de)
EP (1) EP0888309B1 (de)
JP (1) JP4129891B2 (de)
KR (1) KR19990064013A (de)
CN (1) CN1068592C (de)
AT (1) ATE234819T1 (de)
AU (1) AU708002B2 (de)
BG (1) BG63916B1 (de)
CA (1) CA2231535C (de)
CZ (1) CZ291576B6 (de)
DE (1) DE69626862T2 (de)
DK (1) DK0888309T3 (de)
EE (1) EE04436B1 (de)
ES (1) ES2195013T3 (de)
GB (1) GB9520150D0 (de)
HK (1) HK1014951A1 (de)
HU (1) HU224197B1 (de)
IL (1) IL123721A (de)
LT (1) LT4460B (de)
LV (1) LV12108B (de)
NO (1) NO311024B1 (de)
NZ (1) NZ319169A (de)
PL (1) PL189110B1 (de)
PT (1) PT888309E (de)
RO (1) RO120409B1 (de)
RU (1) RU2188194C2 (de)
SI (1) SI9620111B (de)
SK (1) SK283542B6 (de)
UA (1) UA49847C2 (de)
WO (1) WO1997012874A1 (de)

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US6329369B1 (en) 1997-12-04 2001-12-11 Allergan Sales, Inc. Methods of treating pain and other conditions
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US6388090B2 (en) 2000-01-14 2002-05-14 Orion Corporation Imidazole derivatives
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BRPI0720047A2 (pt) 2006-12-13 2013-12-24 Hoffmann La Roche 2-imidazóis como ligantes para receptores associados a aminas de traço (taar)
US20080146523A1 (en) 2006-12-18 2008-06-19 Guido Galley Imidazole derivatives
KR101275405B1 (ko) 2007-02-02 2013-06-17 에프. 호프만-라 로슈 아게 중추 신경계 장애의 치료용 ｔａａｒ1 리간드로서 2-아미노옥사졸린
US8501747B2 (en) 2007-02-13 2013-08-06 Merck Sharp & Dohme Corp. Functionally selective alpha2C adrenoreceptor agonists
US8017642B2 (en) 2007-02-13 2011-09-13 Schering Corporation Functionally selective ALPHA2C adrenoreceptor agonists
WO2008100459A1 (en) 2007-02-13 2008-08-21 Schering Corporation Derivatives and analogs of chroman as functionally selective alpha2c adrenoreceptor agonists
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WO2009016048A1 (en) 2007-07-27 2009-02-05 F. Hoffmann-La Roche Ag 2-azetidinemethaneamines and 2-pyrrolidinemethaneamines as taar-ligands
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RU2692245C2 (ru) 2011-12-11 2019-06-24 Рекро Фарма, Инк. Интраназальные композиции дексмедетомидина и способы их применения
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BR112015001771B1 (pt) * 2012-09-17 2022-08-16 F. Hoffmann-La Roche Ag Derivados de carboxamida de triazol, seu uso e composição farmacêutica que os compreende
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MX2016016488A (es) 2014-08-27 2017-03-30 Hoffmann La Roche Derivados de azetidina sustituidos como ligandos de receptores asociados a aminas en trazas (taar).
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Also Published As

Publication number Publication date
NZ319169A (en) 1999-07-29
CA2231535C (en) 2005-09-20
EP0888309A1 (de) 1999-01-07
SI9620111B (en) 2001-12-31
JP4129891B2 (ja) 2008-08-06
IL123721A0 (en) 1998-10-30
GB9520150D0 (en) 1995-12-06
PL328167A1 (en) 1999-01-18
HU224197B1 (hu) 2005-06-28
NO311024B1 (no) 2001-10-01
NO981496D0 (no) 1998-04-02
BG102324A (en) 1999-01-29
LV12108B (en) 1998-10-20
EP0888309B1 (de) 2003-03-19
IL123721A (en) 2004-07-25
RO120409B1 (ro) 2006-01-30
SK283542B6 (sk) 2003-09-11
US6313311B1 (en) 2001-11-06
PT888309E (pt) 2003-07-31
HUP9802927A2 (hu) 1999-10-28
AU7132796A (en) 1997-04-28
DK0888309T3 (da) 2003-04-22
CN1068592C (zh) 2001-07-18
CA2231535A1 (en) 1997-04-10
NO981496L (no) 1998-04-02
US20020007074A1 (en) 2002-01-17
SI9620111A (sl) 1998-10-31
HK1014951A1 (en) 1999-10-08
CN1198741A (zh) 1998-11-11
PL189110B1 (pl) 2005-06-30
DE69626862D1 (de) 2003-04-24
CZ291576B6 (cs) 2003-04-16
RU2188194C2 (ru) 2002-08-27
ATE234819T1 (de) 2003-04-15
EE04436B1 (et) 2005-02-15
CZ101898A3 (cs) 1998-09-16
KR19990064013A (ko) 1999-07-26
ES2195013T3 (es) 2003-12-01
JP2000507914A (ja) 2000-06-27
BG63916B1 (bg) 2003-06-30
AU708002B2 (en) 1999-07-29
EE9800101A (et) 1998-10-15
LT4460B (lt) 1999-02-25
US6479530B2 (en) 2002-11-12
LT98057A (en) 1998-09-25
SK43998A3 (en) 1998-10-07
LV12108A (lv) 1998-08-20
UA49847C2 (uk) 2002-10-15
HUP9802927A3 (en) 2003-02-28
WO1997012874A1 (en) 1997-04-10

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