DE69616791T2 - Zusammensetzungen und verfahren zum stabilisieren von polymeren - Google Patents

Zusammensetzungen und verfahren zum stabilisieren von polymeren

Info

Publication number
DE69616791T2
DE69616791T2 DE69616791T DE69616791T DE69616791T2 DE 69616791 T2 DE69616791 T2 DE 69616791T2 DE 69616791 T DE69616791 T DE 69616791T DE 69616791 T DE69616791 T DE 69616791T DE 69616791 T2 DE69616791 T2 DE 69616791T2
Authority
DE
Germany
Prior art keywords
composition
chelating agent
weight
polymer
agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69616791T
Other languages
German (de)
English (en)
Other versions
DE69616791D1 (de
Inventor
Fu-Pao Tsao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of DE69616791D1 publication Critical patent/DE69616791D1/de
Application granted granted Critical
Publication of DE69616791T2 publication Critical patent/DE69616791T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/49—Phosphorus-containing compounds
    • C08K5/51—Phosphorus bound to oxygen
    • C08K5/53—Phosphorus bound to oxygen bound to oxygen and to carbon only
    • C08K5/5317—Phosphonic compounds, e.g. R—P(:O)(OR')2

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Dental Preparations (AREA)
DE69616791T 1995-06-22 1996-06-12 Zusammensetzungen und verfahren zum stabilisieren von polymeren Expired - Lifetime DE69616791T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/493,761 US5683993A (en) 1995-06-22 1995-06-22 Compositions and methods for stabilizing polymers
PCT/EP1996/002539 WO1997000669A1 (en) 1995-06-22 1996-06-12 Compositions and methods for stabilizing polymers

Publications (2)

Publication Number Publication Date
DE69616791D1 DE69616791D1 (de) 2001-12-13
DE69616791T2 true DE69616791T2 (de) 2002-05-29

Family

ID=23961593

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69616791T Expired - Lifetime DE69616791T2 (de) 1995-06-22 1996-06-12 Zusammensetzungen und verfahren zum stabilisieren von polymeren

Country Status (13)

Country Link
US (2) US5683993A (enExample)
EP (1) EP0833609B1 (enExample)
JP (3) JP4260881B2 (enExample)
AT (1) ATE208189T1 (enExample)
AU (1) AU715686B2 (enExample)
CA (1) CA2222646C (enExample)
CY (1) CY2323B1 (enExample)
DE (1) DE69616791T2 (enExample)
DK (1) DK0833609T3 (enExample)
ES (1) ES2167581T3 (enExample)
PT (1) PT833609E (enExample)
TW (1) TW358109B (enExample)
WO (1) WO1997000669A1 (enExample)

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ES2284202T3 (es) * 1997-05-14 2007-11-01 Senju Pharmaceutical Co., Ltd. Preparaciones acuosas en suspension con excelente redispersabilidad.
DK0893121T3 (da) * 1997-06-27 2002-06-17 Akzo Nobel Nv Flydende oral medicinopløsning
DE19744113A1 (de) * 1997-10-06 1999-04-15 Mann Gerhard Chem Pharm Fab Dexamethason-Gel
EP0938896A1 (en) * 1998-01-15 1999-09-01 Novartis AG Autoclavable pharmaceutical compositions containing a chelating agent
US5885550A (en) * 1998-07-02 1999-03-23 Vallier; Deandra K. Ophthalmic whitening solution
US6627660B1 (en) * 1999-11-16 2003-09-30 New River Pharmaceuticals Inc. Stabilized thyroxine compounds
WO2002070648A2 (en) 2000-11-17 2002-09-12 Hematech, Llc Expression of xenogenous (human) immunoglobulins in cloned, transgenic ungulates
AU2002360939A1 (en) * 2001-11-21 2003-06-10 Novartis Ag Composition for stabilizing hyaluronic acid
US20040115160A1 (en) * 2002-12-13 2004-06-17 Salamone Joseph C. Quaternary ammonium esters for disinfection and preservation
US20050084468A1 (en) * 2003-10-17 2005-04-21 Colgate-Palmolive Company Antimicrobial cleaning composition
TWI454286B (zh) 2006-03-17 2014-10-01 Johnson & Johnson Vision Care 安定氧化性不安定組合物之方法
JP5160757B2 (ja) * 2006-09-01 2013-03-13 ホーユー株式会社 毛髪脱染剤組成物
TWI394564B (zh) * 2006-09-21 2013-05-01 Alcon Res Ltd 自行保存型水性藥學組成物
WO2008036855A2 (en) * 2006-09-21 2008-03-27 Alcon Research, Ltd. Self-preserved aqueous pharmaceutical compositions
PL2066300T5 (pl) * 2006-09-28 2020-03-31 Novartis Ag Samokonserwujące wodne kompozycje farmaceutyczne
JP5216596B2 (ja) * 2006-10-26 2013-06-19 千寿製薬株式会社 眼科用水性液剤
WO2008121199A2 (en) 2007-03-28 2008-10-09 University Of Iowa Research Foundation Transgenic animal models of disease
US8759321B2 (en) 2007-06-13 2014-06-24 Bausch & Lomb Incorporated Ophthalmic composition with hyaluronic acid and polymeric biguanide
US8119112B2 (en) 2008-01-31 2012-02-21 Bausch & Lomb Incorporated Ophthalmic compositions with an amphoteric surfactant and hyaluronic acid
PL2254549T5 (pl) * 2008-03-17 2019-12-31 Alcon Research, Ltd. Wodne kompozycje farmaceutyczne zawierające kompleksy boran-poliole
US8299079B2 (en) 2009-05-22 2012-10-30 Kaufman Herbert E Preparations and methods for ameliorating or reducing presbyopia
WO2010135731A1 (en) * 2009-05-22 2010-11-25 Kaufman Herbert E Preparations and methods for ameliorating or reducing presbyopia
TWI489997B (zh) 2009-06-19 2015-07-01 Alcon Res Ltd 含有硼酸－多元醇錯合物之水性藥學組成物
PT2709445T (pt) 2011-05-16 2018-11-27 Univ Missouri Animais resistentes ao vírus da síntese reprodutiva e respiratória porcino
US9661831B2 (en) 2011-11-03 2017-05-30 University Of Iowa Research Foundation Transgenic pig models of cystic fibrosis
US20130177599A1 (en) * 2012-01-06 2013-07-11 Insite Vision Incorporated Methods and kits for extending contact lens use
KR101400791B1 (ko) 2012-10-04 2014-05-29 주식회사대성미생물연구소 동물용 복합 기능성 항생제 조성물
WO2016187426A1 (en) 2015-05-19 2016-11-24 Amorphex Therapeutics Llc A device that delivers a sustained low-dose of a myopia-suppressing drug
US10231961B1 (en) 2017-02-07 2019-03-19 Genus Lifesciences Inc. Pharmaceutical compositions and methods of using the same
US10413505B1 (en) 2017-02-07 2019-09-17 Genus Lifesciences Inc. Pharmaceutical compositions and methods of using the same
US10149843B1 (en) 2017-02-07 2018-12-11 Gneus Lifescineces Inc. Pharmaceutical compositions and methods of using the same
CN109387622A (zh) * 2018-03-02 2019-02-26 国家纳米科学中心 一种高分子材料表面修饰方法及其应用

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DE2322883A1 (de) * 1973-05-07 1974-11-28 Roehm Gmbh Wasserloesliche polymerisate
DE2743764C2 (de) * 1977-09-29 1982-07-22 Hoechst Ag, 6000 Frankfurt Wäßrige Kunststoffdispersion auf Basis von Vinylpolymeren
DE2810348A1 (de) * 1978-03-10 1979-09-20 Hoechst Ag Waessrige kunststoffdispersion auf basis von vinylpolymeren
US4303568A (en) * 1979-12-10 1981-12-01 Betz Laboratories, Inc. Corrosion inhibition treatments and method
US4474916A (en) * 1982-07-27 1984-10-02 Basf Aktiengesellschaft Concentrated aqueous solutions of mixtures of organic complexing agents and dispersing agents based on polymeric aliphatic carboxylic acids
ATE151286T1 (de) * 1983-11-14 1997-04-15 Columbia Lab Inc Bioadhäsive mittel
JPS60184013A (ja) * 1984-03-01 1985-09-19 Yoshitomi Pharmaceut Ind Ltd 点眼剤
US4540738A (en) * 1984-12-07 1985-09-10 The Kendall Company Acrylic adhesive composition comprising an alpha amino phosphonic acid or salt having improved stability
US4889689A (en) * 1986-10-14 1989-12-26 Ciba-Geigy Corporation Method of disinfecting a soft contact lens with a diethylene triamine penta(methylenephosphonic acid) stabilized hydrogen peroxide solution
US4900469A (en) * 1986-10-21 1990-02-13 The Clorox Company Thickened peracid precursor compositions
US4812173A (en) * 1987-05-01 1989-03-14 Ciba-Geigy Corporation Stabilized hydrogen peroxide contact lens disinfecting solution
US5192535A (en) * 1988-02-08 1993-03-09 Insite Vision Incorporated Ophthalmic suspensions
DE3805663A1 (de) * 1988-02-24 1989-09-07 Henkel Kgaa Oxaalkanpolyphosphonsaeuren, ihre verwendung als thresholder sowie diese verbindungen enthaltende, komplexierend wirkende zusammensetzungen
ATE141803T1 (de) * 1988-08-04 1996-09-15 Ciba Geigy Ag Verfahren zur konservierung ophthalmischer lösungen und zusammensetzungen dafür
US4960799A (en) * 1988-09-13 1990-10-02 Ciba-Geigy Corporation Stabilized aqueous solutions of pharmaceutically acceptable salts of ortho-(2,6-dichlorophenyl)-aminophenylacetic acid for opthalmic use
US5075104A (en) * 1989-03-31 1991-12-24 Alcon Laboratories, Inc. Ophthalmic carboxy vinyl polymer gel for dry eye syndrome
US5034556A (en) * 1989-04-03 1991-07-23 Ppg Industries, Inc. Reaction products of alpha-aminomethylene phosphonic acids and epoxy compounds and their use in coating compositions
US5300296A (en) * 1989-11-06 1994-04-05 Frank J. Holly Antimicrobial agent for opthalmic formulations
JP3008131B2 (ja) * 1990-11-14 2000-02-14 ロレアル グリセリンから誘導される非イオン両親媒性化合物、その調製方法、相応する中間体化合物及び前記化合物を含有する組成物
EP0564510A1 (en) * 1990-12-27 1993-10-13 Allergan, Inc Method and composition for disinfecting contact lenses
JP3107873B2 (ja) * 1991-09-26 2000-11-13 ユニ・チャーム株式会社 高吸水性ポリマーの経時着色防止方法および経時着色防止剤
ES2087437T3 (es) * 1991-11-26 1996-07-16 Eniricerche Spa Composicion gelificable acuosa que contiene un agente antisineresis.
JP2873530B2 (ja) * 1991-12-13 1999-03-24 参天製薬株式会社 ニュートン型粘性を示すカルボキシビニルポリマー含有点眼液基剤
DE4209722C3 (de) * 1992-03-25 1997-06-19 Medproject Pharma Entwicklungs Tropfbares Gel für die Augenheilkunde
SE500660C2 (sv) * 1992-12-03 1994-08-01 Mo Och Domsjoe Ab Förfarande för framställning av grönlut vid kemikalieåtervinning i sulfat- och sulfitmassafabriker
US5340572A (en) * 1993-02-08 1994-08-23 Insite Vision Incorporated Alkaline ophthalmic suspensions
DE59407521D1 (de) * 1993-08-10 1999-02-04 Ciba Geigy Ag Mercerisiernetzmittel
FR2726762B1 (fr) * 1994-11-10 1997-01-17 Oreal Composition cosmetique ou dermatologique sous forme d'une dispersion d'une phase huileuse dans une phase aqueuse stabilisee a l'aide de particules de gel cubique et son procede d'obtention
US5603929A (en) * 1994-11-16 1997-02-18 Alcon Laboratories, Inc. Preserved ophthalmic drug compositions containing polymeric quaternary ammonium compounds

Also Published As

Publication number Publication date
JP2008248246A (ja) 2008-10-16
TW358109B (en) 1999-05-11
US5683993A (en) 1997-11-04
JP4260881B2 (ja) 2009-04-30
JP2012153710A (ja) 2012-08-16
DK0833609T3 (da) 2002-02-18
AU715686B2 (en) 2000-02-10
JPH11510480A (ja) 1999-09-14
DE69616791D1 (de) 2001-12-13
PT833609E (pt) 2002-04-29
CA2222646C (en) 2009-12-08
WO1997000669A1 (en) 1997-01-09
US5858996A (en) 1999-01-12
EP0833609B1 (en) 2001-11-07
CY2323B1 (en) 2003-11-14
ES2167581T3 (es) 2002-05-16
ATE208189T1 (de) 2001-11-15
AU6355196A (en) 1997-01-22
CA2222646A1 (en) 1997-01-09
EP0833609A1 (en) 1998-04-08

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336

8328 Change in the person/name/address of the agent

Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN