DE69616347T2 - O-Carboxymethylchitosan enthaltende Mittel und ihre Verwendung in Ophthalmika - Google Patents

O-Carboxymethylchitosan enthaltende Mittel und ihre Verwendung in Ophthalmika

Info

Publication number
DE69616347T2
DE69616347T2 DE69616347T DE69616347T DE69616347T2 DE 69616347 T2 DE69616347 T2 DE 69616347T2 DE 69616347 T DE69616347 T DE 69616347T DE 69616347 T DE69616347 T DE 69616347T DE 69616347 T2 DE69616347 T2 DE 69616347T2
Authority
DE
Germany
Prior art keywords
agents
polysaccharide
solution
carboxymethylchitosan
ophthalmic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69616347T
Other languages
English (en)
Other versions
DE69616347D1 (de
Inventor
W Reed
Shau-Fong Yen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Pharma GmbH
Novartis AG
Original Assignee
Novartis Erfindungen Verwaltungs GmbH
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Erfindungen Verwaltungs GmbH, Novartis AG filed Critical Novartis Erfindungen Verwaltungs GmbH
Publication of DE69616347D1 publication Critical patent/DE69616347D1/de
Application granted granted Critical
Publication of DE69616347T2 publication Critical patent/DE69616347T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Inorganic Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69616347T 1995-08-17 1996-08-06 O-Carboxymethylchitosan enthaltende Mittel und ihre Verwendung in Ophthalmika Expired - Fee Related DE69616347T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51642095A 1995-08-17 1995-08-17
PCT/EP1996/003477 WO1997006782A1 (en) 1995-08-17 1996-08-06 Compositions including o-carboxyalkyl chitosan and methods of use in ophthalmics

Publications (2)

Publication Number Publication Date
DE69616347D1 DE69616347D1 (de) 2001-11-29
DE69616347T2 true DE69616347T2 (de) 2002-07-04

Family

ID=24055505

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69616347T Expired - Fee Related DE69616347T2 (de) 1995-08-17 1996-08-06 O-Carboxymethylchitosan enthaltende Mittel und ihre Verwendung in Ophthalmika

Country Status (11)

Country Link
US (1) US5773608A (de)
EP (1) EP0844868B1 (de)
JP (1) JPH11510497A (de)
AT (1) ATE207343T1 (de)
AU (1) AU6789796A (de)
DE (1) DE69616347T2 (de)
DK (1) DK0844868T3 (de)
ES (1) ES2166905T3 (de)
PT (1) PT844868E (de)
TW (1) TW389694B (de)
WO (1) WO1997006782A1 (de)

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DE19617019A1 (de) 1996-04-27 1997-11-06 Beiersdorf Ag Alkyl-2-acetamino-2-desoxy-glucopyranosid-uronsäuren und -Derivate, ihre Herstellung sowie ihre Verwendung als Tenside in kosmetischen und pharmazeutischen Zubereitungen
ES2174388T3 (es) * 1997-06-27 2002-11-01 Akzo Nobel Nv Solucion liquida de medicamento para administracion oral.
CA2212300A1 (en) * 1997-08-04 1999-02-04 Abdellatif Chenite In vitro or in vivo gelfying chitosan and therapeutic uses thereof
DE69917784T2 (de) 1998-07-30 2004-12-02 Vital Living, Inc., Phoenix Flüssige chitosan-enthaltende zusammensetzungen und verfahren zur herstellung und verwendung
AU5878600A (en) * 1999-06-25 2001-01-31 E-Nutriceuticals, Inc. Novel chitosan-containing liquid compositions and methods for their preparation and use
US6537584B1 (en) * 1999-11-12 2003-03-25 Macromed, Inc. Polymer blends that swell in an acidic environment and deswell in a basic environment
ATE318846T1 (de) * 1999-11-12 2006-03-15 Macromed Inc An- und abschwellende polymermischungen
CA2685349C (en) * 1999-11-15 2013-09-17 Bio Syntech Canada Inc. Temperature-controlled and ph-dependant self-gelling biopolymeric aqueous solution
US20030158302A1 (en) * 1999-12-09 2003-08-21 Cyric Chaput Mineral-polymer hybrid composition
WO2001041821A1 (en) * 1999-12-09 2001-06-14 Biosyntech Canada Inc. Mineral-polymer hybrid composition
US6716970B2 (en) 2000-04-21 2004-04-06 Adjuvant Pharmaceuticals, Llc Water soluble, randomly substituted partial N-partial O-acetylated chitosan, preserving compositions containing chitosan, and processes for making thereof
EP1294414B1 (de) * 2000-06-29 2006-03-15 Biosyntech Canada Inc. Zusammensetzung und verfahren zur reparatur und regenerierung von knorpel und anderen geweben
AU2001288120A1 (en) * 2000-09-26 2002-04-08 Kyorin Pharmaceutical Co. Ltd. Liquid prednisolone sodium phosphate preparation
CA2429168C (en) * 2000-11-15 2010-06-08 Bio Syntech Canada Inc. Method for restoring a damaged or degenerated intervertebral disc
US6756363B1 (en) * 2000-11-17 2004-06-29 Wound Healing Of Oklahoma, Inc. Solutions and films of glycated chitosan
AR034372A1 (es) * 2001-06-08 2004-02-18 Novartis Ag Composiciones farmaceuticas
JP5614913B2 (ja) * 2002-07-16 2014-10-29 ピラマル ヘルスケア （カナダ） リミテッド 生細胞又は生物学的活性因子を封入し送達するための、細胞適合性、注射可能、かつ自己ゲル化性のキトサン溶液の組成物
US6896809B2 (en) * 2002-12-20 2005-05-24 Providence Health System - Oregon Methods for purifying chitosan
US7125967B2 (en) 2003-10-08 2006-10-24 Adjuvant Pharmaceuticals, Llc Water-soluble chitosan having low endotoxin concentration and methods for making and using the same
EP1727525A4 (de) * 2004-03-23 2009-12-09 Lytone Enterprise Inc In chitosan eingebettete oder verkapselte kapsel
WO2006028361A1 (es) * 2004-09-09 2006-03-16 Arturo Jimenez Bayardo Implantes y microesferas de liberación prolongada de fármacos de uso oftálmico y metodos para prepararlos
EP1637141B1 (de) * 2004-09-21 2011-11-16 Trobio AB Stabilisierte Protease Zusammensetzungen enthaltend eine Serinprotease, Morpholin-Derivate und reversible Serinprotease- Inhibitoren
EP1945712A4 (de) * 2005-11-04 2013-05-01 Piramal Healthcare Canada Ltd Gelbindung von wässrigen polyelektrolytlösungen durch thermisch induzierte änderungen des ionisationszustands
CN100572388C (zh) * 2005-12-14 2009-12-23 河南省科学院河南省发展计划委员会地理研究所 乙酰水杨酸与壳聚糖-2，6位接枝物制备方法
DE602005016030D1 (de) * 2005-12-23 2009-09-24 Medidom Lab Duroplastische neutralisierte chitosan-zusammensetzung zur bildung eines hydrogels, lyophilisats, und herstellungsverfahren dafür
US8252771B2 (en) * 2007-01-31 2012-08-28 Allergan, Inc. Biomaterials and a method for making and using same
DK2804611T3 (da) * 2012-01-20 2020-11-09 Immunophotonics Inc Chitosanafledte forbindelser
US11773188B2 (en) 2012-01-20 2023-10-03 Immunophotonics, Inc Chitosan-derived compositions
US11111316B2 (en) 2012-01-20 2021-09-07 Immunophotonics, Inc. Chitosan-derived compositions
JP2019513238A (ja) 2016-03-30 2019-05-23 クオリザイム・ダイアグノスティクス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング・ウント・コムパニー・コマンディットゲゼルシャフトＱｕａｌｉｚｙｍｅ Ｄｉａｇｎｏｓｔｉｃｓ Ｇｍｂｈ Ａｎｄ Ｃｏ． Ｋｇ 創傷における微生物感染の検出
AU2017311636B2 (en) 2016-08-19 2023-08-10 Orasis Pharmaceuticals Ltd. Ophthalmic pharmaceutical compositions and uses relating thereto
CN109260145B (zh) * 2018-10-09 2020-12-22 湖北远大天天明制药有限公司 含有珍珠层粉可舒缓眼部疲劳的滴眼液组合物、制备方法与用途

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US4386151A (en) * 1981-06-26 1983-05-31 Polaroid Corporation Diffusion transfer film system with protective layer of copper salt, chitosan and selected polyols
DE3440444A1 (de) * 1984-11-06 1986-05-07 Dechema Deutsche Gesellschaft für chemisches Apparatewesen e.V., 6000 Frankfurt Verfahren zur herstellung grob gekoernter schichtsilikate und deren verwendung als adsorbentien fuer proteine
GB8520085D0 (en) * 1985-08-09 1985-09-18 British Food Mfg Ind Res Foamed food products
US4946870A (en) * 1986-06-06 1990-08-07 Union Carbide Chemicals And Plastics Company Inc. Delivery systems for pharmaceutical or therapeutic actives
IT1190347B (it) * 1986-06-16 1988-02-16 Franco Conti Processo per la preparazione dell'n-dimetilchitosano e suoi impieghi farmacologici
IT1219942B (it) * 1988-05-13 1990-05-24 Fidia Farmaceutici Esteri polisaccaridici
US4956350A (en) * 1988-08-18 1990-09-11 Minnesota Mining And Manufacturing Company Wound filling compositions
US5550187A (en) * 1988-11-21 1996-08-27 Collagen Corporation Method of preparing crosslinked biomaterial compositions for use in tissue augmentation
DE69015775T2 (de) * 1989-10-31 1995-05-11 Howmedica Chitinderivate enthaltende Zusammensetzungen zur Verhütung der Adhäsion.
US5204452A (en) * 1990-11-14 1993-04-20 E. I. Du Pont De Nemours And Company N-halochitosans, their preparation and uses
US5212162A (en) * 1991-03-27 1993-05-18 Alcon Laboratories, Inc. Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions
US5318780A (en) * 1991-10-30 1994-06-07 Mediventures Inc. Medical uses of in situ formed gels
CA2074424A1 (en) * 1992-07-22 1994-01-23 Bryce L. Fanning Acoustic gel
DE69331997T2 (de) * 1992-09-28 2003-01-02 Univ Brown Res Found Chitozanmatrizes für eingekapselte zellen
US5420197A (en) * 1994-01-13 1995-05-30 Hydromer, Inc. Gels formed by the interaction of polyvinylpyrrolidone with chitosan derivatives
EP0665022A1 (de) * 1994-01-28 1995-08-02 Prodex, Inc. Viskoelastische Lösung aus N,O-Carboxymethylchitosan zur opthalmischen Verwendung
US5422116A (en) * 1994-02-18 1995-06-06 Ciba-Geigy Corporation Liquid ophthalmic sustained release delivery system

Also Published As

Publication number Publication date
EP0844868A1 (de) 1998-06-03
PT844868E (pt) 2002-03-28
ATE207343T1 (de) 2001-11-15
DE69616347D1 (de) 2001-11-29
DK0844868T3 (da) 2002-01-28
EP0844868B1 (de) 2001-10-24
TW389694B (en) 2000-05-11
WO1997006782A1 (en) 1997-02-27
AU6789796A (en) 1997-03-12
ES2166905T3 (es) 2002-05-01
JPH11510497A (ja) 1999-09-14
US5773608A (en) 1998-06-30

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee