DE69534778D1 - Cathepsin-02-protease - Google Patents

Cathepsin-02-protease

Info

Publication number
DE69534778D1
DE69534778D1 DE69534778T DE69534778T DE69534778D1 DE 69534778 D1 DE69534778 D1 DE 69534778D1 DE 69534778 T DE69534778 T DE 69534778T DE 69534778 T DE69534778 T DE 69534778T DE 69534778 D1 DE69534778 D1 DE 69534778D1
Authority
DE
Germany
Prior art keywords
cathepsin
protease
antibodies
proteins
relates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69534778T
Other languages
English (en)
Other versions
DE69534778T2 (de
Inventor
Dieter Broemme
Kathleen Okamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Axys Pharmaceuticals Inc
Original Assignee
Arris Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26987129&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69534778(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/330,121 external-priority patent/US5736357A/en
Application filed by Arris Pharmaceutical Corp filed Critical Arris Pharmaceutical Corp
Application granted granted Critical
Publication of DE69534778D1 publication Critical patent/DE69534778D1/de
Publication of DE69534778T2 publication Critical patent/DE69534778T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
DE69534778T 1994-10-27 1995-10-26 Cathepsin-02-protease Expired - Fee Related DE69534778T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/330,121 US5736357A (en) 1994-10-27 1994-10-27 Cathespin O protease
US330121 1994-10-27
US08/536,861 US6544767B1 (en) 1994-10-27 1995-10-02 Cathespin O2 protease
PCT/US1995/013820 WO1996013523A1 (en) 1994-10-27 1995-10-26 Cathepsin o2 protease
US536861 2000-03-27

Publications (2)

Publication Number Publication Date
DE69534778D1 true DE69534778D1 (en) 2006-04-20
DE69534778T2 DE69534778T2 (de) 2006-08-17

Family

ID=26987129

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69534778T Expired - Fee Related DE69534778T2 (de) 1994-10-27 1995-10-26 Cathepsin-02-protease

Country Status (15)

Country Link
US (2) US6544767B1 (de)
EP (1) EP0783527B1 (de)
JP (1) JP3670666B2 (de)
KR (1) KR100473219B1 (de)
CN (1) CN1148382C (de)
AT (1) ATE317441T1 (de)
AU (1) AU711810B2 (de)
CA (1) CA2203765C (de)
DE (1) DE69534778T2 (de)
ES (1) ES2256849T3 (de)
FI (1) FI971777A (de)
HU (1) HU220960B1 (de)
NO (1) NO971875L (de)
NZ (1) NZ296003A (de)
WO (1) WO1996013523A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6403304B1 (en) 1993-04-06 2002-06-11 Forsyth Dental Infirmary For Children Human osteoclast-specific and -related DNA sequences
US5501969A (en) 1994-03-08 1996-03-26 Human Genome Sciences, Inc. Human osteoclast-derived cathepsin
US6586466B2 (en) 1995-10-30 2003-07-01 Smithkline Beecham Corporation Carbohydrazide-protease inhibitors
KR19990067184A (ko) 1995-10-30 1999-08-16 스튜어트 알. 수터, 스티븐 베네티아너, 피터 존 기딩스 프로테아제 억제제
US6274336B1 (en) 1995-10-30 2001-08-14 Smithkline Beecham Corporation Method of inhibiting cathepsin K
EP0812916A3 (de) * 1996-06-14 1998-12-09 Smithkline Beecham Corporation Cathepsin K Gen
WO1998000716A1 (en) * 1996-07-03 1998-01-08 Novadx, Inc. Method for detecting degenerative bone disease
GB9701888D0 (en) * 1997-01-30 1997-03-19 Ciba Geigy Ag Novel methods
US5948669A (en) * 1997-02-26 1999-09-07 Smithkline Beecham Corporation Rat cathepsin K polynucleotide and polypeptide sequence
US20030144175A1 (en) 1998-12-23 2003-07-31 Smithkline Beecham Corporation Protease inhibitors
US6346373B1 (en) * 1999-05-05 2002-02-12 Merck Frosst Canada & Co., Whole cell assay for cathepsin K activity
WO2001000798A2 (en) * 1999-06-25 2001-01-04 Hybritech Incorporated Cloning and expressing of human cathepsin k in mammalian cells
EP1232155A4 (de) 1999-11-10 2002-11-20 Smithkline Beecham Corp Protease inhibitoren
JP2003513924A (ja) 1999-11-10 2003-04-15 スミスクライン・ビーチャム・コーポレイション プロテア−ゼ阻害剤
US6583137B1 (en) 1999-11-10 2003-06-24 Smithkline Beecham Corporation Protease inhibitors
CA2397194C (en) 2000-01-20 2011-05-17 Mark E. Duggan Alpha v integrin receptor antagonists
NZ520588A (en) 2000-03-21 2004-06-25 Smithkline Beecham Corp Protease inhibitors
WO2002038744A2 (en) * 2000-10-18 2002-05-16 Incyte Genomics, Inc. Proteases
CN100408681C (zh) * 2002-06-17 2008-08-06 株式会社日冷 来源于粉红色虾的新型组织蛋白酶l样半胱氨酸蛋白酶
WO2004000838A1 (en) * 2002-06-24 2003-12-31 Axys Pharmaceuticals, Inc. Peptidic compounds as cysteine protease inhibitors
AU2004262903B2 (en) * 2003-07-21 2007-08-23 Novartis Ag Combinations of a Cathepsin K inhibitor and a bisphophonate in the treatment of bone metastasis, tumor growth and tumor-induced bone loss
CN1839114A (zh) 2003-08-21 2006-09-27 默克弗罗斯特加拿大有限公司 组织蛋白酶半胱氨酸蛋白酶抑制剂
CA2539076A1 (en) * 2003-09-23 2005-03-31 Merck Frosst Canada Ltd. Whole cell assay for inhibitors of cathepsin k
WO2005093421A1 (de) * 2004-03-10 2005-10-06 Biovendor Laboratory Medicine, Inc. Enzymimmunoassay zur bestimmung von cathepsin k
US7029902B2 (en) * 2004-03-26 2006-04-18 Applera Corporation Isolated monkey cathepsin S proteins, nucleic acid molecules encoding monkey cathepsin S proteins, and uses thereof
UA87854C2 (en) 2004-06-07 2009-08-25 Мерк Энд Ко., Инк. N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
AU2013202011C1 (en) * 2008-03-06 2015-10-01 Halozyme, Inc. In vivo temporal control of activatable matrix-degrading enzymes
TWI395593B (zh) * 2008-03-06 2013-05-11 Halozyme Inc 可活化的基質降解酵素之活體內暫時性控制
US8901144B2 (en) 2013-02-07 2014-12-02 Scifluor Life Sciences, Llc Fluorinated 3-(2-oxo-3-(3-arylpropyl)imidazolidin-1-yl)-3-arylpropanoic acid derivatives
JP6494528B2 (ja) 2013-02-07 2019-04-03 サイフルーア ライフ サイエンシズ インコーポレイテッド フッ化インテグリンアンタゴニスト
KR20160147007A (ko) 2014-05-30 2016-12-21 화이자 인코포레이티드 선택적인 안드로겐 수용체 조절제로서의 카보니트릴 유도체
AU2016219906B2 (en) 2015-02-19 2020-10-01 Scifluor Life Sciences, Inc. Fluorinated tetrahydronaphthyridinyl nonanoic acid derivatives and uses thereof
WO2023275715A1 (en) 2021-06-30 2023-01-05 Pfizer Inc. Metabolites of selective androgen receptor modulators

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5501969A (en) 1994-03-08 1996-03-26 Human Genome Sciences, Inc. Human osteoclast-derived cathepsin
AU6333296A (en) 1996-06-14 1998-01-07 Human Genome Sciences, Inc. Cathepsin k gene

Also Published As

Publication number Publication date
US6544767B1 (en) 2003-04-08
JP3670666B2 (ja) 2005-07-13
AU711810B2 (en) 1999-10-21
NZ296003A (en) 1999-10-28
NO971875L (no) 1997-06-12
CA2203765C (en) 2002-04-23
HU220960B1 (hu) 2002-07-29
EP0783527A1 (de) 1997-07-16
NO971875D0 (no) 1997-04-23
JPH10512740A (ja) 1998-12-08
WO1996013523A1 (en) 1996-05-09
US20030175937A1 (en) 2003-09-18
CA2203765A1 (en) 1996-05-09
CN1170415A (zh) 1998-01-14
ATE317441T1 (de) 2006-02-15
FI971777A0 (fi) 1997-04-25
KR100473219B1 (ko) 2005-05-16
ES2256849T3 (es) 2006-07-16
DE69534778T2 (de) 2006-08-17
CN1148382C (zh) 2004-05-05
FI971777A (fi) 1997-04-25
AU3968895A (en) 1996-05-23
HUT77049A (hu) 1998-03-02
KR970707153A (ko) 1997-12-01
EP0783527A4 (de) 1998-12-02
EP0783527B1 (de) 2006-02-08

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8339 Ceased/non-payment of the annual fee