DE69529678D1 - Kombinationen von hiv-protease inhibitoren - Google Patents

Kombinationen von hiv-protease inhibitoren

Info

Publication number
DE69529678D1
DE69529678D1 DE69529678T DE69529678T DE69529678D1 DE 69529678 D1 DE69529678 D1 DE 69529678D1 DE 69529678 T DE69529678 T DE 69529678T DE 69529678 T DE69529678 T DE 69529678T DE 69529678 D1 DE69529678 D1 DE 69529678D1
Authority
DE
Germany
Prior art keywords
hiv protease
hiv
protease inhibitors
combinations
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69529678T
Other languages
English (en)
Other versions
DE69529678T2 (de
Inventor
J Deutsch
A Emini
P Vacca
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE69529678D1 publication Critical patent/DE69529678D1/de
Publication of DE69529678T2 publication Critical patent/DE69529678T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
DE69529678T 1994-08-11 1995-08-07 Kombinationen von hiv-protease inhibitoren Expired - Fee Related DE69529678T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US28947494A 1994-08-11 1994-08-11
US33936994A 1994-11-14 1994-11-14
US49246195A 1995-07-20 1995-07-20
PCT/US1995/009956 WO1996004913A1 (en) 1994-08-11 1995-08-07 Hiv protease inhibitor combination

Publications (2)

Publication Number Publication Date
DE69529678D1 true DE69529678D1 (de) 2003-03-27
DE69529678T2 DE69529678T2 (de) 2003-09-25

Family

ID=27403895

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69529678T Expired - Fee Related DE69529678T2 (de) 1994-08-11 1995-08-07 Kombinationen von hiv-protease inhibitoren

Country Status (20)

Country Link
EP (1) EP0774969B8 (de)
JP (1) JPH10504036A (de)
KR (1) KR970704441A (de)
CN (1) CN1101190C (de)
AT (1) ATE232727T1 (de)
AU (1) AU698664B2 (de)
CA (1) CA2197207C (de)
CY (1) CY2360B1 (de)
CZ (1) CZ292577B6 (de)
DE (1) DE69529678T2 (de)
DK (1) DK0774969T3 (de)
ES (1) ES2190456T3 (de)
FI (1) FI970565A (de)
HU (1) HUT76540A (de)
IL (1) IL114808A (de)
MX (1) MX9701121A (de)
NO (1) NO314168B1 (de)
PL (1) PL181578B1 (de)
SK (1) SK18197A3 (de)
WO (1) WO1996004913A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA49803C2 (uk) * 1994-06-03 2002-10-15 Дж.Д. Сьорль Енд Ко Спосіб лікування ретровірусних інфекцій
US6037157A (en) * 1995-06-29 2000-03-14 Abbott Laboratories Method for improving pharmacokinetics
US20020068749A1 (en) * 1996-11-08 2002-06-06 Hideharu Sato Aids remedy

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US517041A (en) * 1894-03-27 Fruit-picker
CA1340588C (en) * 1988-06-13 1999-06-08 Balraj Krishan Handa Amino acid derivatives
ATE196466T1 (de) * 1990-11-19 2000-10-15 Monsanto Co Inhibitoren retroviraler proteasen
DE69126987T2 (de) * 1990-11-19 1998-03-05 Monsanto Co Retrovirale protease-inhibitoren
IE20010533A1 (en) * 1990-11-20 2003-03-05 Abbott Lab Intermediates for preparing retroviral protease inhibiting compounds
SG52731A1 (en) * 1991-11-08 1998-09-28 Merck & Co Inc Hiv protease inhibitors useful for the treatment of aids
DK1302468T3 (da) * 1992-12-29 2009-03-02 Abbott Lab Fremgangsmåder og mellemprodukter til fremstilling af forbindelser, der inhiberer retroviral protease

Also Published As

Publication number Publication date
EP0774969A1 (de) 1997-05-28
JPH10504036A (ja) 1998-04-14
PL181578B1 (pl) 2001-08-31
PL318506A1 (en) 1997-06-23
EP0774969B8 (de) 2003-07-02
ES2190456T3 (es) 2003-08-01
DK0774969T3 (da) 2003-03-31
NO970632L (no) 1997-04-10
IL114808A0 (en) 1995-12-08
AU698664B2 (en) 1998-11-05
AU3361195A (en) 1996-03-07
CA2197207C (en) 2006-10-17
WO1996004913A1 (en) 1996-02-22
DE69529678T2 (de) 2003-09-25
CZ292577B6 (cs) 2003-10-15
ATE232727T1 (de) 2003-03-15
HUT76540A (en) 1997-09-29
CZ38997A3 (en) 1997-11-12
MX9701121A (es) 1997-05-31
CN1101190C (zh) 2003-02-12
EP0774969B1 (de) 2003-02-19
NO970632D0 (no) 1997-02-11
CY2360B1 (en) 2004-06-04
KR970704441A (ko) 1997-09-06
FI970565A0 (fi) 1997-02-10
IL114808A (en) 1999-10-28
CA2197207A1 (en) 1996-02-22
FI970565A (fi) 1997-02-10
SK18197A3 (en) 1997-09-10
CN1160350A (zh) 1997-09-24
NO314168B1 (no) 2003-02-10

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee