DE69519634D1 - Pneumokokken-polysaccharid-rekombinante-pneumolysin-konjugate als impfstoffe für die immunisierung gegen pneumokokken-infektionen - Google Patents
Pneumokokken-polysaccharid-rekombinante-pneumolysin-konjugate als impfstoffe für die immunisierung gegen pneumokokken-infektionenInfo
- Publication number
- DE69519634D1 DE69519634D1 DE69519634T DE69519634T DE69519634D1 DE 69519634 D1 DE69519634 D1 DE 69519634D1 DE 69519634 T DE69519634 T DE 69519634T DE 69519634 T DE69519634 T DE 69519634T DE 69519634 D1 DE69519634 D1 DE 69519634D1
- Authority
- DE
- Germany
- Prior art keywords
- pneumolysin
- pneumococcal
- recombinant
- polysaccharid
- vaccine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 229960005486 vaccine Drugs 0.000 title abstract 2
- 208000035109 Pneumococcal Infections Diseases 0.000 title 1
- 230000003053 immunization Effects 0.000 title 1
- 150000004676 glycans Chemical class 0.000 abstract 4
- 229920001282 polysaccharide Polymers 0.000 abstract 4
- 239000005017 polysaccharide Substances 0.000 abstract 4
- 101710183389 Pneumolysin Proteins 0.000 abstract 3
- 230000002163 immunogen Effects 0.000 abstract 2
- 230000005875 antibody response Effects 0.000 abstract 1
- 230000021615 conjugation Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
- C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1275—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Streptococcus (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Mycology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Pulmonology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/295,305 US5565204A (en) | 1994-08-24 | 1994-08-24 | Pneumococcal polysaccharide-recombinant pneumolysin conjugate vaccines for immunization against pneumococcal infections |
PCT/US1995/010227 WO1996005859A1 (en) | 1994-08-24 | 1995-08-10 | Pneumococcal polysaccharide-recombinant pneumolysin conjugate vaccines for immunization against pneumococcal infections |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69519634D1 true DE69519634D1 (de) | 2001-01-18 |
DE69519634T2 DE69519634T2 (de) | 2001-06-13 |
Family
ID=23137126
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69519634T Expired - Fee Related DE69519634T2 (de) | 1994-08-24 | 1995-08-10 | Pneumokokken-polysaccharid-rekombinante-pneumolysin-konjugate als impfstoffe für die immunisierung gegen pneumokokken-infektionen |
Country Status (14)
Country | Link |
---|---|
US (1) | US5565204A (de) |
EP (1) | EP0778781B1 (de) |
JP (1) | JP3927233B2 (de) |
KR (1) | KR100385411B1 (de) |
AT (1) | ATE198051T1 (de) |
AU (1) | AU704450B2 (de) |
CA (1) | CA2198251C (de) |
DE (1) | DE69519634T2 (de) |
DK (1) | DK0778781T3 (de) |
ES (1) | ES2152421T3 (de) |
GR (1) | GR3035081T3 (de) |
IL (1) | IL115047A (de) |
PT (1) | PT778781E (de) |
WO (1) | WO1996005859A1 (de) |
Families Citing this family (74)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6165762A (en) | 1996-08-16 | 2000-12-26 | Smithkline Beecham Corporation | DNA encoding adenine phosphoribosyltransferase from Streptococcus pneumoniae |
US6420135B1 (en) | 1996-10-31 | 2002-07-16 | Human Genome Sciences, Inc. | Streptococcus pneumoniae polynucleotides and sequences |
CA2284606A1 (en) * | 1997-03-26 | 1998-10-01 | Brigham And Women's Hospital, Inc. | Method for generating saccharide fragments |
US6676943B1 (en) | 1997-04-24 | 2004-01-13 | Regents Of The University Of Minnesota | Human complement C3-degrading protein from Streptococcus pneumoniae |
ATE278418T1 (de) * | 1997-04-24 | 2004-10-15 | Jackson H M Found Military Med | Kopplung unmodifizierter proteinen an haloacyl- oder dihaloacyl-derivatisierten polysacchariden zur herstellung von protein-polysaccharide impfstoffen |
AU740956B2 (en) | 1997-07-21 | 2001-11-15 | Baxter Healthcare Sa | Modified immunogenic pneumolysin compositions as vaccines |
US5882898A (en) * | 1997-08-29 | 1999-03-16 | Smithkline Beecham Corporation | Streptococcus pneumoniae polynucleotides which encode folyl-polyglutamate synthetase (FPGS) polypeptides |
US5965714A (en) * | 1997-10-02 | 1999-10-12 | Connaught Laboratories, Inc. | Method for the covalent attachment of polysaccharides to protein molecules |
US5861281A (en) * | 1997-10-30 | 1999-01-19 | Smithkline Beecham Corporation | Lacc |
US6165763A (en) | 1997-10-30 | 2000-12-26 | Smithkline Beecham Corporation | Ornithine carbamoyltransferase |
US6274719B1 (en) | 1998-04-24 | 2001-08-14 | Smithkline Beecham Corporation | Gcp |
WO2000003744A2 (en) * | 1998-07-14 | 2000-01-27 | American Cyanamid Company | Adjuvant and vaccine compositions containing monophosphoryl lipid a |
US6268177B1 (en) | 1998-09-22 | 2001-07-31 | Smithkline Beecham Corporation | Isolated nucleic acid encoding nucleotide pyrophosphorylase |
WO2000026359A1 (en) * | 1998-11-04 | 2000-05-11 | Smithkline Beecham Corporation | ftsX |
GB9906437D0 (en) * | 1999-03-19 | 1999-05-12 | Smithkline Beecham Biolog | Vaccine |
HU228499B1 (en) * | 1999-03-19 | 2013-03-28 | Smithkline Beecham Biolog | Streptococcus vaccine |
WO2001007465A1 (en) * | 1999-07-22 | 2001-02-01 | Smithkline Beecham Corporation | Ga1R |
GB9918319D0 (en) | 1999-08-03 | 1999-10-06 | Smithkline Beecham Biolog | Vaccine composition |
GB0022742D0 (en) * | 2000-09-15 | 2000-11-01 | Smithkline Beecham Biolog | Vaccine |
EP1355918B9 (de) * | 2000-12-28 | 2012-01-25 | Wyeth LLC | Rekombinantes schutzprotein aus streptococcus pneumoniae |
MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
WO2004015099A2 (en) | 2002-08-02 | 2004-02-19 | Glaxosmithkline Biologicals Sa | Vaccine composition comprising lipooligosaccharide with reduced phase variability |
US7785608B2 (en) * | 2002-08-30 | 2010-08-31 | Wyeth Holdings Corporation | Immunogenic compositions for the prevention and treatment of meningococcal disease |
US7301554B2 (en) * | 2002-09-20 | 2007-11-27 | Ricoh Company, Ltd. | Light scanning device, scanning line adjusting method, scanning line adjusting control method, image forming apparatus, and image forming method |
DK2395073T3 (en) | 2002-11-01 | 2017-10-23 | Glaxosmithkline Biologicals Sa | Process for drying. |
CA2504938C (en) * | 2002-11-07 | 2011-10-11 | Synergy America, Inc. | Compositions and methods for treating or preventing pneumococcal infection |
DE602004010376T2 (de) * | 2003-03-13 | 2008-10-23 | Glaxosmithkline Biologicals S.A. | Verfahren zur reinigung von bakteriellem cytolysin |
AU2004281630A1 (en) | 2003-08-06 | 2005-04-28 | Bio-Manguinhos/Fiocruz | Process for preparing polysaccharide-protein conjugate vaccines |
US8048432B2 (en) | 2003-08-06 | 2011-11-01 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Polysaccharide-protein conjugate vaccines |
WO2005032584A2 (en) | 2003-10-02 | 2005-04-14 | Glaxosmithkline Biologicals S.A. | Pertussis antigens and use thereof in vaccination |
GB0410220D0 (en) | 2004-05-07 | 2004-06-09 | Kirkham Lea Ann | Mutant pneumolysin proteins |
GB0502096D0 (en) * | 2005-02-01 | 2005-03-09 | Chiron Srl | Purification of streptococcal capsular polysaccharide |
GB0505996D0 (en) | 2005-03-23 | 2005-04-27 | Glaxosmithkline Biolog Sa | Fermentation process |
EP2425855A1 (de) | 2005-04-08 | 2012-03-07 | Wyeth LLC | Multivalente Pneumokokken-Polysaccharidproteinkonjugatzusammensetzung |
US20070184072A1 (en) * | 2005-04-08 | 2007-08-09 | Wyeth | Multivalent pneumococcal polysaccharide-protein conjugate composition |
TWI457133B (zh) | 2005-12-13 | 2014-10-21 | Glaxosmithkline Biolog Sa | 新穎組合物 |
GB0607088D0 (en) | 2006-04-07 | 2006-05-17 | Glaxosmithkline Biolog Sa | Vaccine |
LT3017827T (lt) | 2005-12-22 | 2019-01-10 | Glaxosmithkline Biologicals S.A. | Pneumokokinė polisacharidinė konjuguota vakcina |
ZA200805602B (en) | 2006-01-17 | 2009-12-30 | Arne Forsgren | A novel surface exposed haemophilus influenzae protein (protein E; pE) |
WO2007116409A2 (en) | 2006-04-11 | 2007-10-18 | Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science | Improved vaccines comprising multimeric hsp60 peptide carriers |
WO2007144647A2 (en) * | 2006-06-15 | 2007-12-21 | Timothy John Mitchell | Adjuvant compositions |
MX2009001412A (es) | 2006-08-07 | 2009-04-24 | Harvard College | Vacunas de matriz de proteinas y metodos de hacer y administrar tales vacunas. |
CN110064053A (zh) * | 2006-08-07 | 2019-07-30 | 哈佛大学校长及研究员协会 | 蛋白质基质疫苗及这种疫苗的制备和给药方法 |
AR064642A1 (es) | 2006-12-22 | 2009-04-15 | Wyeth Corp | Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi |
EP2386567B1 (de) | 2007-04-13 | 2014-10-29 | The Board Of Regents Of The University Of Oklahoma | Mutanten von cholesterinabhängigen Cytolysinen und Verwendungen davon |
WO2009094730A1 (en) * | 2008-02-01 | 2009-08-06 | Newcastle Innovation Limited | Vaccine compositions |
EP2383035A4 (de) | 2008-12-03 | 2017-11-22 | Kaneka Corporation | Formylgruppenhaltiger poröser träger, adsorbens damit, herstellungsverfahren dafür und verfahren zur herstellung des adsorbens |
GB201003922D0 (en) | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Conjugation process |
JP2013521770A (ja) | 2010-03-10 | 2013-06-13 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | ワクチン組成物 |
SI3246044T2 (sl) | 2010-08-23 | 2024-06-28 | Wyeth Llc | Stabilne formulacije antigenov neisseria meningitidis RLP2086 |
GB201015132D0 (en) | 2010-09-10 | 2010-10-27 | Univ Bristol | Vaccine composition |
ES2585328T5 (es) | 2010-09-10 | 2022-12-14 | Wyeth Llc | Variantes no lipidadas de antígenos ORF2086 de Neisseria meningitidis |
ITMI20111182A1 (it) | 2011-06-28 | 2012-12-29 | Canio Buonavoglia | Vaccino per coronavirus canino |
US9539281B2 (en) | 2011-07-12 | 2017-01-10 | The Brigham And Women's Hospital, Inc. | Lipid-containing PSA compositions, methods of isolation and methods of use thereof |
KR101315599B1 (ko) | 2011-10-25 | 2013-10-10 | 건국대학교 산학협력단 | 폐렴균점막다당질 유형14 (cps14)와 호스래디시 퍼옥시다제의 당단백중합체 |
RU2665841C2 (ru) | 2012-03-09 | 2018-09-04 | Пфайзер Инк. | Композиции neisseria meningitidis и способы их применения |
SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
EP4272750A3 (de) | 2013-02-07 | 2024-01-24 | Children's Medical Center, Corp. | Proteinantigene zum schutz gegen pneumokokkenkolonisation und/oder -befall |
JP6446377B2 (ja) | 2013-03-08 | 2018-12-26 | ファイザー・インク | 免疫原性融合ポリペプチド |
EP3041502A2 (de) | 2013-09-08 | 2016-07-13 | Pfizer Inc. | Neisseria meningitidis-zusammensetzungen und verfahren dafür |
ES2883343T3 (es) | 2014-01-21 | 2021-12-07 | Pfizer | Polisacáridos capsulares de Streptococcus pneumoniae y conjugados de los mismos |
US9107906B1 (en) | 2014-10-28 | 2015-08-18 | Adma Biologics, Inc. | Compositions and methods for the treatment of immunodeficiency |
AU2015349787B2 (en) | 2014-11-21 | 2021-07-29 | The Board Of Regents Of The University Of Oklahoma | Pneumolysin mutants and methods of use thereof |
RU2723045C2 (ru) | 2015-02-19 | 2020-06-08 | Пфайзер Инк. | Композиции neisseria meningitidis и способы их получения |
WO2017031431A1 (en) | 2015-08-19 | 2017-02-23 | President And Fellows Of Harvard College | Lipidated psa compositions and methods |
US11491181B2 (en) | 2016-07-15 | 2022-11-08 | President And Fellows Of Harvard College | Glycolipid compositions and methods of use |
CN118662649A (zh) | 2016-12-30 | 2024-09-20 | Vaxcyte公司 | 具有非天然氨基酸的多肽-抗原缀合物 |
US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
IL267733B2 (en) | 2017-01-31 | 2023-10-01 | Pfizer | NEISSERIA MENINGITIDIS preparations and methods therefor |
US10259865B2 (en) | 2017-03-15 | 2019-04-16 | Adma Biologics, Inc. | Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection |
US10688170B2 (en) | 2017-06-10 | 2020-06-23 | Inventprise, Llc | Multivalent conjugate vaccines with bivalent or multivalent conjugate polysaccharides that provide improved immunogenicity and avidity |
US10729763B2 (en) | 2017-06-10 | 2020-08-04 | Inventprise, Llc | Mixtures of polysaccharide-protein pegylated compounds |
EP3900739A1 (de) | 2020-04-21 | 2021-10-27 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Synthetische streptococcus-pneumoniae-saccharid-konjugate zum konservierten membranprotein |
JP2023537945A (ja) | 2020-08-10 | 2023-09-06 | インベントプライズ・インコーポレイテッド | 出現血清型24fを含む多価肺炎球菌複合糖質ワクチン |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4242501A (en) * | 1979-08-08 | 1980-12-30 | American Cyanamid Company | Purification of pneumococcal capsular polysaccharides |
US4356170A (en) * | 1981-05-27 | 1982-10-26 | Canadian Patents & Development Ltd. | Immunogenic polysaccharide-protein conjugates |
US5360897A (en) * | 1981-08-31 | 1994-11-01 | The University Of Rochester | Immunogenic conjugates of streptococcus pneumonial capsular polymer and toxin or in toxiad |
US4902506A (en) * | 1983-07-05 | 1990-02-20 | The University Of Rochester | Immunogenic conjugates |
US4673574A (en) * | 1981-08-31 | 1987-06-16 | Anderson Porter W | Immunogenic conjugates |
US4761283A (en) * | 1983-07-05 | 1988-08-02 | The University Of Rochester | Immunogenic conjugates |
US4686102A (en) * | 1984-04-12 | 1987-08-11 | American Cyanamid Company | Multivalent pneumococcal vaccine and preparation thereof |
NZ214503A (en) * | 1984-12-20 | 1990-02-26 | Merck & Co Inc | Covalently-modified neutral bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins, and methods of preparing such polysaccharides and conjugates |
US5192540A (en) * | 1988-04-19 | 1993-03-09 | American Cyanamid Company | Haemophilus influenzae type b oxidized polysaccharide-outer membrane protein conjugate vaccine |
IL92816A0 (en) * | 1988-12-22 | 1990-09-17 | Biogrowth Inc | Recombinant dna molecules,hosts,processes and human somatomedin carrier protein-like polypeptides |
IL95578A (en) * | 1989-09-15 | 1998-08-16 | Gen Hospital Corp | A vaccine made from polysaccharide and protein |
US5153312A (en) * | 1990-09-28 | 1992-10-06 | American Cyanamid Company | Oligosaccharide conjugate vaccines |
CA2059692C (en) * | 1991-01-28 | 2004-11-16 | Peter J. Kniskern | Pneumoccoccal polysaccharide conjugate vaccine |
US5371197A (en) * | 1991-09-24 | 1994-12-06 | Merck & Co., Inc. | Protein-dimeric polysaccharide conjugate vaccine |
US5445817A (en) * | 1992-08-21 | 1995-08-29 | The United States Of America As Represented By The Department Of Health And Human Services | Pertussis toxin used as a carrier protein with non-charged saccharides in conjugate vaccines |
-
1994
- 1994-08-24 US US08/295,305 patent/US5565204A/en not_active Expired - Fee Related
-
1995
- 1995-08-10 DK DK95930151T patent/DK0778781T3/da active
- 1995-08-10 PT PT95930151T patent/PT778781E/pt unknown
- 1995-08-10 AU AU33636/95A patent/AU704450B2/en not_active Ceased
- 1995-08-10 ES ES95930151T patent/ES2152421T3/es not_active Expired - Lifetime
- 1995-08-10 EP EP95930151A patent/EP0778781B1/de not_active Expired - Lifetime
- 1995-08-10 CA CA002198251A patent/CA2198251C/en not_active Expired - Fee Related
- 1995-08-10 JP JP50814296A patent/JP3927233B2/ja not_active Expired - Fee Related
- 1995-08-10 DE DE69519634T patent/DE69519634T2/de not_active Expired - Fee Related
- 1995-08-10 WO PCT/US1995/010227 patent/WO1996005859A1/en active IP Right Grant
- 1995-08-10 AT AT95930151T patent/ATE198051T1/de not_active IP Right Cessation
- 1995-08-10 KR KR1019970701180A patent/KR100385411B1/ko not_active IP Right Cessation
- 1995-08-23 IL IL11504795A patent/IL115047A/xx not_active IP Right Cessation
-
2000
- 2000-12-14 GR GR20000402765T patent/GR3035081T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
IL115047A0 (en) | 1995-12-08 |
DE69519634T2 (de) | 2001-06-13 |
WO1996005859A1 (en) | 1996-02-29 |
JP3927233B2 (ja) | 2007-06-06 |
KR100385411B1 (ko) | 2003-12-11 |
EP0778781A1 (de) | 1997-06-18 |
CA2198251C (en) | 2007-06-12 |
EP0778781B1 (de) | 2000-12-13 |
AU704450B2 (en) | 1999-04-22 |
CA2198251A1 (en) | 1996-02-29 |
JPH10504717A (ja) | 1998-05-12 |
PT778781E (pt) | 2001-03-30 |
DK0778781T3 (da) | 2001-01-02 |
KR970705410A (ko) | 1997-10-09 |
GR3035081T3 (en) | 2001-03-30 |
ATE198051T1 (de) | 2000-12-15 |
AU3363695A (en) | 1996-03-14 |
ES2152421T3 (es) | 2001-02-01 |
IL115047A (en) | 2005-08-31 |
US5565204A (en) | 1996-10-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69519634D1 (de) | Pneumokokken-polysaccharid-rekombinante-pneumolysin-konjugate als impfstoffe für die immunisierung gegen pneumokokken-infektionen | |
DK0754055T3 (da) | Gruppe A-streptokok-polysaccharid-immunogen-præparater og metoder | |
FI914564A (fi) | Foerbaettrade konjugerade oligosackaridvacciner. | |
MC2178A1 (fr) | Mutants de la pneumolysine et vaccins a base de pneumocoque prepares a partir de ces mutants | |
EA200801344A1 (ru) | Пневмококковая полисахаридная конъюгатная вакцина | |
NO975546D0 (no) | Antigene gruppe B-streptokokk-type II- og type III-polysakkaridfragmenter med en 2,5-anhydro-D-mannose-terminal struktur samt en konjugatvaksine derav | |
ATE325620T1 (de) | Streptococcus pneumoniae proteine und impfstoffe | |
Alexander et al. | Development of experimental carbohydrate-conjugate vaccines composed of Streptococcus pneumoniae capsular polysaccharides and the universal helper T-lymphocyte epitope (PADRE®) | |
Michon et al. | Multivalent pneumococcal capsular polysaccharide conjugate vaccines employing genetically detoxified pneumolysin as a carrier protein | |
WO2001081380A3 (en) | Immunogenic pneumococcal protein and vaccine compositions thereof | |
Jennings | Further approaches for optimizing polysaccharide-protein conjugate vaccines for prevention of invasive bacterial disease | |
ES2126616T3 (es) | Vacuna pediatrica combinada, con una inmunogenecidad aumentada de cada componente de la vacuna. | |
ATE111745T1 (de) | Antikörper gegen streptococcus. | |
CO5241277A1 (es) | Vacuna |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: WYETH HOLDINGS CORP., MADISON, N.J., US |
|
8339 | Ceased/non-payment of the annual fee |