DE69517810T2 - Verfahren und diastereomere salze nützlich bei der racemattrennung von racemischer 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-alpha,alpha-dimethylphenyl essigsäure sowie entsprechende diastereomere salze - Google Patents

Verfahren und diastereomere salze nützlich bei der racemattrennung von racemischer 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-alpha,alpha-dimethylphenyl essigsäure sowie entsprechende diastereomere salze

Info

Publication number
DE69517810T2
DE69517810T2 DE69517810T DE69517810T DE69517810T2 DE 69517810 T2 DE69517810 T2 DE 69517810T2 DE 69517810 T DE69517810 T DE 69517810T DE 69517810 T DE69517810 T DE 69517810T DE 69517810 T2 DE69517810 T2 DE 69517810T2
Authority
DE
Germany
Prior art keywords
alpha
hydroxydiphenylmethyl
hydroxybutyl
piperidinyl
racemic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69517810T
Other languages
German (de)
English (en)
Other versions
DE69517810D1 (de
Inventor
Mitsuo Nakamura
Masatoshi Shiga
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Publication of DE69517810D1 publication Critical patent/DE69517810D1/de
Application granted granted Critical
Publication of DE69517810T2 publication Critical patent/DE69517810T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69517810T 1994-05-16 1995-04-10 Verfahren und diastereomere salze nützlich bei der racemattrennung von racemischer 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-alpha,alpha-dimethylphenyl essigsäure sowie entsprechende diastereomere salze Expired - Lifetime DE69517810T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24291994A 1994-05-16 1994-05-16
PCT/US1995/004422 WO1995031436A1 (fr) 1994-05-16 1995-04-10 PROCEDE ET SELS DIASTEREOMERES UTILES POUR LA RESOLUTION OPTIQUE DE α-[4-(1,1-DIMETHYLETHYL)PHENYL]-4-(HYDROXYDIPHENYLMETHYL)-1-PIPERIDINEBUTANOL RACEMIQUE ET DE COMPOSES DERIVES

Publications (2)

Publication Number Publication Date
DE69517810D1 DE69517810D1 (de) 2000-08-10
DE69517810T2 true DE69517810T2 (de) 2000-12-14

Family

ID=22916643

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69517810T Expired - Lifetime DE69517810T2 (de) 1994-05-16 1995-04-10 Verfahren und diastereomere salze nützlich bei der racemattrennung von racemischer 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-alpha,alpha-dimethylphenyl essigsäure sowie entsprechende diastereomere salze

Country Status (22)

Country Link
US (3) US20030078429A1 (fr)
EP (1) EP0759904B1 (fr)
JP (1) JPH10503752A (fr)
KR (1) KR100387459B1 (fr)
CN (3) CN1119330C (fr)
AT (1) ATE194328T1 (fr)
AU (1) AU689578B2 (fr)
CA (1) CA2189000C (fr)
DE (1) DE69517810T2 (fr)
DK (1) DK0759904T3 (fr)
ES (1) ES2149357T3 (fr)
FI (1) FI114095B (fr)
GR (1) GR3034444T3 (fr)
HK (2) HK1039485A1 (fr)
IL (1) IL113738A (fr)
MX (1) MX9605611A (fr)
NO (1) NO308031B1 (fr)
NZ (1) NZ284277A (fr)
PT (1) PT759904E (fr)
TW (1) TW424085B (fr)
WO (1) WO1995031436A1 (fr)
ZA (1) ZA953793B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6242464B1 (en) 1996-01-22 2001-06-05 Chiroscience Limited Single isomer methylphenidate and resolution process
MX9805870A (fr) * 1996-01-22 1999-01-31
US5925761A (en) * 1997-02-04 1999-07-20 Sepracor Inc. Synthesis of terfenadine and derivatives
DE10145223A1 (de) * 2001-09-13 2003-04-03 Basf Ag Verfahren zur Herstellung von meso-Zeaxanthin
ITMI20041568A1 (it) * 2004-07-30 2004-10-30 Dipharma Spa "polimorfi di fexofenadina base"
CA2833354C (fr) 2006-03-14 2015-12-15 University Of Southern California Dispositif mems et procede de livraison d'agents therapeutiques
ES2425769T5 (es) 2007-12-20 2017-07-28 University Of Southern California Aparato para la administración de agentes terapéuticos
EP2891501B1 (fr) 2008-05-08 2016-09-21 MiniPumps, LLC Procédés de fabrication de pompes d'administration de médicament
CN104353150A (zh) 2008-05-08 2015-02-18 迷你泵有限责任公司 可植入泵和用于可植入泵的插管
US9333297B2 (en) 2008-05-08 2016-05-10 Minipumps, Llc Drug-delivery pump with intelligent control
US9199035B2 (en) 2008-05-08 2015-12-01 Minipumps, Llc. Drug-delivery pumps with dynamic, adaptive control
SI2387556T1 (sl) * 2009-01-16 2014-09-30 Basf Se Separacija enantiomerne meĺ anice (r)- in (s)-3-amino-1-butanola
CN103497145B (zh) * 2013-10-10 2016-01-27 南昌大学 一种光学纯多奈哌齐的制备工艺
TW202024035A (zh) * 2018-09-28 2020-07-01 南韓商賽特瑞恩股份有限公司 用於製備(-)-琥珀酸西苯唑啉的新穎方法
EP4045499A1 (fr) * 2019-10-17 2022-08-24 Bayer Aktiengesellschaft Procédé de préparation de (2-cyanoéthyl (4s)-4-(4-cyano-2-méthoxy-phényl)-5-hydroxy-2,8-diméthyl-1,4-dihydro-1,6-naphtyridin-3-carboxylate par séparation racémique au moyen d'esters d'acide tartrique diastéréoisomères
IL292180A (en) * 2019-10-17 2022-06-01 Bayer Ag A process for the preparation of 2-cyanoethyl (4s)-4-(4-cyano-2-methoxy-phenyl)-5-ethoxy-8,2-dimethyl-4,1-dihydro-6,1-naphthyridine-3-carboxylate on by resolution of racemates using diastereomeric tartaric acid esters

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3452086A (en) * 1966-04-29 1969-06-24 Bristol Myers Co Substituted tartranilic acid resolving agents
IT951631B (it) * 1971-03-18 1973-07-10 Richardson Merrell Spa Composti utili per la separazione di isomeri ottici geometrici e strutturali e relativo procedimen to di sintesi
US3878217A (en) * 1972-01-28 1975-04-15 Richardson Merrell Inc Alpha-aryl-4-substituted piperidinoalkanol derivatives
FR2201108B1 (fr) * 1972-09-25 1977-12-23 Copier Henri
US4128663A (en) * 1977-03-15 1978-12-05 The Upjohn Company Anilide derivatives as antidepressants
US4285957A (en) * 1979-04-10 1981-08-25 Richardson-Merrell Inc. 1-Piperidine-alkanol derivatives, pharmaceutical compositions thereof, and method of use thereof
US4254129A (en) * 1979-04-10 1981-03-03 Richardson-Merrell Inc. Piperidine derivatives
EP0108817A1 (fr) * 1982-11-06 1984-05-23 Kanegafuchi Chemical Industry Co., Ltd. Composition stable de S-adénosyl-L-méthionine et sa méthode de préparation
JPS59210086A (ja) * 1983-05-13 1984-11-28 Kyowa Hakko Kogyo Co Ltd Ｄｘ―５２―１類及びその塩類
US5011989A (en) * 1987-10-09 1991-04-30 Sumitomo Chemical Company, Limited Optically active hydroxybenzylamine
US4931557A (en) * 1988-10-17 1990-06-05 Eli Lilly And Company Method of resolving cis 3-amino-4-(2-furyl)vinyl)-1-methoxycarbonylmethyl-azetidin-2-one and di-p-toluoyl-tartaric acid salts thereof
US4968837A (en) * 1989-07-28 1990-11-06 Ethyl Corporation Resolution of racemic mixtures

Also Published As

Publication number Publication date
DE69517810D1 (de) 2000-08-10
CA2189000A1 (fr) 1995-11-23
IL113738A0 (en) 1995-08-31
JPH10503752A (ja) 1998-04-07
EP0759904A1 (fr) 1997-03-05
EP0759904B1 (fr) 2000-07-05
NO964858L (no) 1997-01-15
CN1740156A (zh) 2006-03-01
US20030078429A1 (en) 2003-04-24
NO308031B1 (no) 2000-07-10
WO1995031436A1 (fr) 1995-11-23
PT759904E (pt) 2000-10-31
AU2284095A (en) 1995-12-05
HK1088603A1 (en) 2006-11-10
ZA953793B (en) 1996-01-19
FI964566A0 (fi) 1996-11-14
IL113738A (en) 2003-10-31
TW424085B (en) 2001-03-01
AU689578B2 (en) 1998-04-02
FI964566A (fi) 1996-11-14
CN1229346C (zh) 2005-11-30
ES2149357T3 (es) 2000-11-01
HK1039485A1 (en) 2002-04-26
MX9605611A (es) 1998-05-31
CN100369897C (zh) 2008-02-20
CA2189000C (fr) 2002-08-13
FI114095B (fi) 2004-08-13
CN1309121A (zh) 2001-08-22
US20040186137A1 (en) 2004-09-23
NZ284277A (en) 1998-01-26
CN1119330C (zh) 2003-08-27
NO964858D0 (no) 1996-11-15
ATE194328T1 (de) 2000-07-15
GR3034444T3 (en) 2000-12-29
CN1148382A (zh) 1997-04-23
DK0759904T3 (da) 2000-10-02
US20060014793A1 (en) 2006-01-19
KR100387459B1 (ko) 2003-11-20

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: AVENTIS INC. (N.D.GES.D. STAATES PENNSYLVANIA), GR

8327 Change in the person/name/address of the patent owner

Owner name: AVENTISUB II INC., GREENVILLE, DEL., US