NO308031B1 - FremgangsmÕte og diastereomere salter som er anvendbare for optisk oppløsning av racemisk <alfa>-[4-(1,1-dimetyletyl)fenyl]-4- - Google Patents
FremgangsmÕte og diastereomere salter som er anvendbare for optisk oppløsning av racemisk <alfa>-[4-(1,1-dimetyletyl)fenyl]-4-Info
- Publication number
- NO308031B1 NO308031B1 NO964858A NO964858A NO308031B1 NO 308031 B1 NO308031 B1 NO 308031B1 NO 964858 A NO964858 A NO 964858A NO 964858 A NO964858 A NO 964858A NO 308031 B1 NO308031 B1 NO 308031B1
- Authority
- NO
- Norway
- Prior art keywords
- alpha
- dimethylethyl
- phenyl
- racemic
- optical resolution
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 3
- 230000003287 optical effect Effects 0.000 title abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 title 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- IWYDHOAUDWTVEP-SSDOTTSWSA-N (R)-mandelic acid Chemical compound OC(=O)[C@H](O)C1=CC=CC=C1 IWYDHOAUDWTVEP-SSDOTTSWSA-N 0.000 abstract 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- -1 alkyl 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-alpha,alpha-dimethylbenzeneacetates Chemical class 0.000 abstract 1
- RWTNPBWLLIMQHL-UHFFFAOYSA-N fexofenadine Chemical compound C1=CC(C(C)(C(O)=O)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 RWTNPBWLLIMQHL-UHFFFAOYSA-N 0.000 abstract 1
- IWYDHOAUDWTVEP-UHFFFAOYSA-N mandelic acid Chemical compound OC(=O)C(O)C1=CC=CC=C1 IWYDHOAUDWTVEP-UHFFFAOYSA-N 0.000 abstract 1
- 230000001376 precipitating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24291994A | 1994-05-16 | 1994-05-16 | |
| PCT/US1995/004422 WO1995031436A1 (en) | 1994-05-16 | 1995-04-10 | PROCESS AND DIASTEREOMERIC SALTS USEFUL FOR THE OPTICAL RESOLUTION OF RACEMIC α-[4-(1,1-DIMETHYLETHYL)PHENYL]-4-(HYDROXYDIPHENYLMETHYL)-1-PIPERIDINEBUTANOL AND DERIVATIVE COMPOUNDS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO964858D0 NO964858D0 (no) | 1996-11-15 |
| NO964858L NO964858L (no) | 1997-01-15 |
| NO308031B1 true NO308031B1 (no) | 2000-07-10 |
Family
ID=22916643
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO964858A NO308031B1 (no) | 1994-05-16 | 1996-11-15 | FremgangsmÕte og diastereomere salter som er anvendbare for optisk oppløsning av racemisk <alfa>-[4-(1,1-dimetyletyl)fenyl]-4- |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US20030078429A1 (no) |
| EP (1) | EP0759904B1 (no) |
| JP (1) | JPH10503752A (no) |
| KR (1) | KR100387459B1 (no) |
| CN (3) | CN1119330C (no) |
| AT (1) | ATE194328T1 (no) |
| AU (1) | AU689578B2 (no) |
| CA (1) | CA2189000C (no) |
| DE (1) | DE69517810T2 (no) |
| DK (1) | DK0759904T3 (no) |
| ES (1) | ES2149357T3 (no) |
| FI (1) | FI114095B (no) |
| GR (1) | GR3034444T3 (no) |
| HK (2) | HK1039485A1 (no) |
| IL (1) | IL113738A (no) |
| MX (1) | MX9605611A (no) |
| NO (1) | NO308031B1 (no) |
| NZ (1) | NZ284277A (no) |
| PT (1) | PT759904E (no) |
| TW (1) | TW424085B (no) |
| WO (1) | WO1995031436A1 (no) |
| ZA (1) | ZA953793B (no) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6242464B1 (en) | 1996-01-22 | 2001-06-05 | Chiroscience Limited | Single isomer methylphenidate and resolution process |
| MX9805870A (no) * | 1996-01-22 | 1999-01-31 | ||
| US5925761A (en) * | 1997-02-04 | 1999-07-20 | Sepracor Inc. | Synthesis of terfenadine and derivatives |
| DE10145223A1 (de) * | 2001-09-13 | 2003-04-03 | Basf Ag | Verfahren zur Herstellung von meso-Zeaxanthin |
| ITMI20041568A1 (it) * | 2004-07-30 | 2004-10-30 | Dipharma Spa | "polimorfi di fexofenadina base" |
| CA2833354C (en) | 2006-03-14 | 2015-12-15 | University Of Southern California | Mems device and method for delivery of therapeutic agents |
| ES2425769T5 (es) | 2007-12-20 | 2017-07-28 | University Of Southern California | Aparato para la administración de agentes terapéuticos |
| EP2891501B1 (en) | 2008-05-08 | 2016-09-21 | MiniPumps, LLC | Methods of manufacture of drug-delivery pumps |
| CN104353150A (zh) | 2008-05-08 | 2015-02-18 | 迷你泵有限责任公司 | 可植入泵和用于可植入泵的插管 |
| US9333297B2 (en) | 2008-05-08 | 2016-05-10 | Minipumps, Llc | Drug-delivery pump with intelligent control |
| US9199035B2 (en) | 2008-05-08 | 2015-12-01 | Minipumps, Llc. | Drug-delivery pumps with dynamic, adaptive control |
| SI2387556T1 (sl) * | 2009-01-16 | 2014-09-30 | Basf Se | Separacija enantiomerne meĺ anice (r)- in (s)-3-amino-1-butanola |
| CN103497145B (zh) * | 2013-10-10 | 2016-01-27 | 南昌大学 | 一种光学纯多奈哌齐的制备工艺 |
| TW202024035A (zh) * | 2018-09-28 | 2020-07-01 | 南韓商賽特瑞恩股份有限公司 | 用於製備(-)-琥珀酸西苯唑啉的新穎方法 |
| EP4045499A1 (de) * | 2019-10-17 | 2022-08-24 | Bayer Aktiengesellschaft | Verfahren zur herstellung von 2-cyanoethyl (4s)-4-(4-cyano-2-methoxy-phenyl)-5-hydroxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridin-3-carboxylat durch racemat-spaltung mittels diastereomerer weinsäureester |
| IL292180A (en) * | 2019-10-17 | 2022-06-01 | Bayer Ag | A process for the preparation of 2-cyanoethyl (4s)-4-(4-cyano-2-methoxy-phenyl)-5-ethoxy-8,2-dimethyl-4,1-dihydro-6,1-naphthyridine-3-carboxylate on by resolution of racemates using diastereomeric tartaric acid esters |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3452086A (en) * | 1966-04-29 | 1969-06-24 | Bristol Myers Co | Substituted tartranilic acid resolving agents |
| IT951631B (it) * | 1971-03-18 | 1973-07-10 | Richardson Merrell Spa | Composti utili per la separazione di isomeri ottici geometrici e strutturali e relativo procedimen to di sintesi |
| US3878217A (en) * | 1972-01-28 | 1975-04-15 | Richardson Merrell Inc | Alpha-aryl-4-substituted piperidinoalkanol derivatives |
| FR2201108B1 (no) * | 1972-09-25 | 1977-12-23 | Copier Henri | |
| US4128663A (en) * | 1977-03-15 | 1978-12-05 | The Upjohn Company | Anilide derivatives as antidepressants |
| US4285957A (en) * | 1979-04-10 | 1981-08-25 | Richardson-Merrell Inc. | 1-Piperidine-alkanol derivatives, pharmaceutical compositions thereof, and method of use thereof |
| US4254129A (en) * | 1979-04-10 | 1981-03-03 | Richardson-Merrell Inc. | Piperidine derivatives |
| EP0108817A1 (en) * | 1982-11-06 | 1984-05-23 | Kanegafuchi Chemical Industry Co., Ltd. | Stable composition of S-adenosyl-L-methionine and process for preparation thereof |
| JPS59210086A (ja) * | 1983-05-13 | 1984-11-28 | Kyowa Hakko Kogyo Co Ltd | Ｄｘ―５２―１類及びその塩類 |
| US5011989A (en) * | 1987-10-09 | 1991-04-30 | Sumitomo Chemical Company, Limited | Optically active hydroxybenzylamine |
| US4931557A (en) * | 1988-10-17 | 1990-06-05 | Eli Lilly And Company | Method of resolving cis 3-amino-4-(2-furyl)vinyl)-1-methoxycarbonylmethyl-azetidin-2-one and di-p-toluoyl-tartaric acid salts thereof |
| US4968837A (en) * | 1989-07-28 | 1990-11-06 | Ethyl Corporation | Resolution of racemic mixtures |
-
1995
- 1995-04-10 CA CA002189000A patent/CA2189000C/en not_active Expired - Lifetime
- 1995-04-10 AU AU22840/95A patent/AU689578B2/en not_active Expired
- 1995-04-10 WO PCT/US1995/004422 patent/WO1995031436A1/en active IP Right Grant
- 1995-04-10 EP EP95916294A patent/EP0759904B1/en not_active Expired - Lifetime
- 1995-04-10 CN CN95193082A patent/CN1119330C/zh not_active Expired - Lifetime
- 1995-04-10 AT AT95916294T patent/ATE194328T1/de active
- 1995-04-10 ES ES95916294T patent/ES2149357T3/es not_active Expired - Lifetime
- 1995-04-10 CN CNB001201409A patent/CN1229346C/zh not_active Expired - Lifetime
- 1995-04-10 KR KR1019960706571A patent/KR100387459B1/ko not_active IP Right Cessation
- 1995-04-10 CN CNB2005101075877A patent/CN100369897C/zh not_active Expired - Lifetime
- 1995-04-10 NZ NZ284277A patent/NZ284277A/en not_active IP Right Cessation
- 1995-04-10 PT PT95916294T patent/PT759904E/pt unknown
- 1995-04-10 MX MX9605611A patent/MX9605611A/es unknown
- 1995-04-10 DE DE69517810T patent/DE69517810T2/de not_active Expired - Lifetime
- 1995-04-10 JP JP7529641A patent/JPH10503752A/ja not_active Ceased
- 1995-04-10 DK DK95916294T patent/DK0759904T3/da active
- 1995-05-10 ZA ZA953793A patent/ZA953793B/xx unknown
- 1995-05-11 TW TW084104669A patent/TW424085B/zh not_active IP Right Cessation
- 1995-05-15 IL IL11373895A patent/IL113738A/xx not_active IP Right Cessation
-
1996
- 1996-11-14 FI FI964566A patent/FI114095B/fi not_active IP Right Cessation
- 1996-11-15 NO NO964858A patent/NO308031B1/no not_active IP Right Cessation
-
2000
- 2000-09-20 GR GR20000402136T patent/GR3034444T3/el unknown
-
2001
- 2001-12-27 HK HK01109104A patent/HK1039485A1/xx not_active IP Right Cessation
-
2002
- 2002-07-10 US US10/192,444 patent/US20030078429A1/en not_active Abandoned
-
2004
- 2004-01-29 US US10/767,790 patent/US20040186137A1/en not_active Abandoned
-
2005
- 2005-09-15 US US11/227,246 patent/US20060014793A1/en not_active Abandoned
-
2006
- 2006-08-15 HK HK06109035.2A patent/HK1088603A1/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |