DE69516605T2 - Camptothecin-Derivate, ihre Herstellung und Antitumormittel - Google Patents
Camptothecin-Derivate, ihre Herstellung und AntitumormittelInfo
- Publication number
- DE69516605T2 DE69516605T2 DE69516605T DE69516605T DE69516605T2 DE 69516605 T2 DE69516605 T2 DE 69516605T2 DE 69516605 T DE69516605 T DE 69516605T DE 69516605 T DE69516605 T DE 69516605T DE 69516605 T2 DE69516605 T2 DE 69516605T2
- Authority
- DE
- Germany
- Prior art keywords
- hydrogen
- alkyl
- camptothecin derivatives
- production
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000002246 antineoplastic agent Substances 0.000 title abstract 2
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 title abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000006350 alkyl thio alkyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- -1 methoxyethoxymethoxy group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000004417 unsaturated alkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6246660A JPH0873461A (ja) | 1994-09-06 | 1994-09-06 | 新規なカンプトテシン誘導体、その製造法および抗腫瘍剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69516605D1 DE69516605D1 (de) | 2000-06-08 |
| DE69516605T2 true DE69516605T2 (de) | 2000-10-26 |
Family
ID=17151729
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69516605T Expired - Fee Related DE69516605T2 (de) | 1994-09-06 | 1995-09-05 | Camptothecin-Derivate, ihre Herstellung und Antitumormittel |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5843954A (de) |
| EP (1) | EP0700914B1 (de) |
| JP (1) | JPH0873461A (de) |
| KR (1) | KR100351952B1 (de) |
| CN (1) | CN1052482C (de) |
| AT (1) | ATE192447T1 (de) |
| AU (1) | AU688547B2 (de) |
| CA (1) | CA2157128C (de) |
| DE (1) | DE69516605T2 (de) |
| DK (1) | DK0700914T3 (de) |
| ES (1) | ES2146275T3 (de) |
| GR (1) | GR3033798T3 (de) |
| IL (1) | IL114989A (de) |
| NZ (1) | NZ272904A (de) |
| PT (1) | PT700914E (de) |
| RU (1) | RU2133748C1 (de) |
| ZA (1) | ZA957269B (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4094710B2 (ja) * | 1997-11-06 | 2008-06-04 | 株式会社ヤクルト本社 | 新規なカンプトテシン誘導体 |
| FR2792937B1 (fr) | 1999-04-27 | 2001-08-10 | Cemaf | NOUVEAUX DERIVES DE PYRROLO-(3,4-b) QUINOLEINE, LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION A TITRE DE MEDICAMENT |
| EP2266607A3 (de) | 1999-10-01 | 2011-04-20 | Immunogen, Inc. | Immunokonjugate für Krebsbehandlung |
| AR027687A1 (es) | 2000-03-22 | 2003-04-09 | Yakult Honsha Kk | Procedimiento para preparar camptotecina |
| CZ299329B6 (cs) * | 2003-08-26 | 2008-06-18 | Pliva-Lachema A.S. | Zpusob výroby 7-ethyl-10-[ 4-(1-piperidino)-1-piperidino]karbonyloxykamptothecinu |
| CZ299593B6 (cs) * | 2003-12-16 | 2008-09-10 | Pliva-Lachema A. S. | Zpusob výroby 7-ethyl-10-hydroxykamptothecinu |
| ITMI20051348A1 (it) * | 2005-07-14 | 2007-01-15 | Indena Spa | Analoghi della camptotecina loro processo di ottenimento loro uso e formulazioni che li contengono |
| CN100339377C (zh) * | 2005-09-05 | 2007-09-26 | 合肥中科大生物技术有限公司 | 喜树碱衍生物及其制备 |
| CN1319971C (zh) * | 2005-09-09 | 2007-06-06 | 合肥中科大生物技术有限公司 | 喜树碱衍生物及其用途 |
| CN102746314B (zh) * | 2011-04-18 | 2016-07-06 | 华东师范大学 | 含有稳定7元内酯环的喜树碱类化合物、制备方法和用途 |
| US11814394B2 (en) | 2021-11-16 | 2023-11-14 | Genequantum Healthcare (Suzhou) Co., Ltd. | Exatecan derivatives, linker-payloads, and conjugates and thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5839684A (ja) * | 1981-09-04 | 1983-03-08 | Yakult Honsha Co Ltd | １０−置換カンプテシン誘導体の製造法 |
| JPS5951287A (ja) * | 1982-09-17 | 1984-03-24 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体 |
| US4981968A (en) * | 1987-03-31 | 1991-01-01 | Research Triangle Institute | Synthesis of camptothecin and analogs thereof |
| US5049668A (en) * | 1989-09-15 | 1991-09-17 | Research Triangle Institute | 10,11-methylenedioxy-20(RS)-camptothecin analogs |
| US5122606A (en) * | 1987-04-14 | 1992-06-16 | Research Triangle Institute | 10,11-methylenedioxy camptothecins |
| JP2540357B2 (ja) * | 1987-06-24 | 1996-10-02 | 第一製薬株式会社 | 六環性化合物 |
| CA1332413C (en) * | 1987-06-25 | 1994-10-11 | Kabushiki Kaisha Yakult Honsha | Camptothecin derivatives and process for preparing same |
| JP2538792B2 (ja) | 1987-06-25 | 1996-10-02 | 株式会社ヤクルト本社 | 新規なカンプトテシン誘導体 |
| JPH0615547B2 (ja) * | 1988-01-20 | 1994-03-02 | 株式会社ヤクルト本社 | 新規なカンプトテシン誘導体 |
| WO1991004260A2 (en) * | 1989-09-15 | 1991-04-04 | Research Triangle Institute | 10,11-methylenedioxy-20(rs)-camptothecin and 10,11-methylenedioxy-20(s)-camptothecin analogs |
| US5162532A (en) * | 1990-12-20 | 1992-11-10 | North Carolina State University | Intermediates and method of making camptothecin and camptothecin analogs |
-
1994
- 1994-09-06 JP JP6246660A patent/JPH0873461A/ja not_active Ceased
-
1995
- 1995-08-12 KR KR1019950025066A patent/KR100351952B1/ko not_active IP Right Cessation
- 1995-08-17 IL IL11498995A patent/IL114989A/en not_active IP Right Cessation
- 1995-08-29 CA CA002157128A patent/CA2157128C/en not_active Expired - Fee Related
- 1995-08-30 ZA ZA957269A patent/ZA957269B/xx unknown
- 1995-08-31 NZ NZ272904A patent/NZ272904A/en unknown
- 1995-09-05 DK DK95113931T patent/DK0700914T3/da active
- 1995-09-05 AU AU30474/95A patent/AU688547B2/en not_active Ceased
- 1995-09-05 PT PT95113931T patent/PT700914E/pt unknown
- 1995-09-05 ES ES95113931T patent/ES2146275T3/es not_active Expired - Lifetime
- 1995-09-05 RU RU95115049A patent/RU2133748C1/ru not_active IP Right Cessation
- 1995-09-05 AT AT95113931T patent/ATE192447T1/de not_active IP Right Cessation
- 1995-09-05 EP EP95113931A patent/EP0700914B1/de not_active Expired - Lifetime
- 1995-09-05 DE DE69516605T patent/DE69516605T2/de not_active Expired - Fee Related
- 1995-09-06 CN CN95109535A patent/CN1052482C/zh not_active Expired - Fee Related
-
1997
- 1997-11-21 US US08/976,398 patent/US5843954A/en not_active Expired - Fee Related
-
2000
- 2000-06-28 GR GR20000401497T patent/GR3033798T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK0700914T3 (da) | 2000-07-31 |
| PT700914E (pt) | 2000-09-29 |
| AU3047495A (en) | 1996-03-21 |
| CA2157128C (en) | 2006-04-11 |
| GR3033798T3 (en) | 2000-10-31 |
| JPH0873461A (ja) | 1996-03-19 |
| NZ272904A (en) | 1996-08-27 |
| ATE192447T1 (de) | 2000-05-15 |
| AU688547B2 (en) | 1998-03-12 |
| CN1052482C (zh) | 2000-05-17 |
| ES2146275T3 (es) | 2000-08-01 |
| CN1126212A (zh) | 1996-07-10 |
| IL114989A (en) | 1998-09-24 |
| EP0700914A1 (de) | 1996-03-13 |
| ZA957269B (en) | 1996-03-25 |
| CA2157128A1 (en) | 1996-03-07 |
| KR960010644A (ko) | 1996-04-20 |
| IL114989A0 (en) | 1995-12-08 |
| US5843954A (en) | 1998-12-01 |
| EP0700914B1 (de) | 2000-05-03 |
| DE69516605D1 (de) | 2000-06-08 |
| RU2133748C1 (ru) | 1999-07-27 |
| KR100351952B1 (ko) | 2002-12-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |