US6184389B1
(en)
|
1994-01-11 |
2001-02-06 |
Isis Pharmaceuticals, Inc. |
Combinatorial libraries having aminodiol monomer subunits
|
US6828427B1
(en)
|
1994-01-11 |
2004-12-07 |
Isis Pharmaceuticals, Inc. |
Oligomeric aminodiol-containing compounds, libraries thereof, and process of preparing the same
|
ZA95260B
(en)
|
1994-01-13 |
1995-09-28 |
Univ Columbia |
Synthetic receptors libraries and uses thereof
|
US6797522B1
(en)
|
1994-01-13 |
2004-09-28 |
The Trustees Of Columbia University In The City Of New York |
Synthetic receptors
|
US5856083A
(en)
*
|
1994-05-06 |
1999-01-05 |
Pharmacopeia, Inc. |
Lawn assay for compounds that affect enzyme activity or bind to target molecules
|
US5824483A
(en)
*
|
1994-05-18 |
1998-10-20 |
Pence Inc. |
Conformationally-restricted combinatiorial library composition and method
|
US6207826B1
(en)
|
1995-03-27 |
2001-03-27 |
Isis Pharmaceuticals, Inc. |
Macrocyclic compounds having nitrogen-containing linkages
|
JPH10512570A
(ja)
*
|
1995-01-20 |
1998-12-02 |
モレキュメティックス リミテッド |
コンホメーション的に制限された逆ターンライブラリおよびそれらに関連する方法
|
EP0817787A4
(de)
*
|
1995-03-27 |
2000-09-13 |
Isis Pharmaceuticals Inc |
Makrozyklische stickstoffverbindungen
|
US6958245B2
(en)
|
1996-04-25 |
2005-10-25 |
Bioarray Solutions Ltd. |
Array cytometry
|
US7144119B2
(en)
*
|
1996-04-25 |
2006-12-05 |
Bioarray Solutions Ltd. |
System and method for programmable illumination pattern generation
|
ATE366418T1
(de)
*
|
1996-04-25 |
2007-07-15 |
Bioarray Solutions Ltd |
Licht-regulierte, elektrokinetische zusammensetzung von partikeln an oberflächen
|
EP1726958A3
(de)
*
|
1996-04-25 |
2007-07-11 |
BioArray Solutions Ltd. |
Lichtgesteuerte elektrokinetische Anordnung von Partikeln in der Nähe von Oberflächen
|
US7041510B2
(en)
|
1996-04-25 |
2006-05-09 |
Bioarray Solutions Ltd. |
System and method for programmable illumination pattern generation
|
US6387707B1
(en)
*
|
1996-04-25 |
2002-05-14 |
Bioarray Solutions |
Array Cytometry
|
GB9610813D0
(en)
*
|
1996-05-23 |
1996-07-31 |
Pharmacia Spa |
Combinatorial solid phase synthesis of a library of benzufuran derivatives
|
US5731438A
(en)
*
|
1996-08-01 |
1998-03-24 |
Isis Pharmaceuticals, Inc. |
N-(aminoalkyl)-and/or N-(amidoalkyl)-dinitrogen heterocycles
|
US6077954A
(en)
|
1996-08-01 |
2000-06-20 |
Isis Pharmaceuticals, Inc. |
Substituted heterocyclic compounds
|
US5922872A
(en)
*
|
1996-08-01 |
1999-07-13 |
Isis Pharmaceuticals, Inc. |
Meta-benzylic and alpha-amido compositions and methods for preparing same
|
US5798360A
(en)
*
|
1996-08-01 |
1998-08-25 |
Isis Pharmaceuticals, Inc. |
N-(aminoalkyl)- and/or N-(amidoalkyl)- dinitrogen heterocyclic compositions
|
US5817489A
(en)
*
|
1996-08-01 |
1998-10-06 |
Isis Pharmaceuticals, Inc. |
Di-nitrogen heterocycle compositions
|
US6057102A
(en)
*
|
1996-08-08 |
2000-05-02 |
The Aaron Diamond Aids Research Center |
HIV coreceptor mutants
|
WO1998024760A1
(en)
*
|
1996-12-03 |
1998-06-11 |
Graybill Todd L |
Aminobenzenedicarboxylic acid-based combinatorial libraries
|
US5969102A
(en)
|
1997-03-03 |
1999-10-19 |
St. Jude Children's Research Hospital |
Lymphocyte surface receptor that binds CAML, nucleic acids encoding the same and methods of use thereof
|
US20030027126A1
(en)
|
1997-03-14 |
2003-02-06 |
Walt David R. |
Methods for detecting target analytes and enzymatic reactions
|
US7622294B2
(en)
|
1997-03-14 |
2009-11-24 |
Trustees Of Tufts College |
Methods for detecting target analytes and enzymatic reactions
|
JP4302780B2
(ja)
*
|
1997-05-23 |
2009-07-29 |
バイオアレイ ソリューションズ エルエルシー |
マトリックスで結合された化合物の色別コード化とインシトゥ探索
|
US6750344B1
(en)
|
1997-09-05 |
2004-06-15 |
Isis Pharmaceuticals, Inc. |
Amine compounds and combinatorial libraries comprising same
|
WO1999048897A2
(en)
*
|
1998-03-23 |
1999-09-30 |
President And Fellows Of Harvard College |
Synthesis of compounds and libraries of compounds
|
KR20010042373A
(ko)
*
|
1998-03-30 |
2001-05-25 |
린다 에스. 스티븐슨 |
핵 수용체 활성을 조절하는 방법 및 화합물
|
IL141759A0
(en)
*
|
1998-09-03 |
2002-03-10 |
Trellis Bioinformatics Inc |
Multihued labels
|
AU6394399A
(en)
|
1998-09-18 |
2000-04-10 |
Rockefeller University, The |
Lynx, a novel family of receptor ligands in the central nervous system, corresponding nucleic acids and proteins and uses thereof
|
DE19924606A1
(de)
*
|
1999-05-28 |
2000-11-30 |
Graffinity Pharm Design Gmbh |
Ligand-Anker-Konjugate
|
AU7856600A
(en)
|
1999-10-04 |
2001-05-10 |
University Of Medicine And Dentistry Of New Jersey |
Novel carbamates and ureas
|
JP2003514913A
(ja)
*
|
1999-11-24 |
2003-04-22 |
マサチューセッツ インスティテュート オブ テクノロジー |
多糖、天然生成物及びコンビナトリアル・ライブラリの合成に有用な保護基
|
US6458538B1
(en)
*
|
1999-12-14 |
2002-10-01 |
Ptc Therapeutics, Inc. |
Methods of assaying for compounds that inhibit premature translation termination and nonsense-mediated RNA decay
|
US20040033600A1
(en)
|
2001-03-21 |
2004-02-19 |
Palli Subba Reddy |
Ecdysone receptor-based inducible gene expression system
|
AU7299301A
(en)
|
2000-06-21 |
2002-01-02 |
Bioarray Solutions Ltd |
Multianalyte molecular analysis using application-specific random particle arrays
|
US9709559B2
(en)
|
2000-06-21 |
2017-07-18 |
Bioarray Solutions, Ltd. |
Multianalyte molecular analysis using application-specific random particle arrays
|
WO2002012294A2
(en)
|
2000-08-08 |
2002-02-14 |
St. Jude Children's Research Hospital |
Group b streptococcus polypeptides nucleic acids and therapeutic compositions and vaccines thereof
|
US7057704B2
(en)
*
|
2000-09-17 |
2006-06-06 |
Bioarray Solutions Ltd. |
System and method for programmable illumination pattern generation
|
US8105825B2
(en)
|
2000-10-03 |
2012-01-31 |
Intrexon Corporation |
Multiple inducible gene regulation system
|
US20030045005A1
(en)
*
|
2000-10-17 |
2003-03-06 |
Michael Seul |
Light-controlled electrokinetic assembly of particles near surfaces
|
DE10106339A1
(de)
*
|
2001-02-09 |
2002-08-22 |
Hans-Joachim Mueller |
Verfahren zum Hochdurchsatz-Screening von Kandidaten-Verbindungen über die Hochdurchsatz-Direktsynthese von rekombinanten Polypeptiden
|
EP1373470B1
(de)
|
2001-02-20 |
2013-04-24 |
Intrexon Corporation |
Neue substitutionsmutantenrezeptoren und ihre verwendung in einem induzierbaren genexpressionssystem auf basis eines nukleären rezeptors
|
WO2002066615A2
(en)
|
2001-02-20 |
2002-08-29 |
Rheogene, Inc. |
Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system
|
MXPA03007492A
(es)
|
2001-02-20 |
2004-10-15 |
Rheogene Holdings Inc |
Receptores de retinoide x quimerico y su uso en un sistema de expresion de gen inducible basado en receptor de ecdisona novedoso.
|
EP1456346B1
(de)
|
2001-02-20 |
2012-02-15 |
Intrexon Corporation |
Neues induzierbares genexpressionssystem auf ecdysonrezeptor/invertebraten-retinoid-x-rezeptor-basis
|
US20050142545A1
(en)
*
|
2001-04-11 |
2005-06-30 |
Conn Michael M. |
Methods for identifying small molecules that bind specific rna structural motifs
|
US20060228730A1
(en)
*
|
2001-04-11 |
2006-10-12 |
Rando Robert F |
Methods for identifying small molecules that bind specific RNA structural motifs
|
WO2002083822A2
(en)
*
|
2001-04-13 |
2002-10-24 |
Mitrovich Michael J |
Solid lubricant and composition
|
EP1401850A1
(de)
|
2001-06-20 |
2004-03-31 |
Nuevolution A/S |
Nukleosidderivate zur herstellung einer verbindungsbibliothek
|
US7262063B2
(en)
|
2001-06-21 |
2007-08-28 |
Bio Array Solutions, Ltd. |
Directed assembly of functional heterostructures
|
WO2003019183A1
(en)
*
|
2001-08-23 |
2003-03-06 |
Deltagen Research Laboratories, L.L.C. |
Process for the informative and iterative design of a gene-family screening library
|
ES2429132T3
(es)
|
2001-08-31 |
2013-11-13 |
The Rockefeller University |
Atividad de fosfodiesterasa y regulación de la señalización mediada por fosfodiesterasa 1-B en el cerebro
|
US7919269B2
(en)
|
2001-09-26 |
2011-04-05 |
Intrexon Corporation |
Whitefly ecdysone receptor nucleic acids, polypeptides, and uses thereof
|
US7563879B2
(en)
|
2001-09-26 |
2009-07-21 |
Intrexon Corporation |
Leafhopper ecdysone receptor nucleic acids, polypeptides, and uses thereof
|
JP4377689B2
(ja)
|
2001-10-15 |
2009-12-02 |
バイオアレイ ソリューションズ リミテッド |
同時尋問及び酵素仲介検出による多型遺伝子座の複合分析
|
US7202030B2
(en)
*
|
2001-11-01 |
2007-04-10 |
Rensselaer Polytechnic Institute |
Solid-phase array-based biocatalytic transformations
|
IL162838A0
(en)
|
2002-01-04 |
2005-11-20 |
Univ Rockefeller |
Compositions and methods for prevention and treatment peptide-of amyloid- related disorders
|
US7291456B2
(en)
|
2002-01-24 |
2007-11-06 |
The Regents Of The University Of California |
Method for determining differences in molecular interactions and for screening a combinatorial library
|
US20040171062A1
(en)
*
|
2002-02-28 |
2004-09-02 |
Plexxikon, Inc. |
Methods for the design of molecular scaffolds and ligands
|
CN101006177B
(zh)
*
|
2002-03-15 |
2011-10-12 |
纽韦卢森公司 |
改善的用于合成模制分子的方法
|
US20070015230A1
(en)
*
|
2002-04-15 |
2007-01-18 |
Hammond David J |
Identification and characterization of analytes from whole blood
|
CA2482856A1
(en)
*
|
2002-04-15 |
2003-10-30 |
American National Red Cross |
Plasma protein-binding ligands
|
WO2004001010A2
(en)
*
|
2002-06-21 |
2003-12-31 |
Ptc Therapeutics, Inc. |
METHODS FOR IDENTIFYING SMALL MOLECULES THAT MODULATE PREMATURE TRANSLATION TERMINATION AND NONSENSE MEDIATED mRNA DECAY
|
US7927791B2
(en)
*
|
2002-07-24 |
2011-04-19 |
Ptc Therapeutics, Inc. |
Methods for identifying small molecules that modulate premature translation termination and nonsense mediated mRNA decay
|
US10730906B2
(en)
*
|
2002-08-01 |
2020-08-04 |
Nuevolutions A/S |
Multi-step synthesis of templated molecules
|
EP1558751A4
(de)
*
|
2002-09-16 |
2007-08-22 |
Plexxikon Inc |
Kristallstruktur von pim-1-kinase
|
WO2004028682A2
(en)
*
|
2002-09-27 |
2004-04-08 |
Carlsberg A/S |
Spatially encoded polymer matrix
|
ES2640279T3
(es)
|
2002-10-30 |
2017-11-02 |
Nuevolution A/S |
Procedimiento para la síntesis de un complejo bifuncional
|
WO2004047007A1
(en)
|
2002-11-15 |
2004-06-03 |
Bioarray Solutions, Ltd. |
Analysis, secure access to, and transmission of array images
|
US9121110B2
(en)
|
2002-12-19 |
2015-09-01 |
Nuevolution A/S |
Quasirandom structure and function guided synthesis methods
|
ES2619353T3
(es)
|
2003-01-31 |
2017-06-26 |
Mount Sinai School Of Medicine Of New York University |
Terapia de combinación para tratar trastornos de deficiencia de proteínas
|
US7304161B2
(en)
|
2003-02-10 |
2007-12-04 |
Intrexon Corporation |
Diaclhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex
|
WO2004074429A2
(en)
|
2003-02-21 |
2004-09-02 |
Nuevolution A/S |
Method for producing second-generation library
|
US20060269920A1
(en)
*
|
2003-02-21 |
2006-11-30 |
Nuevolution A/S |
Method for obtaining structural information about an encoded molecule
|
US7456315B2
(en)
|
2003-02-28 |
2008-11-25 |
Intrexon Corporation |
Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
|
US20050170431A1
(en)
*
|
2003-02-28 |
2005-08-04 |
Plexxikon, Inc. |
PYK2 crystal structure and uses
|
US20050079548A1
(en)
*
|
2003-07-07 |
2005-04-14 |
Plexxikon, Inc. |
Ligand development using PDE4B crystal structures
|
CA2532403A1
(en)
*
|
2003-07-17 |
2005-02-03 |
James Arnold |
Ppar active compounds
|
US7348338B2
(en)
*
|
2003-07-17 |
2008-03-25 |
Plexxikon, Inc. |
PPAR active compounds
|
WO2005028624A2
(en)
*
|
2003-09-15 |
2005-03-31 |
Plexxikon, Inc. |
Molecular scaffolds for kinase ligand development
|
DE602004023960D1
(de)
|
2003-09-18 |
2009-12-17 |
Nuevolution As |
Methode zur Gewinnung struktureller Informationen kodierter Moleküle und zur Selektion von Verbindungen
|
US7927796B2
(en)
|
2003-09-18 |
2011-04-19 |
Bioarray Solutions, Ltd. |
Number coding for identification of subtypes of coded types of solid phase carriers
|
EP1664722B1
(de)
|
2003-09-22 |
2011-11-02 |
Bioarray Solutions Ltd |
Oberflächenimmobilisierter polyelektrolyt mit mehreren, zur kovalenten bindung an biomoleküle fähigen funktionellen gruppen
|
US7563569B2
(en)
|
2003-10-28 |
2009-07-21 |
Michael Seul |
Optimization of gene expression analysis using immobilized capture probes
|
JP2007509629A
(ja)
|
2003-10-29 |
2007-04-19 |
バイオアレイ ソリューションズ リミテッド |
二本鎖dnaの切断による複合核酸分析
|
PT1696920E
(pt)
|
2003-12-19 |
2015-01-14 |
Plexxikon Inc |
Compostos e métodos para o desenvolvimento de moduladores de ret
|
US20070066641A1
(en)
*
|
2003-12-19 |
2007-03-22 |
Prabha Ibrahim |
Compounds and methods for development of RET modulators
|
US20090239211A1
(en)
*
|
2004-02-17 |
2009-09-24 |
Nuevolution A/S |
Method For Enrichment Involving Elimination By Mismatch Hybridisation
|
US7935510B2
(en)
|
2004-04-30 |
2011-05-03 |
Intrexon Corporation |
Mutant receptors and their use in a nuclear receptor-based inducible gene expression system
|
CN101031293A
(zh)
*
|
2004-05-06 |
2007-09-05 |
普莱希科公司 |
Pde4b抑制剂及其应用
|
US7498342B2
(en)
|
2004-06-17 |
2009-03-03 |
Plexxikon, Inc. |
Compounds modulating c-kit activity
|
US7848889B2
(en)
|
2004-08-02 |
2010-12-07 |
Bioarray Solutions, Ltd. |
Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
|
AU2005279795A1
(en)
*
|
2004-09-03 |
2006-03-09 |
Plexxikon, Inc. |
Bicyclic heteroaryl PDE4B inhibitors
|
JP2008521829A
(ja)
*
|
2004-11-30 |
2008-06-26 |
プレキシコン,インコーポレーテッド |
Ppar活性化合物
|
US20060160135A1
(en)
*
|
2004-12-08 |
2006-07-20 |
Weiru Wang |
SF-1 and LRH-1 modulator development
|
EP1885723A2
(de)
*
|
2005-05-17 |
2008-02-13 |
Plexxikon, Inc. |
Pyrrolo[2,3-b]pyridin-derivative als proteinkinase-hemmer
|
US8486629B2
(en)
|
2005-06-01 |
2013-07-16 |
Bioarray Solutions, Ltd. |
Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
|
US20070021433A1
(en)
|
2005-06-03 |
2007-01-25 |
Jian-Qiang Fan |
Pharmacological chaperones for treating obesity
|
RS52010B
(en)
*
|
2005-06-22 |
2012-04-30 |
Plexxikon Inc. |
DERIVATI PIROLO [2, 3-B] PIRIDINA KAO INHIBITORI PROTEIN KINAZE
|
WO2007005898A2
(en)
|
2005-07-05 |
2007-01-11 |
Cornell Research Foundation, Inc. |
Blocking leukocyte emigration and inflammation by interfering with cd99l2
|
AU2006287513A1
(en)
*
|
2005-09-07 |
2007-03-15 |
Plexxikon, Inc. |
1, 3-disubstituted indole derivatives for use as PPAR modulators
|
AU2006295515A1
(en)
*
|
2005-09-27 |
2007-04-05 |
Polybatics Limited |
Polymer particles and uses thereof
|
SI2341140T1
(sl)
*
|
2005-12-01 |
2017-12-29 |
Nuevolution A/S |
Postopki encimskega kodiranja za učinkovito sintezo velikih knjižnic
|
ES2400676T3
(es)
|
2006-10-11 |
2013-04-11 |
Janssen Pharmaceutica Nv |
Composiciones y métodos para el tratamiento y el diagnóstico de síndrome de intestino irritable
|
WO2008063888A2
(en)
|
2006-11-22 |
2008-05-29 |
Plexxikon, Inc. |
Compounds modulating c-fms and/or c-kit activity and uses therefor
|
RU2009122670A
(ru)
|
2006-12-21 |
2011-01-27 |
Плекссикон, Инк. (Us) |
Соединения и способы для модуляции киназ и показания к их применению
|
PE20121126A1
(es)
*
|
2006-12-21 |
2012-08-24 |
Plexxikon Inc |
Compuestos pirrolo [2,3-b] piridinas como moduladores de quinasa
|
WO2008079909A1
(en)
*
|
2006-12-21 |
2008-07-03 |
Plexxikon, Inc. |
Pyrrolo [2,3-b] pyridines as kinase modulators
|
PE20090159A1
(es)
*
|
2007-03-08 |
2009-02-21 |
Plexxikon Inc |
COMPUESTOS DERIVADOS DE ACIDO INDOL-PROPIONICO COMO MODULADORES PPARs
|
US20100190777A1
(en)
|
2007-07-17 |
2010-07-29 |
Plexxikon Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
KR20170119729A
(ko)
|
2009-02-13 |
2017-10-27 |
엑스-켐, 인크. |
Dna―코딩된 라이브러리의 생성 및 스크리닝 방법
|
EP2414356B1
(de)
*
|
2009-04-03 |
2015-09-02 |
F.Hoffmann-La Roche Ag |
Propan-1-sulfonsäure-{3-[5-(4- chlorphenyl)-1h-pyrrolo[2,3-b]pyridin-3-carbonyl]-2,4-difluorphenyl} amidzusammensetzungen und anwendungen davon
|
US8329724B2
(en)
|
2009-08-03 |
2012-12-11 |
Hoffmann-La Roche Inc. |
Process for the manufacture of pharmaceutically active compounds
|
CN106220623A
(zh)
|
2009-11-06 |
2016-12-14 |
普莱希科公司 |
用于激酶调节的化合物和方法及其适应症
|
LT2558577T
(lt)
|
2010-04-16 |
2019-03-12 |
Nuevolution A/S |
Bifunkciniai kompleksai ir tokių kompleksų gamybos ir naudojimo būdai
|
EA028821B9
(ru)
|
2011-02-07 |
2018-10-31 |
Плексксикон, Инк. |
Соединения и способы для модуляции киназ, а также показания к их применению
|
AR085279A1
(es)
|
2011-02-21 |
2013-09-18 |
Plexxikon Inc |
Formas solidas de {3-[5-(4-cloro-fenil)-1h-pirrolo[2,3-b]piridina-3-carbonil]-2,4-difluor-fenil}-amida del acido propano-1-sulfonico
|
US10865409B2
(en)
|
2011-09-07 |
2020-12-15 |
X-Chem, Inc. |
Methods for tagging DNA-encoded libraries
|
EP2776579B1
(de)
|
2011-11-07 |
2019-05-01 |
The Broad Institute, Inc. |
Propeptidluciferase-fusionsproteine und verfahren zu ihrer anwendung
|
US9150570B2
(en)
|
2012-05-31 |
2015-10-06 |
Plexxikon Inc. |
Synthesis of heterocyclic compounds
|
AU2013289993B2
(en)
|
2012-07-13 |
2018-05-10 |
X-Chem, Inc. |
DNA-encoded libraries having encoding oligonucleotide linkages not readable by polymerases
|
WO2014144380A1
(en)
|
2013-03-15 |
2014-09-18 |
Intrexon Corporation |
Boron-containing diacylhydrazines
|
SG11201701944WA
(en)
|
2014-09-17 |
2017-04-27 |
Intrexon Corp |
Boron-containing diacylhydrazine compounds
|
PL3650458T3
(pl)
*
|
2015-02-24 |
2023-11-06 |
City Of Hope |
Platformy do analiz przesiewowych bibliotek kodowanych chemicznie i adresowanych przestrzennie
|
EP3370518B1
(de)
|
2015-10-14 |
2023-08-23 |
X-Therma, Inc. |
Zusammensetzungen und verfahren zur verringerung der eiskristallbildung
|
EP3387127A1
(de)
|
2015-12-07 |
2018-10-17 |
Erasmus University Medical Center Rotterdam |
Enzymatische ersatztherapie und antisense-therapie für pompe-krankheit
|
EP3243857A1
(de)
|
2016-05-13 |
2017-11-15 |
Centre National de la Recherche Scientifique - CNRS - |
Gleichmässige sequenzdefinierte polyurethane und verwendungen davon als molekulare etiketten
|
NL2017294B1
(en)
|
2016-08-05 |
2018-02-14 |
Univ Erasmus Med Ct Rotterdam |
Natural cryptic exon removal by pairs of antisense oligonucleotides.
|
WO2018195019A1
(en)
|
2017-04-18 |
2018-10-25 |
The Broad Institute Inc. |
Compositions for detecting secretion and methods of use
|