US6828427B1
(en)
|
1994-01-11 |
2004-12-07 |
Isis Pharmaceuticals, Inc. |
Oligomeric aminodiol-containing compounds, libraries thereof, and process of preparing the same
|
US6184389B1
(en)
|
1994-01-11 |
2001-02-06 |
Isis Pharmaceuticals, Inc. |
Combinatorial libraries having aminodiol monomer subunits
|
US6797522B1
(en)
|
1994-01-13 |
2004-09-28 |
The Trustees Of Columbia University In The City Of New York |
Synthetic receptors
|
EP0739486A4
(en)
*
|
1994-01-13 |
1998-09-09 |
Univ Columbia |
SYNTHETIC RECEPTORS, LIBRARIES AND THEIR USE
|
US5856083A
(en)
*
|
1994-05-06 |
1999-01-05 |
Pharmacopeia, Inc. |
Lawn assay for compounds that affect enzyme activity or bind to target molecules
|
US5824483A
(en)
*
|
1994-05-18 |
1998-10-20 |
Pence Inc. |
Conformationally-restricted combinatiorial library composition and method
|
US6207826B1
(en)
|
1995-03-27 |
2001-03-27 |
Isis Pharmaceuticals, Inc. |
Macrocyclic compounds having nitrogen-containing linkages
|
CA2210349A1
(en)
*
|
1995-01-20 |
1996-07-25 |
Molecumetics, Ltd |
Conformationally constrained reverse-turn library and methods relating thereto
|
AU5375896A
(en)
|
1995-03-27 |
1996-10-16 |
Isis Pharmaceuticals, Inc. |
Nitrogenous macrocyclic compounds
|
EP2290364A1
(en)
|
1996-04-25 |
2011-03-02 |
BioArray Solutions Ltd. |
Light-controlled electrokinetic assembly of particles near surfaces
|
US7144119B2
(en)
*
|
1996-04-25 |
2006-12-05 |
Bioarray Solutions Ltd. |
System and method for programmable illumination pattern generation
|
US6387707B1
(en)
*
|
1996-04-25 |
2002-05-14 |
Bioarray Solutions |
Array Cytometry
|
EP1726958A3
(en)
*
|
1996-04-25 |
2007-07-11 |
BioArray Solutions Ltd. |
Light-controlled electrokinetic assembly of particles near surfaces
|
US6958245B2
(en)
|
1996-04-25 |
2005-10-25 |
Bioarray Solutions Ltd. |
Array cytometry
|
US7041510B2
(en)
|
1996-04-25 |
2006-05-09 |
Bioarray Solutions Ltd. |
System and method for programmable illumination pattern generation
|
GB9610813D0
(en)
*
|
1996-05-23 |
1996-07-31 |
Pharmacia Spa |
Combinatorial solid phase synthesis of a library of benzufuran derivatives
|
US6077954A
(en)
|
1996-08-01 |
2000-06-20 |
Isis Pharmaceuticals, Inc. |
Substituted heterocyclic compounds
|
US5798360A
(en)
*
|
1996-08-01 |
1998-08-25 |
Isis Pharmaceuticals, Inc. |
N-(aminoalkyl)- and/or N-(amidoalkyl)- dinitrogen heterocyclic compositions
|
US5731438A
(en)
*
|
1996-08-01 |
1998-03-24 |
Isis Pharmaceuticals, Inc. |
N-(aminoalkyl)-and/or N-(amidoalkyl)-dinitrogen heterocycles
|
US5922872A
(en)
*
|
1996-08-01 |
1999-07-13 |
Isis Pharmaceuticals, Inc. |
Meta-benzylic and alpha-amido compositions and methods for preparing same
|
US5817489A
(en)
|
1996-08-01 |
1998-10-06 |
Isis Pharmaceuticals, Inc. |
Di-nitrogen heterocycle compositions
|
US6057102A
(en)
*
|
1996-08-08 |
2000-05-02 |
The Aaron Diamond Aids Research Center |
HIV coreceptor mutants
|
US6127191A
(en)
*
|
1996-12-03 |
2000-10-03 |
3-Dimensional Pharmaceuticals, Inc. |
Aminobenzenedicarboxylic acid-based combinatorial libraries
|
US5969102A
(en)
|
1997-03-03 |
1999-10-19 |
St. Jude Children's Research Hospital |
Lymphocyte surface receptor that binds CAML, nucleic acids encoding the same and methods of use thereof
|
US7622294B2
(en)
|
1997-03-14 |
2009-11-24 |
Trustees Of Tufts College |
Methods for detecting target analytes and enzymatic reactions
|
US20030027126A1
(en)
|
1997-03-14 |
2003-02-06 |
Walt David R. |
Methods for detecting target analytes and enzymatic reactions
|
AU756945B2
(en)
*
|
1997-05-23 |
2003-01-30 |
Bioarray Solutions Ltd |
Color-encoding and in-situ interrogation of matrix-coupled chemical compounds
|
US6750344B1
(en)
|
1997-09-05 |
2004-06-15 |
Isis Pharmaceuticals, Inc. |
Amine compounds and combinatorial libraries comprising same
|
JP2002507617A
(ja)
*
|
1998-03-23 |
2002-03-12 |
プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ |
化合物および化合物のライブラリの合成
|
WO1999050658A2
(en)
*
|
1998-03-30 |
1999-10-07 |
The Regents Of The University Of California |
Methods and compounds for modulating nuclear receptor activity
|
EP1110090B1
(en)
*
|
1998-09-03 |
2009-03-25 |
Trellis Bioscience, Inc. |
Multihued labels
|
AU6394399A
(en)
|
1998-09-18 |
2000-04-10 |
Rockefeller University, The |
Lynx, a novel family of receptor ligands in the central nervous system, corresponding nucleic acids and proteins and uses thereof
|
DE19924606A1
(de)
*
|
1999-05-28 |
2000-11-30 |
Graffinity Pharm Design Gmbh |
Ligand-Anker-Konjugate
|
WO2001025188A1
(en)
*
|
1999-10-04 |
2001-04-12 |
University Of Medicine And Dentistry Of New Jersey |
Novel carbamates and ureas
|
EP1233970A2
(en)
*
|
1999-11-24 |
2002-08-28 |
Massachusetts Institute Of Technology |
Protecting groups useful in the synthesis of polysaccharides, natural products, and combinatorial libraries
|
US6458538B1
(en)
*
|
1999-12-14 |
2002-10-01 |
Ptc Therapeutics, Inc. |
Methods of assaying for compounds that inhibit premature translation termination and nonsense-mediated RNA decay
|
US20040033600A1
(en)
|
2001-03-21 |
2004-02-19 |
Palli Subba Reddy |
Ecdysone receptor-based inducible gene expression system
|
ES2259666T3
(es)
|
2000-06-21 |
2006-10-16 |
Bioarray Solutions Ltd |
Analisis molecular de multiples analitos usando series de particulas aleatorias con especificidad de aplicacion.
|
US9709559B2
(en)
|
2000-06-21 |
2017-07-18 |
Bioarray Solutions, Ltd. |
Multianalyte molecular analysis using application-specific random particle arrays
|
EP1810978B1
(en)
|
2000-08-08 |
2013-02-13 |
St. Jude Children's Research Hospital |
Group B streptococcus polypeptides nucleic acids and therapeutic composition and vaccines thereof
|
US7057704B2
(en)
*
|
2000-09-17 |
2006-06-06 |
Bioarray Solutions Ltd. |
System and method for programmable illumination pattern generation
|
US8105825B2
(en)
|
2000-10-03 |
2012-01-31 |
Intrexon Corporation |
Multiple inducible gene regulation system
|
US20030045005A1
(en)
*
|
2000-10-17 |
2003-03-06 |
Michael Seul |
Light-controlled electrokinetic assembly of particles near surfaces
|
DE10106339A1
(de)
*
|
2001-02-09 |
2002-08-22 |
Hans-Joachim Mueller |
Verfahren zum Hochdurchsatz-Screening von Kandidaten-Verbindungen über die Hochdurchsatz-Direktsynthese von rekombinanten Polypeptiden
|
EP1534738B1
(en)
|
2001-02-20 |
2012-06-20 |
Intrexon Corporation |
Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system
|
MXPA03007493A
(es)
|
2001-02-20 |
2004-10-15 |
Rheogene Holdings Inc |
Nuevo sistema de expresion genetica inducible a base de receptor de ecdisona/receptor x retinoide de invertebrado.
|
CA2445796C
(en)
|
2001-02-20 |
2014-09-16 |
Rheogene, Inc. |
Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system
|
DK1572862T3
(da)
|
2001-02-20 |
2012-11-26 |
Intrexon Corp |
Kimære, retinoide x-receptorer og deres anvendelse i et hidtil ukendt ecdysonrecepttorbaseret inducerbart genekspressionssystem
|
US20050142545A1
(en)
*
|
2001-04-11 |
2005-06-30 |
Conn Michael M. |
Methods for identifying small molecules that bind specific rna structural motifs
|
US20060228730A1
(en)
*
|
2001-04-11 |
2006-10-12 |
Rando Robert F |
Methods for identifying small molecules that bind specific RNA structural motifs
|
WO2002083822A2
(en)
*
|
2001-04-13 |
2002-10-24 |
Mitrovich Michael J |
Solid lubricant and composition
|
EP1401850A1
(en)
|
2001-06-20 |
2004-03-31 |
Nuevolution A/S |
Nucleoside derivatives for library preparation
|
US7262063B2
(en)
|
2001-06-21 |
2007-08-28 |
Bio Array Solutions, Ltd. |
Directed assembly of functional heterostructures
|
WO2003019183A1
(en)
*
|
2001-08-23 |
2003-03-06 |
Deltagen Research Laboratories, L.L.C. |
Process for the informative and iterative design of a gene-family screening library
|
US20030211040A1
(en)
|
2001-08-31 |
2003-11-13 |
Paul Greengard |
Phosphodiesterase activity and regulation of phosphodiesterase 1B-mediated signaling in brain
|
MXPA04002810A
(es)
|
2001-09-26 |
2005-06-06 |
Rheogene Holdings Inc |
Acidos nucleicos receptores de ecdisona de saltarilla, polipeptidos, y sus usos.
|
CA2459807C
(en)
|
2001-09-26 |
2013-09-03 |
Jianzhong Zhang |
Whitefly ecdysone receptor nucleic acids, polypeptides, and uses thereof
|
CA2741049C
(en)
|
2001-10-15 |
2019-02-05 |
Bioarray Solutions, Ltd. |
Multiplexed analysis of polymorphic loci by probe elongation-mediated detection
|
WO2003037829A2
(en)
*
|
2001-11-01 |
2003-05-08 |
Rensselaer Polytechnic Institute |
Solid-phase array-based biocatalytic transformations
|
WO2003057165A2
(en)
|
2002-01-04 |
2003-07-17 |
The Rockefeller University |
COMPOSITIONS AND METHODS FOR PREVENTION AND TREATMENT OF AMYLOID-β PEPTIDE-RELATED DISORDERS
|
US7291456B2
(en)
|
2002-01-24 |
2007-11-06 |
The Regents Of The University Of California |
Method for determining differences in molecular interactions and for screening a combinatorial library
|
US20040171062A1
(en)
*
|
2002-02-28 |
2004-09-02 |
Plexxikon, Inc. |
Methods for the design of molecular scaffolds and ligands
|
CN101006177B
(zh)
|
2002-03-15 |
2011-10-12 |
纽韦卢森公司 |
改善的用于合成模制分子的方法
|
CA2482856A1
(en)
*
|
2002-04-15 |
2003-10-30 |
American National Red Cross |
Plasma protein-binding ligands
|
US20070015230A1
(en)
*
|
2002-04-15 |
2007-01-18 |
Hammond David J |
Identification and characterization of analytes from whole blood
|
US7291461B2
(en)
*
|
2002-06-21 |
2007-11-06 |
Ptc Therapeutics, Inc. |
Methods for identifying small molecules that modulate premature translation termination and nonsense mRNA decay
|
EP1543157A4
(en)
*
|
2002-07-24 |
2006-11-15 |
Ptc Therapeutics Inc |
METHODS FOR IDENTIFYING SMALL MOLECULES MODULATING PREMATURE TRANSLATION TERMINATION AND DEGRADATION OF INDUCED MRNA BY NON-SENSE MUTATION
|
AU2003247266A1
(en)
*
|
2002-08-01 |
2004-02-23 |
Nuevolution A/S |
Multi-step synthesis of templated molecules
|
AU2003272548A1
(en)
*
|
2002-09-16 |
2004-04-30 |
Plexxikon, Inc. |
Crystal structure of pim-1 kinase
|
EP1545762A2
(en)
*
|
2002-09-27 |
2005-06-29 |
Carlsberg A/S |
Spatially encoded polymer matrix
|
DK3299463T3
(da)
|
2002-10-30 |
2020-12-07 |
Nuevolution As |
Enzymatisk kodning
|
US7526114B2
(en)
|
2002-11-15 |
2009-04-28 |
Bioarray Solutions Ltd. |
Analysis, secure access to, and transmission of array images
|
EP2175019A3
(en)
|
2002-12-19 |
2011-04-06 |
Nuevolution A/S |
Quasirandom structure and function guided synthesis methods
|
EP2332567B1
(en)
|
2003-01-31 |
2015-04-08 |
The Mount Sinai School of Medicine of New York University |
Combination therapy for treating protein deficiency disorders
|
US7304161B2
(en)
|
2003-02-10 |
2007-12-04 |
Intrexon Corporation |
Diaclhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex
|
EP1597395A2
(en)
|
2003-02-21 |
2005-11-23 |
Nuevolution A/S |
Method for producing second-generation library
|
US20060269920A1
(en)
*
|
2003-02-21 |
2006-11-30 |
Nuevolution A/S |
Method for obtaining structural information about an encoded molecule
|
EP1627045A2
(en)
*
|
2003-02-28 |
2006-02-22 |
Plexxikon, Inc. |
Pyk2 crystal structure and uses
|
US7456315B2
(en)
|
2003-02-28 |
2008-11-25 |
Intrexon Corporation |
Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
|
US20050079548A1
(en)
*
|
2003-07-07 |
2005-04-14 |
Plexxikon, Inc. |
Ligand development using PDE4B crystal structures
|
RU2356889C2
(ru)
*
|
2003-07-17 |
2009-05-27 |
Плекссикон, Инк. |
Соединения, являющиеся активными по отношению к рецепторам, активируемым пролифератором пероксисом
|
US7348338B2
(en)
*
|
2003-07-17 |
2008-03-25 |
Plexxikon, Inc. |
PPAR active compounds
|
US20050164300A1
(en)
*
|
2003-09-15 |
2005-07-28 |
Plexxikon, Inc. |
Molecular scaffolds for kinase ligand development
|
EP1670939B1
(en)
*
|
2003-09-18 |
2009-11-04 |
Nuevolution A/S |
A method for obtaining structural information concerning an encoded molecule and method for selecting compounds
|
WO2005029705A2
(en)
|
2003-09-18 |
2005-03-31 |
Bioarray Solutions, Ltd. |
Number coding for identification of subtypes of coded types of solid phase carriers
|
ES2375962T3
(es)
|
2003-09-22 |
2012-03-07 |
Bioarray Solutions Ltd |
Polielectrolito inmovilizado en superficie con múltiples grupos funcionales capaces de unirse covalentemente a biomoléculas.
|
CA2899287A1
(en)
|
2003-10-28 |
2005-05-12 |
Bioarray Solutions Ltd. |
Optimization of gene expression analysis using immobilized capture probes
|
AU2004287069B2
(en)
|
2003-10-29 |
2009-07-16 |
Bioarray Solutions, Ltd. |
Multiplexed nucleic acid analysis by fragmentation of double-stranded DNA
|
US20070066641A1
(en)
*
|
2003-12-19 |
2007-03-22 |
Prabha Ibrahim |
Compounds and methods for development of RET modulators
|
EP1696920B8
(en)
*
|
2003-12-19 |
2015-05-06 |
Plexxikon Inc. |
Compounds and methods for development of ret modulators
|
EP1723255B1
(en)
*
|
2004-02-17 |
2010-12-29 |
Nuevolution A/S |
Method for enrichment involving elimination by mismatch hybridisation
|
US7935510B2
(en)
|
2004-04-30 |
2011-05-03 |
Intrexon Corporation |
Mutant receptors and their use in a nuclear receptor-based inducible gene expression system
|
JP2008503446A
(ja)
|
2004-05-06 |
2008-02-07 |
プレキシコン,インコーポレーテッド |
Pde4b阻害剤及びその使用
|
US7498342B2
(en)
|
2004-06-17 |
2009-03-03 |
Plexxikon, Inc. |
Compounds modulating c-kit activity
|
US7848889B2
(en)
|
2004-08-02 |
2010-12-07 |
Bioarray Solutions, Ltd. |
Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
|
CA2583428A1
(en)
*
|
2004-09-03 |
2006-03-09 |
Plexxikon, Inc. |
Bicyclic heteroaryl pde4b inhibitors
|
EP1819673A2
(en)
*
|
2004-11-30 |
2007-08-22 |
Plexxikon, Inc. |
Indole derivatives for use as ppar active compounds
|
US20060160135A1
(en)
*
|
2004-12-08 |
2006-07-20 |
Weiru Wang |
SF-1 and LRH-1 modulator development
|
CA2608733A1
(en)
*
|
2005-05-17 |
2007-02-01 |
Plexxikon, Inc. |
Pyrrol (2,3-b) pyridine derivatives protein kinase inhibitors
|
US8486629B2
(en)
|
2005-06-01 |
2013-07-16 |
Bioarray Solutions, Ltd. |
Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
|
US20070021433A1
(en)
|
2005-06-03 |
2007-01-25 |
Jian-Qiang Fan |
Pharmacological chaperones for treating obesity
|
EP3088400A1
(en)
*
|
2005-06-22 |
2016-11-02 |
Plexxikon Inc. |
Pyrrolo[2,3-b]pyridine derivatives as protein kinase inhibitors
|
CN101437539B
(zh)
|
2005-07-05 |
2013-10-02 |
康奈尔研究基金会(有限公司) |
通过干扰cd99l2阻断白细胞迁出和炎症
|
NZ567162A
(en)
*
|
2005-09-07 |
2011-06-30 |
Plexxikon Inc |
1, 3-disubstituted indole derivatives for use as PPAR modulators
|
CA2623705A1
(en)
*
|
2005-09-27 |
2007-04-05 |
Bernd Helmut Adam Rehm |
Polymer particles and uses thereof
|
DK2341140T3
(da)
|
2005-12-01 |
2017-11-06 |
Nuevolution As |
Fremgangsmåde til enzymatisk kodning ved effektiv syntese af store biblioteker
|
DK2074230T3
(da)
|
2006-10-11 |
2013-02-25 |
Janssen Pharmaceutica Nv |
Sammensætninger og fremgangsmåder til behandling og diagnosticering af colon irritabile
|
WO2008063888A2
(en)
|
2006-11-22 |
2008-05-29 |
Plexxikon, Inc. |
Compounds modulating c-fms and/or c-kit activity and uses therefor
|
WO2008079909A1
(en)
*
|
2006-12-21 |
2008-07-03 |
Plexxikon, Inc. |
Pyrrolo [2,3-b] pyridines as kinase modulators
|
PE20121126A1
(es)
*
|
2006-12-21 |
2012-08-24 |
Plexxikon Inc |
Compuestos pirrolo [2,3-b] piridinas como moduladores de quinasa
|
MX2009006688A
(es)
|
2006-12-21 |
2009-06-30 |
Plexxikon Inc |
Compuestos y metodos para modulacion de cinasas, e indicaciones para ello.
|
PE20090159A1
(es)
*
|
2007-03-08 |
2009-02-21 |
Plexxikon Inc |
COMPUESTOS DERIVADOS DE ACIDO INDOL-PROPIONICO COMO MODULADORES PPARs
|
NZ582772A
(en)
|
2007-07-17 |
2012-06-29 |
Plexxikon Inc |
Compounds and methods for kinase modulation, and indications therefor
|
NZ594420A
(en)
|
2009-02-13 |
2013-06-28 |
Chem Inc X |
Methods of creating and screening dna-encoded libraries
|
EA031116B1
(ru)
*
|
2009-04-03 |
2018-11-30 |
Ф. Хоффманн-Ля Рош Аг |
КРИСТАЛЛИЧЕСКИЕ ПОЛИМОРФНЫЕ ФОРМЫ {3-[5-(4-ХЛОРФЕНИЛ)-1H-ПИРРОЛО[2,3-b]ПИРИДИН-3-КАРБОНИЛ]-2,4-ДИФТОРФЕНИЛ}АМИДА ПРОПАН-1-СУЛЬФОНОВОЙ КИСЛОТЫ
|
US8329724B2
(en)
|
2009-08-03 |
2012-12-11 |
Hoffmann-La Roche Inc. |
Process for the manufacture of pharmaceutically active compounds
|
MX2012005284A
(es)
|
2009-11-06 |
2012-06-28 |
Plexxikon Inc |
Compuestos y metodos para la modulacion de cinasas. e indicaciones para ello.
|
US11225655B2
(en)
|
2010-04-16 |
2022-01-18 |
Nuevolution A/S |
Bi-functional complexes and methods for making and using such complexes
|
PT2672967T
(pt)
|
2011-02-07 |
2018-12-07 |
Plexxikon Inc |
Compostos e métodos de modulação da quinase e suas indicações
|
TWI558702B
(zh)
|
2011-02-21 |
2016-11-21 |
普雷辛肯公司 |
醫藥活性物質的固態形式
|
BR112014005205A2
(pt)
|
2011-09-07 |
2017-03-21 |
X-Chem Inc |
métodos para etiquetar bibliotecas codificadas com dna
|
EP2776579B1
(en)
|
2011-11-07 |
2019-05-01 |
The Broad Institute, Inc. |
Propeptide-luciferase fusion proteins and methods of use thereof
|
US9150570B2
(en)
|
2012-05-31 |
2015-10-06 |
Plexxikon Inc. |
Synthesis of heterocyclic compounds
|
CN110257493A
(zh)
|
2012-07-13 |
2019-09-20 |
X-化学有限公司 |
具有聚合酶不可读的编码性寡核苷酸连接的dna编码文库
|
ES2683329T3
(es)
|
2013-03-15 |
2018-09-26 |
Intrexon Corporation |
Diacilhidrazinas que contienen boro
|
EP3194359B1
(en)
|
2014-09-17 |
2020-04-08 |
Intrexon Corporation |
Boron-containing diacylhydrazine compounds
|
AU2016338410B2
(en)
|
2015-10-14 |
2021-07-15 |
X-Therma, Inc. |
Compositions and methods for reducing ice crystal formation
|
US10993995B2
(en)
|
2015-12-07 |
2021-05-04 |
Erasmus University Medical Center Rotterdam |
Enzymatic replacement therapy and antisense therapy for pompe disease
|
EP3243857A1
(en)
*
|
2016-05-13 |
2017-11-15 |
Centre National de la Recherche Scientifique - CNRS - |
Uniform sequence-defined polyurethanes and uses thereof as molecular labels
|
NL2017294B1
(en)
|
2016-08-05 |
2018-02-14 |
Univ Erasmus Med Ct Rotterdam |
Natural cryptic exon removal by pairs of antisense oligonucleotides.
|
EP3612629A1
(en)
|
2017-04-18 |
2020-02-26 |
The Broad Institute, Inc. |
Compositions for detecting secretion and methods of use
|