DE69433315T2 - Verfahren und System zur segmentierten Durchflussanalyse von Probenflüssigkeiten - Google Patents

Verfahren und System zur segmentierten Durchflussanalyse von Probenflüssigkeiten Download PDF

Info

Publication number
DE69433315T2
DE69433315T2 DE69433315T DE69433315T DE69433315T2 DE 69433315 T2 DE69433315 T2 DE 69433315T2 DE 69433315 T DE69433315 T DE 69433315T DE 69433315 T DE69433315 T DE 69433315T DE 69433315 T2 DE69433315 T2 DE 69433315T2
Authority
DE
Germany
Prior art keywords
line
sample liquid
pump
test pack
capsule
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69433315T
Other languages
German (de)
English (en)
Other versions
DE69433315D1 (de
Inventor
Anand Monroe Kumar
Paul Yorktown Heights Gherson
Milt Somers Pelavin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Bayer Corp
Original Assignee
Bayer AG
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG, Bayer Corp filed Critical Bayer AG
Publication of DE69433315D1 publication Critical patent/DE69433315D1/de
Application granted granted Critical
Publication of DE69433315T2 publication Critical patent/DE69433315T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers
    • B01F33/451—Magnetic mixers; Mixers with magnetically driven stirrers wherein the mixture is directly exposed to an electromagnetic field without use of a stirrer, e.g. for material comprising ferromagnetic particles or for molten metal
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N2035/1025—Fluid level sensing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/117497—Automated chemical analysis with a continuously flowing sample or carrier stream
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/117497—Automated chemical analysis with a continuously flowing sample or carrier stream
    • Y10T436/118339—Automated chemical analysis with a continuously flowing sample or carrier stream with formation of a segmented stream

Landscapes

  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
DE69433315T 1993-08-13 1994-08-01 Verfahren und System zur segmentierten Durchflussanalyse von Probenflüssigkeiten Expired - Fee Related DE69433315T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/106,254 US5399497A (en) 1992-02-26 1993-08-13 Capsule chemistry sample liquid analysis system and method
US106254 1993-08-13

Publications (2)

Publication Number Publication Date
DE69433315D1 DE69433315D1 (de) 2003-12-18
DE69433315T2 true DE69433315T2 (de) 2004-08-26

Family

ID=22310386

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69433315T Expired - Fee Related DE69433315T2 (de) 1993-08-13 1994-08-01 Verfahren und System zur segmentierten Durchflussanalyse von Probenflüssigkeiten

Country Status (9)

Country Link
US (1) US5399497A (ja)
EP (1) EP0638809B1 (ja)
JP (1) JP3505689B2 (ja)
AU (1) AU676547B2 (ja)
CA (1) CA2124304C (ja)
DE (1) DE69433315T2 (ja)
DK (1) DK0638809T3 (ja)
ES (1) ES2211873T3 (ja)
IL (1) IL109689A (ja)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3115501B2 (ja) * 1994-06-15 2000-12-11 プレシジョン・システム・サイエンス株式会社 分注機を利用した磁性体の脱着制御方法及びこの方法によって処理される各種装置
US5631167A (en) * 1995-07-31 1997-05-20 Bayer Corporation Capsule chemistry analytical methods employing dioxetane chemiluminescence
US5721370A (en) * 1995-07-31 1998-02-24 Lumigen Inc. Water soluble tri-substituted 1,2-dioxetane compounds and assay compositions having increased storage stability
US5777135A (en) * 1995-07-31 1998-07-07 Lumigen, Inc. Di-substituted 1,2-dioxetane compounds having increased water solubility and assay compositions
WO1997039359A1 (en) * 1996-04-15 1997-10-23 Dade International Inc. Apparatus and method for analysis
US5714388A (en) * 1996-08-14 1998-02-03 Bayer Corporation Apparatus and method for detecting chemiluminescent light
EP1032840A1 (de) * 1997-11-19 2000-09-06 ABION Beteiligungs- und Verwaltungsgesellschaft mbH Mehrkanalsystem zur durchführung chemischer, biologischer und/oder biochemischer analyseverfahren
JP3551293B2 (ja) * 1998-02-02 2004-08-04 東洋紡績株式会社 核酸抽出装置
US6117391A (en) * 1998-06-18 2000-09-12 Bayer Corporation Cup handling subsystem for an automated clinical chemistry analyzer system
US6348354B1 (en) * 1998-07-06 2002-02-19 Bayer Corporation Method and apparatus for controlling a stream of liquid test packages in a capsule chemistry analysis system
US6261847B1 (en) * 1998-07-10 2001-07-17 Bayer Corporation Sample dilution module with offset mixing chamber
US6290912B1 (en) * 1998-07-14 2001-09-18 Bayer Corporation Read head for luminometer
US6623971B2 (en) * 1999-01-11 2003-09-23 Bayer Corporation Method and apparatus for conducting a stat immunoassay analysis in a capsule chemistry analysis system
US6524456B1 (en) * 1999-08-12 2003-02-25 Ut-Battelle, Llc Microfluidic devices for the controlled manipulation of small volumes
US6610499B1 (en) * 2000-08-31 2003-08-26 The Regents Of The University Of California Capillary array and related methods
US6902938B1 (en) * 2000-10-10 2005-06-07 Jeol Usa, Inc. Chemical analysis method for multiplexed samples
US6689621B2 (en) 2000-11-29 2004-02-10 Liquid Logic, Llc Fluid dispensing system and valve control
US6887429B1 (en) * 2001-01-26 2005-05-03 Global Fia Apparatus and method for automated medical diagnostic tests
US6613579B2 (en) * 2001-02-02 2003-09-02 Global Fia, Inc. Sequential injection liquid-liquid extraction
US7514270B2 (en) * 2002-04-12 2009-04-07 Instrumentation Laboratory Company Immunoassay probe
US7488309B2 (en) 2002-07-03 2009-02-10 Bioanalytical Systems, Inc. Device and method for drug delivery to animals
JP2004317420A (ja) * 2003-04-18 2004-11-11 Hitachi Software Eng Co Ltd キャピラリー利用測定装置
DE10322942A1 (de) * 2003-05-19 2004-12-09 Hans-Knöll-Institut für Naturstoff-Forschung e.V. Vorrichtung zum Positionieren und Ausschleusen von in Separationsmedium eingebetteten Fluidkompartimenten
DE10322893A1 (de) * 2003-05-19 2004-12-16 Hans-Knöll-Institut für Naturstoff-Forschung e.V. Vorrichtung und Verfahren zum Zudosieren von Reaktionsflüssigkeiten zu in Separationsmedium eingebetteten Flüssigkeitskompartimenten
US7247487B2 (en) * 2003-06-18 2007-07-24 Ortho-Clinical Diagnostics Reducing working fluid dilution in liquid systems
AU2004312893B2 (en) 2003-12-31 2010-06-17 President And Fellows Of Harvard College Assay device and method
US7439069B2 (en) * 2004-02-27 2008-10-21 Nippoldt Douglas D Blood coagulation test cartridge, system, and method
US7422905B2 (en) * 2004-02-27 2008-09-09 Medtronic, Inc. Blood coagulation test cartridge, system, and method
US7399637B2 (en) * 2004-04-19 2008-07-15 Medtronic, Inc. Blood coagulation test cartridge, system, and method
US8211386B2 (en) 2004-06-08 2012-07-03 Biokit, S.A. Tapered cuvette and method of collecting magnetic particles
US7338804B2 (en) * 2004-11-24 2008-03-04 Siemens Healthcare Diagnostics Inc. Automated clinical analyzer reagent formulation
US20060172425A1 (en) * 2005-02-01 2006-08-03 Bayer Healthcare, Llc Colored buffer solution for automated clinical analyzer
US20070082342A1 (en) * 2005-02-14 2007-04-12 Braig James R Near-patient module for analyte detection system
US20070068573A1 (en) * 2005-08-22 2007-03-29 Applera Corporation Device and method for microfluidic control of a first fluid in contact with a second fluid, wherein the first and second fluids are immiscible
US7704457B2 (en) * 2005-11-18 2010-04-27 Patton Charles J Automatic, field portable analyzer using discrete sample aliquots
US20080080302A1 (en) * 2006-09-29 2008-04-03 Fujifilm Corporation Droplet mixing method and apparatus
US7980905B2 (en) * 2007-11-25 2011-07-19 C-Mar Holdings, Ltd. Method and apparatus for providing power to a marine vessel
EP2072133A1 (en) * 2007-12-20 2009-06-24 Koninklijke Philips Electronics N.V. Multi-compartment device with magnetic particles
US8783121B2 (en) * 2009-03-19 2014-07-22 Shumadzu Corporation Liquid collecting system and a method therefor
DE102009023068A1 (de) * 2009-05-28 2010-12-02 RATIONAL Technische Lösungen GmbH Dosiergerät insbesondere für analytische Aufgaben
CA2767114A1 (en) * 2010-03-25 2011-09-29 Bio-Rad Laboratories, Inc. Droplet transport system for detection
DE102012109026A1 (de) * 2012-09-25 2014-03-27 Eads Deutschland Gmbh Detektionsvorrichtung und Detektionsverfahren zur automatischen Bestimmung von Biomasse
CN105074416B (zh) * 2013-03-15 2019-01-11 M·L·贝尔 分析装置和分析方法
CN105339497A (zh) * 2013-06-18 2016-02-17 基因细胞生物系统有限公司 生物分子分离和热加工
GB201321433D0 (en) * 2013-12-04 2014-01-15 Isis Innovation Controling fluid micro compartments
WO2015095239A1 (en) 2013-12-18 2015-06-25 Optiscan Biomedical Corporation Systems and methods for detecting leaks
WO2017199670A1 (ja) * 2016-05-18 2017-11-23 テルモ株式会社 血液検査システムおよび血液検査システムの制御方法
GB201704760D0 (en) * 2017-01-05 2017-05-10 Illumina Inc Reagent nozzle sipper mixing system and method
IT201800004630A1 (it) * 2018-04-17 2019-10-17 Apparato e procedimento per la determinazione della velocita' di sedimentazione del sangue e di altri parametri ad essa correlati
CN118795127A (zh) * 2023-04-13 2024-10-18 深圳市帝迈生物技术有限公司 血液分析仪

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3970518A (en) * 1975-07-01 1976-07-20 General Electric Company Magnetic separation of biological particles
US4018886A (en) * 1975-07-01 1977-04-19 General Electric Company Diagnostic method and device employing protein-coated magnetic particles
GB1575805A (en) * 1976-03-12 1980-10-01 Technicon Instr Automatic diagnostic apparatus
GB1576427A (en) * 1976-04-29 1980-10-08 English Clays Lovering Pochin Magnetic separators
US4418039A (en) * 1976-12-27 1983-11-29 Technicon Instruments Corporation Solute transfer technique
US4219335A (en) * 1978-09-18 1980-08-26 E. I. Du Pont De Nemours And Company Immunochemical testing using tagged reagents
US4297337A (en) * 1979-04-13 1981-10-27 Corning Glass Works Solid-phase immunoassays using magnetic glass
US4259291A (en) * 1979-07-13 1981-03-31 Technicon Instruments Corporation Metering device
US4253846A (en) * 1979-11-21 1981-03-03 Technicon Instruments Corporation Method and apparatus for automated analysis of fluid samples
US4657868A (en) * 1980-01-15 1987-04-14 Rolf Saxholm Apparatus for testing reactions
JPS576338A (en) * 1980-06-12 1982-01-13 Kyoto Daiichi Kagaku:Kk Method and device for measuring degree of flocculation of finely divided particles quantitatively
DE3134861C2 (de) * 1981-09-03 1985-04-04 Siegfried 4054 Nettetal André Magnetfilter
DE3200988A1 (de) * 1982-01-14 1983-07-28 Thomas A. Dr. 6900 Heidelberg Reed Verfahren und vorrichtung zur abtrennung von organischen stoffen aus einer suspension oder loesung
US4452773A (en) * 1982-04-05 1984-06-05 Canadian Patents And Development Limited Magnetic iron-dextran microspheres
US4853336A (en) * 1982-11-15 1989-08-01 Technicon Instruments Corporation Single channel continuous flow system
US4517302A (en) * 1982-11-15 1985-05-14 Technicon Instruments Corporation Continuous flow metering apparatus
US4628037A (en) * 1983-05-12 1986-12-09 Advanced Magnetics, Inc. Binding assays employing magnetic particles
GB8314523D0 (en) * 1983-05-25 1983-06-29 Lowe C R Diagnostic device
DE3336255A1 (de) * 1983-10-05 1985-04-18 Krupp Polysius Ag, 4720 Beckum Vorrichtung zur abscheidung ferromagnetischer partikel aus einer truebe
GB8401368D0 (en) * 1984-01-19 1984-02-22 Amersham Int Plc Assay method
US4677067A (en) * 1984-06-22 1987-06-30 Bio-Magnetech Corporation Magnetotactic bacteria in clinical assay, immunoassay, and cell separation procedures and the like
FI842992A0 (fi) * 1984-07-26 1984-07-26 Labsystems Oy Immunologiskt definitionsfoerfarande.
FI844027A (fi) * 1984-10-12 1986-04-13 Labsystems Oy Immunologiskt bestaemningsfoerfarande.
DE3522365A1 (de) * 1985-06-22 1987-01-02 Bayer Ag Trenngeraet fuer magnetische partikel aus fluessiger phase
JPH0628594B2 (ja) * 1985-08-07 1994-04-20 東ソー株式会社 生化学反応用撹拌装置
JPH0737989B2 (ja) * 1986-07-04 1995-04-26 東ソー株式会社 免疫反応の測定方法および装置
US4784758A (en) * 1986-08-27 1988-11-15 Engelhard Corporation Process for removing magnetic particles from a suspension of solids in a liquid
NO162946C (no) * 1987-08-21 1990-03-14 Otto Soerensen Anordning for magnetisk separasjon av celler.
US5045473A (en) * 1987-07-14 1991-09-03 Technicon Instruments Corporation Apparatus and method for the separation and/or formation of immicible liquid streams
US4913883A (en) * 1987-07-20 1990-04-03 Hitachi, Ltd. Particle agglutination immunoassay apparatus
US5158871A (en) * 1988-02-12 1992-10-27 University Of Connecticut Method of using magnetic particles for isolating, collecting and assaying diagnostic ligates
US5123901A (en) * 1988-02-25 1992-06-23 Carew E Bayne Method for separating pathogenic or toxic agents from a body fluid and return to body
US5147529A (en) * 1988-08-10 1992-09-15 E. I. Du Pont De Nemours And Company Method for automatically processing magnetic solid phase reagents
US5134079A (en) * 1989-03-27 1992-07-28 International Technidyne Corp. Fluid sample collection and delivery system and methods particularly adapted for body fluid sampling
JPH02307059A (ja) * 1989-05-23 1990-12-20 Seiko Instr Inc 反応容器
US5130027A (en) * 1989-09-19 1992-07-14 The University Of Colorado Foundation, Inc. Stationary magnetically stabilized fluidized bed for protein separation and purification
US5186827A (en) * 1991-03-25 1993-02-16 Immunicon Corporation Apparatus for magnetic separation featuring external magnetic means
US5268147A (en) * 1992-02-26 1993-12-07 Miles, Inc. Reversible direction capsule chemistry sample liquid analysis system and method

Also Published As

Publication number Publication date
EP0638809A3 (en) 1997-02-19
JP3505689B2 (ja) 2004-03-08
CA2124304C (en) 2005-11-29
DE69433315D1 (de) 2003-12-18
AU676547B2 (en) 1997-03-13
EP0638809A2 (en) 1995-02-15
JPH0755817A (ja) 1995-03-03
ES2211873T3 (es) 2004-07-16
IL109689A0 (en) 1994-08-26
CA2124304A1 (en) 1995-02-14
US5399497A (en) 1995-03-21
EP0638809B1 (en) 2003-11-12
AU6347494A (en) 1995-02-23
IL109689A (en) 1996-11-14
DK0638809T3 (da) 2004-03-22

Similar Documents

Publication Publication Date Title
DE69433315T2 (de) Verfahren und System zur segmentierten Durchflussanalyse von Probenflüssigkeiten
DE69331075T2 (de) Vorrichtung und Verfahren zur Analyse von Probenflüssigkeiten mit umkehrbarer Strömung
DE68927011T2 (de) Flüssigkeitsanalyseapparat mit sehr geringem übertrag und zugehöriges verfahren
DE69504574T2 (de) Magnetscheideverfahren und -vorrichtung bei Gebrauch einer Pipette.
DE68928695T2 (de) Saug- und spendevorrichtung für flüssigmuster
DE69015033T2 (de) Pipette, Pipettenrohr, diese verwendendes Probenanalysegerät und Verfahren zur Mischung und Pipettierung von Flüssigkeiten.
DE69309152T2 (de) Vorrichtung und Verfahren zur räumlich begrenzten Reaktion und Detektion
DE69429159T2 (de) Verfahren für einen spezifischen Bindungstest mit magnetischen Teilchen
DE69904726T2 (de) Automatisches immunoassay-gerät mit flexiblem hebearm
DE69913947T2 (de) Färbegerät für mikroskop-plättchen mit "random access" und trennung von flüssigem müll
DE69205170T2 (de) Automatisches geraet mit mehreren linearen bahnen fuer duerchfuehrung von immunologischen testen.
EP1446668B1 (de) Vorrichtung und verfahren zum behandeln von magnetpartikeln
DE19944713C2 (de) Chemisches Analysegerät
DE2710438A1 (de) Verfahren und vorrichtung zum analysieren eines fluids
DE3122887A1 (de) Verfahren und vorrichtung zur quantitativen bestimmung eines agglutinationsgrades von partikeln
DE4032817C2 (de) Flüssigchromatographie-Verfahren und -Gerät
DE202010004968U1 (de) Probenteller
DE3042915A1 (de) Verfahren und vorrichtung zur automatischen analyse von fluidproben
DE69429230T2 (de) Vorrichtung und verfahren zur automatischen prüfung von proben
DE1673103A1 (de) Verfahren und Einrichtung fuer automatische Analysen
EP2369343A1 (de) Vorrichtung und Verfahren zur Manipulation oder Untersuchung einer flüssigen Probe
DE3402304C2 (ja)
DE10020704A1 (de) Biochip zur Archivierung und labormedizinischen Analyse von biologischem Probenmaterial, Verfahren zu dessen Herstellung sowie dessen Verwendung in diagnostischen Verfahren
DE112016000223T5 (de) Mikrofluidik-Sondenkopf zum Verarbeiten einer Sequenz von Flüssigkeitsvolumina, getrennt durch Abstandhalter
DE3838361C2 (ja)

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee