DE69433315D1 - Verfahren und System zur segmentierten Durchflussanalyse von Probenflüssigkeiten - Google Patents
Verfahren und System zur segmentierten Durchflussanalyse von ProbenflüssigkeitenInfo
- Publication number
- DE69433315D1 DE69433315D1 DE69433315T DE69433315T DE69433315D1 DE 69433315 D1 DE69433315 D1 DE 69433315D1 DE 69433315 T DE69433315 T DE 69433315T DE 69433315 T DE69433315 T DE 69433315T DE 69433315 D1 DE69433315 D1 DE 69433315D1
- Authority
- DE
- Germany
- Prior art keywords
- flow analysis
- sample liquids
- segmented flow
- segmented
- liquids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers
- B01F33/451—Magnetic mixers; Mixers with magnetically driven stirrers wherein the mixture is directly exposed to an electromagnetic field without use of a stirrer, e.g. for material comprising ferromagnetic particles or for molten metal
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
- G01N2035/1025—Fluid level sensing
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
- Y10T436/117497—Automated chemical analysis with a continuously flowing sample or carrier stream
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
- Y10T436/117497—Automated chemical analysis with a continuously flowing sample or carrier stream
- Y10T436/118339—Automated chemical analysis with a continuously flowing sample or carrier stream with formation of a segmented stream
Landscapes
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Sampling And Sample Adjustment (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US106254 | 1979-12-21 | ||
US08/106,254 US5399497A (en) | 1992-02-26 | 1993-08-13 | Capsule chemistry sample liquid analysis system and method |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69433315D1 true DE69433315D1 (de) | 2003-12-18 |
DE69433315T2 DE69433315T2 (de) | 2004-08-26 |
Family
ID=22310386
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69433315T Expired - Fee Related DE69433315T2 (de) | 1993-08-13 | 1994-08-01 | Verfahren und System zur segmentierten Durchflussanalyse von Probenflüssigkeiten |
Country Status (9)
Country | Link |
---|---|
US (1) | US5399497A (de) |
EP (1) | EP0638809B1 (de) |
JP (1) | JP3505689B2 (de) |
AU (1) | AU676547B2 (de) |
CA (1) | CA2124304C (de) |
DE (1) | DE69433315T2 (de) |
DK (1) | DK0638809T3 (de) |
ES (1) | ES2211873T3 (de) |
IL (1) | IL109689A (de) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3115501B2 (ja) * | 1994-06-15 | 2000-12-11 | プレシジョン・システム・サイエンス株式会社 | 分注機を利用した磁性体の脱着制御方法及びこの方法によって処理される各種装置 |
US5777135A (en) * | 1995-07-31 | 1998-07-07 | Lumigen, Inc. | Di-substituted 1,2-dioxetane compounds having increased water solubility and assay compositions |
US5721370A (en) * | 1995-07-31 | 1998-02-24 | Lumigen Inc. | Water soluble tri-substituted 1,2-dioxetane compounds and assay compositions having increased storage stability |
US5631167A (en) * | 1995-07-31 | 1997-05-20 | Bayer Corporation | Capsule chemistry analytical methods employing dioxetane chemiluminescence |
WO1997039359A1 (en) * | 1996-04-15 | 1997-10-23 | Dade International Inc. | Apparatus and method for analysis |
US5714388A (en) * | 1996-08-14 | 1998-02-03 | Bayer Corporation | Apparatus and method for detecting chemiluminescent light |
DE59803938D1 (de) * | 1997-11-19 | 2002-05-29 | Biognosis Gmbh | Vorrichtung zur sequentiellen ausgabe von fliessfähigen reagenzien |
JP3551293B2 (ja) * | 1998-02-02 | 2004-08-04 | 東洋紡績株式会社 | 核酸抽出装置 |
US6117391A (en) * | 1998-06-18 | 2000-09-12 | Bayer Corporation | Cup handling subsystem for an automated clinical chemistry analyzer system |
US6348354B1 (en) * | 1998-07-06 | 2002-02-19 | Bayer Corporation | Method and apparatus for controlling a stream of liquid test packages in a capsule chemistry analysis system |
US6261847B1 (en) * | 1998-07-10 | 2001-07-17 | Bayer Corporation | Sample dilution module with offset mixing chamber |
US6290912B1 (en) * | 1998-07-14 | 2001-09-18 | Bayer Corporation | Read head for luminometer |
US6623971B2 (en) | 1999-01-11 | 2003-09-23 | Bayer Corporation | Method and apparatus for conducting a stat immunoassay analysis in a capsule chemistry analysis system |
US6524456B1 (en) * | 1999-08-12 | 2003-02-25 | Ut-Battelle, Llc | Microfluidic devices for the controlled manipulation of small volumes |
US6610499B1 (en) * | 2000-08-31 | 2003-08-26 | The Regents Of The University Of California | Capillary array and related methods |
US6902938B1 (en) * | 2000-10-10 | 2005-06-07 | Jeol Usa, Inc. | Chemical analysis method for multiplexed samples |
US6689621B2 (en) | 2000-11-29 | 2004-02-10 | Liquid Logic, Llc | Fluid dispensing system and valve control |
US6887429B1 (en) * | 2001-01-26 | 2005-05-03 | Global Fia | Apparatus and method for automated medical diagnostic tests |
US6613579B2 (en) * | 2001-02-02 | 2003-09-02 | Global Fia, Inc. | Sequential injection liquid-liquid extraction |
JP2005522679A (ja) * | 2002-04-12 | 2005-07-28 | インストゥルメンテイション ラボラトリー カンパニー | イムノアッセイプローブ |
US7488309B2 (en) | 2002-07-03 | 2009-02-10 | Bioanalytical Systems, Inc. | Device and method for drug delivery to animals |
JP2004317420A (ja) * | 2003-04-18 | 2004-11-11 | Hitachi Software Eng Co Ltd | キャピラリー利用測定装置 |
DE10322942A1 (de) * | 2003-05-19 | 2004-12-09 | Hans-Knöll-Institut für Naturstoff-Forschung e.V. | Vorrichtung zum Positionieren und Ausschleusen von in Separationsmedium eingebetteten Fluidkompartimenten |
DE10322893A1 (de) * | 2003-05-19 | 2004-12-16 | Hans-Knöll-Institut für Naturstoff-Forschung e.V. | Vorrichtung und Verfahren zum Zudosieren von Reaktionsflüssigkeiten zu in Separationsmedium eingebetteten Flüssigkeitskompartimenten |
US7247487B2 (en) * | 2003-06-18 | 2007-07-24 | Ortho-Clinical Diagnostics | Reducing working fluid dilution in liquid systems |
US7736890B2 (en) * | 2003-12-31 | 2010-06-15 | President And Fellows Of Harvard College | Assay device and method |
US7439069B2 (en) * | 2004-02-27 | 2008-10-21 | Nippoldt Douglas D | Blood coagulation test cartridge, system, and method |
US7422905B2 (en) * | 2004-02-27 | 2008-09-09 | Medtronic, Inc. | Blood coagulation test cartridge, system, and method |
US7399637B2 (en) * | 2004-04-19 | 2008-07-15 | Medtronic, Inc. | Blood coagulation test cartridge, system, and method |
US8211386B2 (en) | 2004-06-08 | 2012-07-03 | Biokit, S.A. | Tapered cuvette and method of collecting magnetic particles |
US7338804B2 (en) * | 2004-11-24 | 2008-03-04 | Siemens Healthcare Diagnostics Inc. | Automated clinical analyzer reagent formulation |
US20060172425A1 (en) * | 2005-02-01 | 2006-08-03 | Bayer Healthcare, Llc | Colored buffer solution for automated clinical analyzer |
US20060216209A1 (en) * | 2005-02-14 | 2006-09-28 | Braig James R | Analyte detection system with distributed sensing |
WO2007024800A2 (en) * | 2005-08-22 | 2007-03-01 | Applera Corporation | Device and method for making discrete volumes of a first fluid in contact with a second fluid, which are immiscible with each other |
US7704457B2 (en) * | 2005-11-18 | 2010-04-27 | Patton Charles J | Automatic, field portable analyzer using discrete sample aliquots |
US20080080302A1 (en) * | 2006-09-29 | 2008-04-03 | Fujifilm Corporation | Droplet mixing method and apparatus |
US7980905B2 (en) * | 2007-11-25 | 2011-07-19 | C-Mar Holdings, Ltd. | Method and apparatus for providing power to a marine vessel |
EP2072133A1 (de) * | 2007-12-20 | 2009-06-24 | Koninklijke Philips Electronics N.V. | Mehrkammervorrichtung mit magnetischen Partikeln |
WO2011120020A1 (en) | 2010-03-25 | 2011-09-29 | Quantalife, Inc. | Droplet transport system for detection |
WO2010106580A1 (ja) * | 2009-03-19 | 2010-09-23 | 株式会社島津製作所 | 液体採取装置およびその方法 |
DE102009023068A1 (de) * | 2009-05-28 | 2010-12-02 | RATIONAL Technische Lösungen GmbH | Dosiergerät insbesondere für analytische Aufgaben |
DE102012109026A1 (de) * | 2012-09-25 | 2014-03-27 | Eads Deutschland Gmbh | Detektionsvorrichtung und Detektionsverfahren zur automatischen Bestimmung von Biomasse |
CN105074416B (zh) * | 2013-03-15 | 2019-01-11 | M·L·贝尔 | 分析装置和分析方法 |
AU2014300649A1 (en) * | 2013-06-18 | 2015-12-10 | Gencell Biosystems Ltd. | Biomolecule isolation and thermal processing |
GB201321433D0 (en) * | 2013-12-04 | 2014-01-15 | Isis Innovation | Controling fluid micro compartments |
WO2015095239A1 (en) | 2013-12-18 | 2015-06-25 | Optiscan Biomedical Corporation | Systems and methods for detecting leaks |
EP3459460A4 (de) * | 2016-05-18 | 2020-01-29 | Terumo Kabushiki Kaisha | Blutinspektionssystem und blutinspektionssystemsteuerungsverfahren |
GB201704760D0 (en) * | 2017-01-05 | 2017-05-10 | Illumina Inc | Reagent nozzle sipper mixing system and method |
IT201800004630A1 (it) * | 2018-04-17 | 2019-10-17 | Apparato e procedimento per la determinazione della velocita' di sedimentazione del sangue e di altri parametri ad essa correlati | |
CN118795127A (zh) * | 2023-04-13 | 2024-10-18 | 深圳市帝迈生物技术有限公司 | 血液分析仪 |
Family Cites Families (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3970518A (en) * | 1975-07-01 | 1976-07-20 | General Electric Company | Magnetic separation of biological particles |
US4018886A (en) * | 1975-07-01 | 1977-04-19 | General Electric Company | Diagnostic method and device employing protein-coated magnetic particles |
GB1575805A (en) * | 1976-03-12 | 1980-10-01 | Technicon Instr | Automatic diagnostic apparatus |
GB1576427A (en) * | 1976-04-29 | 1980-10-08 | English Clays Lovering Pochin | Magnetic separators |
US4418039A (en) * | 1976-12-27 | 1983-11-29 | Technicon Instruments Corporation | Solute transfer technique |
US4219335A (en) * | 1978-09-18 | 1980-08-26 | E. I. Du Pont De Nemours And Company | Immunochemical testing using tagged reagents |
US4297337A (en) * | 1979-04-13 | 1981-10-27 | Corning Glass Works | Solid-phase immunoassays using magnetic glass |
US4259291A (en) * | 1979-07-13 | 1981-03-31 | Technicon Instruments Corporation | Metering device |
US4253846A (en) * | 1979-11-21 | 1981-03-03 | Technicon Instruments Corporation | Method and apparatus for automated analysis of fluid samples |
US4657868A (en) * | 1980-01-15 | 1987-04-14 | Rolf Saxholm | Apparatus for testing reactions |
JPS576338A (en) * | 1980-06-12 | 1982-01-13 | Kyoto Daiichi Kagaku:Kk | Method and device for measuring degree of flocculation of finely divided particles quantitatively |
DE3134861C2 (de) * | 1981-09-03 | 1985-04-04 | Siegfried 4054 Nettetal André | Magnetfilter |
DE3200988A1 (de) * | 1982-01-14 | 1983-07-28 | Thomas A. Dr. 6900 Heidelberg Reed | Verfahren und vorrichtung zur abtrennung von organischen stoffen aus einer suspension oder loesung |
US4452773A (en) * | 1982-04-05 | 1984-06-05 | Canadian Patents And Development Limited | Magnetic iron-dextran microspheres |
US4517302A (en) * | 1982-11-15 | 1985-05-14 | Technicon Instruments Corporation | Continuous flow metering apparatus |
US4853336A (en) * | 1982-11-15 | 1989-08-01 | Technicon Instruments Corporation | Single channel continuous flow system |
US4628037A (en) * | 1983-05-12 | 1986-12-09 | Advanced Magnetics, Inc. | Binding assays employing magnetic particles |
GB8314523D0 (en) * | 1983-05-25 | 1983-06-29 | Lowe C R | Diagnostic device |
DE3336255A1 (de) * | 1983-10-05 | 1985-04-18 | Krupp Polysius Ag, 4720 Beckum | Vorrichtung zur abscheidung ferromagnetischer partikel aus einer truebe |
GB8401368D0 (en) * | 1984-01-19 | 1984-02-22 | Amersham Int Plc | Assay method |
US4677067A (en) * | 1984-06-22 | 1987-06-30 | Bio-Magnetech Corporation | Magnetotactic bacteria in clinical assay, immunoassay, and cell separation procedures and the like |
FI842992A0 (fi) * | 1984-07-26 | 1984-07-26 | Labsystems Oy | Immunologiskt definitionsfoerfarande. |
FI844027A (fi) * | 1984-10-12 | 1986-04-13 | Labsystems Oy | Immunologiskt bestaemningsfoerfarande. |
DE3522365A1 (de) * | 1985-06-22 | 1987-01-02 | Bayer Ag | Trenngeraet fuer magnetische partikel aus fluessiger phase |
JPH0628594B2 (ja) * | 1985-08-07 | 1994-04-20 | 東ソー株式会社 | 生化学反応用撹拌装置 |
JPH0737989B2 (ja) * | 1986-07-04 | 1995-04-26 | 東ソー株式会社 | 免疫反応の測定方法および装置 |
US4784758A (en) * | 1986-08-27 | 1988-11-15 | Engelhard Corporation | Process for removing magnetic particles from a suspension of solids in a liquid |
NO162946C (no) * | 1987-08-21 | 1990-03-14 | Otto Soerensen | Anordning for magnetisk separasjon av celler. |
US5045473A (en) * | 1987-07-14 | 1991-09-03 | Technicon Instruments Corporation | Apparatus and method for the separation and/or formation of immicible liquid streams |
US4913883A (en) * | 1987-07-20 | 1990-04-03 | Hitachi, Ltd. | Particle agglutination immunoassay apparatus |
US5158871A (en) * | 1988-02-12 | 1992-10-27 | University Of Connecticut | Method of using magnetic particles for isolating, collecting and assaying diagnostic ligates |
US5123901A (en) * | 1988-02-25 | 1992-06-23 | Carew E Bayne | Method for separating pathogenic or toxic agents from a body fluid and return to body |
US5147529A (en) * | 1988-08-10 | 1992-09-15 | E. I. Du Pont De Nemours And Company | Method for automatically processing magnetic solid phase reagents |
US5134079A (en) * | 1989-03-27 | 1992-07-28 | International Technidyne Corp. | Fluid sample collection and delivery system and methods particularly adapted for body fluid sampling |
JPH02307059A (ja) * | 1989-05-23 | 1990-12-20 | Seiko Instr Inc | 反応容器 |
US5130027A (en) * | 1989-09-19 | 1992-07-14 | The University Of Colorado Foundation, Inc. | Stationary magnetically stabilized fluidized bed for protein separation and purification |
US5186827A (en) * | 1991-03-25 | 1993-02-16 | Immunicon Corporation | Apparatus for magnetic separation featuring external magnetic means |
US5268147A (en) * | 1992-02-26 | 1993-12-07 | Miles, Inc. | Reversible direction capsule chemistry sample liquid analysis system and method |
-
1993
- 1993-08-13 US US08/106,254 patent/US5399497A/en not_active Expired - Lifetime
-
1994
- 1994-05-19 IL IL10968994A patent/IL109689A/en not_active IP Right Cessation
- 1994-05-25 CA CA002124304A patent/CA2124304C/en not_active Expired - Fee Related
- 1994-06-01 AU AU63474/94A patent/AU676547B2/en not_active Ceased
- 1994-06-24 JP JP16490994A patent/JP3505689B2/ja not_active Expired - Fee Related
- 1994-08-01 ES ES94111964T patent/ES2211873T3/es not_active Expired - Lifetime
- 1994-08-01 DK DK94111964T patent/DK0638809T3/da active
- 1994-08-01 DE DE69433315T patent/DE69433315T2/de not_active Expired - Fee Related
- 1994-08-01 EP EP94111964A patent/EP0638809B1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
IL109689A (en) | 1996-11-14 |
JP3505689B2 (ja) | 2004-03-08 |
AU6347494A (en) | 1995-02-23 |
EP0638809A2 (de) | 1995-02-15 |
IL109689A0 (en) | 1994-08-26 |
US5399497A (en) | 1995-03-21 |
JPH0755817A (ja) | 1995-03-03 |
ES2211873T3 (es) | 2004-07-16 |
DK0638809T3 (da) | 2004-03-22 |
CA2124304A1 (en) | 1995-02-14 |
EP0638809A3 (de) | 1997-02-19 |
AU676547B2 (en) | 1997-03-13 |
CA2124304C (en) | 2005-11-29 |
DE69433315T2 (de) | 2004-08-26 |
EP0638809B1 (de) | 2003-11-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |