DE69331075D1 - Vorrichtung und Verfahren zur Analyse von Probenflüssigkeiten mit umkehrbarer Strömung - Google Patents

Vorrichtung und Verfahren zur Analyse von Probenflüssigkeiten mit umkehrbarer Strömung

Info

Publication number
DE69331075D1
DE69331075D1 DE69331075T DE69331075T DE69331075D1 DE 69331075 D1 DE69331075 D1 DE 69331075D1 DE 69331075 T DE69331075 T DE 69331075T DE 69331075 T DE69331075 T DE 69331075T DE 69331075 D1 DE69331075 D1 DE 69331075D1
Authority
DE
Germany
Prior art keywords
sample liquids
reversible flow
analyzing sample
analyzing
reversible
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69331075T
Other languages
English (en)
Other versions
DE69331075T2 (de
Inventor
George Zabetakis
Paul G Gherson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Bayer Corp
Original Assignee
Bayer AG
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG, Bayer Corp filed Critical Bayer AG
Application granted granted Critical
Publication of DE69331075D1 publication Critical patent/DE69331075D1/de
Publication of DE69331075T2 publication Critical patent/DE69331075T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers
    • B01F33/451—Magnetic mixers; Mixers with magnetically driven stirrers wherein the mixture is directly exposed to an electromagnetic field without use of a stirrer, e.g. for material comprising ferromagnetic particles or for molten metal
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N2035/1025—Fluid level sensing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/117497—Automated chemical analysis with a continuously flowing sample or carrier stream
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/117497—Automated chemical analysis with a continuously flowing sample or carrier stream
    • Y10T436/118339—Automated chemical analysis with a continuously flowing sample or carrier stream with formation of a segmented stream

Landscapes

  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Sampling And Sample Adjustment (AREA)
DE69331075T 1992-02-26 1993-02-15 Vorrichtung und Verfahren zur Analyse von Probenflüssigkeiten mit umkehrbarer Strömung Expired - Fee Related DE69331075T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/846,269 US5268147A (en) 1992-02-26 1992-02-26 Reversible direction capsule chemistry sample liquid analysis system and method

Publications (2)

Publication Number Publication Date
DE69331075D1 true DE69331075D1 (de) 2001-12-13
DE69331075T2 DE69331075T2 (de) 2002-03-21

Family

ID=25297402

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69331075T Expired - Fee Related DE69331075T2 (de) 1992-02-26 1993-02-15 Vorrichtung und Verfahren zur Analyse von Probenflüssigkeiten mit umkehrbarer Strömung

Country Status (9)

Country Link
US (1) US5268147A (de)
EP (1) EP0562260B1 (de)
JP (1) JP3256818B2 (de)
AU (1) AU653486B2 (de)
CA (1) CA2083322C (de)
DE (1) DE69331075T2 (de)
DK (1) DK0562260T3 (de)
ES (1) ES2164647T3 (de)
IL (1) IL103782A (de)

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US5631167A (en) * 1995-07-31 1997-05-20 Bayer Corporation Capsule chemistry analytical methods employing dioxetane chemiluminescence
US5714388A (en) * 1996-08-14 1998-02-03 Bayer Corporation Apparatus and method for detecting chemiluminescent light
EP1032471B1 (de) * 1997-11-19 2002-04-24 Biognosis GmbH Vorrichtung zur sequentiellen ausgabe von fliessfähigen reagenzien
US6348354B1 (en) * 1998-07-06 2002-02-19 Bayer Corporation Method and apparatus for controlling a stream of liquid test packages in a capsule chemistry analysis system
US6022747A (en) * 1998-07-10 2000-02-08 Bayer Corporation Blood clot detector
US6261847B1 (en) * 1998-07-10 2001-07-17 Bayer Corporation Sample dilution module with offset mixing chamber
US6315952B1 (en) 1998-10-05 2001-11-13 The University Of New Mexico Plug flow cytometry for high throughput screening and drug discovery
US6623971B2 (en) * 1999-01-11 2003-09-23 Bayer Corporation Method and apparatus for conducting a stat immunoassay analysis in a capsule chemistry analysis system
US6890487B1 (en) 1999-09-30 2005-05-10 Science & Technology Corporation ©UNM Flow cytometry for high throughput screening
US7416903B2 (en) * 1999-09-30 2008-08-26 Stc.Unm Wavy interface mixer
EP1274508B1 (de) * 2000-04-03 2007-12-05 Parabol Technologies S.A. Vorrichtung zur abgabe von genau kontrollierten kleinen flüssigkeitsmengen
US6610499B1 (en) * 2000-08-31 2003-08-26 The Regents Of The University Of California Capillary array and related methods
US6902938B1 (en) * 2000-10-10 2005-06-07 Jeol Usa, Inc. Chemical analysis method for multiplexed samples
WO2002037079A2 (en) * 2000-11-06 2002-05-10 The Government Of The United States Of America, As Represented By The Secretary Of Health And Human Services Sample delivery system with laminar mixing for microvolume biosensing
US6689621B2 (en) 2000-11-29 2004-02-10 Liquid Logic, Llc Fluid dispensing system and valve control
JP2004535572A (ja) * 2001-06-13 2004-11-25 ケニス エフ． ウーヘンハイマー， 自動化流体操作システムおよび方法
US20040028559A1 (en) * 2001-11-06 2004-02-12 Peter Schuck Sample delivery system with laminar mixing for microvolume biosensing
WO2003086637A1 (en) 2002-04-12 2003-10-23 Instrumentation Laboratory Company Immunoassay probe
US7488309B2 (en) 2002-07-03 2009-02-10 Bioanalytical Systems, Inc. Device and method for drug delivery to animals
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JP2004317420A (ja) * 2003-04-18 2004-11-11 Hitachi Software Eng Co Ltd キャピラリー利用測定装置
DE10322893A1 (de) * 2003-05-19 2004-12-16 Hans-Knöll-Institut für Naturstoff-Forschung e.V. Vorrichtung und Verfahren zum Zudosieren von Reaktionsflüssigkeiten zu in Separationsmedium eingebetteten Flüssigkeitskompartimenten
DE10322942A1 (de) * 2003-05-19 2004-12-09 Hans-Knöll-Institut für Naturstoff-Forschung e.V. Vorrichtung zum Positionieren und Ausschleusen von in Separationsmedium eingebetteten Fluidkompartimenten
EP1776181B1 (de) 2004-01-26 2013-09-11 The President and Fellows of Harvard College Fluidzuführsystem und -verfahren
US8030057B2 (en) * 2004-01-26 2011-10-04 President And Fellows Of Harvard College Fluid delivery system and method
US8211386B2 (en) 2004-06-08 2012-07-03 Biokit, S.A. Tapered cuvette and method of collecting magnetic particles
US7338804B2 (en) * 2004-11-24 2008-03-04 Siemens Healthcare Diagnostics Inc. Automated clinical analyzer reagent formulation
US20060172425A1 (en) * 2005-02-01 2006-08-03 Bayer Healthcare, Llc Colored buffer solution for automated clinical analyzer
WO2007024778A2 (en) * 2005-08-22 2007-03-01 Applera Corporation Device, system and method for depositing processed immiscible-fluid-discrete-volumes
US7704457B2 (en) * 2005-11-18 2010-04-27 Patton Charles J Automatic, field portable analyzer using discrete sample aliquots
US20080080302A1 (en) * 2006-09-29 2008-04-03 Fujifilm Corporation Droplet mixing method and apparatus
JP5305361B2 (ja) 2007-05-04 2013-10-02 オプコ・ダイアグノスティクス・リミテッド・ライアビリティ・カンパニー 流体コネクタおよびマイクロ流体システム
DE102007032951B4 (de) 2007-07-14 2010-09-02 Karlsruher Institut für Technologie Vorrichtung und Verfahren zur Zuführung eines Flüssigkeitsstroms aus mindestens zwei Flüssigkeitsabschnitten in eine Messzelle
US7980905B2 (en) * 2007-11-25 2011-07-19 C-Mar Holdings, Ltd. Method and apparatus for providing power to a marine vessel
DK2376226T3 (en) 2008-12-18 2018-10-15 Opko Diagnostics Llc IMPROVED REAGENT STORAGE IN MICROFLUIDIC SYSTEMS AND RELATED ARTICLES AND PROCEDURES
DE202010018623U1 (de) 2009-02-02 2018-12-07 Opko Diagnostics, Llc Strukturen zur Steuerung der Lichtwechselwirkung mit mikrofluidischen Vorrichtungen
JP5340760B2 (ja) * 2009-02-12 2013-11-13 倉敷紡績株式会社 流体制御方法及び流体制御装置
US8823943B2 (en) 2009-05-21 2014-09-02 Intellicyt Corporation System and method for separating samples in a continuous flow
US9752964B1 (en) 2009-06-22 2017-09-05 Stc.Unm Flow cytometry apparatus pulling sample stream through observation chamber
WO2011066361A1 (en) 2009-11-24 2011-06-03 Claros Diagnostics, Inc. Fluid mixing and delivery in microfluidic systems
WO2011130625A1 (en) 2010-04-16 2011-10-20 Claros Diagnostics, Inc. Feedback control in microfluidic systems
USD645971S1 (en) 2010-05-11 2011-09-27 Claros Diagnostics, Inc. Sample cassette
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US9588027B2 (en) 2013-03-13 2017-03-07 UPKO Diagnostics, LLC Mixing of fluids in fluidic systems
PL3030645T3 (pl) * 2013-08-08 2023-03-13 Illumina, Inc. Układ płynowy do podawania odczynnika do celi przepływowej
WO2015116978A1 (en) * 2014-01-31 2015-08-06 Carnegie Mellon University Device and method for clinical data sampling and specimen banking
WO2016094766A1 (en) 2014-12-12 2016-06-16 Opko Diagnostics, Llc Fluidic systems comprising an incubation channel, including fluidic systems formed by molding
CN107206382B (zh) 2015-02-13 2020-03-10 西门子医疗保健诊断公司 在移液操作期间提供减少的残留的方法和设备
USD804682S1 (en) 2015-08-10 2017-12-05 Opko Diagnostics, Llc Multi-layered sample cassette
CA3005084A1 (en) 2015-12-11 2017-06-15 Opko Diagnostics, Llc Fluidic systems involving incubation of samples and/or reagents
US11547957B2 (en) * 2017-05-11 2023-01-10 Emd Millipore Corporation Method of maintaining narrow residence time distributions in continuous flow systems
IT201800004630A1 (it) * 2018-04-17 2019-10-17 Apparato e procedimento per la determinazione della velocita' di sedimentazione del sangue e di altri parametri ad essa correlati
EP3586964A1 (de) * 2018-06-27 2020-01-01 Inorevia Verfahren zur manipulation von tröpfchen in einem kanal

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Also Published As

Publication number Publication date
EP0562260A2 (de) 1993-09-29
AU653486B2 (en) 1994-09-29
JP3256818B2 (ja) 2002-02-18
DK0562260T3 (da) 2002-02-25
CA2083322A1 (en) 1993-08-27
DE69331075T2 (de) 2002-03-21
AU2984092A (en) 1993-09-02
US5268147A (en) 1993-12-07
IL103782A0 (en) 1993-04-04
EP0562260A3 (de) 1994-02-23
ES2164647T3 (es) 2002-03-01
JPH0658942A (ja) 1994-03-04
EP0562260B1 (de) 2001-11-07
CA2083322C (en) 2004-04-13
IL103782A (en) 1994-06-24

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee