DE69432033D1 - Adrenomedullin - Google Patents

Adrenomedullin

Info

Publication number
DE69432033D1
DE69432033D1 DE69432033T DE69432033T DE69432033D1 DE 69432033 D1 DE69432033 D1 DE 69432033D1 DE 69432033 T DE69432033 T DE 69432033T DE 69432033 T DE69432033 T DE 69432033T DE 69432033 D1 DE69432033 D1 DE 69432033D1
Authority
DE
Germany
Prior art keywords
proam
proadrenomedullin
peptide
adrenomedullin
peptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69432033T
Other languages
English (en)
Other versions
DE69432033T2 (de
Inventor
Kazuo Kitamura
Kenji Kangawa
Hisayuki Matsuo
Tanenao Eto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Publication of DE69432033D1 publication Critical patent/DE69432033D1/de
Application granted granted Critical
Publication of DE69432033T2 publication Critical patent/DE69432033T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/003—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by transforming the C-terminal amino acid to amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/13—Labelling of peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Fats And Perfumes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
DE69432033T 1993-04-26 1994-04-25 Adrenomedullin Expired - Lifetime DE69432033T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP9985693 1993-04-26
JP18310793 1993-07-23
JP29873693 1993-11-29
JP6079035A JP2774769B2 (ja) 1993-04-26 1994-04-18 アドレノメデュリン

Publications (2)

Publication Number Publication Date
DE69432033D1 true DE69432033D1 (de) 2003-02-27
DE69432033T2 DE69432033T2 (de) 2003-09-25

Family

ID=27466245

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69432033T Expired - Lifetime DE69432033T2 (de) 1993-04-26 1994-04-25 Adrenomedullin

Country Status (9)

Country Link
US (4) US5639855A (de)
EP (1) EP0622458B1 (de)
JP (1) JP2774769B2 (de)
KR (1) KR100312443B1 (de)
AT (1) ATE231553T1 (de)
CA (1) CA2122112C (de)
DE (1) DE69432033T2 (de)
DK (1) DK0622458T3 (de)
ES (1) ES2191674T3 (de)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69602756T2 (de) * 1995-08-18 2000-02-10 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Rockville Funktionelle rolle von adrenomedullin(am) und dem gen-verwandten produkt(pamp) in der menschlichen pathologie und physiologie
US5888963A (en) * 1996-04-18 1999-03-30 Auckland Uniservices Limited Treatment of bone disorders with adrenomedullin
US6440421B1 (en) 1996-04-18 2002-08-27 Auchkland Uniservices Limited Treatment of bone disorders with adrenomedullin or adrenomedullin agonists
DE69836689D1 (de) 1997-09-26 2007-02-01 Auckland Uniservices Ltd Verwendung von Amylin, Adrenomedullin und deren Analoga zur Behandlung von Knorpeldefekten
WO2000078338A1 (fr) * 1999-06-23 2000-12-28 Shionogi & Co., Ltd. Compositions favorisant l'allongement passif des muscles lisses vesiculaires
ATE403435T1 (de) * 1999-06-23 2008-08-15 Shionogi & Co Inhibitoren der uterus-kontraktion
FR2821080B1 (fr) * 2001-02-20 2003-12-19 Sanofi Synthelabo Anticorps specifique de l'adrenomedulline humaine, composition pharmaceutique le contenant, ses applications therapeutiques
CN1753909A (zh) * 2002-03-19 2006-03-29 株式会社康福来 肽,含有该肽的药物组合物和用于治疗癌症的药物组合物
EP1575417A4 (de) * 2002-09-30 2007-07-04 Bayer Pharmaceuticals Corp Verfahren zur vorhersage und prognose von krebs und berwachung der krebstherapie
WO2004032708A2 (en) * 2002-10-04 2004-04-22 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Vasoregulating compounds and methods of their use
CA2504953C (en) * 2002-11-07 2013-08-20 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services A new target for angiogenesis and anti-angiogenesis therapy
US6727277B1 (en) 2002-11-12 2004-04-27 Kansas State University Research Foundation Compounds affecting cholesterol absorption
DE10316583A1 (de) * 2003-04-10 2004-10-28 B.R.A.H.M.S Aktiengesellschaft Bestimmung eines midregionalen Proadrenomedullin-Teilpeptids in biologischen Flüssigkeiten zu diagnostischen Zwecken, sowie Immunoassays für die Durchführung einer solchen Bestimmung
AU2004273057C1 (en) * 2003-09-08 2011-06-30 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Non-peptide agonists and antagonists of adrenomedullin and gastrin releasing peptide
US20060099608A1 (en) * 2004-03-29 2006-05-11 Medstar Research Institute Methods of diagnosing cardiovascular disease
US8703693B2 (en) * 2004-03-31 2014-04-22 The Feinstein Institute For Medical Research Adrenomedullin and adrenomedullin binding protein for ischemia/reperfusion treatment
CA2562957C (en) 2004-03-31 2013-05-21 The Feinstein Institute For Medical Research Adrenomedullin and adrenomedullin binding protein for ischemia/reperfusion treatment
EP1844158A4 (de) * 2004-12-06 2010-09-08 Univ Johns Hopkins Biomarker für entzündliche darmerkrankung
DE102005003687A1 (de) 2005-01-26 2006-07-27 Sphingo Tec Gmbh Immunoassay zur Bestimmung der Freisetzung von Neurotensin in die Zirkulation
WO2006095711A1 (ja) * 2005-03-07 2006-09-14 Japan As Represented By General Director Of Agency Of National Cardiovascular Center アドレノメデュリンを用いて障害組織を再生または修復する方法
JP4505640B2 (ja) * 2005-04-12 2010-07-21 国立大学法人 宮崎大学 心筋障害の予防又は治療剤
US20080317720A1 (en) * 2005-04-14 2008-12-25 Noritoshi Nagaya Fat-Derived Progenitor Cell and Use Thereof
DE102005036094A1 (de) * 2005-08-01 2007-02-08 B.R.A.H.M.S Ag In vitro Verfahren zur Diagnose von neurodegenerativen Erkrankungen
WO2007062676A1 (en) 2005-12-01 2007-06-07 B.R.A.H.M.S. Aktiengesellschaft Methods for the diagnosis and treatment of critically ill patients with endothelin, endothelin agonists and adrenomedullin antagonists
US8906857B2 (en) * 2005-12-01 2014-12-09 B.R.A.H.M.S. Gmbh Methods for the diagnosis and treatment of critically ill patients with endothelin, endothelin agonists and adrenomedullin antagonists
DE102006060112A1 (de) 2006-12-20 2008-06-26 Brahms Aktiengesellschaft Diagnose und Risikostratifizierung mittels dem neuen Marker CT-proADM
CN101945659A (zh) 2008-02-19 2011-01-12 国立大学法人旭川医科大学 肾上腺髓质素产生增强剂
WO2012096411A1 (ja) 2011-01-12 2012-07-19 国立大学法人宮崎大学 難治性炎症性腸疾患の予防又は治療方法
ES2387240B2 (es) * 2011-01-31 2013-04-26 Fundación Rioja Salud Péptido capaz de aumentar la velocidad de desplazamiento de una kinesina o su homóloga funcional sobre microtúbulos.
WO2013072513A1 (en) * 2011-11-16 2013-05-23 Adrenomed Ag Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for use in therapy of an acute disease or acute condition of a patient for stabilizing the circulation
AU2012338734B2 (en) 2011-11-16 2017-08-24 Adrenomed Ag Anti-adrenomedullin (ADM) antibody or anti-ADM antibody fragment or anti-ADM non-Ig scaffold for regulating the fluid balance in a patient having a chronic or acute disease
ES2938653T3 (es) 2011-11-16 2023-04-13 Adrenomed Ag Anticuerpo antiadrenomedulina (ADM) o fragmento de anticuerpo anti-ADM o andamiaje no Ig anti-ADM para la prevención o la reducción de una disfunción orgánica o una insuficiencia orgánica en un paciente que presenta una enfermedad crónica o aguda o una afección aguda
KR102047443B1 (ko) * 2011-11-16 2019-11-25 아드레노메드 아게 요법에 사용하기 위한 항-아드레노메둘린 (adm) 항체 또는 항-adm 항체 단편 또는 항-adm 비-ig 스캐폴드
PT2780717T (pt) * 2011-11-16 2017-02-16 Sphingotec Gmbh Ensaios de adrenomedulina e processos para a determinação de adrenomedulina madura
US11067586B2 (en) 2011-11-16 2021-07-20 Sphingotec Gmbh Adrenomedullin assays and methods for determining mature adrenomedullin
SG11201402362VA (en) 2011-11-16 2014-06-27 Adrenomed Ag Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for reducing the risk of mortality in a patient having a chronic or acute disease or acute condition
ES2830036T3 (es) * 2013-03-20 2021-06-02 Sphingotec Gmbh Adrenomedulina para guiar una terapia de disminución de la presión sanguínea
US11414474B2 (en) 2014-03-20 2022-08-16 University Of Miyazaki Long-acting adrenomedullin derivatives
CU20170038A7 (es) * 2014-09-26 2017-10-05 Bayer Pharma AG Derivados de adrenomedulina estabililzados especialmente útiles en el tratamiento y/o prevención de trastornos cardiovasculares, edematosos y/o inflamatorios
KR102152437B1 (ko) * 2015-09-18 2020-09-07 고쿠리츠 다이가쿠 호징 미야자키 다이가쿠 장시간 작용형 아드레노메둘린 유도체
MX2019000003A (es) 2016-07-08 2019-08-29 Sphingotec Gmbh Adrenomodulina para evaluar la congestión en un individuo con insuficiencia cardiaca aguda.
EP3339324A1 (de) 2016-12-22 2018-06-27 sphingotec GmbH Anti-adrenomedullin (adm)-antikörper oder anti-adm antikörperfragment oder anti-adm-nicht-ig-gerüst zur verwendung in einer intervention und therapie von verstopfung bei einem darauf angewiesenen patienten
BR112019011713A2 (pt) 2016-12-16 2019-10-15 Adrenomed Ag anticorpo anti-adrenomedulina (adm) ou fragmento de anticorpo anti-adm ou arcabouço anti-adm não ig para uso na intervenção e terapia da congestão em um paciente com necessidade da mesma
JP7001285B2 (ja) * 2017-03-29 2022-01-19 国立大学法人 宮崎大学 長時間作用型アドレノメデュリン誘導体
EP3438668A1 (de) 2017-08-04 2019-02-06 B.R.A.H.M.S GmbH Diagnose und risikostratifizierung von pilzinfektionen
US20220268761A1 (en) 2017-10-18 2022-08-25 Adrenomed Ag Therapy monitoring under treatment with an anti-adrenomedullin (adm) binder
EP3502706A1 (de) 2017-12-20 2019-06-26 B.R.A.H.M.S GmbH Workflow für risikobewertung und patientenmanagement unter verwendung von procalcitonin und midregional-proadrenomedullin
SG11202006686SA (en) 2018-02-08 2020-08-28 Sphingotec Gmbh Adrenomedullin (adm) for diagnosis and/or prediction of dementia and anti-adrenomedullin binder for use in therapy or prevention of dementia
EP3715851A1 (de) 2019-03-29 2020-09-30 B.R.A.H.M.S GmbH Verschreibung von fernpatientenmanagement auf der basis von biomarkern
CA3124744A1 (en) 2019-03-29 2020-10-08 B.R.A.H.M.S Gmbh Prescription of remote patient management based on biomarkers
EP3871689A1 (de) 2020-02-26 2021-09-01 sphingotec GmbH Anti-adm-antikörper, die an den freien n-terminus binden, für einen beschleunigten übergang von adm-gly zu bio-adm bei patienten mit einem adm-gly/bio-adm-verhältnis über einem schwellenwert und kombination mit vitamin c
CA3168978A1 (en) 2020-02-27 2021-09-02 Andreas Bergmann Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for use in therapy or prevention of shock
EP4111204A1 (de) 2020-02-27 2023-01-04 4TEEN4 Pharmaceuticals GmbH Dpp3 zur therapieführung, überwachung und stratifizierung von nt-adm-antikörpern bei patienten mit schock
EP4121772A1 (de) 2020-03-16 2023-01-25 sphingotec GmbH Proadrenomedullin oder fragment davon bei patienten mit coronavirusinfektion und behandlungen mit bindemittel gegen adrenomedullin
JP7499533B2 (ja) 2020-04-02 2024-06-14 国立大学法人 宮崎大学 新規アドレノメデュリン類縁体、その製造方法及びその医薬用途
EP4023218A1 (de) 2020-12-02 2022-07-06 S-Form Pharma Kombinationstherapie für patienten mit akuter und/oder anhaltender dyspnoe
JP2024519321A (ja) 2021-05-07 2024-05-10 シュピーンゴテック ゲゼルシャフト ミット ベシュレンクテル ハフツング 重篤患者におけるコルチコステロイドの療法層別化のための成熟アドレノメデュリン
WO2024023369A1 (en) 2022-07-29 2024-02-01 Adrenomed Ag Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for use in therapy or prevention of shock
WO2024023368A1 (en) 2022-07-29 2024-02-01 4TEEN4 Pharmaceuticals GmbH Prediction of an increase of dpp3 in a patient with septic shock

Family Cites Families (3)

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US4708934A (en) * 1984-09-27 1987-11-24 Unigene Laboratories, Inc. α-amidation enzyme
JPH04282399A (ja) * 1991-03-08 1992-10-07 Fujisawa Pharmaceut Co Ltd 放射性ヨウ素標識インシュリン様成長因子ｉ
WO1995004752A1 (en) * 1993-08-09 1995-02-16 Biomeasure, Inc. Therapeutic peptide derivatives

Also Published As

Publication number Publication date
CA2122112C (en) 1999-02-16
US5837823A (en) 1998-11-17
EP0622458A2 (de) 1994-11-02
JPH07196693A (ja) 1995-08-01
ES2191674T3 (es) 2003-09-16
US5910416A (en) 1999-06-08
JP2774769B2 (ja) 1998-07-09
US5830703A (en) 1998-11-03
EP0622458B1 (de) 2003-01-22
AU6064894A (en) 1994-10-27
KR100312443B1 (ko) 2002-02-28
EP0622458A3 (en) 1996-06-12
DE69432033T2 (de) 2003-09-25
AU678212B2 (en) 1997-05-22
US5639855A (en) 1997-06-17
DK0622458T3 (da) 2003-05-19
ATE231553T1 (de) 2003-02-15
CA2122112A1 (en) 1994-10-27

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