DE69418243T2 - N-Heteroaryl-N'-Phenylharnstoffderivate, ihre Herstellung und Verwendung - Google Patents

N-Heteroaryl-N'-Phenylharnstoffderivate, ihre Herstellung und Verwendung

Info

Publication number
DE69418243T2
DE69418243T2 DE69418243T DE69418243T DE69418243T2 DE 69418243 T2 DE69418243 T2 DE 69418243T2 DE 69418243 T DE69418243 T DE 69418243T DE 69418243 T DE69418243 T DE 69418243T DE 69418243 T2 DE69418243 T2 DE 69418243T2
Authority
DE
Germany
Prior art keywords
groups
group
alkyl
alkyl groups
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69418243T
Other languages
German (de)
English (en)
Other versions
DE69418243D1 (de
Inventor
Kenji Horiuchi
Yoshimitsu Matsui
Masashi Nagamine
Kenji Yamamoto
Masanori Yoshida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nihon Nohyaku Co Ltd
Original Assignee
Nihon Nohyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=13229879&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69418243(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Nihon Nohyaku Co Ltd filed Critical Nihon Nohyaku Co Ltd
Application granted granted Critical
Publication of DE69418243D1 publication Critical patent/DE69418243D1/de
Publication of DE69418243T2 publication Critical patent/DE69418243T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/92—Naphthofurans; Hydrogenated naphthofurans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/66—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/74—Naphthothiophenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Furan Compounds (AREA)
  • Indole Compounds (AREA)
DE69418243T 1993-02-27 1994-02-25 N-Heteroaryl-N'-Phenylharnstoffderivate, ihre Herstellung und Verwendung Expired - Fee Related DE69418243T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6346093 1993-02-27

Publications (2)

Publication Number Publication Date
DE69418243D1 DE69418243D1 (de) 1999-06-10
DE69418243T2 true DE69418243T2 (de) 1999-09-30

Family

ID=13229879

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69418243T Expired - Fee Related DE69418243T2 (de) 1993-02-27 1994-02-25 N-Heteroaryl-N'-Phenylharnstoffderivate, ihre Herstellung und Verwendung

Country Status (14)

Country Link
US (2) US5464863A (cg-RX-API-DMAC7.html)
EP (1) EP0613894B1 (cg-RX-API-DMAC7.html)
JP (1) JP3143766B2 (cg-RX-API-DMAC7.html)
KR (1) KR940019701A (cg-RX-API-DMAC7.html)
CN (1) CN1051311C (cg-RX-API-DMAC7.html)
AT (1) ATE179706T1 (cg-RX-API-DMAC7.html)
AU (1) AU679021B2 (cg-RX-API-DMAC7.html)
CA (1) CA2116286A1 (cg-RX-API-DMAC7.html)
DE (1) DE69418243T2 (cg-RX-API-DMAC7.html)
DK (1) DK0613894T3 (cg-RX-API-DMAC7.html)
ES (1) ES2133430T3 (cg-RX-API-DMAC7.html)
GR (1) GR3030165T3 (cg-RX-API-DMAC7.html)
NZ (1) NZ250916A (cg-RX-API-DMAC7.html)
TW (1) TW279858B (cg-RX-API-DMAC7.html)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW234123B (cg-RX-API-DMAC7.html) * 1992-12-16 1994-11-11 Takeda Pharm Industry Co Ltd
NZ264063A (en) * 1993-08-13 1995-11-27 Nihon Nohyaku Co Ltd N-(2-phenylpyrid-3-yl)- and n-(4-phenylpyrimidin-5-yl)-n'-phenylurea derivatives and pharmaceutical compositions
FR2734816B1 (fr) * 1995-05-31 1997-07-04 Adir Nouveaux aryl (alkyl) propylamides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US5773459A (en) * 1995-06-07 1998-06-30 Sugen, Inc. Urea- and thiourea-type compounds
US5606075A (en) * 1995-06-07 1997-02-25 Eli Lilly And Company Process for the synthesis of benzo[b]thiophenes
US5567828A (en) * 1995-06-07 1996-10-22 Eli Lilly And Company Compounds and compositions with nitrogen-containing non-basic side
AU679887B2 (en) * 1995-09-11 1997-07-10 Nihon Nohyaku Co., Ltd. Azole derivatives, their use, production and usage
EP0915653A1 (en) * 1996-06-27 1999-05-19 Smithkline Beecham Corporation Il-8 receptor antagonists
US6455566B1 (en) 1997-09-03 2002-09-24 Wyeth Substituted 1-aryl-3-heteroaryl-thioureas (or isothioureas) as antiatherosclerotic agents
TW415942B (en) * 1997-09-03 2000-12-21 American Home Prod Novel substituted 1-aryl-3-heteroaryl-thioureas and substituted 1-aryl-3-heteroaryl-isothioureas as antiatherosclerotic agents
JP2002529444A (ja) * 1998-11-12 2002-09-10 アリアド・ファーマシューティカルズ・インコーポレイテッド 二環式シグナル伝達阻害剤、それを含む組成物とその用途
US6974806B2 (en) * 2000-07-13 2005-12-13 Takeda Pharmaceutical Company Limited Lipid-rich plaque inhibitors
AU2002211901A1 (en) 2000-10-10 2002-04-22 Smithkline Beecham Corporation Substituted indoles, pharmaceutical compositions containing such indoles and their use as PPAR-gamma binding agents
WO2002047723A1 (en) * 2000-12-11 2002-06-20 Takeda Chemical Industries, Ltd. Medicinal compositions having improved water-solubility
US20040019096A1 (en) * 2001-10-23 2004-01-29 Vlassios Andronis Novel formulations of carvedilol
WO2003099773A1 (en) 2002-05-24 2003-12-04 Millennium Pharmaceuticals, Inc. Ccr9 inhibitors and methods of use thereof
AR041834A1 (es) * 2002-10-29 2005-06-01 Smithkline Beecham Corp Compuesto de difenilurea sustituido con sulfonamida, composicion farmaceutica que lo comprende y su uso para preparar dicha composicion
CN101077867B (zh) 2002-11-18 2012-10-10 坎莫森特里克斯公司 芳基磺酰胺
US7227035B2 (en) 2002-11-18 2007-06-05 Chemocentryx Bis-aryl sulfonamides
US7420055B2 (en) 2002-11-18 2008-09-02 Chemocentryx, Inc. Aryl sulfonamides
US7741519B2 (en) 2007-04-23 2010-06-22 Chemocentryx, Inc. Bis-aryl sulfonamides
SE0303480D0 (sv) * 2003-12-19 2003-12-19 Biovitrum Ab Benzofuranes
CN1997278B (zh) * 2004-04-20 2014-04-23 艾森生物(杭州)有限公司 有取代的有机硫化合物及其使用方法
CA2644809A1 (en) * 2006-03-02 2007-09-07 Astellas Pharma Inc. 17 .beta. hsd type 5 inhibitor
MX2008013600A (es) * 2006-04-21 2008-10-31 Smithkline Beechman Corp Antagonistas del receptor de interleuquina-8.
MX2008013599A (es) * 2006-04-21 2008-10-31 Smithkline Beechman Corp Antagonistas del receptor il-8.
CL2007001829A1 (es) * 2006-06-23 2008-01-25 Smithkline Beecham Corp P-toluensulfonato de n-[4-cloro-2-hidroxi-3-(piperazina-1-sulfonil)fenil]-n-(2-cloro-3-fluorofenil)urea;procedimiento de preparacion;composicion farmaceutica;combinacion farmaceutica;y uso en el tratamiento de una enfermedad mediada por la quiimioquina il-8, tales como asma y epoc.
US7785218B2 (en) * 2007-03-26 2010-08-31 Acushnet Company Custom milled iron set
WO2011062955A2 (en) 2009-11-18 2011-05-26 University Of Massachusetts Compounds for modulating tlr2
CN104529830B (zh) * 2015-01-15 2016-08-24 成都丽凯手性技术有限公司 一种制备脲类化合物的新方法
GB201521059D0 (en) * 2015-11-30 2016-01-13 Isis Innovation Inhibitors of metallo-beta-lactamases
EP4441037A1 (en) 2021-12-01 2024-10-09 Pfizer Inc. 3-phenyl-1-benzothiophene-2-carboxylic acid derivatives as branched-chain alpha keto acid dehydrogenase kinase inhibitors for the treatment of diabetes, kidney diseases, nash and heart failure

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1054655B (it) * 1975-08-27 1981-11-30 Lepetit Spa Derivati condensati del l isochinolina
FR2375228A1 (fr) * 1976-12-23 1978-07-21 Parcor Nouveaux benzothiophenes, leurs procedes de preparation et leur application notamment comme hypolipemiants et hypocholesterolemiants
JPH0753714B2 (ja) * 1988-07-12 1995-06-07 武田薬品工業株式会社 Ａｃａｔ阻害剤、キノリン誘導体及びその製造法
CN1028754C (zh) * 1988-07-12 1995-06-07 武田药品工业株式会社 喹啉衍生物的制备方法
AU632809B2 (en) * 1989-05-25 1993-01-14 Takeda Chemical Industries Ltd. Benzocycloalkane benzopyran and benzothiopyran urea derivatives and production thereof
FR2674522B1 (fr) * 1991-03-26 1993-07-16 Lipha Nouveaux derives de l'indole, procedes de preparation et medicaments les contenant.
IL101785A0 (en) * 1991-05-10 1992-12-30 Fujisawa Pharmaceutical Co Urea derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
AU4028393A (en) * 1992-05-28 1993-12-30 Pfizer Inc. New (N)-aryl and (N)-heteroarylurea derivatives as inhibitors of acyl coenzyme a:cholesterol acyl transferase (ACAT)
TW234123B (cg-RX-API-DMAC7.html) * 1992-12-16 1994-11-11 Takeda Pharm Industry Co Ltd

Also Published As

Publication number Publication date
NZ250916A (en) 1995-08-28
GR3030165T3 (en) 1999-08-31
EP0613894A1 (en) 1994-09-07
CA2116286A1 (en) 1994-08-28
ES2133430T3 (es) 1999-09-16
ATE179706T1 (de) 1999-05-15
JPH06340647A (ja) 1994-12-13
AU5636494A (en) 1994-09-01
TW279858B (cg-RX-API-DMAC7.html) 1996-07-01
JP3143766B2 (ja) 2001-03-07
US5464863A (en) 1995-11-07
EP0613894B1 (en) 1999-05-06
CN1100417A (zh) 1995-03-22
DE69418243D1 (de) 1999-06-10
USRE36832E (en) 2000-08-22
AU679021B2 (en) 1997-06-19
KR940019701A (ko) 1994-09-14
CN1051311C (zh) 2000-04-12
DK0613894T3 (da) 1999-11-01

Similar Documents

Publication Publication Date Title
DE69418243T2 (de) N-Heteroaryl-N'-Phenylharnstoffderivate, ihre Herstellung und Verwendung
DE69205327T2 (de) Harnstoffderivate, Verfahren zu ihrer Herstellung und diese enthaltende Medikamente.
EP0254322B1 (en) Benzimidazole derivatives
DE60015296T2 (de) Indolderivate und ihre verwendung als mcp-1 rezeptor antagonisten
DE69818831T2 (de) Indolderivate als mcp-1 rezeptor antagonisten
CZ281070B6 (cs) Slučenina farmakologicky účinné pro centrální nervový systém
HU184966B (en) Process for producing phenyl-piperazine derivatives of anti-agression activity
EP0005205A1 (de) Substituierte 5,6-Dimethylpyrrolo(2,3-d)pyrimidine, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
EP0327986A2 (de) Arzeneimittel enthaltend Lactame, neue substituierte Lactame und Verfahren zu ihrer Herstellung
EP0053767B1 (de) Tricyclische Cytosinderivate zur Verwendung in Arzneimitteln und Verfahren zu ihrer Herstellung
DE2149249A1 (de) 6-Arylpyrimidine
WO1996034856A1 (en) 2-ureido-benzamide derivatives
EP0058341A1 (de) Azepinderivate, ihre Herstellung und diese enthaltende Arzneimittel
DE69020394T2 (de) Aldose-Reductase-Inhibitor.
AU2001280004A1 (en) Substituted phthalides as anti-convulsive drugs
DE3615180C2 (de) Disubstituierte 1,4-Piperazinylderivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Mittel
EP0456133B1 (de) Hydrazone
EP0409048A2 (de) Aminoalkylsubstituierte 2-Aminothiazole und diese enthaltende therapeutische Mittel
US20040122040A1 (en) Bicyclic guanidine derivatives and therapeutic uses thereof
EP0066774A1 (de) Neue 1,4,9,10-Tetrahydro-pyrazolo(4,3-e)pyrido(3,2-b)(1,4)-diazepin-10-one, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
EP0041242B1 (de) Carbamoyloxyamino-1,4-benzodiazepine, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
DE69222818T2 (de) Kondensierte Naphthyridinderivate
DE60117517T2 (de) Indolderivate als mcp-1 rezeptor antagonisten
JPH0764844B2 (ja) ピリダジノピロロイソキノリン誘導体
US3790572A (en) 2-hydroxyalkyl-4,5-dihydropyridazin-3(2h)-one derivatives

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee