GR3030165T3 - N-heteroaryl-n'-phenylurea derivatives, their production and use. - Google Patents

N-heteroaryl-n'-phenylurea derivatives, their production and use.

Info

Publication number
GR3030165T3
GR3030165T3 GR990401227T GR990401227T GR3030165T3 GR 3030165 T3 GR3030165 T3 GR 3030165T3 GR 990401227 T GR990401227 T GR 990401227T GR 990401227 T GR990401227 T GR 990401227T GR 3030165 T3 GR3030165 T3 GR 3030165T3
Authority
GR
Greece
Prior art keywords
heteroaryl
production
phenylurea derivatives
phenylurea
derivatives
Prior art date
Application number
GR990401227T
Other languages
Greek (el)
English (en)
Inventor
Masashi Nagamine
Kenji Yamamoto
Yoshimitsu Matsui
Kenji Horiuchi
Masanori Yoshida
Original Assignee
Nihon Nohyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=13229879&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GR3030165(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Nihon Nohyaku Co Ltd filed Critical Nihon Nohyaku Co Ltd
Publication of GR3030165T3 publication Critical patent/GR3030165T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/92—Naphthofurans; Hydrogenated naphthofurans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/66—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/74—Naphthothiophenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Furan Compounds (AREA)
  • Indole Compounds (AREA)
GR990401227T 1993-02-27 1999-05-07 N-heteroaryl-n'-phenylurea derivatives, their production and use. GR3030165T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6346093 1993-02-27

Publications (1)

Publication Number Publication Date
GR3030165T3 true GR3030165T3 (en) 1999-08-31

Family

ID=13229879

Family Applications (1)

Application Number Title Priority Date Filing Date
GR990401227T GR3030165T3 (en) 1993-02-27 1999-05-07 N-heteroaryl-n'-phenylurea derivatives, their production and use.

Country Status (14)

Country Link
US (2) US5464863A (cg-RX-API-DMAC7.html)
EP (1) EP0613894B1 (cg-RX-API-DMAC7.html)
JP (1) JP3143766B2 (cg-RX-API-DMAC7.html)
KR (1) KR940019701A (cg-RX-API-DMAC7.html)
CN (1) CN1051311C (cg-RX-API-DMAC7.html)
AT (1) ATE179706T1 (cg-RX-API-DMAC7.html)
AU (1) AU679021B2 (cg-RX-API-DMAC7.html)
CA (1) CA2116286A1 (cg-RX-API-DMAC7.html)
DE (1) DE69418243T2 (cg-RX-API-DMAC7.html)
DK (1) DK0613894T3 (cg-RX-API-DMAC7.html)
ES (1) ES2133430T3 (cg-RX-API-DMAC7.html)
GR (1) GR3030165T3 (cg-RX-API-DMAC7.html)
NZ (1) NZ250916A (cg-RX-API-DMAC7.html)
TW (1) TW279858B (cg-RX-API-DMAC7.html)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW234123B (cg-RX-API-DMAC7.html) * 1992-12-16 1994-11-11 Takeda Pharm Industry Co Ltd
NZ264063A (en) * 1993-08-13 1995-11-27 Nihon Nohyaku Co Ltd N-(2-phenylpyrid-3-yl)- and n-(4-phenylpyrimidin-5-yl)-n'-phenylurea derivatives and pharmaceutical compositions
FR2734816B1 (fr) * 1995-05-31 1997-07-04 Adir Nouveaux aryl (alkyl) propylamides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US5773459A (en) * 1995-06-07 1998-06-30 Sugen, Inc. Urea- and thiourea-type compounds
US5606075A (en) * 1995-06-07 1997-02-25 Eli Lilly And Company Process for the synthesis of benzo[b]thiophenes
US5567828A (en) * 1995-06-07 1996-10-22 Eli Lilly And Company Compounds and compositions with nitrogen-containing non-basic side
AU679887B2 (en) * 1995-09-11 1997-07-10 Nihon Nohyaku Co., Ltd. Azole derivatives, their use, production and usage
EP0915653A1 (en) * 1996-06-27 1999-05-19 Smithkline Beecham Corporation Il-8 receptor antagonists
US6455566B1 (en) 1997-09-03 2002-09-24 Wyeth Substituted 1-aryl-3-heteroaryl-thioureas (or isothioureas) as antiatherosclerotic agents
TW415942B (en) * 1997-09-03 2000-12-21 American Home Prod Novel substituted 1-aryl-3-heteroaryl-thioureas and substituted 1-aryl-3-heteroaryl-isothioureas as antiatherosclerotic agents
JP2002529444A (ja) * 1998-11-12 2002-09-10 アリアド・ファーマシューティカルズ・インコーポレイテッド 二環式シグナル伝達阻害剤、それを含む組成物とその用途
US6974806B2 (en) * 2000-07-13 2005-12-13 Takeda Pharmaceutical Company Limited Lipid-rich plaque inhibitors
AU2002211901A1 (en) 2000-10-10 2002-04-22 Smithkline Beecham Corporation Substituted indoles, pharmaceutical compositions containing such indoles and their use as PPAR-gamma binding agents
WO2002047723A1 (en) * 2000-12-11 2002-06-20 Takeda Chemical Industries, Ltd. Medicinal compositions having improved water-solubility
US20040019096A1 (en) * 2001-10-23 2004-01-29 Vlassios Andronis Novel formulations of carvedilol
WO2003099773A1 (en) 2002-05-24 2003-12-04 Millennium Pharmaceuticals, Inc. Ccr9 inhibitors and methods of use thereof
AR041834A1 (es) * 2002-10-29 2005-06-01 Smithkline Beecham Corp Compuesto de difenilurea sustituido con sulfonamida, composicion farmaceutica que lo comprende y su uso para preparar dicha composicion
CN101077867B (zh) 2002-11-18 2012-10-10 坎莫森特里克斯公司 芳基磺酰胺
US7227035B2 (en) 2002-11-18 2007-06-05 Chemocentryx Bis-aryl sulfonamides
US7420055B2 (en) 2002-11-18 2008-09-02 Chemocentryx, Inc. Aryl sulfonamides
US7741519B2 (en) 2007-04-23 2010-06-22 Chemocentryx, Inc. Bis-aryl sulfonamides
SE0303480D0 (sv) * 2003-12-19 2003-12-19 Biovitrum Ab Benzofuranes
CN1997278B (zh) * 2004-04-20 2014-04-23 艾森生物(杭州)有限公司 有取代的有机硫化合物及其使用方法
CA2644809A1 (en) * 2006-03-02 2007-09-07 Astellas Pharma Inc. 17 .beta. hsd type 5 inhibitor
MX2008013600A (es) * 2006-04-21 2008-10-31 Smithkline Beechman Corp Antagonistas del receptor de interleuquina-8.
MX2008013599A (es) * 2006-04-21 2008-10-31 Smithkline Beechman Corp Antagonistas del receptor il-8.
CL2007001829A1 (es) * 2006-06-23 2008-01-25 Smithkline Beecham Corp P-toluensulfonato de n-[4-cloro-2-hidroxi-3-(piperazina-1-sulfonil)fenil]-n-(2-cloro-3-fluorofenil)urea;procedimiento de preparacion;composicion farmaceutica;combinacion farmaceutica;y uso en el tratamiento de una enfermedad mediada por la quiimioquina il-8, tales como asma y epoc.
US7785218B2 (en) * 2007-03-26 2010-08-31 Acushnet Company Custom milled iron set
WO2011062955A2 (en) 2009-11-18 2011-05-26 University Of Massachusetts Compounds for modulating tlr2
CN104529830B (zh) * 2015-01-15 2016-08-24 成都丽凯手性技术有限公司 一种制备脲类化合物的新方法
GB201521059D0 (en) * 2015-11-30 2016-01-13 Isis Innovation Inhibitors of metallo-beta-lactamases
EP4441037A1 (en) 2021-12-01 2024-10-09 Pfizer Inc. 3-phenyl-1-benzothiophene-2-carboxylic acid derivatives as branched-chain alpha keto acid dehydrogenase kinase inhibitors for the treatment of diabetes, kidney diseases, nash and heart failure

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1054655B (it) * 1975-08-27 1981-11-30 Lepetit Spa Derivati condensati del l isochinolina
FR2375228A1 (fr) * 1976-12-23 1978-07-21 Parcor Nouveaux benzothiophenes, leurs procedes de preparation et leur application notamment comme hypolipemiants et hypocholesterolemiants
JPH0753714B2 (ja) * 1988-07-12 1995-06-07 武田薬品工業株式会社 Ａｃａｔ阻害剤、キノリン誘導体及びその製造法
CN1028754C (zh) * 1988-07-12 1995-06-07 武田药品工业株式会社 喹啉衍生物的制备方法
AU632809B2 (en) * 1989-05-25 1993-01-14 Takeda Chemical Industries Ltd. Benzocycloalkane benzopyran and benzothiopyran urea derivatives and production thereof
FR2674522B1 (fr) * 1991-03-26 1993-07-16 Lipha Nouveaux derives de l'indole, procedes de preparation et medicaments les contenant.
IL101785A0 (en) * 1991-05-10 1992-12-30 Fujisawa Pharmaceutical Co Urea derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
AU4028393A (en) * 1992-05-28 1993-12-30 Pfizer Inc. New (N)-aryl and (N)-heteroarylurea derivatives as inhibitors of acyl coenzyme a:cholesterol acyl transferase (ACAT)
TW234123B (cg-RX-API-DMAC7.html) * 1992-12-16 1994-11-11 Takeda Pharm Industry Co Ltd

Also Published As

Publication number Publication date
NZ250916A (en) 1995-08-28
EP0613894A1 (en) 1994-09-07
CA2116286A1 (en) 1994-08-28
ES2133430T3 (es) 1999-09-16
ATE179706T1 (de) 1999-05-15
JPH06340647A (ja) 1994-12-13
AU5636494A (en) 1994-09-01
DE69418243T2 (de) 1999-09-30
TW279858B (cg-RX-API-DMAC7.html) 1996-07-01
JP3143766B2 (ja) 2001-03-07
US5464863A (en) 1995-11-07
EP0613894B1 (en) 1999-05-06
CN1100417A (zh) 1995-03-22
DE69418243D1 (de) 1999-06-10
USRE36832E (en) 2000-08-22
AU679021B2 (en) 1997-06-19
KR940019701A (ko) 1994-09-14
CN1051311C (zh) 2000-04-12
DK0613894T3 (da) 1999-11-01

Similar Documents

Publication Publication Date Title
GR3030165T3 (en) N-heteroaryl-n'-phenylurea derivatives, their production and use.
HU9600834D0 (en) Quinazoline derivatives
HUT59109A (en) Process for producing hydroxymethyl-(methylenecyclopentyl)-purines and -pyrimidines, their pharmaceutically acceptable salts and pharmaceutical compositions comprising same
AU643489B2 (en) Antibacterial agents - II
AU1025795A (en) Prolineamide derivatives
AU4523797A (en) Atherosclerosis treatment
DE69637876D1 (de) Ng und zwischenprodukt dafür
DE69200290D1 (de) Thienopyridin -Derivative und diese enthaltende Arzneimittel.
AU4616993A (en) Substituted cyclohexane derivatives, processes for their preparation and the use of the compounds for treating diseases
AU5835190A (en) Antitumor substance be-13793c
AU6063398A (en) Pyrrolidine derivative, anti-ulcer drug, and antibacterial drug
AU670491B2 (en) Pharmaceutical for the treatment of skin disorders
HUT71512A (en) N-(3-chlorophenyl)-piperazine derivatives for producing alkyl-trazodon derivatives and process for producing them
SE9702716D0 (sv) Substituted phenylazacycloalkanes in the treatment of cognitive disorders
AU631209B2 (en) Carboxamide derivatives
AU3210593A (en) Improvements in or relating to organic compounds
EP0189916A3 (en) 3-(pyrrolidinio)methyl-3-cephem derivatives, pharmaceutical composition and process for the production thereof
HUT75124A (en) Use of bicyclolactam derivatives for producing pharmaceutical compositions having anxiolytic activity
HUT52478A (en) Process for producing glycerin derivatives and pharmaceutical compositions comprising same
EP0784973A3 (en) Quinoxaline derivatives for treating tinnitus
AU7589298A (en) 5-{(heteroaryl)alkyl}-3-oxo-pyrido{1,2-(a)}benzimidazole-4-c arboxamide derivatives useful in treating central nervous system disorders
AU686104B2 (en) Substituted amidinonaphthyl ester derivatives
EP0250755A3 (en) Fluorine derivatives of vitamin d3 and process for producing the same
AU1099688A (en) Substituted 3-phenyl-7h-thiazolo(2,2-b)(1,2,4)triazin-7-ones, a process for the preparation thereof, medicaments containing same and the use thereof, and also some intermediates formed in the preparation of the compounds mentioned
IL98914A0 (en) Process for the preparation of 6-(substituted aminopropionyl)derivatives of forskolin