DE69404835T2 - Triesters von phosphorothioaten oligonukleotiden und verfahren zur herstellung - Google Patents

Triesters von phosphorothioaten oligonukleotiden und verfahren zur herstellung

Info

Publication number
DE69404835T2
DE69404835T2 DE69404835T DE69404835T DE69404835T2 DE 69404835 T2 DE69404835 T2 DE 69404835T2 DE 69404835 T DE69404835 T DE 69404835T DE 69404835 T DE69404835 T DE 69404835T DE 69404835 T2 DE69404835 T2 DE 69404835T2
Authority
DE
Germany
Prior art keywords
pct
phosphorothioat
triesters
oligonucleotides
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69404835T
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English (en)
Other versions
DE69404835D1 (de
Inventor
Jean-Louis Imbach
Bernard Rayner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Original Assignee
Centre National de la Recherche Scientifique CNRS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS filed Critical Centre National de la Recherche Scientifique CNRS
Publication of DE69404835D1 publication Critical patent/DE69404835D1/de
Application granted granted Critical
Publication of DE69404835T2 publication Critical patent/DE69404835T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DE69404835T 1993-05-12 1994-05-11 Triesters von phosphorothioaten oligonukleotiden und verfahren zur herstellung Expired - Fee Related DE69404835T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9305706A FR2705099B1 (fr) 1993-05-12 1993-05-12 Oligonucléotides phosphorothioates triesters et procédé de préparation.
PCT/FR1994/000563 WO1994026764A1 (fr) 1993-05-12 1994-05-11 Oligonucleotides phosphorothioates triesters et procede de preparation

Publications (2)

Publication Number Publication Date
DE69404835D1 DE69404835D1 (de) 1997-09-11
DE69404835T2 true DE69404835T2 (de) 1998-03-12

Family

ID=9447046

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69404835T Expired - Fee Related DE69404835T2 (de) 1993-05-12 1994-05-11 Triesters von phosphorothioaten oligonukleotiden und verfahren zur herstellung

Country Status (7)

Country Link
US (1) US5770713A (de)
EP (1) EP0698034B1 (de)
AT (1) ATE156488T1 (de)
CA (1) CA2162684A1 (de)
DE (1) DE69404835T2 (de)
FR (1) FR2705099B1 (de)
WO (1) WO1994026764A1 (de)

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CA2162684A1 (en) 1994-11-24
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US5770713A (en) 1998-06-23
FR2705099A1 (fr) 1994-11-18
EP0698034B1 (de) 1997-08-06
FR2705099B1 (fr) 1995-08-04
EP0698034A1 (de) 1996-02-28

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