DE69402694D1 - Taxolderivate, deren Herstellung und diese enthaltende pharmazeutische Zusammenstellungen. - Google Patents
Taxolderivate, deren Herstellung und diese enthaltende pharmazeutische Zusammenstellungen.Info
- Publication number
- DE69402694D1 DE69402694D1 DE69402694T DE69402694T DE69402694D1 DE 69402694 D1 DE69402694 D1 DE 69402694D1 DE 69402694 T DE69402694 T DE 69402694T DE 69402694 T DE69402694 T DE 69402694T DE 69402694 D1 DE69402694 D1 DE 69402694D1
- Authority
- DE
- Germany
- Prior art keywords
- radical
- preparation
- pharmaceutical compositions
- general formula
- compositions containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 150000004579 taxol derivatives Chemical class 0.000 title 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001602 bicycloalkyls Chemical group 0.000 abstract 2
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- -1 heterocyclyl radical Chemical class 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 150000003254 radicals Chemical class 0.000 abstract 2
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 150000005840 aryl radicals Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- LEVJVKGPFAQPOI-UHFFFAOYSA-N phenylmethanone Chemical group O=[C]C1=CC=CC=C1 LEVJVKGPFAQPOI-UHFFFAOYSA-N 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9302370A FR2702212B1 (fr) | 1993-03-02 | 1993-03-02 | Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent. |
| PCT/FR1994/000222 WO1994020484A1 (fr) | 1993-03-02 | 1994-02-28 | Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69402694D1 true DE69402694D1 (de) | 1997-05-22 |
| DE69402694T2 DE69402694T2 (de) | 1997-10-16 |
Family
ID=9444565
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69402694T Expired - Lifetime DE69402694T2 (de) | 1993-03-02 | 1994-02-28 | Taxolderivate, deren Herstellung und diese enthaltende pharmazeutische Zusammenstellungen. |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US5556877A (de) |
| EP (1) | EP0687259B1 (de) |
| JP (1) | JP3782443B2 (de) |
| KR (1) | KR960701034A (de) |
| AT (1) | ATE151763T1 (de) |
| AU (1) | AU683449B2 (de) |
| CZ (1) | CZ223795A3 (de) |
| DE (1) | DE69402694T2 (de) |
| DK (1) | DK0687259T3 (de) |
| ES (1) | ES2101513T3 (de) |
| FI (1) | FI954111A (de) |
| FR (1) | FR2702212B1 (de) |
| GR (1) | GR3023162T3 (de) |
| NO (1) | NO953452L (de) |
| NZ (1) | NZ262137A (de) |
| PL (1) | PL310441A1 (de) |
| SK (1) | SK107295A3 (de) |
| WO (1) | WO1994020484A1 (de) |
| ZA (1) | ZA941387B (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6794523B2 (en) | 1991-09-23 | 2004-09-21 | Florida State University | Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them |
| FR2698361B1 (fr) * | 1992-11-20 | 1995-01-13 | Rhone Poulenc Rorer Sa | Procédé de préparation d'un acide oxazolidine-1,3 carboxylique-5. |
| FR2706457B1 (fr) * | 1993-06-16 | 1995-07-28 | Rhone Poulenc Rorer Sa | Procédé de préparation d'un acide oxazolidinecarboxylique utile pour préparer des taxoïdes thérapeutiquement actifs. |
| US5760251A (en) * | 1995-08-11 | 1998-06-02 | Sepracor, Inc. | Taxol process and compounds |
| DK0914102T3 (da) | 1996-05-24 | 2006-01-09 | Angiotech Pharm Inc | Præparater og fremgangsmåder til behandling eller forebyggelse af syddomme i legemskanaler |
| FR2750989B1 (fr) * | 1996-07-09 | 1998-09-25 | Rhone Poulenc Rorer Sa | Procede de monoacylation d'hydroxy taxanes |
| US6495579B1 (en) | 1996-12-02 | 2002-12-17 | Angiotech Pharmaceuticals, Inc. | Method for treating multiple sclerosis |
| US6515016B2 (en) | 1996-12-02 | 2003-02-04 | Angiotech Pharmaceuticals, Inc. | Composition and methods of paclitaxel for treating psoriasis |
| US20030157187A1 (en) * | 1996-12-02 | 2003-08-21 | Angiotech Pharmaceuticals, Inc. | Compositions and methods for treating or preventing inflammatory diseases |
| US7288665B1 (en) * | 1997-08-18 | 2007-10-30 | Florida State University | Process for selective derivatization of taxanes |
| DK1178979T3 (da) | 1999-05-17 | 2004-03-22 | Bristol Myers Squibb Co | Hidtil ukendte reaktionsbetingelser til spaltning af silylethere ved fremstillingen af paclitaxel (Taxol(R)) og paclitaxelanaloge |
| CA2368151A1 (en) | 2000-02-02 | 2001-08-09 | Florida State University Research Foundation, Inc. | C10 carbonate substituted taxanes as antitumor agents |
| BR0104350A (pt) | 2000-02-02 | 2002-01-02 | Univ Florida State Res Found | Taxanos de c10 acetato heterossubstituìdo como agentes antitumor |
| US6649632B2 (en) | 2000-02-02 | 2003-11-18 | Fsu Research Foundation, Inc. | C10 ester substituted taxanes |
| EP1562927B1 (de) * | 2002-10-09 | 2009-05-13 | Chatham Biotec Ltd. | Thio-analoga von paclitaxel und deren vorprodukte |
| US7202370B2 (en) * | 2003-10-27 | 2007-04-10 | Conor Medsystems, Inc. | Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III |
| HN2005000054A (es) | 2004-02-13 | 2009-02-18 | Florida State University Foundation Inc | Taxanos sustituidos con esteres de ciclopentilo en c10 |
| JP2011517455A (ja) | 2008-03-31 | 2011-06-09 | フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド | Ｃ（１０）エチルエステルおよびｃ（１０）シクロプロピルエステル置換タキサン |
| CN102408397B (zh) * | 2011-10-19 | 2014-08-20 | 上海贝美医药科技有限公司 | 紫杉烷类衍生物及其制备方法 |
| WO2017004478A1 (en) | 2015-07-01 | 2017-01-05 | The Research Foundation For The State University Of New York | Third generation taxoids and methods of using same |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2601675B1 (fr) * | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent |
| US5430160A (en) * | 1991-09-23 | 1995-07-04 | Florida State University | Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides |
| US5254703A (en) * | 1992-04-06 | 1993-10-19 | Florida State University | Semi-synthesis of taxane derivatives using metal alkoxides and oxazinones |
| WO1993021173A1 (en) * | 1992-04-17 | 1993-10-28 | Abbott Laboratories | Taxol derivatives |
| IL108444A0 (en) * | 1993-01-29 | 1994-04-12 | Univ Florida State | C2 taxane derivatives and pharmaceutical compositions containing them |
-
1993
- 1993-03-02 FR FR9302370A patent/FR2702212B1/fr not_active Expired - Fee Related
-
1994
- 1994-02-28 AT AT94908385T patent/ATE151763T1/de active
- 1994-02-28 KR KR1019950703730A patent/KR960701034A/ko not_active Application Discontinuation
- 1994-02-28 JP JP51965294A patent/JP3782443B2/ja not_active Expired - Lifetime
- 1994-02-28 NZ NZ262137A patent/NZ262137A/en unknown
- 1994-02-28 EP EP94908385A patent/EP0687259B1/de not_active Expired - Lifetime
- 1994-02-28 DE DE69402694T patent/DE69402694T2/de not_active Expired - Lifetime
- 1994-02-28 CZ CZ952237A patent/CZ223795A3/cs unknown
- 1994-02-28 PL PL94310441A patent/PL310441A1/xx unknown
- 1994-02-28 WO PCT/FR1994/000222 patent/WO1994020484A1/fr not_active Application Discontinuation
- 1994-02-28 DK DK94908385.1T patent/DK0687259T3/da active
- 1994-02-28 ZA ZA941387A patent/ZA941387B/xx unknown
- 1994-02-28 AU AU61446/94A patent/AU683449B2/en not_active Expired - Fee Related
- 1994-02-28 SK SK1072-95A patent/SK107295A3/sk unknown
- 1994-02-28 ES ES94908385T patent/ES2101513T3/es not_active Expired - Lifetime
- 1994-03-02 US US08/204,128 patent/US5556877A/en not_active Expired - Lifetime
-
1995
- 1995-09-01 FI FI954111A patent/FI954111A/fi not_active Application Discontinuation
- 1995-09-01 NO NO953452A patent/NO953452L/no unknown
-
1996
- 1996-02-27 US US08/607,854 patent/US5654449A/en not_active Expired - Lifetime
-
1997
- 1997-04-17 GR GR960402947T patent/GR3023162T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK0687259T3 (da) | 1997-05-26 |
| DE69402694T2 (de) | 1997-10-16 |
| FR2702212A1 (fr) | 1994-09-09 |
| NO953452D0 (no) | 1995-09-01 |
| PL310441A1 (en) | 1995-12-11 |
| NO953452L (no) | 1995-09-01 |
| SK107295A3 (en) | 1996-06-05 |
| GR3023162T3 (en) | 1997-07-30 |
| AU683449B2 (en) | 1997-11-13 |
| US5654449A (en) | 1997-08-05 |
| JPH08509959A (ja) | 1996-10-22 |
| EP0687259B1 (de) | 1997-04-16 |
| FI954111A0 (fi) | 1995-09-01 |
| NZ262137A (en) | 1997-11-24 |
| CZ223795A3 (en) | 1995-12-13 |
| JP3782443B2 (ja) | 2006-06-07 |
| EP0687259A1 (de) | 1995-12-20 |
| FI954111A (fi) | 1995-09-01 |
| KR960701034A (ko) | 1996-02-24 |
| US5556877A (en) | 1996-09-17 |
| ATE151763T1 (de) | 1997-05-15 |
| ZA941387B (en) | 1994-09-29 |
| AU6144694A (en) | 1994-09-26 |
| ES2101513T3 (es) | 1997-07-01 |
| FR2702212B1 (fr) | 1995-04-07 |
| WO1994020484A1 (fr) | 1994-09-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE243688T1 (de) | Taxol derivate, deren herstellung und diese enthaltende pharmazeutische zusammensetzungen | |
| DE69402694D1 (de) | Taxolderivate, deren Herstellung und diese enthaltende pharmazeutische Zusammenstellungen. | |
| AU2212292A (en) | Novel furyl and thienyl substituted taxanes and pharmaceutical compositions containing them | |
| EA199800588A1 (ru) | Новые таксоиды, их получение и содержащие их фармацевтические композиции | |
| ES2096329T3 (es) | Procedimiento para la preparacion de derivados del taxano. | |
| DE69103206D1 (de) | Neue Derivate des Aminopiperidins, Aminopyrrolidins und des Aminoperhydroazepins, Verfahren zur Herstellung und diese enthaltende Arzneimittel. | |
| CA2214322A1 (fr) | Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent | |
| DK0630428T3 (da) | Fremgangsmåde til fremstilling af taxanderivater | |
| DE69508781D1 (de) | Texol-derivate, deren herstellung und diese enthaltende pharmazeutische zusammenstellungen |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: AVENTIS PHARMA S.A., ANTONY, FR |
|
| 8328 | Change in the person/name/address of the agent |
Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN |
|
| 8328 | Change in the person/name/address of the agent |
Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, 80335 MUENC |