NO953452L - Nye taxoider, deres fremstilling og farmasöytiske preparater inneholdende forbindelsene - Google Patents

Nye taxoider, deres fremstilling og farmasöytiske preparater inneholdende forbindelsene

Info

Publication number
NO953452L
NO953452L NO953452A NO953452A NO953452L NO 953452 L NO953452 L NO 953452L NO 953452 A NO953452 A NO 953452A NO 953452 A NO953452 A NO 953452A NO 953452 L NO953452 L NO 953452L
Authority
NO
Norway
Prior art keywords
compounds
preparation
cycloalkyl
pharmaceutical compositions
compositions containing
Prior art date
Application number
NO953452A
Other languages
English (en)
Other versions
NO953452D0 (no
Inventor
Herve Bouchard
Jean-Dominique Bourzat
Alain Commercon
Jean-Pierre Pulicani
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of NO953452L publication Critical patent/NO953452L/no
Publication of NO953452D0 publication Critical patent/NO953452D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

Nye taxoider med den generelle formel (I): OH OH OCOR-, (i) der Ar betyr en arylrest, R betyr et hydrogenatom eller en acetyl- eller alkoksy- acetylrest, Rj betyr en benzoylrest eller en rest Rg-O-CO-, der R2 betyr en alkyl-, alkenyl-, cykloalkyl-, cykloalkenyl-, bl- cykloalkyl-, fenyl- eller heterocyklylrest og R3 betyr en alkyl-, alkenyl-. cykloalkyl-, cykloalkenyl-, blcykloalkyl-, eventuelt substituert (bortsett fra Ikke-substltuert fenyl) aryl- eller heterocyklylrest. Forbindelsene med den generelle formel (I) oppviser Interessante ant l Umoral e egenskaper. Forblndelsenes fremstilling beskrives.
NO953452A 1993-03-02 1995-09-01 Nye taxoider, deres fremstilling og farmasöytiske preparater inneholdende forbindelsene NO953452D0 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9302370A FR2702212B1 (fr) 1993-03-02 1993-03-02 Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
PCT/FR1994/000222 WO1994020484A1 (fr) 1993-03-02 1994-02-28 Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
NO953452L true NO953452L (no) 1995-09-01
NO953452D0 NO953452D0 (no) 1995-09-01

Family

ID=9444565

Family Applications (1)

Application Number Title Priority Date Filing Date
NO953452A NO953452D0 (no) 1993-03-02 1995-09-01 Nye taxoider, deres fremstilling og farmasöytiske preparater inneholdende forbindelsene

Country Status (19)

Country Link
US (2) US5556877A (no)
EP (1) EP0687259B1 (no)
JP (1) JP3782443B2 (no)
KR (1) KR960701034A (no)
AT (1) ATE151763T1 (no)
AU (1) AU683449B2 (no)
CZ (1) CZ223795A3 (no)
DE (1) DE69402694T2 (no)
DK (1) DK0687259T3 (no)
ES (1) ES2101513T3 (no)
FI (1) FI954111A0 (no)
FR (1) FR2702212B1 (no)
GR (1) GR3023162T3 (no)
NO (1) NO953452D0 (no)
NZ (1) NZ262137A (no)
PL (1) PL310441A1 (no)
SK (1) SK107295A3 (no)
WO (1) WO1994020484A1 (no)
ZA (1) ZA941387B (no)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6794523B2 (en) 1991-09-23 2004-09-21 Florida State University Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them
FR2698361B1 (fr) * 1992-11-20 1995-01-13 Rhone Poulenc Rorer Sa Procédé de préparation d'un acide oxazolidine-1,3 carboxylique-5.
FR2706457B1 (fr) * 1993-06-16 1995-07-28 Rhone Poulenc Rorer Sa Procédé de préparation d'un acide oxazolidinecarboxylique utile pour préparer des taxoïdes thérapeutiquement actifs.
US5760251A (en) * 1995-08-11 1998-06-02 Sepracor, Inc. Taxol process and compounds
DE69734060T2 (de) 1996-05-24 2006-06-29 Angiotech Pharmaceuticals, Inc., Vancouver Zubereitungen und verfahren zur behandlung oder prävention von krankheiten der körperpassagewege
FR2750989B1 (fr) * 1996-07-09 1998-09-25 Rhone Poulenc Rorer Sa Procede de monoacylation d'hydroxy taxanes
US6515016B2 (en) 1996-12-02 2003-02-04 Angiotech Pharmaceuticals, Inc. Composition and methods of paclitaxel for treating psoriasis
US20030157187A1 (en) * 1996-12-02 2003-08-21 Angiotech Pharmaceuticals, Inc. Compositions and methods for treating or preventing inflammatory diseases
US6495579B1 (en) 1996-12-02 2002-12-17 Angiotech Pharmaceuticals, Inc. Method for treating multiple sclerosis
US7288665B1 (en) * 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
CA2373819A1 (en) 1999-05-17 2000-11-23 Bristol-Myers Squibb Company Novel reaction conditions for the cleavage of silyl ethers in the preparation of paclitaxel (taxol) and paclitaxel analogues
US6649632B2 (en) 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
CA2368151A1 (en) 2000-02-02 2001-08-09 Florida State University Research Foundation, Inc. C10 carbonate substituted taxanes as antitumor agents
CA2368502A1 (en) 2000-02-02 2001-08-09 Florida State University Research Foundation, Inc. C10 heterosubstituted acetate taxanes as antitumor agents
AU2003273671A1 (en) * 2002-10-09 2004-05-04 Phytogen Life Sciences, Inc. Novel taxanes and methods related to use and preparation thereof
US7202370B2 (en) * 2003-10-27 2007-04-10 Conor Medsystems, Inc. Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III
SV2006002010A (es) 2004-02-13 2006-08-23 Univ Florida State Res Found Taxanos sustituidos con esteres de ciclopentilo en c10
CA2718567A1 (en) 2008-03-31 2009-12-03 Florida State University Research Foundation, Inc. C(10) ethyl ester and c(10) cyclopropyl ester substituted taxanes
CN102408397B (zh) * 2011-10-19 2014-08-20 上海贝美医药科技有限公司 紫杉烷类衍生物及其制备方法
EP3316880B1 (en) 2015-07-01 2021-09-01 The Research Foundation for The State University of New York Third generation taxoids and use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US5430160A (en) * 1991-09-23 1995-07-04 Florida State University Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides
US5254703A (en) * 1992-04-06 1993-10-19 Florida State University Semi-synthesis of taxane derivatives using metal alkoxides and oxazinones
CA2130578A1 (en) * 1992-04-17 1993-10-28 Geewananda P. Gunawardana Taxol derivatives
IL108444A0 (en) * 1993-01-29 1994-04-12 Univ Florida State C2 taxane derivatives and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
ZA941387B (en) 1994-09-29
FR2702212B1 (fr) 1995-04-07
WO1994020484A1 (fr) 1994-09-15
NZ262137A (en) 1997-11-24
FI954111A (fi) 1995-09-01
DE69402694D1 (de) 1997-05-22
ATE151763T1 (de) 1997-05-15
GR3023162T3 (en) 1997-07-30
FR2702212A1 (fr) 1994-09-09
EP0687259B1 (fr) 1997-04-16
FI954111A0 (fi) 1995-09-01
DE69402694T2 (de) 1997-10-16
SK107295A3 (en) 1996-06-05
JP3782443B2 (ja) 2006-06-07
AU683449B2 (en) 1997-11-13
US5654449A (en) 1997-08-05
CZ223795A3 (en) 1995-12-13
EP0687259A1 (fr) 1995-12-20
PL310441A1 (en) 1995-12-11
AU6144694A (en) 1994-09-26
KR960701034A (ko) 1996-02-24
US5556877A (en) 1996-09-17
JPH08509959A (ja) 1996-10-22
ES2101513T3 (es) 1997-07-01
DK0687259T3 (da) 1997-05-26
NO953452D0 (no) 1995-09-01

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