DE69334134D1 - Wässrige Formulierung enthaltend Menschliches Wachstumshormon - Google Patents
Wässrige Formulierung enthaltend Menschliches WachstumshormonInfo
- Publication number
- DE69334134D1 DE69334134D1 DE69334134T DE69334134T DE69334134D1 DE 69334134 D1 DE69334134 D1 DE 69334134D1 DE 69334134 T DE69334134 T DE 69334134T DE 69334134 T DE69334134 T DE 69334134T DE 69334134 D1 DE69334134 D1 DE 69334134D1
- Authority
- DE
- Germany
- Prior art keywords
- growth hormone
- formulation containing
- human growth
- aqueous formulation
- containing human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH] (Somatotropin)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US92340192A | 1992-07-31 | 1992-07-31 | |
US923401 | 1992-07-31 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69334134D1 true DE69334134D1 (de) | 2007-05-31 |
DE69334134T2 DE69334134T2 (de) | 2007-12-20 |
Family
ID=25448638
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69334134T Expired - Lifetime DE69334134T2 (de) | 1992-07-31 | 1993-07-29 | Wässrige Formulierung enthaltend Menschliches Wachstumshormon |
DE69329651T Expired - Lifetime DE69329651T3 (de) | 1992-07-31 | 1993-07-29 | Wässrige arzneizusammensetzung, welche das menschliche wachstumshormon enthält |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69329651T Expired - Lifetime DE69329651T3 (de) | 1992-07-31 | 1993-07-29 | Wässrige arzneizusammensetzung, welche das menschliche wachstumshormon enthält |
Country Status (15)
Country | Link |
---|---|
EP (2) | EP0652766B2 (de) |
JP (2) | JP4018133B2 (de) |
AT (2) | ATE197405T1 (de) |
AU (1) | AU686567C (de) |
CA (3) | CA2337745C (de) |
DE (2) | DE69334134T2 (de) |
DK (2) | DK0652766T4 (de) |
ES (2) | ES2286868T3 (de) |
GR (1) | GR3035144T3 (de) |
IL (1) | IL106524A (de) |
MD (1) | MD1699F2 (de) |
MX (1) | MX9304613A (de) |
NZ (1) | NZ255158A (de) |
PT (1) | PT652766E (de) |
WO (1) | WO1994003198A1 (de) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5763394A (en) * | 1988-04-15 | 1998-06-09 | Genentech, Inc. | Human growth hormone aqueous formulation |
US5981485A (en) | 1997-07-14 | 1999-11-09 | Genentech, Inc. | Human growth hormone aqueous formulation |
US5849704A (en) * | 1991-12-20 | 1998-12-15 | Novo Nordisk A/S | Pharmaceutical formulation |
US5849700A (en) * | 1991-12-20 | 1998-12-15 | Novo Nordisk A/S | Pharmaceutical formulation |
DK204791D0 (da) * | 1991-12-20 | 1991-12-20 | Novo Nordisk As | Hidtil ukendt farmaceutisk praeparat |
US6022858A (en) * | 1991-12-20 | 2000-02-08 | Novo Nordisk A/S | Pharmaceutical formulation of human-growth hormone pretreated with zinc salt |
SE9201073D0 (sv) * | 1992-04-03 | 1992-04-03 | Kabi Pharmacia Ab | Protein formulation |
US5877016A (en) | 1994-03-18 | 1999-03-02 | Genentech, Inc. | Human trk receptors and neurotrophic factor inhibitors |
DE69420872T2 (de) * | 1994-06-17 | 2000-01-13 | Applied Research Systems | Hgh enthaltende pharmazeutische zubereitungen |
US5631225A (en) * | 1994-10-13 | 1997-05-20 | Novo Nordisk A/S | Pharmaceutical formulation |
US5547696A (en) * | 1994-10-13 | 1996-08-20 | Novo Nordisk A/S | Pharmaceutical formulation |
US5654278A (en) * | 1994-10-13 | 1997-08-05 | Novo Nordisk A/S | Composition and method comprising growth hormone and leucine |
US5705482A (en) * | 1995-01-13 | 1998-01-06 | Novo Nordisk A/S | Pharmaceutical formulation |
US5552385A (en) * | 1995-06-05 | 1996-09-03 | Novo Nordisk A/S | Pharmaceutical formulation |
US6790439B1 (en) * | 1995-06-07 | 2004-09-14 | Zymogenetics, Inc. | Thrombopoietin compositions |
US6267958B1 (en) | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
SE9502927D0 (sv) * | 1995-08-24 | 1995-08-24 | Pharmacia Ab | Solution containing IGF-I |
GB9526733D0 (en) | 1995-12-30 | 1996-02-28 | Delta Biotechnology Ltd | Fusion proteins |
AUPN801296A0 (en) | 1996-02-12 | 1996-03-07 | Csl Limited | Stabilised growth hormone formulation and method of preparation thereof |
US20070179096A1 (en) | 1996-04-24 | 2007-08-02 | Novo Nordisk A/S | Pharmaceutical Formulation |
US20020077461A1 (en) * | 1996-04-24 | 2002-06-20 | Soren Bjorn | Pharmaceutical formulation |
SE9704405D0 (sv) * | 1997-11-28 | 1997-11-28 | Pharmacia & Upjohn Ab | New syringe |
JP3723857B2 (ja) * | 1998-02-04 | 2005-12-07 | 日本ケミカルリサーチ株式会社 | ヒト成長ホルモン含有水性医薬組成物 |
PL346127A1 (en) * | 1998-07-23 | 2002-01-28 | Lilly Co Eli | Fsh and fsh variant formulations, products and methods |
US20030166525A1 (en) | 1998-07-23 | 2003-09-04 | Hoffmann James Arthur | FSH Formulation |
TR200200034T2 (tr) * | 1999-07-12 | 2002-05-21 | Grandis Biotech Gmbh | Büyüme hormonu formülasyonları. |
CA2747325A1 (en) | 2000-04-12 | 2001-10-25 | Human Genome Sciences, Inc. | Albumin fusion proteins |
WO2001087322A2 (en) * | 2000-05-17 | 2001-11-22 | Bionebraska, Inc. | Peptide pharmaceutical formulations |
GB2371227A (en) * | 2001-01-10 | 2002-07-24 | Grandis Biotech Gmbh | Crystallisation - resistant aqueous growth hormone formulations |
ES2425738T3 (es) | 2001-12-21 | 2013-10-17 | Human Genome Sciences, Inc. | Proteínas de fusión de la albúmina |
US20080194481A1 (en) | 2001-12-21 | 2008-08-14 | Human Genome Sciences, Inc. | Albumin Fusion Proteins |
WO2004004780A1 (en) * | 2002-07-09 | 2004-01-15 | Sandoz Ag | Liquid formulations with high concentration of human growth hormone (hgh) comprising phenol |
CA2512052C (en) | 2002-12-31 | 2016-06-21 | Altus Pharmaceuticals Inc. | Human growth hormone crystals and methods for preparing them |
MXPA05010635A (es) | 2003-04-02 | 2005-12-12 | Ares Trading Sa | Formulaciones farmaceuticas liquidas de hormona estimulante de foliculos y hormona luteinizante junto con un surfactante no ionico. |
EP1638595B1 (de) | 2003-06-20 | 2013-03-20 | Ares Trading S.A. | Gefriergetrocknete fsh / lh formulierungen |
EP1706150B1 (de) * | 2003-12-23 | 2012-04-25 | Pharmacia Corporation | Stabiles Wachstumshormon-Flüssigformulierung |
MXPA06009072A (es) | 2004-02-09 | 2007-03-29 | Human Genome Sciences Inc | Proteinas de fusion de albumina. |
WO2005105148A2 (en) * | 2004-04-07 | 2005-11-10 | Ares Trading S.A.- | Liquid growth hormone formulation |
AU2007258609B2 (en) | 2006-06-07 | 2013-01-24 | Human Genome Sciences, Inc. | Albumin fusion proteins |
BRPI0621841B8 (pt) | 2006-07-06 | 2021-05-25 | Daewoong Co Ltd | formulação líquida |
DK2486916T3 (en) * | 2006-12-18 | 2015-06-15 | Ajinomoto Althea Inc | Formulations of Human Growth Hormone |
US8283333B2 (en) | 2009-07-01 | 2012-10-09 | Protiva Biotherapeutics, Inc. | Lipid formulations for nucleic acid delivery |
KR101614983B1 (ko) * | 2009-11-17 | 2016-04-22 | 입센 파마 에스.에이.에스 | Hgh 및 rhigf―1의 조합물을 위한 제제 |
TWI508737B (zh) | 2010-01-22 | 2015-11-21 | 諾佛 儂迪克股份有限公司 | 具有延長的活體內功效的生長激素 |
RU2012134974A (ru) | 2010-01-22 | 2014-02-27 | Ново Нордиск Хелс Кеа Аг | Стабилизированное соединение гормона роста |
WO2012000104A1 (en) | 2010-06-30 | 2012-01-05 | Protiva Biotherapeutics, Inc. | Non-liposomal systems for nucleic acid delivery |
KR101337797B1 (ko) * | 2010-07-14 | 2013-12-06 | 한미사이언스 주식회사 | 지속형 인간 성장 호르몬 결합체 액상 제제 |
WO2013014196A1 (en) * | 2011-07-25 | 2013-01-31 | Sandoz Ag | Aqueous formulation comprising at least a neutral salt and a biopharmaceutical protein |
US10064951B2 (en) * | 2012-03-30 | 2018-09-04 | Hanmi Science Co., Ltd. | Liquid formulation of highly concentrated long-acting human growth hormone conjugate |
JP5487276B2 (ja) * | 2012-11-12 | 2014-05-07 | デウン カンパニー,リミテッド | ヒト成長ホルモンを含有する安定した液状製剤 |
ES2841123T3 (es) * | 2013-04-05 | 2021-07-07 | Formulacion Del Compuesto De La Hormona De Crecimiento | Formulación del compuesto de la hormona de crecimiento |
CN113425835B (zh) * | 2020-03-23 | 2024-03-19 | 常州健益生物制药有限公司 | 一种生长激素原料药溶液、水针剂及其制备方法 |
CN112494638B (zh) * | 2020-12-22 | 2023-12-19 | 深圳科兴药业有限公司 | 一种人生长激素注射剂组合物及其制备方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4783441A (en) * | 1979-04-30 | 1988-11-08 | Hoechst Aktiengesellschaft | Aqueous protein solutions stable to denaturation |
DE3325223A1 (de) * | 1983-07-13 | 1985-01-24 | Hoechst Ag, 6230 Frankfurt | Gegen denaturierung bestaendige, waessrige proteinloesungen, verfahren zu ihrer herstellung und ihre verwendung |
EP0211601A3 (de) | 1985-07-30 | 1988-01-13 | International Minerals And Chemical Corporation | Stabilisierung von Wachstumshormonen |
ES2044941T5 (es) * | 1987-08-21 | 1999-02-16 | Mallinckrodt Group Inc | Estabilizador de hormonas promotoras del crecimiento. |
US5096885A (en) * | 1988-04-15 | 1992-03-17 | Genentech, Inc. | Human growth hormone formulation |
US4904043A (en) * | 1988-06-15 | 1990-02-27 | American Telephone And Telegraph Company, At&T Bell Laboratories | Optical data link dual wavelength coupler |
US5182258A (en) * | 1989-03-20 | 1993-01-26 | Orbon Corporation | Systemic delivery of polypeptides through the eye |
GB9007052D0 (en) * | 1990-03-29 | 1990-05-30 | Skua Investments Ltd | Pharmaceutical formulations |
US5126324A (en) * | 1990-06-07 | 1992-06-30 | Genentech, Inc. | Method of enhancing growth in patients using combination therapy |
US5210017A (en) * | 1990-11-19 | 1993-05-11 | Genentech, Inc. | Ligand-mediated immunofunctional hormone binding protein assay method |
-
1993
- 1993-07-29 IL IL10652493A patent/IL106524A/xx not_active IP Right Cessation
- 1993-07-29 MD MD96-0246A patent/MD1699F2/ro unknown
- 1993-07-29 JP JP50543994A patent/JP4018133B2/ja not_active Expired - Lifetime
- 1993-07-29 DE DE69334134T patent/DE69334134T2/de not_active Expired - Lifetime
- 1993-07-29 ES ES99107148T patent/ES2286868T3/es not_active Expired - Lifetime
- 1993-07-29 CA CA002337745A patent/CA2337745C/en not_active Expired - Lifetime
- 1993-07-29 EP EP93918499A patent/EP0652766B2/de not_active Expired - Lifetime
- 1993-07-29 CA CA002139358A patent/CA2139358C/en not_active Expired - Lifetime
- 1993-07-29 ES ES93918499T patent/ES2153385T5/es not_active Expired - Lifetime
- 1993-07-29 NZ NZ255158A patent/NZ255158A/en not_active IP Right Cessation
- 1993-07-29 AU AU47927/93A patent/AU686567C/en not_active Expired
- 1993-07-29 DE DE69329651T patent/DE69329651T3/de not_active Expired - Lifetime
- 1993-07-29 AT AT93918499T patent/ATE197405T1/de active
- 1993-07-29 PT PT93918499T patent/PT652766E/pt unknown
- 1993-07-29 DK DK93918499T patent/DK0652766T4/da active
- 1993-07-29 AT AT99107148T patent/ATE359824T1/de active
- 1993-07-29 WO PCT/US1993/007149 patent/WO1994003198A1/en active IP Right Grant
- 1993-07-29 EP EP99107148A patent/EP0955062B1/de not_active Revoked
- 1993-07-29 DK DK99107148T patent/DK0955062T3/da active
- 1993-07-29 CA CA002489978A patent/CA2489978A1/en not_active Abandoned
- 1993-07-30 MX MX9304613A patent/MX9304613A/es active IP Right Grant
-
2000
- 2000-12-27 GR GR20000402832T patent/GR3035144T3/el unknown
-
2006
- 2006-10-16 JP JP2006280928A patent/JP2007045841A/ja not_active Withdrawn
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK0955062T3 (da) | Vandig formulering indeholdende humant væksthormon | |
FI933393A0 (fi) | Agglomererade hydrofila komplex med flerfasiga frigoeringsegenskaper | |
IL126463A0 (en) | A pharmaceutical formulation containing growth hormone an amino acid and a non-ionic detergent | |
CZ307715A3 (cs) | Způsob lyofilizace vodné farmaceutické formulace faktoru VIII prosté albuminu | |
ATE203411T1 (de) | Lagerstabile wässrige pharmazeutische zubereitungen von g-csf | |
MX9710206A (es) | Composicion farmaceutica de amiodarone para administracion parenteral. | |
CA2226548A1 (en) | Lyophilized hepatocyte growth factor preparations | |
GR3032546T3 (en) | Use of azoles as virucidal agents in solutions of biologically active proteins | |
ES2138053T3 (es) | Formulacion insecticida solida. | |
DK248987A (da) | Farmaceutiske praeparater til forbedring af sammensaetningen af lipider i blod | |
KR950700743A (ko) | 프로스타사이클린류를 활성성분으로서 함유하는 외용 피부치료제 조성물(dermatologic preparation composition containing prostacyclin as active ingredient) | |
FI880027A (fi) | Antibakteriellt lyofiliserat preparat. | |
SE8400971L (sv) | Profylaktiskt och lekande medel for arterioskleros | |
GB2021581A (en) | Stabilisation of PGl2 derivatives | |
EP0509098A4 (en) | Ataractic | |
EP0456988A3 (en) | Use of naproxen as mydriatic agent | |
ITMI920760U1 (it) | Struttura di utensile del tipo fresca o simile particolarmente per l'esecuzione di interventi chirurgici di implantollogia odontoiatrica | |
IT1255237B (it) | Composizione farmaceuticaidrofila ad attivita' antiinfiammatoria |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8363 | Opposition against the patent |