CA1223831A
(en)
|
1982-06-23 |
1987-07-07 |
Dean Engelhardt |
Modified nucleotides, methods of preparing and utilizing and compositions containing the same
|
US5646042A
(en)
*
|
1992-08-26 |
1997-07-08 |
Ribozyme Pharmaceuticals, Inc. |
C-myb targeted ribozymes
|
US5891684A
(en)
*
|
1992-10-15 |
1999-04-06 |
Ribozyme Pharmaceuticals, Inc. |
Base-modified enzymatic nucleic acid
|
US5616488A
(en)
*
|
1992-12-07 |
1997-04-01 |
Ribozyme Pharmaceuticals, Inc. |
IL-5 targeted ribozymes
|
US5612215A
(en)
*
|
1992-12-07 |
1997-03-18 |
Ribozyme Pharmaceuticals, Inc. |
Stromelysin targeted ribozymes
|
US5837542A
(en)
*
|
1992-12-07 |
1998-11-17 |
Ribozyme Pharmaceuticals, Inc. |
Intercellular adhesion molecule-1 (ICAM-1) ribozymes
|
US5658780A
(en)
*
|
1992-12-07 |
1997-08-19 |
Ribozyme Pharmaceuticals, Inc. |
Rel a targeted ribozymes
|
US5811300A
(en)
*
|
1992-12-07 |
1998-09-22 |
Ribozyme Pharmaceuticals, Inc. |
TNF-α ribozymes
|
DK0748382T3
(da)
*
|
1993-09-02 |
2003-02-17 |
Ribozyme Pharm Inc |
Enzymatisk nukleinsyre indeholdende ikke-nukleotid
|
AU7623194A
(en)
*
|
1993-09-03 |
1995-03-22 |
Vpi Holdings Ltd. |
Oligonucleotides with rna cleavage activity
|
US5861288A
(en)
*
|
1993-10-18 |
1999-01-19 |
Ribozyme Pharmaceuticals, Inc. |
Catalytic DNA
|
AU8088694A
(en)
*
|
1993-10-27 |
1995-05-22 |
Ribozyme Pharmaceuticals, Inc. |
2'-amido and 2'-peptido modified oligonucleotides
|
CA2176035A1
(en)
*
|
1993-11-08 |
1995-05-18 |
Nassim Usman |
Base-modified enzymatic nucleic acid
|
US5631359A
(en)
*
|
1994-10-11 |
1997-05-20 |
Ribozyme Pharmaceuticals, Inc. |
Hairpin ribozymes
|
US5693532A
(en)
*
|
1994-11-04 |
1997-12-02 |
Ribozyme Pharmaceuticals, Inc. |
Respiratory syncytial virus ribozymes
|
US5639647A
(en)
|
1994-03-29 |
1997-06-17 |
Ribozyme Pharmaceuticals, Inc. |
2'-deoxy-2'alkylnucleotide containing nucleic acid
|
US6103890A
(en)
*
|
1994-05-18 |
2000-08-15 |
Ribozyme Pharmaceuticals, Inc. |
Enzymatic nucleic acids that cleave C-fos
|
US5633133A
(en)
*
|
1994-07-14 |
1997-05-27 |
Long; David M. |
Ligation with hammerhead ribozymes
|
US5599706A
(en)
*
|
1994-09-23 |
1997-02-04 |
Stinchcomb; Dan T. |
Ribozymes targeted to apo(a) mRNA
|
US5700923A
(en)
*
|
1994-09-29 |
1997-12-23 |
Hybridon, Inc. |
Finderons and methods of their preparation and use
|
US5650502A
(en)
*
|
1994-11-09 |
1997-07-22 |
Hybridon, Inc. |
Ribozyme analogs having rigid non-nucleotidic linkers
|
US5672501A
(en)
*
|
1994-12-23 |
1997-09-30 |
Ribozyme Pharmaceuticals, Inc. |
Base-modified enzymatic nucleic acid
|
US5716824A
(en)
*
|
1995-04-20 |
1998-02-10 |
Ribozyme Pharmaceuticals, Inc. |
2'-O-alkylthioalkyl and 2-C-alkylthioalkyl-containing enzymatic nucleic acids (ribozymes)
|
US5545729A
(en)
*
|
1994-12-22 |
1996-08-13 |
Hybridon, Inc. |
Stabilized ribozyme analogs
|
US5705388A
(en)
*
|
1994-12-23 |
1998-01-06 |
Ribozyme Pharmaceuticals, Inc. |
CETP Ribozymes
|
US5663064A
(en)
*
|
1995-01-13 |
1997-09-02 |
University Of Vermont |
Ribozymes with RNA protein binding site
|
US5877021A
(en)
|
1995-07-07 |
1999-03-02 |
Ribozyme Pharmaceuticals, Inc. |
B7-1 targeted ribozymes
|
US20030207837A1
(en)
*
|
1995-07-07 |
2003-11-06 |
Ribozyme Pharmaceuticals, Inc. |
Method and reagent for the induction of graft tolerance and reversal of immune responses
|
US6346398B1
(en)
|
1995-10-26 |
2002-02-12 |
Ribozyme Pharmaceuticals, Inc. |
Method and reagent for the treatment of diseases or conditions related to levels of vascular endothelial growth factor receptor
|
US7034009B2
(en)
|
1995-10-26 |
2006-04-25 |
Sirna Therapeutics, Inc. |
Enzymatic nucleic acid-mediated treatment of ocular diseases or conditions related to levels of vascular endothelial growth factor receptor (VEGF-R)
|
JP2000501284A
(ja)
*
|
1995-11-14 |
2000-02-08 |
ビムラックス ホールディングズ,リミテッド |
Rna切断活性を有するキメラオリゴマー
|
US5998203A
(en)
|
1996-04-16 |
1999-12-07 |
Ribozyme Pharmaceuticals, Inc. |
Enzymatic nucleic acids containing 5'-and/or 3'-cap structures
|
US6274369B1
(en)
*
|
1996-02-02 |
2001-08-14 |
Invitrogen Corporation |
Method capable of increasing competency of bacterial cell transformation
|
US5807743A
(en)
*
|
1996-12-03 |
1998-09-15 |
Ribozyme Pharmaceuticals, Inc. |
Interleukin-2 receptor gamma-chain ribozymes
|
US6248878B1
(en)
|
1996-12-24 |
2001-06-19 |
Ribozyme Pharmaceuticals, Inc. |
Nucleoside analogs
|
DK0971946T3
(da)
*
|
1997-01-21 |
2006-10-30 |
Gen Hospital Corp |
Selektion af proteiner ved anvendelse af RNA-protein-fusioner
|
US6057156A
(en)
|
1997-01-31 |
2000-05-02 |
Robozyme Pharmaceuticals, Inc. |
Enzymatic nucleic acid treatment of diseases or conditions related to levels of epidermal growth factor receptors
|
US6159951A
(en)
*
|
1997-02-13 |
2000-12-12 |
Ribozyme Pharmaceuticals Inc. |
2'-O-amino-containing nucleoside analogs and polynucleotides
|
US6251666B1
(en)
|
1997-03-31 |
2001-06-26 |
Ribozyme Pharmaceuticals, Inc. |
Nucleic acid catalysts comprising L-nucleotide analogs
|
US5942395A
(en)
*
|
1997-05-09 |
1999-08-24 |
Universite De Montreal |
Hybrid ribozymes and methods of use
|
US6548657B1
(en)
|
1997-06-09 |
2003-04-15 |
Ribozyme Pharmaceuticals, Inc. |
Method for screening nucleic acid catalysts
|
US6280936B1
(en)
|
1997-06-09 |
2001-08-28 |
Ribozyme Pharmaceuticals, Inc. |
Method for screening nucleic acid catalysts
|
US6183959B1
(en)
|
1997-07-03 |
2001-02-06 |
Ribozyme Pharmaceuticals, Inc. |
Method for target site selection and discovery
|
US6316612B1
(en)
|
1997-08-22 |
2001-11-13 |
Ribozyme Pharmaceuticals, Inc. |
Xylofuranosly-containing nucleoside phosphoramidites and polynucleotides
|
CA2304813A1
(en)
*
|
1997-09-22 |
1999-04-08 |
Fritz Eckstein |
Nucleic acid catalysts with endonuclease activity
|
US6656731B1
(en)
|
1997-09-22 |
2003-12-02 |
Max Planck Gesellschaft Zur Forderung Der Wissenschaften E.V. |
Nucleic acid catalysts with endonuclease activity
|
US6054576A
(en)
*
|
1997-10-02 |
2000-04-25 |
Ribozyme Pharmaceuticals, Inc. |
Deprotection of RNA
|
US6617438B1
(en)
|
1997-11-05 |
2003-09-09 |
Sirna Therapeutics, Inc. |
Oligoribonucleotides with enzymatic activity
|
US6127535A
(en)
|
1997-11-05 |
2000-10-03 |
Ribozyme Pharmaceuticals, Inc. |
Nucleoside triphosphates and their incorporation into oligonucleotides
|
US20020147143A1
(en)
|
1998-03-18 |
2002-10-10 |
Corixa Corporation |
Compositions and methods for the therapy and diagnosis of lung cancer
|
WO1999050277A1
(en)
|
1998-03-28 |
1999-10-07 |
University Of Utah Research Foundation |
Circular, hairpin, circular/hairpin, lariat, and hairpin-lariat hammerhead ribozymes
|
EP1071753A2
(de)
|
1998-04-20 |
2001-01-31 |
Ribozyme Pharmaceuticals, Inc. |
Nukeinsäure moleküle mit einer neuen chemischen zusammensetzung die fähig sind die expression von gene zu modulieren
|
US6995259B1
(en)
|
1998-10-23 |
2006-02-07 |
Sirna Therapeutics, Inc. |
Method for the chemical synthesis of oligonucleotides
|
AU4807400A
(en)
|
1999-04-30 |
2000-11-17 |
University Of Florida |
Adeno-associated virus-delivered ribozyme compositions and methods of use
|
US6831171B2
(en)
|
2000-02-08 |
2004-12-14 |
Yale University |
Nucleic acid catalysts with endonuclease activity
|
US7833992B2
(en)
|
2001-05-18 |
2010-11-16 |
Merck Sharpe & Dohme |
Conjugates and compositions for cellular delivery
|
US7491805B2
(en)
|
2001-05-18 |
2009-02-17 |
Sirna Therapeutics, Inc. |
Conjugates and compositions for cellular delivery
|
US8202979B2
(en)
|
2002-02-20 |
2012-06-19 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid
|
US8273866B2
(en)
|
2002-02-20 |
2012-09-25 |
Merck Sharp & Dohme Corp. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SINA)
|
US20070026394A1
(en)
|
2000-02-11 |
2007-02-01 |
Lawrence Blatt |
Modulation of gene expression associated with inflammation proliferation and neurite outgrowth using nucleic acid based technologies
|
US20040002068A1
(en)
|
2000-03-01 |
2004-01-01 |
Corixa Corporation |
Compositions and methods for the detection, diagnosis and therapy of hematological malignancies
|
JP2004513615A
(ja)
|
2000-06-28 |
2004-05-13 |
コリクサ コーポレイション |
肺癌の治療および診断のための組成物および方法
|
US8568766B2
(en)
|
2000-08-24 |
2013-10-29 |
Gattadahalli M. Anantharamaiah |
Peptides and peptide mimetics to treat pathologies associated with eye disease
|
US7125660B2
(en)
*
|
2000-09-13 |
2006-10-24 |
Archemix Corp. |
Nucleic acid sensor molecules and methods of using same
|
CA2418724A1
(en)
*
|
2000-09-13 |
2002-03-21 |
Archemix Corporation |
Target activated nucleic acid biosensor and methods of using same
|
AU2001296846B2
(en)
|
2000-10-12 |
2007-07-05 |
University Of Rochester |
Compositions that inhibit proliferation of cancer cells
|
CA2441071C
(en)
|
2001-03-14 |
2010-06-22 |
Myriad Genetics, Inc. |
Tsg101-gag interaction and use thereof
|
JP2005504513A
(ja)
|
2001-05-09 |
2005-02-17 |
コリクサ コーポレイション |
前立腺癌の治療及び診断のための組成物及び方法
|
US20050148530A1
(en)
|
2002-02-20 |
2005-07-07 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
|
EP1572067A4
(de)
|
2001-05-18 |
2009-05-13 |
Sirna Therapeutics Inc |
Konjugate und zusammensetzungen für die zelluläre freisetzung
|
US7109165B2
(en)
|
2001-05-18 |
2006-09-19 |
Sirna Therapeutics, Inc. |
Conjugates and compositions for cellular delivery
|
US9994853B2
(en)
|
2001-05-18 |
2018-06-12 |
Sirna Therapeutics, Inc. |
Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference
|
US7205399B1
(en)
|
2001-07-06 |
2007-04-17 |
Sirna Therapeutics, Inc. |
Methods and reagents for oligonucleotide synthesis
|
ES2405790T3
(es)
|
2001-12-17 |
2013-06-03 |
Corixa Corporation |
Composiciones y métodos para la terapia y el diagnóstico de enfermedad inflamatoria del intestino
|
DE60332756D1
(de)
|
2002-02-06 |
2010-07-08 |
Vicor Technologies Inc |
Anti-infarkt-moleküle
|
US20050042632A1
(en)
*
|
2002-02-13 |
2005-02-24 |
Sirna Therapeutics, Inc. |
Antibodies having specificity for nucleic acids
|
US9181551B2
(en)
|
2002-02-20 |
2015-11-10 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
US9657294B2
(en)
|
2002-02-20 |
2017-05-23 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
AU2003207708A1
(en)
|
2002-02-20 |
2003-09-09 |
Sirna Therapeutics, Inc. |
Rna interference mediated inhibition of map kinase genes
|
WO2003093452A2
(en)
*
|
2002-02-26 |
2003-11-13 |
University Of Utah Research Foundation |
Variants of nedd4l associated with hypertension and viral budding
|
US20030195164A1
(en)
*
|
2002-04-16 |
2003-10-16 |
Veli-Matti Kahari |
Novel ribozyme and its use
|
US6989442B2
(en)
|
2002-07-12 |
2006-01-24 |
Sirna Therapeutics, Inc. |
Deprotection and purification of oligonucleotides and their derivatives
|
US7655790B2
(en)
|
2002-07-12 |
2010-02-02 |
Sirna Therapeutics, Inc. |
Deprotection and purification of oligonucleotides and their derivatives
|
CA2495478A1
(en)
|
2002-08-05 |
2004-02-12 |
University Of Rochester |
Protein transducing domain/deaminase chimeric proteins, related compounds, and uses thereof
|
US7956176B2
(en)
|
2002-09-05 |
2011-06-07 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
US20080260744A1
(en)
|
2002-09-09 |
2008-10-23 |
Omeros Corporation |
G protein coupled receptors and uses thereof
|
EP1578767A4
(de)
*
|
2002-12-04 |
2008-01-09 |
Algos Therapeutics Inc |
Verfahren und materialien zur modulation von trpm2
|
ES2428628T3
(es)
*
|
2002-12-12 |
2013-11-08 |
Novartis Vaccines And Diagnostics, Inc. |
Dispositivo y método para pruebas de sangre en línea usando biochips
|
EP1622572B1
(de)
|
2003-04-30 |
2017-12-20 |
Sirna Therapeutics, Inc. |
Konjugate und zusammensetzungen für die zelluläre abgabe
|
JP2005017116A
(ja)
*
|
2003-06-26 |
2005-01-20 |
Sharp Corp |
光学式エンコーダ用受光素子
|
US20060019914A1
(en)
|
2004-02-11 |
2006-01-26 |
University Of Tennessee Research Foundation |
Inhibition of tumor growth and invasion by anti-matrix metalloproteinase DNAzymes
|
EP1735009A4
(de)
|
2004-03-12 |
2011-03-30 |
Alnylam Pharmaceuticals Inc |
Irna mittel targeting vegf
|
CA2557532A1
(en)
|
2004-04-23 |
2005-11-10 |
Angela M. Christiano |
Inhibition of hairless protein mrna
|
US20060040882A1
(en)
|
2004-05-04 |
2006-02-23 |
Lishan Chen |
Compostions and methods for enhancing delivery of nucleic acids into cells and for modifying expression of target genes in cells
|
US10508277B2
(en)
|
2004-05-24 |
2019-12-17 |
Sirna Therapeutics, Inc. |
Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference
|
AU2005272920B2
(en)
|
2004-08-10 |
2011-05-12 |
Institute For Multiple Myeloma And Bone Cancer Research |
Methods of regulating differentiation and treating of multiple myeloma
|
US7568565B2
(en)
*
|
2004-08-17 |
2009-08-04 |
Nes Technologies, Inc |
Device, a system and a method for transferring vibrational energy
|
EP1831235B1
(de)
|
2004-12-16 |
2013-02-20 |
The Regents of The University of California |
Arzneimittel für die lungen
|
US8129124B2
(en)
|
2005-02-02 |
2012-03-06 |
The Uab Research Foundation |
Agents and methods related to reducing resistance to apoptosis-inducing death receptor agonists
|
EP2551282A3
(de)
|
2005-03-23 |
2013-02-13 |
Genmab A/S |
Antikörper gegen CD38 zur Behandling von multiplem Myelom
|
PL1866414T3
(pl)
|
2005-03-31 |
2012-10-31 |
Calando Pharmaceuticals Inc |
Inhibitory podjednostki 2 reduktazy rybonukleotydowej i ich zastosowania
|
EP2062980B1
(de)
|
2005-06-28 |
2011-08-31 |
Medtronic, Inc. |
Verfahren und Nukleotid-Sequenzen, die bevorzugt die Expression eines mutierten Huntingtin-Genes unterdrücken
|
WO2007044607A2
(en)
*
|
2005-10-06 |
2007-04-19 |
Emthrax, Llc |
Methods and compositions relating to anthrax spore glycoproteins as vaccines
|
US8080534B2
(en)
|
2005-10-14 |
2011-12-20 |
Phigenix, Inc |
Targeting PAX2 for the treatment of breast cancer
|
EP1934331A4
(de)
|
2005-10-14 |
2009-01-21 |
Musc Found For Res Dev |
Pax2 als ziel für die induktion von defb1-vermittelter tumorimmunität und krebstherapie
|
CN103215293B
(zh)
|
2006-01-27 |
2015-10-28 |
比奥根Ma公司 |
Nogo受体拮抗剂
|
KR101547579B1
(ko)
|
2006-03-31 |
2015-08-27 |
알닐람 파마슈티칼스 인코포레이티드 |
Eg5 유전자의 발현을 억제하는 이본쇄 리보핵산
|
EP2010226B1
(de)
|
2006-04-07 |
2014-01-15 |
The Research Foundation of State University of New York |
Transcobalaminrezeptor-Polypeptide, -Nukleinsäuren und -Modulatoren sowie entsprechende Verfahren zur Verwendung für die Modulation von Zellwachstum und die Behandlung von Krebs und Cobalaminmangel
|
US8598333B2
(en)
|
2006-05-26 |
2013-12-03 |
Alnylam Pharmaceuticals, Inc. |
SiRNA silencing of genes expressed in cancer
|
EP2471815B1
(de)
|
2006-07-11 |
2016-03-30 |
University Of Medicine And Dentistry Of New Jersey |
Proteine, Nukleinsäuren zu deren Kodierung und entsprechende Verwendungsverfahren
|
AU2007297535C1
(en)
|
2006-09-21 |
2017-11-23 |
University Of Florida Research Foundation, Inc. |
Compositions and methods related to protein displacement therapy for myotonic distrophy
|
EP2099467B1
(de)
|
2006-10-03 |
2017-05-10 |
University Of Medicine And Dentistry Of New Jersey |
Atap-proteine, für diese kodierende nukleinsäuren und entsprechende verwendungsverfahren
|
WO2008067040A2
(en)
|
2006-10-06 |
2008-06-05 |
University Of Utah Research Foundation |
Method of detecting ocular diseases and pathologic conditions and treatment of same
|
EP2061901A2
(de)
|
2006-10-31 |
2009-05-27 |
Noxxon Pharma AG |
Verfahren zum nachweis eines einzel- oder doppelsträngigen nukleinsäuremoleküls
|
WO2008136852A2
(en)
|
2006-11-01 |
2008-11-13 |
University Of Rochester |
Methods and compositions related to the structure and function of apobec3g
|
CA2672297A1
(en)
|
2006-12-11 |
2008-06-19 |
University Of Utah Research Foundation |
Compositions and methods for treating pathologic angiogenesis and vascular permeability
|
US20100129358A1
(en)
|
2006-12-22 |
2010-05-27 |
University Of Utah Research Foundation |
Method of detecting ocular diseases and pathologic conditions and treatment of same
|
LT2494993T
(lt)
|
2007-05-04 |
2018-12-27 |
Marina Biotech, Inc. |
Aminorūgščių lipidai ir jų panaudojimas
|
DK2682400T5
(da)
|
2007-08-28 |
2017-11-27 |
Uab Research Foundation |
Syntetiske apolipoprotein E-efterlignende polypeptider og fremgangsmåder til anvendelse
|
JP2010537638A
(ja)
|
2007-08-28 |
2010-12-09 |
ユーエービー リサーチ ファウンデーション |
合成アポリポ蛋白質e模倣ポリペプチドおよび使用方法
|
US8183221B2
(en)
|
2007-09-05 |
2012-05-22 |
Medtronic, Inc. |
Suppression of SCN9A gene expression and/or function for the treatment of pain
|
CA2706317C
(en)
|
2007-12-03 |
2017-06-13 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Doc1 compositions and methods for treating cancer
|
CA2910760C
(en)
|
2007-12-04 |
2019-07-09 |
Muthiah Manoharan |
Targeting lipids
|
EP2224912B1
(de)
|
2008-01-02 |
2016-05-11 |
TEKMIRA Pharmaceuticals Corporation |
Verbesserte zusammensetzungen und verfahren zur freisetzung von nukleinsäuren
|
US20090233993A1
(en)
*
|
2008-03-06 |
2009-09-17 |
Burnham Institute For Medical Research |
Compositions and methods for inhibiting gsk3 activity and uses thereof
|
CA2720473A1
(en)
|
2008-04-04 |
2009-10-08 |
Calando Pharmaceuticals, Inc. |
Compositions and use of epas1 inhibitors
|
NZ588583A
(en)
|
2008-04-15 |
2012-08-31 |
Protiva Biotherapeutics Inc |
Novel lipid formulations for nucleic acid delivery
|
EP2280995A2
(de)
*
|
2008-04-29 |
2011-02-09 |
Wyeth LLC |
Verfahren zur behandlung von entzündungen
|
EP2288922B1
(de)
|
2008-05-08 |
2016-08-17 |
University of Utah Research Foundation |
Sensorische rezeptoren für chronische müdigkeit und schmerzen und verwendungen dafür
|
ATE550024T1
(de)
|
2008-05-30 |
2012-04-15 |
Univ Yale |
Gezielte oligonucleotid-zusammensetzungen zur modifizierung der genexpression
|
EP2633864A1
(de)
|
2008-07-25 |
2013-09-04 |
The Regents of the University of Colorado |
Clip-Hemmer und Verfahren zur Modulation der Immunfunktion
|
EP3025727A1
(de)
|
2008-10-02 |
2016-06-01 |
The J. David Gladstone Institutes |
Verfahren zur behandlung von lebererkrankungen
|
WO2010042877A1
(en)
|
2008-10-09 |
2010-04-15 |
Tekmira Pharmaceuticals Corporation |
Improved amino lipids and methods for the delivery of nucleic acids
|
AU2009305639B2
(en)
|
2008-10-16 |
2016-06-23 |
Marina Biotech, Inc. |
Processes and compositions for liposomal and efficient delivery of gene silencing therapeutics
|
EP3199553B1
(de)
|
2008-10-29 |
2019-04-24 |
Circular Commitment Company |
Methoden und mittel zur diagnose und behandlung von hepatozellulärem karzinom
|
KR20220150995A
(ko)
|
2008-11-10 |
2022-11-11 |
알닐람 파마슈티칼스 인코포레이티드 |
치료제 운반용 신규 지질 및 조성물
|
EP2370080A1
(de)
|
2008-12-02 |
2011-10-05 |
University of Utah Research Foundation |
Pde1 als zieltherapeutikum bei herzkrankheiten
|
CA2751342C
(en)
|
2009-01-29 |
2019-05-07 |
Alnylam Pharmaceuticals, Inc. |
Lipid formulations comprising cationic lipid and a targeting lipid comprising n-acetyl galactosamine for delivery of nucleic acid
|
US20100215660A1
(en)
|
2009-02-23 |
2010-08-26 |
Sarwar Hashmi |
Kruppel-like factors and fat regulation
|
EP2756845B1
(de)
|
2009-04-03 |
2017-03-15 |
Dicerna Pharmaceuticals, Inc. |
Verfahren und Zusammensetzungen für spezifische KRAS-Hemmung mit asymmetrischer Doppelstrang-RNA
|
EP3199165B1
(de)
|
2009-04-03 |
2022-06-08 |
Dicerna Pharmaceuticals, Inc. |
Verfahren und zusammensetzungen für spezifische kras-hemmung mit asymmetrischer doppelstrang-rna
|
PT2417257E
(pt)
|
2009-04-10 |
2016-06-03 |
Universität Bern |
Oligonucleótidos triciclo-dna anti-sentido, composições, e métodos para o tratamento de doença
|
CN102481378A
(zh)
|
2009-04-13 |
2012-05-30 |
法国健康和医学研究院 |
Hpv颗粒及其用途
|
AU2010245933B2
(en)
|
2009-05-05 |
2016-06-16 |
Arbutus Biopharma Corporation |
Methods of delivering oligonucleotides to immune cells
|
SG10201402054UA
(en)
|
2009-05-05 |
2014-09-26 |
Muthiah Manoharan |
Lipid compositions
|
US9080186B2
(en)
|
2009-05-16 |
2015-07-14 |
Agave Pharma, Incorporated |
Compositions comprising cationic amphiphiles and colipids for delivering therapeutic molecules
|
CN104873464B
(zh)
|
2009-06-10 |
2018-06-22 |
阿布特斯生物制药公司 |
改进的脂质制剂
|
US8283333B2
(en)
|
2009-07-01 |
2012-10-09 |
Protiva Biotherapeutics, Inc. |
Lipid formulations for nucleic acid delivery
|
US20110060000A1
(en)
|
2009-09-10 |
2011-03-10 |
Maurizio Grimaldi |
Acridine analogs in the treatment of gliomas
|
WO2011039646A2
(en)
|
2009-09-30 |
2011-04-07 |
Inserm (Institut National De La Sante Et De La Recherche Medicale) |
Papilloma virus -like particles for targeted gene delivery
|
US8450090B2
(en)
|
2009-10-06 |
2013-05-28 |
The Regents Of The University Of Colorado, A Body Corporate |
Compositions and methods for promoting fatty acid production in plants
|
US20120270930A1
(en)
|
2009-10-29 |
2012-10-25 |
Academisch Ziekenhuis Leiden H.O.D.N. Lumc |
Methods and compositions for dysferlin exon-skipping
|
CA3044884A1
(en)
|
2009-12-07 |
2011-06-16 |
Arbutus Biopharma Corporation |
Compositions for nucleic acid delivery
|
US20130017223A1
(en)
|
2009-12-18 |
2013-01-17 |
The University Of British Columbia |
Methods and compositions for delivery of nucleic acids
|
EA201201113A1
(ru)
|
2010-02-10 |
2013-03-29 |
Новартис Аг |
Способы и соединения для роста мышц
|
US9714446B2
(en)
|
2010-02-11 |
2017-07-25 |
Nanostring Technologies, Inc. |
Compositions and methods for the detection of small RNAs
|
US20110207789A1
(en)
|
2010-02-19 |
2011-08-25 |
Ye Fang |
Methods related to casein kinase ii (ck2) inhibitors and the use of purinosome-disrupting ck2 inhibitors for anti-cancer therapy agents
|
WO2011119842A1
(en)
|
2010-03-25 |
2011-09-29 |
The J. David Gladstone Institutes |
Compositions and methods for treating neurological disorders
|
WO2011120023A1
(en)
|
2010-03-26 |
2011-09-29 |
Marina Biotech, Inc. |
Nucleic acid compounds for inhibiting survivin gene expression uses thereof
|
WO2011133584A2
(en)
|
2010-04-19 |
2011-10-27 |
Marina Biotech, Inc. |
Nucleic acid compounds for inhibiting hras gene expression and uses thereof
|
SG184876A1
(en)
|
2010-04-23 |
2012-11-29 |
Univ Florida |
Raav-guanylate cyclase compositions and methods for treating leber's congenital amaurosis-1 (lca1)
|
US20130190383A1
(en)
|
2010-04-26 |
2013-07-25 |
Marina Biotech, Inc. |
Nucleic acid compounds with conformationally restricted monomers and uses thereof
|
WO2011139843A2
(en)
|
2010-04-28 |
2011-11-10 |
Marina Biotech, Inc. |
Multi-sirna compositions for reducing gene expression
|
CA3146952A1
(en)
|
2010-07-06 |
2012-01-12 |
Dicerna Pharmaceuticals, Inc. |
Methods and compositions for the specific inhibition of beta-catenin by double-stranded rna
|
US10064885B2
(en)
|
2010-07-09 |
2018-09-04 |
Massachusetts Institute Of Technology |
Metabolic gene, enzyme, and flux targets for cancer therapy
|
WO2012016188A2
(en)
|
2010-07-30 |
2012-02-02 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for delivery of active agents
|
WO2012016184A2
(en)
|
2010-07-30 |
2012-02-02 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for delivery of active agents
|
KR20130137160A
(ko)
|
2010-08-24 |
2013-12-16 |
머크 샤프 앤드 돔 코포레이션 |
내부의 비-핵산 스페이서를 함유하는 단일-가닥 RNAi 작용제
|
SG188666A1
(en)
|
2010-09-30 |
2013-05-31 |
Agency Science Tech & Res |
Methods and reagents for detection and treatment of esophageal metaplasia
|
EP2632472B1
(de)
|
2010-10-29 |
2017-12-13 |
Sirna Therapeutics, Inc. |
Durch rna-interferenz vermittelte inhibition einer genexpression unter verwendung von short-interfering-nukleinsäuren (sina)
|
US9072766B2
(en)
|
2010-11-18 |
2015-07-07 |
Beth Israel Deaconess Medical Center, Inc. |
Methods of treating obesity by inhibiting nicotinamide N-methyl transferase (NNMT)
|
WO2012099755A1
(en)
|
2011-01-11 |
2012-07-26 |
Alnylam Pharmaceuticals, Inc. |
Pegylated lipids and their use for drug delivery
|
JP5972283B2
(ja)
|
2011-01-11 |
2016-08-17 |
フェイト セラピューティクス,インコーポレイテッド |
新規のWnt組成物およびそのような組成物の治療的使用
|
AU2012304358B2
(en)
|
2011-09-07 |
2017-07-20 |
Marina Biotech Inc. |
Synthesis and uses of nucleic acid compounds with conformationally restricted monomers
|
WO2013049328A1
(en)
|
2011-09-27 |
2013-04-04 |
Alnylam Pharmaceuticals, Inc. |
Di-aliphatic substituted pegylated lipids
|
US9738727B2
(en)
|
2011-10-14 |
2017-08-22 |
Genentech, Inc. |
Anti-HtrA1 antibodies and methods of use
|
EP2766501B1
(de)
|
2011-10-14 |
2020-01-01 |
Accugenomics, Inc. |
Quantitative Nukleinsäureamplifikation
|
DK2790736T3
(en)
|
2011-12-12 |
2018-05-07 |
Oncoimmunin Inc |
In vivo delivery of oligonucleotides
|
US9562072B2
(en)
|
2011-12-27 |
2017-02-07 |
The J. David Gladstone Institutes |
Compositions and methods for regulating glucose metabolism
|
WO2013119877A1
(en)
|
2012-02-07 |
2013-08-15 |
Aura Biosciences, Inc. |
Virion-derived nanospheres for selective delivery of therapeutic and diagnostic agents to cancer cells
|
KR102239887B1
(ko)
|
2012-02-24 |
2021-04-13 |
아뷰터스 바이오파마 코포레이션 |
트리알킬 양이온성 지질 및 그의 사용 방법
|
EP3553181A1
(de)
|
2012-05-25 |
2019-10-16 |
Accugenomics, Inc. |
Nukleinsäureamplifikation und anwendung davon
|
KR101520383B1
(ko)
|
2012-08-02 |
2015-05-15 |
에이비온 주식회사 |
Hpv 감염과 관련된 암의 치료용 조성물
|
WO2014143643A1
(en)
|
2013-03-15 |
2014-09-18 |
The Regents Of The University Of California, A California Corporation |
Acyclic nucleoside phosphonate diesters
|
DK3444350T3
(da)
|
2013-07-03 |
2022-02-07 |
Dicerna Pharmaceuticals Inc |
Fremgangsmåder og sammensætninger til specifik hæmning af alpha-1 antitrypsin ved dobbeltstrenget rna
|
DK3019200T3
(da)
|
2013-07-11 |
2022-06-20 |
Alnylam Pharmaceuticals Inc |
Oligonukleotid-ligand-konjugater og fremgangsmåde til fremstiling deraf
|
US9163284B2
(en)
|
2013-08-09 |
2015-10-20 |
President And Fellows Of Harvard College |
Methods for identifying a target site of a Cas9 nuclease
|
PL3046583T3
(pl)
|
2013-09-18 |
2019-10-31 |
Aura Biosciences Inc |
Koniugaty cząstek wirusopodobnych do leczenia nowotworów
|
PT3049085T
(pt)
|
2013-09-26 |
2021-10-01 |
Beth Israel Deaconess Medical Ct Inc |
Inibidores de sgk1 no tratamento da síndrome do qt longo
|
US9365610B2
(en)
|
2013-11-18 |
2016-06-14 |
Arcturus Therapeutics, Inc. |
Asymmetric ionizable cationic lipid for RNA delivery
|
AU2014348212C1
(en)
|
2013-11-18 |
2018-11-29 |
Arcturus Therapeutics, Inc. |
Ionizable cationic lipid for RNA delivery
|
US10772974B2
(en)
|
2013-11-18 |
2020-09-15 |
Beth Israel Deaconess Medical Center, Inc. |
Compositions and methods for cardiac regeneration
|
RU2744194C2
(ru)
|
2013-12-02 |
2021-03-03 |
Фио Фармасьютикалс Корп |
Иммунотерапия рака
|
US20150176076A1
(en)
|
2013-12-20 |
2015-06-25 |
Acetylon Pharmaceuticals, Inc. |
Histone deacetylase 6 (hdac6) biomarkers in multiple myeloma
|
ES2749855T3
(es)
|
2013-12-27 |
2020-03-24 |
Dicerna Pharmaceuticals Inc |
Procedimientos y composiciones para la inhibición específica de glicolato oxidasa (hao1) por ARN bicatenario
|
US9458464B2
(en)
|
2014-06-23 |
2016-10-04 |
The Johns Hopkins University |
Treatment of neuropathic pain
|
US10077453B2
(en)
|
2014-07-30 |
2018-09-18 |
President And Fellows Of Harvard College |
CAS9 proteins including ligand-dependent inteins
|
BR112017001860A2
(pt)
|
2014-07-31 |
2018-02-27 |
Uab Research Foundation |
peptídeo sintético, composição farmacêutica, métodos, regime de dosagem, e, anticorpo monoclonal
|
SI3194411T1
(sl)
|
2014-09-15 |
2022-07-29 |
The Regents Of The University Of California |
Nukleotidni analogi
|
AU2015330670B2
(en)
|
2014-10-10 |
2022-01-06 |
Novo Nordisk Health Care Ag |
Therapeutic inhibition of lactate dehydrogenase and agents therefor
|
EP3206751A4
(de)
|
2014-10-14 |
2018-06-13 |
The J. David Gladstone Institutes |
Zusammensetzungen und verfahren zur reaktivierung von latentem immundefizienzvirus
|
CN107207428A
(zh)
|
2014-11-18 |
2017-09-26 |
阿克丘勒斯治疗公司 |
用于rna递送的可电离阳离子脂质
|
ES2747842T3
(es)
|
2014-12-15 |
2020-03-11 |
Dicerna Pharmaceuticals Inc |
Acidos nucleicos de doble hebra modificados por ligando
|
US11273167B2
(en)
|
2015-08-03 |
2022-03-15 |
The Regents Of The University Of California |
Compositions and methods for modulating ABHD2 activity
|
EP3350191B9
(de)
|
2015-09-15 |
2021-12-22 |
The Regents of the University of California |
Nukleotidanaloga
|
KR102440160B1
(ko)
|
2015-10-30 |
2022-09-02 |
제넨테크, 인크. |
항-HtrA1 항체 및 이의 사용 방법
|
CN108473950A
(zh)
|
2015-10-30 |
2018-08-31 |
美国政府卫生与公众服务部 |
靶向癌症治疗
|
MA45471A
(fr)
|
2016-04-01 |
2019-02-06 |
Avidity Biosciences Llc |
Acides nucléiques de phosphatidylinositol-3-kinase et leurs utilisations
|
MA45468A
(fr)
|
2016-04-01 |
2019-02-06 |
Avidity Biosciences Llc |
Acides nucléiques myc et utilisations
|
MA45328A
(fr)
|
2016-04-01 |
2019-02-06 |
Avidity Biosciences Llc |
Compositions acide nucléique-polypeptide et utilisations de celles-ci
|
MA45470A
(fr)
|
2016-04-01 |
2019-02-06 |
Avidity Biosciences Llc |
Acides nucléiques kras et leurs utilisations
|
MA45349A
(fr)
|
2016-04-01 |
2019-02-06 |
Avidity Biosciences Llc |
Acides nucléiques egfr et leurs utilisations
|
MA45469A
(fr)
|
2016-04-01 |
2019-02-06 |
Avidity Biosciences Llc |
Acides nucléiques de bêta-caténine et leurs utilisations
|
EP3463388A4
(de)
|
2016-05-24 |
2020-01-01 |
Emory University |
Partikel mit rna-spaltenden nukleobasenpolymeren und verwendungen zur behandlung von entzündlichen erkrankungen
|
US11123435B2
(en)
|
2016-08-03 |
2021-09-21 |
H. Lee Moffitt Cancer Center And Research Institute, Inc. |
TLR9 targeted therapeutics
|
CA3033327A1
(en)
|
2016-08-09 |
2018-02-15 |
President And Fellows Of Harvard College |
Programmable cas9-recombinase fusion proteins and uses thereof
|
CA3034094A1
(en)
|
2016-08-16 |
2018-02-22 |
Bluebird Bio, Inc. |
Il-10 receptor alpha homing endonuclease variants, compositions, and methods of use
|
EP3504335A4
(de)
|
2016-08-23 |
2020-04-15 |
Bluebird Bio, Inc. |
Tim3-homing-endonuklease-varianten, zusammensetzungen und verfahren zur verwendung
|
KR102622910B1
(ko)
|
2016-09-08 |
2024-01-10 |
2세븐티 바이오, 인코포레이티드 |
Pd-1 호밍 엔도뉴클레아제 변이체, 조성물 및 사용 방법
|
AU2017362484B2
(en)
|
2016-11-17 |
2021-12-16 |
2Seventy Bio, Inc. |
TGFβ signal convertor
|
US10383952B2
(en)
|
2016-12-21 |
2019-08-20 |
Arcturus Therapeutics, Inc. |
Ionizable cationic lipid for RNA delivery
|
WO2018119163A1
(en)
|
2016-12-21 |
2018-06-28 |
Payne Joseph E |
Ionizable cationic lipid for rna delivery
|
US10526284B2
(en)
|
2016-12-21 |
2020-01-07 |
Arcturus Therapeutics, Inc. |
Ionizable cationic lipid for RNA delivery
|
WO2018119359A1
(en)
|
2016-12-23 |
2018-06-28 |
President And Fellows Of Harvard College |
Editing of ccr5 receptor gene to protect against hiv infection
|
MX2019008199A
(es)
|
2017-01-06 |
2019-11-25 |
Avidity Biosciences Llc |
Composiciones de acido nucleico polipeptido y metodos de induccion de la omision de exon.
|
WO2018152325A1
(en)
|
2017-02-15 |
2018-08-23 |
Bluebird Bio, Inc. |
Donor repair templates multiplex genome editing
|
US11898179B2
(en)
|
2017-03-09 |
2024-02-13 |
President And Fellows Of Harvard College |
Suppression of pain by gene editing
|
GB201711809D0
(en)
|
2017-07-21 |
2017-09-06 |
Governors Of The Univ Of Alberta |
Antisense oligonucleotide
|
CN111801345A
(zh)
|
2017-07-28 |
2020-10-20 |
哈佛大学的校长及成员们 |
使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物
|
WO2019139645A2
(en)
|
2017-08-30 |
2019-07-18 |
President And Fellows Of Harvard College |
High efficiency base editors comprising gam
|
US11306312B2
(en)
|
2017-09-01 |
2022-04-19 |
Thomas Jefferson University |
Compositions and methods for MYC messenger RNA inhibitors
|
MA50753A
(fr)
|
2017-10-04 |
2020-08-12 |
Avidity Biosciences Inc |
Compositions d'acide nucléique-polypeptide et utilisations de celles-ci
|
WO2019079347A1
(en)
|
2017-10-16 |
2019-04-25 |
The Broad Institute, Inc. |
USES OF BASIC EDITORS ADENOSINE
|
EP3720448A4
(de)
|
2017-12-06 |
2021-11-03 |
Avidity Biosciences, Inc. |
Zusammensetzungen und verfahren zur behandlung von muskelatrophie und myotonischer dystrophie
|
US11685906B2
(en)
|
2018-12-06 |
2023-06-27 |
Arcturus Therapeutics, Inc. |
Compositions and methods for treating ornithine transcarbamylase deficiency
|
JP2022513482A
(ja)
|
2018-12-21 |
2022-02-08 |
アビディティー バイオサイエンシーズ,インク. |
抗トランスフェリン受容体抗体およびその使用
|
KR20210143230A
(ko)
|
2019-03-19 |
2021-11-26 |
더 브로드 인스티튜트, 인코퍼레이티드 |
뉴클레오티드 서열을 편집하기 위한 방법 및 조성물
|
WO2020210751A1
(en)
|
2019-04-12 |
2020-10-15 |
The Broad Institute, Inc. |
System for genome editing
|
EP3980436A4
(de)
|
2019-06-06 |
2023-12-20 |
Avidity Biosciences, Inc. |
Nukleinsäurepolypeptidzusammensetzungen und verwendungen davon
|
ES2918001A2
(es)
|
2019-08-14 |
2022-07-13 |
Acuitas Therapeutics Inc |
Nanoparticulas lipidicas mejoradas para el suministro de acidos nucleicos
|
CN115666589A
(zh)
|
2020-03-19 |
2023-01-31 |
艾维迪提生物科学公司 |
治疗面肩肱型肌营养不良的组合物和方法
|
CN115697418A
(zh)
|
2020-03-27 |
2023-02-03 |
艾维迪提生物科学公司 |
治疗肌营养不良的组合物和方法
|
CN116096873A
(zh)
|
2020-05-08 |
2023-05-09 |
布罗德研究所股份有限公司 |
同时编辑靶标双链核苷酸序列的两条链的方法和组合物
|
IL302594A
(en)
|
2020-11-09 |
2023-07-01 |
1E Therapeutics Ltd |
Methods based on catalytic sequences for the treatment or prevention of bacterial infections
|
CN116829715A
(zh)
|
2020-12-18 |
2023-09-29 |
耶达研究及发展有限公司 |
用于治疗chd2单倍体不足的组合物及其识别方法
|
EP4267741A2
(de)
|
2020-12-28 |
2023-11-01 |
1E Therapeutics, Ltd. |
P21-mrna-zielbereiche zum silencing
|
EP4267742A2
(de)
|
2020-12-28 |
2023-11-01 |
1E Therapeutics, Ltd. |
Auf p21-mrna abzielende dnazyme
|
IL307298A
(en)
|
2021-03-31 |
2023-11-01 |
Entrada Therapeutics Inc |
Cell-penetrating circular peptides
|
WO2022235586A1
(en)
|
2021-05-03 |
2022-11-10 |
Astellas Institute For Regenerative Medicine |
Methods of generating mature corneal endothelial cells
|
IL308353A
(en)
|
2021-05-10 |
2024-01-01 |
Entrada Therapeutics Inc |
Compositions and methods for modulating tissue distribution of intracellular therapies
|
WO2022240721A1
(en)
|
2021-05-10 |
2022-11-17 |
Entrada Therapeutics, Inc. |
Compositions and methods for modulating interferon regulatory factor-5 (irf-5) activity
|
CA3217463A1
(en)
|
2021-05-10 |
2022-11-17 |
Ziqing QIAN |
Compositions and methods for modulating mrna splicing
|
CN117730149A
(zh)
|
2021-06-14 |
2024-03-19 |
2赛文缇生物公司 |
单链rna纯化方法
|
AU2022298774A1
(en)
|
2021-06-23 |
2023-12-14 |
Entrada Therapeutics, Inc. |
Antisense compounds and methods for targeting cug repeats
|
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(en)
|
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2023-02-09 |
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1'-alkyl modified ribose derivatives and methods of use
|
CA3231330A1
(en)
|
2021-09-16 |
2023-03-23 |
Avidity Biosciences, Inc. |
Compositions and methods of treating facioscapulohumeral muscular dystrophy
|
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(en)
|
2021-09-22 |
2023-08-03 |
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2'-alkyl or 3'- alkyl modified ribose derivatives and methods of use
|
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(en)
|
2021-10-05 |
2024-04-11 |
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Polyhydroxylated cyclopentane derivatives and methods of use
|
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(en)
|
2022-01-31 |
2023-08-03 |
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Ionizable cationic lipids for lipid nanoparticles
|
WO2023144792A1
(en)
|
2022-01-31 |
2023-08-03 |
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Poly(alkyloxazoline)-lipid conjugates and lipid particles containing same
|
US20230346819A1
(en)
|
2022-02-22 |
2023-11-02 |
Sanegene Bio Usa Inc. |
5'-modified carbocyclic ribonucleotide derivatives and methods of use
|
WO2024015796A1
(en)
|
2022-07-11 |
2024-01-18 |
Sanegene Bio Usa Inc. |
Optimized 2'- modified ribose derivatives and methods of use
|